JP2019513761A5 - - Google Patents
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- JP2019513761A5 JP2019513761A5 JP2018553102A JP2018553102A JP2019513761A5 JP 2019513761 A5 JP2019513761 A5 JP 2019513761A5 JP 2018553102 A JP2018553102 A JP 2018553102A JP 2018553102 A JP2018553102 A JP 2018553102A JP 2019513761 A5 JP2019513761 A5 JP 2019513761A5
- Authority
- JP
- Japan
- Prior art keywords
- fibrosis
- pharmaceutical composition
- composition according
- cholangitis
- tgfβ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305425.7 | 2016-04-11 | ||
| EP16305425 | 2016-04-11 | ||
| PCT/EP2017/055878 WO2017178172A1 (en) | 2016-04-11 | 2017-03-13 | Methods of treatment for cholestatic and fibrotic diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513761A JP2019513761A (ja) | 2019-05-30 |
| JP2019513761A5 true JP2019513761A5 (https=) | 2020-03-26 |
| JP6894923B2 JP6894923B2 (ja) | 2021-06-30 |
Family
ID=55755536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553102A Active JP6894923B2 (ja) | 2016-04-11 | 2017-03-13 | 胆汁うっ滞性及び線維性の疾患の処置方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US20170290812A1 (https=) |
| EP (3) | EP3777854B1 (https=) |
| JP (1) | JP6894923B2 (https=) |
| KR (1) | KR102431257B1 (https=) |
| CN (1) | CN109069648B (https=) |
| AU (1) | AU2017249602B2 (https=) |
| DK (2) | DK3777855T3 (https=) |
| EA (2) | EA201892298A1 (https=) |
| ES (3) | ES2935185T3 (https=) |
| HR (1) | HRP20201954T1 (https=) |
| HU (2) | HUE052886T2 (https=) |
| IL (1) | IL262052B (https=) |
| LT (1) | LT3442580T (https=) |
| MD (1) | MD3442580T2 (https=) |
| MX (1) | MX384261B (https=) |
| MY (1) | MY195437A (https=) |
| PH (1) | PH12018502142B1 (https=) |
| PL (1) | PL3442580T3 (https=) |
| PT (2) | PT3442580T (https=) |
| SG (2) | SG11201808402RA (https=) |
| SI (1) | SI3442580T1 (https=) |
| WO (1) | WO2017178172A1 (https=) |
| ZA (1) | ZA201807389B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6894923B2 (ja) | 2016-04-11 | 2021-06-30 | ジェンフィＧｅｎｆｉｔ | 胆汁うっ滞性及び線維性の疾患の処置方法 |
| JP2019513762A (ja) * | 2016-04-11 | 2019-05-30 | ジェンフィＧｅｎｆｉｔ | 胆汁うっ滞及び線維症の処置方法 |
| WO2018167103A1 (en) | 2017-03-13 | 2018-09-20 | Genfit | Pharmaceutical compositions for combination therapy |
| BR112019019519A2 (pt) * | 2017-03-21 | 2020-04-22 | Novalead Pharma Inc | agente terapêutico para a inibição de fosfodiesterase e seus distúrbios relacionados |
| JP7365054B2 (ja) * | 2017-11-17 | 2023-10-19 | ケスター，ヒューバート | リンパ管平滑筋腫症及びその他の疾患に使用するための［２－［（５－ニトロ－１，３－チアゾール－２－イル）カルバモイル］フェニル］エタノエート |
| EP3639822A1 (en) * | 2018-10-15 | 2020-04-22 | Universität Regensburg | Compound for use in the treatment of a disease characterized by dysregulated mucus production and/or secretion |
| JP7631217B2 (ja) | 2019-04-10 | 2025-02-18 | ジェンフィット | 式（ｉ）の化合物及びｇｌｐ－１受容体アゴニストを含む組合せ療法 |
| CA3130518A1 (en) * | 2019-04-12 | 2020-10-15 | Nicolas STANKOVIC-VALENTIN | Nitazoxanide and thiazolides for use in the treatment of diseases associated with oxidative stress |
| CN110205302B (zh) * | 2019-06-24 | 2021-03-23 | 扬州大学 | 一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用 |
| CN110478357A (zh) * | 2019-07-23 | 2019-11-22 | 哈尔滨医科大学 | 硝唑尼特及其体内代谢物在抗肥胖、降血脂、抗脂肪肝及抗动脉粥样硬化中的应用 |
| CN110368498A (zh) * | 2019-08-26 | 2019-10-25 | 瑞希(重庆)生物科技有限公司 | 一种促进伤口愈合的制剂及其制备方法 |
| JP7741800B2 (ja) | 2019-10-28 | 2025-09-18 | ジェンフィット | 抗酸化性質を有する併用療法 |
| CN113398125B (zh) * | 2020-03-16 | 2024-05-03 | 绍兴君科臻元医药科技有限公司 | 替唑尼特药物组合物及其医药用途 |
| KR20230110284A (ko) * | 2020-11-17 | 2023-07-21 | 장피트 | 간부전 치료 방법 |
| CN116507343A (zh) * | 2020-11-17 | 2023-07-28 | 基恩菲特公司 | 治疗肝衰竭的方法 |
| CN115197164B (zh) * | 2021-04-12 | 2025-04-01 | 杜心赟 | 新型噻唑类化合物及其制备方法和用途 |
