JP2019515888A5 - - Google Patents
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- Publication number
- JP2019515888A5 JP2019515888A5 JP2018551293A JP2018551293A JP2019515888A5 JP 2019515888 A5 JP2019515888 A5 JP 2019515888A5 JP 2018551293 A JP2018551293 A JP 2018551293A JP 2018551293 A JP2018551293 A JP 2018551293A JP 2019515888 A5 JP2019515888 A5 JP 2019515888A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dexamethasone
- patient
- cellular immunotherapy
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 26
- 229960003957 dexamethasone Drugs 0.000 claims description 15
- 239000003862 glucocorticoid Substances 0.000 claims description 13
- 229960004618 prednisone Drugs 0.000 claims description 4
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims 32
- 238000009169 immunotherapy Methods 0.000 claims 15
- 230000001413 cellular effect Effects 0.000 claims 14
- 210000004698 lymphocyte Anatomy 0.000 claims 13
- 238000011467 adoptive cell therapy Methods 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 230000000779 depleting effect Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 210000000987 immune system Anatomy 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 230000001093 anti-cancer Effects 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 210000004324 lymphatic system Anatomy 0.000 claims 4
- 238000001959 radiotherapy Methods 0.000 claims 4
- 238000009825 accumulation Methods 0.000 claims 3
- 229940125721 immunosuppressive agent Drugs 0.000 claims 3
- 239000003018 immunosuppressive agent Substances 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000013462 Interleukin-12 Human genes 0.000 claims 2
- 108010065805 Interleukin-12 Proteins 0.000 claims 2
- 102000003812 Interleukin-15 Human genes 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102000000704 Interleukin-7 Human genes 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 238000002659 cell therapy Methods 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- PIDANAQULIKBQS-RNUIGHNZSA-N meprednisone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)CC2=O PIDANAQULIKBQS-RNUIGHNZSA-N 0.000 claims 1
- 229960001810 meprednisone Drugs 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 3
- 229960002537 betamethasone Drugs 0.000 description 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 2
- 241001416152 Bos frontalis Species 0.000 description 1
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762480414P | 2017-04-01 | 2017-04-01 | |
| US62/480,414 | 2017-04-01 | ||
| US201862613697P | 2018-01-04 | 2018-01-04 | |
| US62/613,697 | 2018-01-04 | ||
| US201862624454P | 2018-01-31 | 2018-01-31 | |
| US62/624,454 | 2018-01-31 | ||
| PCT/US2018/025517 WO2018183927A1 (en) | 2017-04-01 | 2018-03-30 | Replacement of cytotoxic preconditioning before cellular immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020049116A Division JP7162632B2 (ja) | 2017-04-01 | 2020-03-19 | 細胞免疫療法前の細胞毒性プレコンディショニングの代替 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019515888A JP2019515888A (ja) | 2019-06-13 |
| JP2019515888A5 true JP2019515888A5 (cg-RX-API-DMAC7.html) | 2019-11-28 |
| JP6748221B2 JP6748221B2 (ja) | 2020-08-26 |
Family
ID=62111173
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551293A Active JP6748221B2 (ja) | 2017-04-01 | 2018-03-30 | 細胞免疫療法前の細胞毒性プレコンディショニングの代替 |
