JP2017524362A5 - - Google Patents
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- Publication number
- JP2017524362A5 JP2017524362A5 JP2017505099A JP2017505099A JP2017524362A5 JP 2017524362 A5 JP2017524362 A5 JP 2017524362A5 JP 2017505099 A JP2017505099 A JP 2017505099A JP 2017505099 A JP2017505099 A JP 2017505099A JP 2017524362 A5 JP2017524362 A5 JP 2017524362A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- binding fragment
- seq
- αklotho
- cdr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101001139093 Homo sapiens Klotho Proteins 0.000 claims description 56
- 102100020686 Klotho Human genes 0.000 claims description 56
- 239000012634 fragment Substances 0.000 claims description 56
- 230000027455 binding Effects 0.000 claims description 54
- 229920001184 polypeptide Polymers 0.000 claims description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 13
- 208000020832 chronic kidney disease Diseases 0.000 claims description 12
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 11
- 208000033626 Renal failure acute Diseases 0.000 claims description 11
- 201000011040 acute kidney failure Diseases 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 238000003556 assay Methods 0.000 claims description 9
- 238000002965 ELISA Methods 0.000 claims description 5
- 238000003018 immunoassay Methods 0.000 claims description 5
- 238000010494 dissociation reaction Methods 0.000 claims description 4
- 230000005593 dissociations Effects 0.000 claims description 4
- 238000012286 ELISA Assay Methods 0.000 claims description 3
- 230000002860 competitive effect Effects 0.000 claims description 3
- 230000007774 longterm Effects 0.000 claims description 3
- 102100024802 Fibroblast growth factor 23 Human genes 0.000 claims description 2
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims description 2
- 101001051973 Homo sapiens Fibroblast growth factor 23 Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000000539 dimer Substances 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 230000009870 specific binding Effects 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 5
- 238000004393 prognosis Methods 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 229940126864 fibroblast growth factor Drugs 0.000 description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
- 238000001114 immunoprecipitation Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000012520 frozen sample Substances 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462031477P | 2014-07-31 | 2014-07-31 | |
| US62/031,477 | 2014-07-31 | ||
| PCT/CA2015/050728 WO2016015162A1 (en) | 2014-07-31 | 2015-07-31 | ANTIBODIES WITH HIGH AFFINITY FOR αKLOTHO |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524362A JP2017524362A (ja) | 2017-08-31 |
| JP2017524362A5 true JP2017524362A5 (enExample) | 2018-09-06 |
| JP6612324B2 JP6612324B2 (ja) | 2019-11-27 |
Family
ID=55216538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505099A Expired - Fee Related JP6612324B2 (ja) | 2014-07-31 | 2015-07-31 | αＫｌｏｔｈｏに対して高親和性を有する抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10228374B2 (enExample) |
| EP (1) | EP3174986A4 (enExample) |
| JP (1) | JP6612324B2 (enExample) |
| CA (1) | CA2955039C (enExample) |
| WO (1) | WO2016015162A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017132772A1 (en) * | 2016-02-03 | 2017-08-10 | The Governing Council Of The University Of Toronto | Antibodies and elisas for alpha klotho |
| CA3077518C (en) * | 2016-09-07 | 2021-10-19 | Frederic Fellouse | Synthetic antibodies against vegf and their uses |
| US11026625B2 (en) | 2017-08-08 | 2021-06-08 | Fresenius Medical Care Holdings, Inc. | Systems and methods for treating and estimating progression of chronic kidney disease |
| CA3101100A1 (en) * | 2017-12-06 | 2019-06-13 | Klotho Therapeutics, Inc. | Products and methods for assessing and increasing klotho protein levels |
| CN117886943A (zh) | 2017-12-29 | 2024-04-16 | 耶鲁大学 | 用于疾病和病症治疗和预防的抗-肾酶抗体 |
| US12234500B2 (en) | 2017-12-29 | 2025-02-25 | Yale University | Methods for measuring Renalase |
| WO2020047505A1 (en) * | 2018-08-30 | 2020-03-05 | The Uab Research Foundation | Production and detection of bioactive soluble klotho protein |
| CN117805395A (zh) * | 2023-12-29 | 2024-04-02 | 上海药明合联生物技术有限公司 | 一种比较抗体偶联药物和抗体的亲和力的方法及其应用 |
| CN120943965A (zh) * | 2025-10-16 | 2025-11-14 | 广东医科大学附属医院 | 一种αKL蛋白抗体及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO2013184218A1 (en) | 2012-06-05 | 2013-12-12 | Msm Protein Technologies | Human monoclonal antibodies against human chemokine receptor ccr6 |
| CN107614020A (zh) | 2015-03-18 | 2018-01-19 | 免疫生化公司 | 靶向细胞内肿瘤相关抗原的用于治疗癌症的缀合物 |
| WO2017132772A1 (en) | 2016-02-03 | 2017-08-10 | The Governing Council Of The University Of Toronto | Antibodies and elisas for alpha klotho |
-
2015
- 2015-07-31 US US15/500,478 patent/US10228374B2/en active Active
- 2015-07-31 CA CA2955039A patent/CA2955039C/en active Active
- 2015-07-31 WO PCT/CA2015/050728 patent/WO2016015162A1/en not_active Ceased
- 2015-07-31 EP EP15827668.3A patent/EP3174986A4/en not_active Withdrawn
- 2015-07-31 JP JP2017505099A patent/JP6612324B2/ja not_active Expired - Fee Related
-
2019
- 2019-01-29 US US16/261,141 patent/US10697963B2/en not_active Expired - Fee Related