| AU2022271607A1 (en) * | 2021-05-11 | 2023-10-26 | Genfit | Nitazoxanide in the treatment of sepsis |
| CN116077502B (zh) * | 2021-11-05 | 2025-12-23 | 广州医科大学附属妇女儿童医疗中心 | 叶酸在预防、诊断和治疗胆道闭锁中的应用 |
| AU2023355753A1 (en) * | 2022-10-04 | 2025-04-03 | Genfit | Nitazoxanide for the treatment of hepatic impairment |
| CN116911513B (zh) * | 2023-02-07 | 2024-07-26 | 中国药科大学 | 硝唑尼特及其体内代谢物替唑尼特在制备抗心衰药物中的应用 |
| WO2025063816A1 (ko) * | 2023-09-21 | 2025-03-27 | 오토텔릭바이오 주식회사 | 티아졸 유도체 화합물을 포함하는 자궁 섬유화증 치료용 조성물 |
| CN117838690B (zh) * | 2023-10-09 | 2024-09-13 | 中国药科大学 | 一种治疗以ampk激活为治疗靶点的疾病的复方药物及其应用 |
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| GB1437800A (en) | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| GB1440212A (en) | 1973-08-29 | 1976-06-23 | Phavic Sprl | Derivatives of 2-phenoxyacetamido-5-nitrothiazoles |
| US5968961A (en) | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5965590A (en) | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| MX9604483A (es) | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5935591A (en) | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
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| WO2002051442A1 (en) | 2000-12-26 | 2002-07-04 | Takeda Chemical Industries, Ltd. | Concomitant drugs |
| ZA200602755B (en) | 2003-09-06 | 2007-06-27 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
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| EP1971594A2 (en) | 2005-11-21 | 2008-09-24 | Biogen Idec MA Inc. | Substituted pyrazalones |
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| GB0619500D0 (en) | 2006-10-03 | 2006-11-08 | Univ Keele | Treatment of fibrosis |
| ES2550755T3 (es) | 2007-08-03 | 2015-11-12 | Romark Laboratories, L.C. | Compuestos de tiazolida sustituidos con alquilsulfonilo |
| US20110177999A1 (en) * | 2007-08-09 | 2011-07-21 | Vertex Pharmaceuticals Incorporated | Therapeutic Combinations Useful in Treating CFTR Related Diseases |
| KR101045572B1 (ko) | 2007-08-14 | 2011-07-01 | 주식회사 엘지화학 | Ｃｌｏｓｔｒｉｄｉｕｍ ｐｒｏｐｉｏｎｉｃｕｍ 유래의프로피오닐―ＣｏＡ 트랜스퍼라아제 변이체 및 상기변이체를 이용한 락테이트 중합체 또는 락테이트공중합체의 제조방법 |
| JP5715820B2 (ja) | 2007-09-18 | 2015-05-13 | スタンフォード ユニバーシティー | フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物 |
| US9149463B2 (en) * | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| US20100016262A1 (en) | 2007-10-18 | 2010-01-21 | Yale University | Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis |
| EP2408449A4 (en) * | 2009-03-18 | 2012-08-08 | Univ Leland Stanford Junior | METHOD AND COMPOSITIONS FOR TREATING FLAVIVIRIDAE VIRUS INFECTIONS |
| NZ596538A (en) | 2009-05-12 | 2014-04-30 | Romark Lab Lc | Haloalkyl heteroaryl benzamide compounds |
| CN108042535A (zh) | 2009-06-26 | 2018-05-18 | 罗马克实验室有限公司 | 用于治疗流感的化合物和方法 |
| KR101961601B1 (ko) | 2009-11-16 | 2019-03-25 | 유니버시티 오브 조지아 리서치 파운데이션, 인코포레이티드 | 바이러스 감염 치료를 위한 ２＇―플루오로―６＇―메틸렌 카보사이클릭 뉴클레오사이드 및 방법 |
| US8816074B2 (en) | 2009-11-16 | 2014-08-26 | University of Georgia Foundation, Inc. | 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections |
| CA2798330A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
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| US8697739B2 (en) | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
| EP2609095A4 (en) | 2010-08-27 | 2014-06-18 | Calcimedica Inc | COMPOUNDS MODULATING INTRACELLULAR CALCIUM |
| AU2011323682B2 (en) | 2010-11-01 | 2016-06-23 | Romark Laboratories L.C. | Alkylsulfinyl-substituted thiazolide compounds |
| EP2680859B1 (en) | 2011-03-02 | 2022-04-27 | Jerome Schentag | Compositions, methods of treatment and diagnostics for treatment of hepatic steatosis alone or in combination with a hepatitis c virus infection |