| JP2020049116A Active JP7162632B2 (ja) | 2017-04-01 | 2020-03-19 | 細胞免疫療法前の細胞毒性プレコンディショニングの代替 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020049116A Active JP7162632B2 (ja) | 2017-04-01 | 2020-03-19 | 細胞免疫療法前の細胞毒性プレコンディショニングの代替 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11219628B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3490605B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6748221B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102509006B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110475571B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018243753A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019020214A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3054443A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2954311T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL269209B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2019011679A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201907744QA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018183927A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
| WO2025019711A2 (en) * | 2023-07-19 | 2025-01-23 | Dermtech, Inc. | Predicting therapeutic response based on biomarker signatures |
| BR112019020214A2 (pt) | 2017-04-01 | 2020-04-22 | Avm Biotechnology Llc | substituição do pré-condicionamento citotóxico antes da imunoterapia celular |
| CA3066361A1 (en) | 2017-06-07 | 2018-12-13 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
| EP3710076B1 (en) | 2017-11-13 | 2023-12-27 | Shifamed Holdings, LLC | Intravascular fluid movement devices, systems, and methods of use |
| CN112004563B (zh) | 2018-02-01 | 2024-08-06 | 施菲姆德控股有限责任公司 | 血管内血泵以及使用和制造方法 |
| WO2019204462A2 (en) | 2018-04-17 | 2019-10-24 | Celldex Therapeutics, Inc. | Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs |
| US12161857B2 (en) | 2018-07-31 | 2024-12-10 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| EP3488851A1 (en) * | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
| EP3632446B3 (en) | 2018-10-03 | 2024-01-24 | AVM Biotechnology, LLC | Immunoablative therapies |
| WO2020073047A1 (en) | 2018-10-05 | 2020-04-09 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| BR112021009365A2 (pt) * | 2018-11-14 | 2021-08-10 | Avm Biotechnology, Llc | formulação de glicocorticoide estável |
| EP3880216B1 (en) * | 2018-11-16 | 2025-04-09 | Rapa Therapeutics, LLC | Methods for treating cancer with manufactured t cells |
| WO2020123444A1 (en) * | 2018-12-11 | 2020-06-18 | Celldex Therapeutics, Inc. | Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy |
| JP2022540616A (ja) | 2019-07-12 | 2022-09-16 | シファメド・ホールディングス・エルエルシー | 血管内血液ポンプならびに製造および使用の方法 |
| WO2021016372A1 (en) | 2019-07-22 | 2021-01-28 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
| US12465748B2 (en) | 2019-08-07 | 2025-11-11 | Supira Medical, Inc. | Catheter blood pumps and collapsible pump housings |
| WO2021062260A1 (en) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible blood conduits |
| EP4034192B1 (en) | 2019-09-25 | 2025-12-24 | Supira Medical, Inc. | Intravascular blood pump systems and methods of use and control thereof |
| EP4501393A3 (en) | 2019-09-25 | 2025-04-09 | Shifamed Holdings, LLC | Catheter blood pumps and collapsible pump housings |
| IL292665B1 (en) * | 2019-11-06 | 2025-10-01 | Kite Pharma Inc | Chimeric antigen receptor T cell therapy |
| EP4072650A4 (en) | 2019-12-11 | 2024-01-10 | Shifamed Holdings, LLC | Descending aorta and vena cava blood pumps |
