IL262061B2 - Chimeric flt-3 receptors and methods of using them - Google Patents

Chimeric flt-3 receptors and methods of using them

Info

Publication number
IL262061B2
IL262061B2 IL262061A IL26206118A IL262061B2 IL 262061 B2 IL262061 B2 IL 262061B2 IL 262061 A IL262061 A IL 262061A IL 26206118 A IL26206118 A IL 26206118A IL 262061 B2 IL262061 B2 IL 262061B2
Authority
IL
Israel
Prior art keywords
seq
region
amino acid
heavy chain
light chain
Prior art date
Application number
IL262061A
Other languages
English (en)
Hebrew (he)
Other versions
IL262061A (en
IL262061B (en
Original Assignee
Amgen Inc
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Kite Pharma Inc filed Critical Amgen Inc
Publication of IL262061A publication Critical patent/IL262061A/en
Publication of IL262061B publication Critical patent/IL262061B/en
Publication of IL262061B2 publication Critical patent/IL262061B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C12N15/09—Recombinant DNA-technology
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2510/00—Genetically modified cells

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  • Proteomics, Peptides & Aminoacids (AREA)
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IL262061A 2016-04-01 2017-03-31 Chimeric flt-3 receptors and methods of using them IL262061B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317219P 2016-04-01 2016-04-01
PCT/US2017/025613 WO2017173410A1 (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof

Publications (3)

Publication Number Publication Date
IL262061A IL262061A (en) 2018-11-29
IL262061B IL262061B (en) 2022-11-01
IL262061B2 true IL262061B2 (en) 2023-03-01

Family

ID=58530714

Family Applications (2)

Application Number Title Priority Date Filing Date
IL296966A IL296966A (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof
IL262061A IL262061B2 (en) 2016-04-01 2017-03-31 Chimeric flt-3 receptors and methods of using them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL296966A IL296966A (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof

Country Status (26)

Country Link
US (2) US20190183931A1 (OSRAM)
EP (1) EP3436479A1 (OSRAM)
JP (3) JP2019516352A (OSRAM)
KR (2) KR102694879B1 (OSRAM)
CN (1) CN109641956A (OSRAM)
AR (2) AR109626A1 (OSRAM)
AU (3) AU2017240801A1 (OSRAM)
BR (1) BR112018070187A8 (OSRAM)
CA (1) CA3019655A1 (OSRAM)
CL (1) CL2018002792A1 (OSRAM)
CO (1) CO2018011804A2 (OSRAM)
CR (2) CR20180518A (OSRAM)
EA (1) EA201892193A1 (OSRAM)
IL (2) IL296966A (OSRAM)
MA (1) MA44507A (OSRAM)
MX (1) MX2023013729A (OSRAM)
MY (2) MY210545A (OSRAM)
NZ (1) NZ746925A (OSRAM)
PE (2) PE20241061A1 (OSRAM)
PH (1) PH12018502118B1 (OSRAM)
SA (1) SA518400154B1 (OSRAM)
SG (2) SG10201911963VA (OSRAM)
TN (1) TN2018000337A1 (OSRAM)
TW (2) TW202313669A (OSRAM)
UA (1) UA128326C2 (OSRAM)
WO (1) WO2017173410A1 (OSRAM)

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