JP2019513761A5 - - Google Patents
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- JP2019513761A5 JP2019513761A5 JP2018553102A JP2018553102A JP2019513761A5 JP 2019513761 A5 JP2019513761 A5 JP 2019513761A5 JP 2018553102 A JP2018553102 A JP 2018553102A JP 2018553102 A JP2018553102 A JP 2018553102A JP 2019513761 A5 JP2019513761 A5 JP 2019513761A5
- Authority
- JP
- Japan
- Prior art keywords
- fibrosis
- pharmaceutical composition
- composition according
- cholangitis
- tgfβ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305425 | 2016-04-11 | ||
| EP16305425.7 | 2016-04-11 | ||
| PCT/EP2017/055878 WO2017178172A1 (en) | 2016-04-11 | 2017-03-13 | Methods of treatment for cholestatic and fibrotic diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513761A JP2019513761A (ja) | 2019-05-30 |
| JP2019513761A5 true JP2019513761A5 (https=) | 2020-03-26 |
| JP6894923B2 JP6894923B2 (ja) | 2021-06-30 |
Family
ID=55755536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553102A Active JP6894923B2 (ja) | 2016-04-11 | 2017-03-13 | 胆汁うっ滞性及び線維性の疾患の処置方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US20170290812A1 (https=) |
| EP (3) | EP3777854B1 (https=) |
| JP (1) | JP6894923B2 (https=) |
| KR (1) | KR102431257B1 (https=) |
| CN (1) | CN109069648B (https=) |
| AU (1) | AU2017249602B2 (https=) |
| DK (2) | DK3442580T3 (https=) |
| EA (2) | EA202191466A1 (https=) |
| ES (3) | ES2928408T3 (https=) |
| HR (1) | HRP20201954T1 (https=) |
| HU (2) | HUE052886T2 (https=) |
| IL (1) | IL262052B (https=) |
| LT (1) | LT3442580T (https=) |
| MD (1) | MD3442580T2 (https=) |
| MX (1) | MX384261B (https=) |
| MY (1) | MY195437A (https=) |
| PH (1) | PH12018502142B1 (https=) |
| PL (1) | PL3442580T3 (https=) |
| PT (2) | PT3777855T (https=) |
| SG (2) | SG11201808402RA (https=) |
| SI (1) | SI3442580T1 (https=) |
| WO (1) | WO2017178172A1 (https=) |
| ZA (1) | ZA201807389B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA202191466A1 (ru) | 2016-04-11 | 2021-12-31 | Женфит | Способы лечения холестатических и фибротических заболеваний |
| WO2017178174A1 (en) * | 2016-04-11 | 2017-10-19 | Genfit | Methods of treatment of cholestasis and fibrosis |
| KR20190122806A (ko) * | 2017-03-13 | 2019-10-30 | 장피트 | 조합 치료요법용 약학 조성물 |
| US11147779B2 (en) * | 2017-03-21 | 2021-10-19 | Supreet K. Deshpande | Therapeutic agent for phosphodiesterase inhibition and its related disorders |
| JP7365054B2 (ja) * | 2017-11-17 | 2023-10-19 | ケスター，ヒューバート | リンパ管平滑筋腫症及びその他の疾患に使用するための［２－［（５－ニトロ－１，３－チアゾール－２－イル）カルバモイル］フェニル］エタノエート |
| EP3639822A1 (en) * | 2018-10-15 | 2020-04-22 | Universität Regensburg | Compound for use in the treatment of a disease characterized by dysregulated mucus production and/or secretion |
| CN113677336B (zh) | 2019-04-10 | 2024-04-30 | 基恩菲特公司 | 包含式(i)化合物和glp-1受体激动剂的组合疗法 |
| CA3130518A1 (en) * | 2019-04-12 | 2020-10-15 | Nicolas STANKOVIC-VALENTIN | Nitazoxanide and thiazolides for use in the treatment of diseases associated with oxidative stress |
| CN110205302B (zh) * | 2019-06-24 | 2021-03-23 | 扬州大学 | 一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用 |
| CN110478357A (zh) * | 2019-07-23 | 2019-11-22 | 哈尔滨医科大学 | 硝唑尼特及其体内代谢物在抗肥胖、降血脂、抗脂肪肝及抗动脉粥样硬化中的应用 |
| CN110368498A (zh) * | 2019-08-26 | 2019-10-25 | 瑞希(重庆)生物科技有限公司 | 一种促进伤口愈合的制剂及其制备方法 |
| CA3153784A1 (en) | 2019-10-28 | 2021-05-06 | Nicolas STANKOVIC-VALENTIN | Combination therapy of elafibranor and nitazoxanide having antioxident properties |
| CN113398125B (zh) | 2020-03-16 | 2024-05-03 | 绍兴君科臻元医药科技有限公司 | 替唑尼特药物组合物及其医药用途 |
| CN116507343A (zh) * | 2020-11-17 | 2023-07-28 | 基恩菲特公司 | 治疗肝衰竭的方法 |
| CA3196479A1 (en) * | 2020-11-17 | 2022-05-27 | Philippe Delataille | Methods of treatment of liver failure |
| CN115197164B (zh) * | 2021-04-12 | 2025-04-01 | 杜心赟 | 新型噻唑类化合物及其制备方法和用途 |