| CN113189340A (zh) * | 2020-01-14 | 2021-07-30 | 中国医学科学院基础医学研究所 | 细胞焦亡通路在细胞治疗中的用途 |
| US12252701B2 (en) | 2020-02-20 | 2025-03-18 | Kite Pharma, Inc. | Chimeric antigen receptor T cell therapy |
| BR112022016803A2 (pt) | 2020-02-28 | 2022-11-08 | Avm Biotechnology Llc | População de linfócitos e métodos para produzir os mesmos |
| CN111443210B (zh) * | 2020-04-10 | 2023-09-22 | 青海大学附属医院 | 泡型包虫病早期诊疗生物标志物及其应用 |
| CN115989038A (zh) * | 2020-04-10 | 2023-04-18 | 北卡罗莱纳州立大学 | 使用材料支架的增强的哺乳动物细胞病毒转导 |
| BR112022021691A2 (pt) | 2020-04-29 | 2022-12-20 | Avm Biotechnology Llc | Moduladores de receptor de glicocorticoide (gr) para tratar um vírus sars-cov-2 |
| KR20230018422A (ko) | 2020-06-01 | 2023-02-07 | 에이브이엠 바이오테크놀로지, 엘엘씨 | Icam-조절제를 이용한 치료 방법 |
| CN113797313A (zh) * | 2020-06-11 | 2021-12-17 | 华北制药集团新药研究开发有限责任公司 | 卡非佐米作为冠状病毒广谱抑制剂的新用途 |
| EP4208538A4 (en) * | 2020-09-01 | 2023-11-08 | The National Institute for Biotechnology in the Negev Ltd. | Immune system restoration by cell therapy |
| CN113322233A (zh) * | 2021-04-19 | 2021-08-31 | 格源致善(上海)生物科技有限公司 | 一种改进的基于新生抗原反应性t细胞的制备方法及应用 |
| EP4326286A4 (en) * | 2021-04-23 | 2025-03-12 | Myeloid Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR CONDITIONING PATIENTS FOR CELL THERAPY |
| CN116063401B (zh) * | 2021-08-13 | 2023-12-01 | 中国人民解放军总医院 | 阻断型靶向pd-l1的超高亲和力小蛋白及用途 |
| JP2024533093A (ja) | 2021-09-01 | 2024-09-12 | エーブイエム・バイオテクノロジー・エルエルシー | リンパ球集団およびその産生方法 |
| CN114031678A (zh) * | 2021-12-08 | 2022-02-11 | 中国科学院新疆理化技术研究所 | 一种条斑钳蝎毒素多肽组分的制备方法及其应用 |
| CN114767828A (zh) * | 2022-04-25 | 2022-07-22 | 中国人民解放军海军军医大学 | 伊沙佐米在制备抗蜱传脑炎病毒、西尼罗病毒、黄热病毒和基孔肯雅热病毒感染药物中的应用 |
| CN115785203B (zh) * | 2022-06-10 | 2024-03-12 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标10及其用途 |
| CN116606352B (zh) * | 2023-07-14 | 2023-09-29 | 诺赛联合(北京)生物医学科技有限公司 | 一种抗菌修复功能的组合物凝胶在妇科疾病中的应用 |
| KR20250139235A (ko) | 2025-07-15 | 2025-09-23 | 김종구 | V-aemi 기반 인공지능 감정 음악 창작 시스템 및 그 방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
| GB9323199D0 (en) | 1993-11-10 | 1994-01-05 | Falkenberg J H F | Leukaemia treatment |
| DE69739210D1 (de) | 1997-12-16 | 2009-02-26 | Univ Zuerich | Diagnostik für übertragbare spongiforme Enzephalopathie |
| US6406699B1 (en) | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
| US20030099621A1 (en) * | 2001-11-29 | 2003-05-29 | Robert Chow | Stem cell screening and transplantation therapy for HIV infection |
| IL146970A0 (en) | 2001-12-06 | 2002-08-14 | Yeda Res & Dev | Migration of haematopoietic stem cells and progenitor cells to the liver |
| EP1499347A2 (en) | 2002-03-15 | 2005-01-26 | Department of Veterans Affairs, Rehabilitation R&D Service | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
| KR100822149B1 (ko) | 2002-05-17 | 2008-04-15 | 셀진 코포레이션 | 암 및 기타 질병의 치료 및 관리를 위해 면역 조절화합물을 이용하는 방법 및 조성물 |
| GB0310593D0 (en) | 2003-05-08 | 2003-06-11 | Leuven K U Res & Dev | Peptidic prodrugs |
| US20040247574A1 (en) | 2003-05-27 | 2004-12-09 | Christopherson Kent W. | Methods for enhancing stem cell engraftment during transplantation |
| WO2006071778A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| PL1874821T3 (pl) * | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Kombinacja przeciwciał i glikokortykoidów do leczenia raka |
| RU2486204C2 (ru) | 2005-07-22 | 2013-06-27 | Уай'З Терапьютикс Ко., Лтд. | Антитела против сd26 и способы их применения |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| GB0700058D0 (en) | 2007-01-03 | 2007-02-07 | Scancell Aps | Anti-tumor vaccine based on normal cells |
