JP2019512262A5 - - Google Patents

Info

Publication number

JP2019512262A5

JP2019512262A5 JP2018560245A JP2018560245A JP2019512262A5 JP 2019512262 A5 JP2019512262 A5 JP 2019512262A5 JP 2018560245 A JP2018560245 A JP 2018560245A JP 2018560245 A JP2018560245 A JP 2018560245A JP 2019512262 A5 JP2019512262 A5 JP 2019512262A5

Authority

JP

Japan

Prior art keywords

seq

antibody

acid sequence

amino acid

nucleic acid

Prior art date

2017-02-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims 14
• 150000007523 nucleic acids Chemical group 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
• 150000001413 amino acids Chemical class 0.000 claims 7
• 230000000295 complement effect Effects 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 230000002022 anti-cellular effect Effects 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 101710112752 Cytotoxin Proteins 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 3
• 231100000599 cytotoxic agent Toxicity 0.000 claims 3
• 239000002619 cytotoxin Substances 0.000 claims 3
• 210000002889 endothelial cell Anatomy 0.000 claims 3
• 239000013598 vector Substances 0.000 claims 3
• 239000012623 DNA damaging agent Substances 0.000 claims 2
• 241000196324 Embryophyta Species 0.000 claims 2
• 102100040510 Galectin-3-binding protein Human genes 0.000 claims 2
• 101000884275 Homo sapiens Endosialin Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 2
• 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims 2
• 229940100198 alkylating agent Drugs 0.000 claims 2
• 239000002168 alkylating agent Substances 0.000 claims 2
• 230000000340 anti-metabolite Effects 0.000 claims 2
• 239000002256 antimetabolite Substances 0.000 claims 2
• 229940100197 antimetabolite Drugs 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 230000002538 fungal effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• FBUTXZSKZCQABC-UHFFFAOYSA-N 2-amino-1-methyl-7h-purine-6-thione Chemical compound S=C1N(C)C(N)=NC2=C1NC=N2 FBUTXZSKZCQABC-UHFFFAOYSA-N 0.000 claims 1
• 101000669426 Aspergillus restrictus Ribonuclease mitogillin Proteins 0.000 claims 1
• 231100000699 Bacterial toxin Toxicity 0.000 claims 1
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 201000009030 Carcinoma Diseases 0.000 claims 1
• 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
• 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
• 101710144543 Endosialin Proteins 0.000 claims 1
• 102100038083 Endosialin Human genes 0.000 claims 1
• 201000008808 Fibrosarcoma Diseases 0.000 claims 1
• 101710197901 Galectin-3-binding protein Proteins 0.000 claims 1
• 101000967904 Homo sapiens Galectin-3-binding protein Proteins 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 102000029749 Microtubule Human genes 0.000 claims 1
• 108091022875 Microtubule Proteins 0.000 claims 1
• 206010029260 Neuroblastoma Diseases 0.000 claims 1
• 229940123573 Protein synthesis inhibitor Drugs 0.000 claims 1
• 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims 1
• 108010083644 Ribonucleases Proteins 0.000 claims 1
• 102000006382 Ribonucleases Human genes 0.000 claims 1
• 108090000829 Ribosome Inactivating Proteins Proteins 0.000 claims 1
• 108010039491 Ricin Proteins 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 229940122803 Vinca alkaloid Drugs 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 108010001818 alpha-sarcin Proteins 0.000 claims 1
• 210000004102 animal cell Anatomy 0.000 claims 1
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 239000003080 antimitotic agent Substances 0.000 claims 1
• FIVPIPIDMRVLAY-UHFFFAOYSA-N aspergillin Natural products C1C2=CC=CC(O)C2N2C1(SS1)C(=O)N(C)C1(CO)C2=O FIVPIPIDMRVLAY-UHFFFAOYSA-N 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 239000000688 bacterial toxin Substances 0.000 claims 1
• 239000011230 binding agent Substances 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical class COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims 1
• 239000012636 effector Substances 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• FIVPIPIDMRVLAY-RBJBARPLSA-N gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 claims 1
• 208000029824 high grade glioma Diseases 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 238000003384 imaging method Methods 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 229940043355 kinase inhibitor Drugs 0.000 claims 1
• 238000002372 labelling Methods 0.000 claims 1
• 206010024627 liposarcoma Diseases 0.000 claims 1
• 201000011614 malignant glioma Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000004688 microtubule Anatomy 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000002636 mycotoxin Substances 0.000 claims 1
• 230000001613 neoplastic effect Effects 0.000 claims 1
• 201000008968 osteosarcoma Diseases 0.000 claims 1
• 230000005298 paramagnetic effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
• 239000003123 plant toxin Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 239000000007 protein synthesis inhibitor Substances 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1
• 206010042863 synovial sarcoma Diseases 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108700012359 toxins Proteins 0.000 claims 1
• 230000009261 transgenic effect Effects 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1
• 210000005167 vascular cell Anatomy 0.000 claims 1
• 210000005166 vasculature Anatomy 0.000 claims 1