JP2019513004A5 - - Google Patents
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- JP2019513004A5 JP2019513004A5 JP2018540464A JP2018540464A JP2019513004A5 JP 2019513004 A5 JP2019513004 A5 JP 2019513004A5 JP 2018540464 A JP2018540464 A JP 2018540464A JP 2018540464 A JP2018540464 A JP 2018540464A JP 2019513004 A5 JP2019513004 A5 JP 2019513004A5
- Authority
- JP
- Japan
- Prior art keywords
- cdr
- seq
- residues
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims description 62
- 101001139093 Homo sapiens Klotho Proteins 0.000 claims description 56
- 102100020686 Klotho Human genes 0.000 claims description 56
- 229920001184 polypeptide Polymers 0.000 claims description 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 30
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 10
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 4
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000539 dimer Substances 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 150000001413 amino acids Chemical group 0.000 claims 40
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 239000000523 sample Substances 0.000 description 25
- 238000000034 method Methods 0.000 description 19
- 150000007523 nucleic acids Chemical class 0.000 description 11
- 208000020832 chronic kidney disease Diseases 0.000 description 9
- 238000003018 immunoassay Methods 0.000 description 9
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 238000003556 assay Methods 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 208000009304 Acute Kidney Injury Diseases 0.000 description 7
- 208000033626 Renal failure acute Diseases 0.000 description 7
- 201000011040 acute kidney failure Diseases 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000004393 prognosis Methods 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 241000283984 Rodentia Species 0.000 description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
- 238000001114 immunoprecipitation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662290776P | 2016-02-03 | 2016-02-03 | |
| US62/290,776 | 2016-02-03 | ||
| PCT/CA2017/050127 WO2017132772A1 (en) | 2016-02-03 | 2017-02-03 | Antibodies and elisas for alpha klotho |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513004A JP2019513004A (ja) | 2019-05-23 |
| JP2019513004A5 true JP2019513004A5 (enExample) | 2020-03-19 |
| JP6682641B2 JP6682641B2 (ja) | 2020-04-15 |
Family
ID=59499231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540464A Expired - Fee Related JP6682641B2 (ja) | 2016-02-03 | 2017-02-03 | αKlothoに対する抗体およびELISA |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10663474B2 (enExample) |
| EP (1) | EP3411482A4 (enExample) |
| JP (1) | JP6682641B2 (enExample) |
| CA (1) | CA3012873A1 (enExample) |
| WO (1) | WO2017132772A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10228374B2 (en) | 2014-07-31 | 2019-03-12 | The Governng Council of the University of Toronto | Antibodies with high affinity for alpha-Klotho |
| WO2017132772A1 (en) | 2016-02-03 | 2017-08-10 | The Governing Council Of The University Of Toronto | Antibodies and elisas for alpha klotho |
| US11026625B2 (en) | 2017-08-08 | 2021-06-08 | Fresenius Medical Care Holdings, Inc. | Systems and methods for treating and estimating progression of chronic kidney disease |
| CN120943965A (zh) * | 2025-10-16 | 2025-11-14 | 广东医科大学附属医院 | 一种αKL蛋白抗体及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2877081C (en) * | 2011-09-27 | 2020-09-22 | The Governing Council Of The University Of Toronto | Molecular display method |
| WO2013184218A1 (en) | 2012-06-05 | 2013-12-12 | Msm Protein Technologies | Human monoclonal antibodies against human chemokine receptor ccr6 |
| US10228374B2 (en) | 2014-07-31 | 2019-03-12 | The Governng Council of the University of Toronto | Antibodies with high affinity for alpha-Klotho |
| US9697298B2 (en) | 2014-08-07 | 2017-07-04 | Etas Embedded Systems Canada Inc. | ID tag authentication system and method |
| CN107614020A (zh) | 2015-03-18 | 2018-01-19 | 免疫生化公司 | 靶向细胞内肿瘤相关抗原的用于治疗癌症的缀合物 |
| WO2017132772A1 (en) | 2016-02-03 | 2017-08-10 | The Governing Council Of The University Of Toronto | Antibodies and elisas for alpha klotho |
-
2017
- 2017-02-03 WO PCT/CA2017/050127 patent/WO2017132772A1/en not_active Ceased
- 2017-02-03 JP JP2018540464A patent/JP6682641B2/ja not_active Expired - Fee Related
- 2017-02-03 EP EP17746682.8A patent/EP3411482A4/en not_active Withdrawn
- 2017-02-03 US US16/075,033 patent/US10663474B2/en not_active Expired - Fee Related
- 2017-02-03 CA CA3012873A patent/CA3012873A1/en active Pending
-
2020
- 2020-05-22 US US16/881,667 patent/US11143661B2/en not_active Expired - Fee Related