JP2019511918A5 - - Google Patents
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- Publication number
- JP2019511918A5 JP2019511918A5 JP2018545182A JP2018545182A JP2019511918A5 JP 2019511918 A5 JP2019511918 A5 JP 2019511918A5 JP 2018545182 A JP2018545182 A JP 2018545182A JP 2018545182 A JP2018545182 A JP 2018545182A JP 2019511918 A5 JP2019511918 A5 JP 2019511918A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- rodent
- tmprss
- humanized
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283984 Rodentia Species 0.000 claims 80
- 108090000623 proteins and genes Proteins 0.000 claims 64
- 210000004027 cell Anatomy 0.000 claims 16
- 101150109926 Tmprss2 gene Proteins 0.000 claims 13
- 239000002773 nucleotide Substances 0.000 claims 13
- 125000003729 nucleotide group Chemical group 0.000 claims 13
- 108700024394 Exon Proteins 0.000 claims 12
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 101100260872 Mus musculus Tmprss4 gene Proteins 0.000 claims 9
- 101150089613 Tmprss11d gene Proteins 0.000 claims 9
- 101100099740 Homo sapiens TMPRSS11D gene Proteins 0.000 claims 8
- 101000798702 Homo sapiens Transmembrane protease serine 4 Proteins 0.000 claims 8
- 230000001086 cytosolic effect Effects 0.000 claims 8
- 108020004705 Codon Proteins 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 101000798707 Homo sapiens Transmembrane protease serine 13 Proteins 0.000 claims 2
- 101100207058 Mus musculus Tmprss2 gene Proteins 0.000 claims 2
- 108020005038 Terminator Codon Proteins 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000049800 human TMPRSS2 Human genes 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301023P | 2016-02-29 | 2016-02-29 | |
| US62/301,023 | 2016-02-29 | ||
| PCT/US2017/019574 WO2017151453A1 (en) | 2016-02-29 | 2017-02-27 | Rodents having a humanized tmprss gene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511918A JP2019511918A (ja) | 2019-05-09 |
| JP2019511918A5 true JP2019511918A5 (OSRAM) | 2020-04-09 |
| JP6980674B2 JP6980674B2 (ja) | 2021-12-15 |
Family
ID=58264641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545182A Active JP6980674B2 (ja) | 2016-02-29 | 2017-02-27 | ヒト化ｔｍｐｒｓｓ遺伝子を有する齧歯類 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US10070632B2 (OSRAM) |
| EP (2) | EP3895529A1 (OSRAM) |
| JP (1) | JP6980674B2 (OSRAM) |
| KR (2) | KR102775366B1 (OSRAM) |
| CN (1) | CN109068621B (OSRAM) |
| AU (1) | AU2017228293B2 (OSRAM) |
| CA (1) | CA3014645C (OSRAM) |
| DK (1) | DK3422845T3 (OSRAM) |
| ES (1) | ES2886958T3 (OSRAM) |
| IL (1) | IL261139B (OSRAM) |
| PT (1) | PT3422845T (OSRAM) |
| RU (1) | RU2749715C2 (OSRAM) |
| SG (2) | SG11201807038UA (OSRAM) |
| WO (1) | WO2017151453A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3014645C (en) * | 2016-02-29 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| EP3585162B1 (en) * | 2017-09-29 | 2023-08-30 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| IL276164B2 (en) | 2018-01-26 | 2024-11-01 | Regeneron Pharma | Anti-tmprss2 antibodies and antigen-binding fragments |
| HUE067361T2 (hu) | 2018-07-16 | 2024-10-28 | Regeneron Pharma | Ditra betegség rágcsáló modelljei és alkalmazásaik |
| US11470828B2 (en) | 2019-01-17 | 2022-10-18 | Regeneran Pharmaceuticals, Inc. | Rodent model of mood disorders |
| IL294529A (en) | 2020-02-10 | 2022-09-01 | Regeneron Pharma | Anti-tmprss2 antibodies and antigen-binding fragments |
| CN115161326B (zh) * | 2021-06-21 | 2024-09-24 | 百奥赛图(北京)医药科技股份有限公司 | Sost基因人源化非人动物及其构建方法和应用 |
| US20250049006A1 (en) * | 2021-12-20 | 2025-02-13 | C/O Regeneron Pharmaceuticals, Inc. | Non-human animals comprising humanized ace2 and tmprss loci |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002065266A (ja) * | 2000-08-28 | 2002-03-05 | Teijin Ltd | 気道特異的トリプシン様酵素およびその利用法 |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AU2002359781A1 (en) * | 2001-12-20 | 2003-07-09 | The Regents Of The University Of California | Triple transgenic mouse model of alzheimer's disease |
| US20050026255A1 (en) * | 2002-06-25 | 2005-02-03 | Morser John Michael | Corin, a serine protease |
| EP1558731A4 (en) * | 2002-10-04 | 2007-01-10 | Schering Ag | MODIFIED HEPSINE MOLECULES COMPRISING A SUBSTITUTION ACTIVATION SEQUENCE AND USES THEREOF |
| CA2527361A1 (en) * | 2003-06-11 | 2004-12-23 | Schering Aktiengesellschaft | Novel modified corin molecules having substitute activation sequences and uses thereof |
| US7491865B2 (en) * | 2004-08-19 | 2009-02-17 | Fred Hutchinson Cancer Research Center | Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| KR101069089B1 (ko) * | 2006-05-23 | 2011-09-30 | 아이알엠 엘엘씨 | 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물 |