| CN117241795A (zh) * | 2021-05-11 | 2023-12-15 | 基恩菲特公司 | 治疗脓毒症的硝唑尼特 |
| CN116077502B (zh) * | 2021-11-05 | 2025-12-23 | 广州医科大学附属妇女儿童医疗中心 | 叶酸在预防、诊断和治疗胆道闭锁中的应用 |
| WO2024074515A1 (en) * | 2022-10-04 | 2024-04-11 | Genfit | Nitazoxanide for the treatment of hepatic impairment |
| CN116911513B (zh) * | 2023-02-07 | 2024-07-26 | 中国药科大学 | 硝唑尼特及其体内代谢物替唑尼特在制备抗心衰药物中的应用 |
| WO2025063816A1 (ko) * | 2023-09-21 | 2025-03-27 | 오토텔릭바이오 주식회사 | 티아졸 유도체 화합물을 포함하는 자궁 섬유화증 치료용 조성물 |
| CN117838690B (zh) * | 2023-10-09 | 2024-09-13 | 中国药科大学 | 一种治疗以ampk激活为治疗靶点的疾病的复方药物及其应用 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1437800A (en) | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| GB1440212A (en) | 1973-08-29 | 1976-06-23 | Phavic Sprl | Derivatives of 2-phenoxyacetamido-5-nitrothiazoles |
| US5968961A (en) | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| MX9604483A (es) | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5965590A (en) | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5935591A (en) | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
| US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| EP1354603A1 (en) | 2000-12-26 | 2003-10-22 | Takeda Chemical Industries, Ltd. | Concomitant drugs |
| RU2006111093A (ru) | 2003-09-06 | 2007-10-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы атр-связывающих кассетных транспортеров |
| UA90864C2 (en) | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US20100056505A1 (en) | 2005-11-21 | 2010-03-04 | Biogen Idec Ma Inc. | Substituted Pyrazalones |
| AP2907A (en) * | 2006-01-09 | 2014-05-31 | Romark Lab Lc | Viral hepatitis treatment |
| CA2639910A1 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| GB0619500D0 (en) | 2006-10-03 | 2006-11-08 | Univ Keele | Treatment of fibrosis |
| EP2178852B9 (en) | 2007-08-03 | 2016-06-22 | Romark Laboratories, L.C. | Alkylsulfonyl-substituted thiazolide compounds |
| US20110177999A1 (en) * | 2007-08-09 | 2011-07-21 | Vertex Pharmaceuticals Incorporated | Therapeutic Combinations Useful in Treating CFTR Related Diseases |
| KR101045572B1 (ko) | 2007-08-14 | 2011-07-01 | 주식회사 엘지화학 | Ｃｌｏｓｔｒｉｄｉｕｍ ｐｒｏｐｉｏｎｉｃｕｍ 유래의프로피오닐―ＣｏＡ 트랜스퍼라아제 변이체 및 상기변이체를 이용한 락테이트 중합체 또는 락테이트공중합체의 제조방법 |
| US9149463B2 (en) * | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| EP2203168B1 (en) | 2007-09-18 | 2014-07-16 | Stanford University | Compositions for treating a flaviviridae family viral infection |
| US20100016262A1 (en) | 2007-10-18 | 2010-01-21 | Yale University | Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis |
| WO2010107739A2 (en) * | 2009-03-18 | 2010-09-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a flaviviridae family viral infection |
| PE20121118A1 (es) | 2009-05-12 | 2012-09-05 | Romark Lab Lc | Compuestos de haloalquil heteroaril benzamida |
| AP2012006064A0 (en) | 2009-06-26 | 2012-02-29 | Romark Lab Lc | Compounds and methods for treating influenza. |
| US8816074B2 (en) | 2009-11-16 | 2014-08-26 | University of Georgia Foundation, Inc. | 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections |
| AU2010319999B2 (en) | 2009-11-16 | 2014-01-16 | University Of Georgia Research Foundation, Inc. | 2'-Fluoro-6'-methylene carbocyclic nucleosides and methods of treating viral infections |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| US8697739B2 (en) | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
| EP2609095A4 (en) | 2010-08-27 | 2014-06-18 | Calcimedica Inc | COMPOUNDS MODULATING INTRACELLULAR CALCIUM |
| CN103269593A (zh) | 2010-11-01 | 2013-08-28 | 罗马克实验室有限公司 | 烷基亚磺酰基取代的噻唑化物化合物 |
| KR20190060879A (ko) | 2011-03-02 | 2019-06-03 | 제롬 쉔타그 | 단독으로 또는 c형 간염 바이러스 감염과 결합되는 간 지방증의 치료를 위한 조성물, 방법 및 진단 |
| CN103648282B (zh) | 2011-05-16 | 2017-02-15 | 罗马克实验室有限公司 | 噻唑化物类化合物用于预防和治疗病毒性疾病、癌症和由细胞内感染引起的疾病的用途 |
