JP2015523863A5 - - Google Patents
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- Publication number
- JP2015523863A5 JP2015523863A5 JP2015517447A JP2015517447A JP2015523863A5 JP 2015523863 A5 JP2015523863 A5 JP 2015523863A5 JP 2015517447 A JP2015517447 A JP 2015517447A JP 2015517447 A JP2015517447 A JP 2015517447A JP 2015523863 A5 JP2015523863 A5 JP 2015523863A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- rodent
- humanized
- exon
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010002586 Interleukin-7 Proteins 0.000 claims description 47
- 241000283984 Rodentia Species 0.000 claims description 39
- 101001043807 Homo sapiens Interleukin-7 Proteins 0.000 claims description 34
- 102000052622 human IL7 Human genes 0.000 claims description 34
- 102000000704 Interleukin-7 Human genes 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 108700024394 Exon Proteins 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 239000002299 complementary DNA Substances 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 241000700159 Rattus Species 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 101150101112 7 gene Proteins 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 101001043808 Mus musculus Interleukin-7 Proteins 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 7
- 108091023045 Untranslated Region Proteins 0.000 description 3
- 241000699800 Cricetinae Species 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 108700028369 Alleles Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660976P | 2012-06-18 | 2012-06-18 | |
| US61/660,976 | 2012-06-18 | ||
| US201261740074P | 2012-12-20 | 2012-12-20 | |
| US61/740,074 | 2012-12-20 | ||
| US13/795,765 | 2013-03-12 | ||
| US13/795,765 US8962913B2 (en) | 2012-06-18 | 2013-03-12 | Humanized IL-7 rodents |
| PCT/US2013/045788 WO2013192030A1 (en) | 2012-06-18 | 2013-06-14 | Humanized il-7 rodents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523863A JP2015523863A (ja) | 2015-08-20 |
| JP2015523863A5 true JP2015523863A5 (OSRAM) | 2016-05-19 |
| JP6174134B2 JP6174134B2 (ja) | 2017-08-02 |
Family
ID=49757275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517447A Expired - Fee Related JP6174134B2 (ja) | 2012-06-18 | 2013-06-14 | ヒト化ｉｌ−７齧歯類 |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US8962913B2 (OSRAM) |
| EP (2) | EP2861063A1 (OSRAM) |
| JP (1) | JP6174134B2 (OSRAM) |
| KR (1) | KR20150027752A (OSRAM) |
| CN (2) | CN105779467A (OSRAM) |
| AU (1) | AU2013277457B2 (OSRAM) |
| BR (1) | BR112014029892A2 (OSRAM) |
| CA (1) | CA2873134A1 (OSRAM) |
| CY (1) | CY1119071T1 (OSRAM) |
| DK (1) | DK2859793T3 (OSRAM) |
| ES (1) | ES2626965T3 (OSRAM) |
| HK (1) | HK1203761A1 (OSRAM) |
| HR (1) | HRP20170974T1 (OSRAM) |
| HU (1) | HUE034592T2 (OSRAM) |
| IL (3) | IL235773B (OSRAM) |
| IN (1) | IN2014DN10189A (OSRAM) |
| LT (1) | LT2859793T (OSRAM) |
| MX (1) | MX363540B (OSRAM) |
| NZ (1) | NZ702943A (OSRAM) |
| PL (1) | PL2859793T3 (OSRAM) |
| PT (1) | PT2859793T (OSRAM) |
| RS (1) | RS56039B1 (OSRAM) |
| RU (1) | RU2654565C2 (OSRAM) |
| SG (3) | SG10201609569PA (OSRAM) |
| SI (1) | SI2859793T1 (OSRAM) |
| SM (1) | SMT201700313T1 (OSRAM) |
| WO (1) | WO2013192030A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2564695B1 (en) | 2009-07-08 | 2015-04-15 | Kymab Limited | Animal models and therapeutic molecules |
| CN103945689B (zh) | 2011-09-19 | 2016-10-19 | 科马布有限公司 | 免疫球蛋白基因多样性的操纵及多抗体治疗剂 |
| US9072086B2 (en) * | 2012-03-05 | 2015-06-30 | Samsung Electronics Co., Ltd. | HARQ-ACK signal transmission in response to detection of control channel type in case of multiple control channel types |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| KR102407354B1 (ko) | 2013-09-23 | 2022-06-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물 |
| AU2014330922A1 (en) | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| SI3138397T1 (sl) | 2013-10-15 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
| MX358206B (es) | 2013-11-19 | 2018-08-09 | Regeneron Pharma | Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion. |
| US9795121B2 (en) | 2014-05-05 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Humanized C3 animals |
| NO2785538T3 (OSRAM) | 2014-05-07 | 2018-08-04 | ||
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| CN107896479B (zh) * | 2015-04-13 | 2021-07-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
| ES2908669T3 (es) | 2016-02-04 | 2022-05-03 | Regeneron Pharma | Animales no humanos que tienen un gen ANGPTL8 modificado genéticamente |
| PT3422845T (pt) | 2016-02-29 | 2021-08-26 | Regeneron Pharma | Roedores com um gene tmprss humanizado |
| EP4276185A3 (en) | 2017-09-29 | 2024-02-21 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| US11589562B2 (en) | 2018-07-16 | 2023-02-28 | Regeneran Pharmaceuticals, Inc. | Mouse model of DITRA disease and uses thereof |