| GB0821624D0 (en) * | 2008-11-26 | 2008-12-31 | Eisai London Res Lab Ltd | Assay |
| WO2010081173A2 (en) * | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| EP3417701B1 (en) | 2009-10-06 | 2021-12-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| RU2577978C2 (ru) | 2011-02-15 | 2016-03-20 | Ридженерон Фармасьютикалз, Инк. | Гуманизированные m-csf мыши |
| SG10201510056SA (en) | 2011-10-28 | 2016-01-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| RU2751240C2 (ru) | 2011-10-28 | 2021-07-12 | Регенерон Фармасьютикалс, Инк. | Гуманизированные il-6 и рецептор il-6 |
| NZ631105A (en) * | 2012-04-16 | 2016-09-30 | Regeneron Pharma | Methods for treating or preventing influenza virus infection by administering a serine protease inhibitor |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| CA2876904C (en) * | 2012-06-22 | 2019-12-03 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| NZ746089A (en) | 2012-09-07 | 2020-05-29 | Institute For Res In Biomedicine Irb | Genetically modified non-human animals and methods of use thereof |
| ES2748662T3 (es) | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| CA2900832A1 (en) | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| JP6475172B2 (ja) | 2013-02-20 | 2019-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ラットの遺伝子組換え |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| EP3456831B1 (en) | 2013-04-16 | 2021-07-14 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
| EP3003387A1 (en) | 2013-06-04 | 2016-04-13 | Cytomx Therapeutics Inc. | Compositions and methods for conjugating activatable antibodies |
| SMT202500280T1 (it) | 2013-09-23 | 2025-09-12 | Regeneron Pharma | Animali non umani aventi un gene umanizzato della proteina regolatrice del segnale |
| TR201904342T4 (tr) | 2013-10-15 | 2019-05-21 | Regeneron Pharma | Hümani̇ze il-15 hayvanlar |
| EP3071024B1 (en) * | 2013-11-19 | 2018-09-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| EP3430898A1 (en) | 2013-11-19 | 2019-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| SMT202000332T1 (it) | 2014-04-08 | 2020-07-08 | Regeneron Pharma | Animali non umani aventi recettori fc-gamma umanizzati |
| NO2785538T3 (OSRAM) | 2014-05-07 | 2018-08-04 | ||
| KR102821645B1 (ko) | 2014-05-19 | 2025-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| DK3157956T3 (da) | 2014-06-19 | 2020-04-27 | Regeneron Pharma | Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 |
| BR112017010793A2 (pt) | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| ES2969389T3 (es) | 2014-12-05 | 2024-05-17 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 47 humanizado |
| EP4399969A3 (en) | 2014-12-09 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| PT3376857T (pt) | 2015-11-20 | 2021-05-27 | Regeneron Pharma | Animais não humanos com um gene humanizado 3 de ativação de linfócitos |
| CA3014645C (en) | 2016-02-29 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| KR101693243B1 (ko) | 2016-06-15 | 2017-01-05 | 재단법인 한국파스퇴르연구소 | 인플루엔자 바이러스의 복제에 관여하는 신규 인간 유전자 및 이의 용도 |
-
2017
- 2017-02-27 CA CA3014645A patent/CA3014645C/en active Active
- 2017-02-27 SG SG11201807038UA patent/SG11201807038UA/en unknown
- 2017-02-27 CN CN201780010404.0A patent/CN109068621B/zh active Active
- 2017-02-27 JP JP2018545182A patent/JP6980674B2/ja active Active
- 2017-02-27 SG SG10202001578RA patent/SG10202001578RA/en unknown
- 2017-02-27 RU RU2018131152A patent/RU2749715C2/ru active
- 2017-02-27 KR KR1020237003004A patent/KR102775366B1/ko active Active
- 2017-02-27 US US15/442,857 patent/US10070632B2/en active Active
- 2017-02-27 EP EP21170433.3A patent/EP3895529A1/en active Pending
- 2017-02-27 ES ES17709888T patent/ES2886958T3/es active Active
- 2017-02-27 PT PT177098886T patent/PT3422845T/pt unknown
- 2017-02-27 DK DK17709888.6T patent/DK3422845T3/da active
- 2017-02-27 KR KR1020187026552A patent/KR102493894B1/ko active Active
- 2017-02-27 EP EP17709888.6A patent/EP3422845B1/en active Active
- 2017-02-27 WO PCT/US2017/019574 patent/WO2017151453A1/en not_active Ceased
- 2017-02-27 AU AU2017228293A patent/AU2017228293B2/en active Active
- 2017-06-16 US US15/624,774 patent/US10070631B2/en active Active
-
2018
- 2018-08-02 US US16/052,700 patent/US10863729B2/en active Active
- 2018-08-13 IL IL261139A patent/IL261139B/en unknown
-
2020
- 2020-11-17 US US17/099,942 patent/US11910787B2/en active Active
-
2024
- 2024-01-16 US US18/413,096 patent/US20240147971A1/en active Pending
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