JP2019513748A5 - - Google Patents

Info

Publication number

JP2019513748A5

JP2019513748A5 JP2018552804A JP2018552804A JP2019513748A5 JP 2019513748 A5 JP2019513748 A5 JP 2019513748A5 JP 2018552804 A JP2018552804 A JP 2018552804A JP 2018552804 A JP2018552804 A JP 2018552804A JP 2019513748 A5 JP2019513748 A5 JP 2019513748A5

Authority

JP

Japan

Prior art keywords

seq

fxii

subject

pharmaceutical composition

inhibitor

Prior art date

2017-04-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 claims 16
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• 229920001184 polypeptide Polymers 0.000 claims 8
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 3
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