| US9856240B2 (en) | 2011-10-19 | 2018-01-02 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2013059879A1 (en) * | 2011-10-26 | 2013-05-02 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| WO2013082469A2 (en) | 2011-12-02 | 2013-06-06 | University Of Vermont And State Agricultural College | Methods and compositions for treating infections |
| WO2014036528A2 (en) | 2012-08-31 | 2014-03-06 | Ixchel Pharma, Llc | Agents useful for treating obesity, diabetes and related disorders |
| WO2014059333A1 (en) | 2012-10-12 | 2014-04-17 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US9974767B2 (en) | 2014-07-14 | 2018-05-22 | University Of Washington | Statins in the treatment of muscular dystrophies and myopathies |
| CN107105660A (zh) | 2014-11-11 | 2017-08-29 | 罗马克实验室有限公司 | 使用替唑尼特、其类似物或盐的前药的治疗组合物和治疗方法 |
| US20190070154A1 (en) | 2015-06-24 | 2019-03-07 | Duke University | New methods of use for an anti-diarrhea agent |
| CN109152760B (zh) | 2016-04-11 | 2022-09-23 | 基恩菲特公司 | 胆汁淤积性和纤维化疾病的治疗方法 |
| WO2017178174A1 (en) | 2016-04-11 | 2017-10-19 | Genfit | Methods of treatment of cholestasis and fibrosis |
| EA202191466A1 (ru) | 2016-04-11 | 2021-12-31 | Женфит | Способы лечения холестатических и фибротических заболеваний |
-
2017
- 2017-03-13 EA EA202191466A patent/EA202191466A1/ru unknown
- 2017-03-13 SI SI201730549T patent/SI3442580T1/sl unknown
- 2017-03-13 EP EP20194454.3A patent/EP3777854B1/en active Active
- 2017-03-13 DK DK17710285.2T patent/DK3442580T3/da active
- 2017-03-13 JP JP2018553102A patent/JP6894923B2/ja active Active
- 2017-03-13 EA EA201892298A patent/EA201892298A1/ru unknown
- 2017-03-13 PT PT201944584T patent/PT3777855T/pt unknown
- 2017-03-13 PH PH1/2018/502142A patent/PH12018502142B1/en unknown
- 2017-03-13 HU HUE17710285A patent/HUE052886T2/hu unknown
- 2017-03-13 MY MYPI2018001719A patent/MY195437A/en unknown
- 2017-03-13 US US15/457,158 patent/US20170290812A1/en not_active Abandoned
- 2017-03-13 ES ES20194454T patent/ES2928408T3/es active Active
- 2017-03-13 EP EP20194458.4A patent/EP3777855B1/en active Active
- 2017-03-13 WO PCT/EP2017/055878 patent/WO2017178172A1/en not_active Ceased
- 2017-03-13 EP EP17710285.2A patent/EP3442580B1/en active Active
- 2017-03-13 AU AU2017249602A patent/AU2017249602B2/en active Active
- 2017-03-13 HU HUE20194458A patent/HUE060671T2/hu unknown
- 2017-03-13 LT LTEP17710285.2T patent/LT3442580T/lt unknown
- 2017-03-13 SG SG11201808402RA patent/SG11201808402RA/en unknown
- 2017-03-13 ES ES17710285T patent/ES2839453T3/es active Active
- 2017-03-13 MX MX2018012287A patent/MX384261B/es unknown
- 2017-03-13 PL PL17710285T patent/PL3442580T3/pl unknown
- 2017-03-13 PT PT177102852T patent/PT3442580T/pt unknown
- 2017-03-13 DK DK20194458.4T patent/DK3777855T3/da active
- 2017-03-13 CN CN201780023160.XA patent/CN109069648B/zh active Active
- 2017-03-13 MD MDE20190213T patent/MD3442580T2/ro unknown
- 2017-03-13 ES ES20194458T patent/ES2935185T3/es active Active
- 2017-03-13 SG SG10202004425XA patent/SG10202004425XA/en unknown
- 2017-03-13 KR KR1020187032681A patent/KR102431257B1/ko active Active
- 2017-03-13 HR HRP20201954TT patent/HRP20201954T1/hr unknown
- 2017-12-11 US US15/837,889 patent/US10130612B2/en active Active
- 2017-12-14 US US15/842,234 patent/US10130613B2/en active Active
- 2017-12-14 US US15/841,981 patent/US10117856B2/en active Active
- 2017-12-14 US US15/841,777 patent/US10117855B2/en active Active
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2018
- 2018-09-19 US US16/135,945 patent/US20190000813A1/en not_active Abandoned
- 2018-10-02 IL IL262052A patent/IL262052B/en unknown
- 2018-11-05 ZA ZA2018/07389A patent/ZA201807389B/en unknown
-
2020
- 2020-06-24 US US16/910,756 patent/US11103484B2/en active Active
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