| CN107096032A (zh) | 2011-05-16 | 2017-08-29 | 罗马克实验室有限公司 | 在有需要的对象中刺激免疫应答的方法 |
| WO2013059677A1 (en) | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| AU2013202269A1 (en) * | 2011-10-26 | 2013-05-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| WO2013082469A2 (en) | 2011-12-02 | 2013-06-06 | University Of Vermont And State Agricultural College | Methods and compositions for treating infections |
| EP2890370B1 (en) | 2012-08-31 | 2019-10-09 | The Regents of the University of California | Agents useful for treating obesity, diabetes and related disorders |
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| US9974767B2 (en) | 2014-07-14 | 2018-05-22 | University Of Washington | Statins in the treatment of muscular dystrophies and myopathies |
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| US20190070154A1 (en) | 2015-06-24 | 2019-03-07 | Duke University | New methods of use for an anti-diarrhea agent |
| KR102410951B1 (ko) | 2016-04-11 | 2022-06-20 | 장피트 | 담즙정체성 및 섬유증 질환의 치료 방법 |
| JP2019513762A (ja) | 2016-04-11 | 2019-05-30 | ジェンフィＧｅｎｆｉｔ | 胆汁うっ滞及び線維症の処置方法 |
| JP6894923B2 (ja) | 2016-04-11 | 2021-06-30 | ジェンフィＧｅｎｆｉｔ | 胆汁うっ滞性及び線維性の疾患の処置方法 |
-
2017
- 2017-03-13 JP JP2018553102A patent/JP6894923B2/ja active Active
- 2017-03-13 HU HUE17710285A patent/HUE052886T2/hu unknown
- 2017-03-13 HR HRP20201954TT patent/HRP20201954T1/hr unknown
- 2017-03-13 SG SG11201808402RA patent/SG11201808402RA/en unknown
- 2017-03-13 ES ES20194458T patent/ES2935185T3/es active Active
- 2017-03-13 EP EP20194454.3A patent/EP3777854B1/en active Active
- 2017-03-13 ES ES20194454T patent/ES2928408T3/es active Active
- 2017-03-13 WO PCT/EP2017/055878 patent/WO2017178172A1/en not_active Ceased
- 2017-03-13 PL PL17710285T patent/PL3442580T3/pl unknown
- 2017-03-13 LT LTEP17710285.2T patent/LT3442580T/lt unknown
- 2017-03-13 HU HUE20194458A patent/HUE060671T2/hu unknown
- 2017-03-13 PT PT177102852T patent/PT3442580T/pt unknown
- 2017-03-13 EA EA201892298A patent/EA201892298A1/ru unknown
- 2017-03-13 DK DK20194458.4T patent/DK3777855T3/da active
- 2017-03-13 CN CN201780023160.XA patent/CN109069648B/zh active Active
- 2017-03-13 PT PT201944584T patent/PT3777855T/pt unknown
- 2017-03-13 EP EP17710285.2A patent/EP3442580B1/en active Active
- 2017-03-13 PH PH1/2018/502142A patent/PH12018502142B1/en unknown
- 2017-03-13 ES ES17710285T patent/ES2839453T3/es active Active
- 2017-03-13 SG SG10202004425XA patent/SG10202004425XA/en unknown
- 2017-03-13 DK DK17710285.2T patent/DK3442580T3/da active
- 2017-03-13 AU AU2017249602A patent/AU2017249602B2/en active Active
- 2017-03-13 KR KR1020187032681A patent/KR102431257B1/ko active Active
- 2017-03-13 MX MX2018012287A patent/MX384261B/es unknown
- 2017-03-13 EP EP20194458.4A patent/EP3777855B1/en active Active
- 2017-03-13 EA EA202191466A patent/EA202191466A1/ru unknown
- 2017-03-13 MD MDE20190213T patent/MD3442580T2/ro unknown
- 2017-03-13 US US15/457,158 patent/US20170290812A1/en not_active Abandoned
- 2017-03-13 MY MYPI2018001719A patent/MY195437A/en unknown
- 2017-03-13 SI SI201730549T patent/SI3442580T1/sl unknown
- 2017-12-11 US US15/837,889 patent/US10130612B2/en active Active
- 2017-12-14 US US15/842,234 patent/US10130613B2/en active Active
- 2017-12-14 US US15/841,981 patent/US10117856B2/en active Active
- 2017-12-14 US US15/841,777 patent/US10117855B2/en active Active
-
2018
- 2018-09-19 US US16/135,945 patent/US20190000813A1/en not_active Abandoned
- 2018-10-02 IL IL262052A patent/IL262052B/en unknown
- 2018-11-05 ZA ZA2018/07389A patent/ZA201807389B/en unknown
-
2020
- 2020-06-24 US US16/910,756 patent/US11103484B2/en active Active
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