| WO2020147829A1 (zh) * | 2019-01-17 | 2020-07-23 | 北京百奥赛图基因生物技术有限公司 | 人源化转基因动物 |
| IL286905B2 (en) | 2019-04-04 | 2024-06-01 | Regeneron Pharma | Non-human animals containing the human coagulation factor 12 locus |
| KR20220016869A (ko) | 2019-06-04 | 2022-02-10 | 리제너론 파마슈티칼스 인코포레이티드 | 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| BR112021022722A2 (pt) | 2019-06-07 | 2022-01-04 | Regeneron Pharma | Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente |
| CN112430621B (zh) * | 2019-08-09 | 2022-09-27 | 百奥赛图(北京)医药科技股份有限公司 | Il2ra基因人源化的非人动物的构建方法及应用 |
| KR20220133248A (ko) * | 2020-01-28 | 2022-10-04 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 pnpla3 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| KR102316506B1 (ko) | 2020-02-26 | 2021-10-22 | 차의과학대학교 산학협력단 | 동물 면역계의 인간화 활성을 촉진하는 방법 |
| CN111926039B (zh) * | 2020-09-23 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Il-13基因人源化的非人动物的构建方法和应用 |
| IL303724A (en) * | 2020-12-21 | 2023-08-01 | Regeneron Pharma | Non-human animals with a humanized TSLP gene, a humanized TSLP receptor gene, and/or a humanized IL7RA gene |
| WO2022247936A1 (en) * | 2021-05-28 | 2022-12-01 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric cd36 |
| KR20250067149A (ko) * | 2022-09-08 | 2025-05-14 | 더 잭슨 래보라토리 | 인간화 면역결핍 마우스 모델 |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| WO2001015521A1 (en) | 1999-08-31 | 2001-03-08 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| CN101302517B (zh) * | 2008-02-03 | 2010-11-03 | 中国科学院广州生物医药与健康研究院 | 人白细胞介素7在真核宿主中表达的方法 |
| ES2908587T3 (es) * | 2009-10-06 | 2022-05-03 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| BR112014008529A2 (pt) | 2011-10-28 | 2017-04-18 | Regeneron Pharma | il-6 humanizado e receptor de il-6 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
-
2013
- 2013-03-12 US US13/795,765 patent/US8962913B2/en not_active Expired - Fee Related
- 2013-06-14 BR BR112014029892A patent/BR112014029892A2/pt not_active Application Discontinuation
- 2013-06-14 KR KR1020147035047A patent/KR20150027752A/ko not_active Ceased
- 2013-06-14 RS RS20170543A patent/RS56039B1/sr unknown
- 2013-06-14 EP EP13739875.6A patent/EP2861063A1/en not_active Withdrawn
- 2013-06-14 WO PCT/US2013/045788 patent/WO2013192030A1/en not_active Ceased
- 2013-06-14 PT PT141955021T patent/PT2859793T/pt unknown
- 2013-06-14 SG SG10201609569PA patent/SG10201609569PA/en unknown
- 2013-06-14 ES ES14195502.1T patent/ES2626965T3/es active Active
- 2013-06-14 EP EP14195502.1A patent/EP2859793B1/en active Active
- 2013-06-14 CA CA2873134A patent/CA2873134A1/en not_active Abandoned
- 2013-06-14 HU HUE14195502A patent/HUE034592T2/en unknown
- 2013-06-14 JP JP2015517447A patent/JP6174134B2/ja not_active Expired - Fee Related
- 2013-06-14 SM SM20170313T patent/SMT201700313T1/it unknown
- 2013-06-14 LT LTEP14195502.1T patent/LT2859793T/lt unknown
- 2013-06-14 RU RU2014148107A patent/RU2654565C2/ru not_active IP Right Cessation
- 2013-06-14 NZ NZ702943A patent/NZ702943A/en not_active IP Right Cessation
- 2013-06-14 CN CN201610168011.XA patent/CN105779467A/zh active Pending
- 2013-06-14 PL PL14195502T patent/PL2859793T3/pl unknown
- 2013-06-14 SI SI201330664A patent/SI2859793T1/sl unknown
- 2013-06-14 MX MX2014015679A patent/MX363540B/es unknown
- 2013-06-14 HK HK15104315.3A patent/HK1203761A1/xx unknown
- 2013-06-14 SG SG11201407370QA patent/SG11201407370QA/en unknown
- 2013-06-14 SG SG10201609576YA patent/SG10201609576YA/en unknown
- 2013-06-14 AU AU2013277457A patent/AU2013277457B2/en not_active Ceased
- 2013-06-14 CN CN201380031333.4A patent/CN104378976B/zh not_active Expired - Fee Related
- 2013-06-14 DK DK14195502.1T patent/DK2859793T3/en active
-
2014
- 2014-11-18 IL IL235773A patent/IL235773B/en active IP Right Grant
- 2014-11-24 US US14/551,538 patent/US9232776B2/en not_active Expired - Fee Related
- 2014-11-28 IN IN10189DEN2014 patent/IN2014DN10189A/en unknown
-
2015
- 2015-11-10 US US14/937,270 patent/US20160052986A1/en not_active Abandoned
-
2016
- 2016-11-21 US US15/357,021 patent/US9737059B2/en not_active Expired - Fee Related
-
2017
- 2017-05-31 CY CY20171100577T patent/CY1119071T1/el unknown
- 2017-06-27 HR HRP20170974TT patent/HRP20170974T1/hr unknown
- 2017-07-14 US US15/649,797 patent/US9974291B2/en not_active Expired - Fee Related
-
2018
- 2018-04-24 US US15/960,642 patent/US10314298B2/en not_active Expired - Fee Related
- 2018-06-25 IL IL260250A patent/IL260250B/en not_active IP Right Cessation
-
2019
- 2019-05-01 US US16/400,074 patent/US20190343093A1/en not_active Abandoned
- 2019-08-13 IL IL26867419A patent/IL268674A/en unknown
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