| CA2677214A1 (en) | 2007-02-01 | 2008-08-07 | Nephrogen, Llc | Potentiation of stem cell homing and treatment of organ dysfunction or organ failure |
| EP2288387B1 (en) * | 2008-05-23 | 2013-02-13 | Argos Therapeutics, Inc. | Novel soluble cd83 polypeptides, formulations and methods of use |
| US20090299269A1 (en) | 2008-05-29 | 2009-12-03 | John Foley | Vascular stimulation to aid intravascular cell replacement therapy |
| WO2009152186A1 (en) | 2008-06-09 | 2009-12-17 | American Stem Cell, Inc. | Methods for enhancing cell therapy efficacy including treatment with cd26 peptidase inhibitors |
| ES2627043T3 (es) | 2008-06-09 | 2017-07-26 | Targazyme, Inc. | Aumento de la eficacia de la terapia celular incluyendo tratamiento con alfa 1-3 fucoslitransferasa |
| US20100055107A1 (en) * | 2008-07-31 | 2010-03-04 | Defu Zeng | Methods for preventing hematological malignancies and graft versus host disease by anti-cd3 preconditioning |
| US10426740B1 (en) * | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
| WO2012024519A2 (en) * | 2010-08-18 | 2012-02-23 | Theresa Deisher | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| JP2014509841A (ja) | 2011-01-18 | 2014-04-24 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 癌を治療するための組成物および方法 |
| EP2532740A1 (en) | 2011-06-11 | 2012-12-12 | Michael Schmück | Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy |
| US10421960B2 (en) | 2011-09-16 | 2019-09-24 | The Trustees Of The University Of Pennsylvania | RNA engineered T cells for the treatment of cancer |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| PL3888674T3 (pl) * | 2014-04-07 | 2024-09-23 | Novartis Ag | Leczenie nowotworu złośliwego z zastosowaniem chimerycznego receptora antygenowego anty-CD19 |
| US20180002427A1 (en) * | 2015-01-26 | 2018-01-04 | Cellectis | Cll1-specific multi-chain chimeric antigen receptor |
| IL312426B1 (en) | 2015-05-28 | 2025-10-01 | Kite Pharma Inc | Methods for training patients for T-cell therapy |
| EP3548047A4 (en) * | 2016-11-30 | 2020-07-01 | Intrexon Corporation | ADMINISTRATION OF STEROIDS AND IMMUNOTHERAPY |
| BR112019020214A2 (pt) | 2017-04-01 | 2020-04-22 | Avm Biotechnology Llc | substituição do pré-condicionamento citotóxico antes da imunoterapia celular |
| EP3488851A1 (en) * | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
-
2018
- 2018-03-30 BR BR112019020214A patent/BR112019020214A2/pt unknown
- 2018-03-30 CA CA3054443A patent/CA3054443A1/en active Pending
- 2018-03-30 AU AU2018243753A patent/AU2018243753A1/en not_active Abandoned
- 2018-03-30 EP EP18722262.5A patent/EP3490605B1/en active Active
- 2018-03-30 WO PCT/US2018/025517 patent/WO2018183927A1/en not_active Ceased
- 2018-03-30 ES ES18722262T patent/ES2954311T3/es active Active
- 2018-03-30 MX MX2019011679A patent/MX2019011679A/es unknown
- 2018-03-30 SG SG11201907744QA patent/SG11201907744QA/en unknown
- 2018-03-30 JP JP2018551293A patent/JP6748221B2/ja active Active
- 2018-03-30 CN CN201880021900.0A patent/CN110475571B/zh active Active
- 2018-03-30 KR KR1020197031661A patent/KR102509006B1/ko active Active
- 2018-03-30 IL IL269209A patent/IL269209B2/en unknown
- 2018-05-10 US US15/976,630 patent/US11219628B2/en active Active
-
2020
- 2020-03-19 JP JP2020049116A patent/JP7162632B2/ja active Active
-
2021
- 2021-12-06 US US17/542,712 patent/US20220160729A1/en active Pending
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