JP2017213006A5 - - Google Patents

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Publication number
JP2017213006A5
JP2017213006A5 JP2017177761A JP2017177761A JP2017213006A5 JP 2017213006 A5 JP2017213006 A5 JP 2017213006A5 JP 2017177761 A JP2017177761 A JP 2017177761A JP 2017177761 A JP2017177761 A JP 2017177761A JP 2017213006 A5 JP2017213006 A5 JP 2017213006A5
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JP
Japan
Prior art keywords
rodent
dpp4
mouse
gene
dpp4 gene
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JP2017177761A
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English (en)
Japanese (ja)
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JP6636486B2 (ja
JP2017213006A (ja
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Publication of JP2017213006A5 publication Critical patent/JP2017213006A5/ja
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JP2017177761A 2014-05-30 2017-09-15 ヒト化ジペプチジルペプチダーゼｉｖ（ｄｐｐ４）動物 Active JP6636486B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201462005476P 2014-05-30 2014-05-30
US62/005,476 2014-05-30
US201462051626P 2014-09-17 2014-09-17
US62/051,626 2014-09-17
US201462072692P 2014-10-30 2014-10-30
US62/072,692 2014-10-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016566982A Division JP6212659B2 (ja) 2014-05-30 2015-05-28 ヒト化ジペプチジルペプチダーゼｉｖ（ｄｐｐ４）動物

Publications (3)

Publication Number Publication Date
JP2017213006A JP2017213006A (ja) 2017-12-07
JP2017213006A5 true JP2017213006A5 (OSRAM) 2018-04-05
JP6636486B2 JP6636486B2 (ja) 2020-01-29

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ID=53366330

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016566982A Active JP6212659B2 (ja) 2014-05-30 2015-05-28 ヒト化ジペプチジルペプチダーゼｉｖ（ｄｐｐ４）動物
JP2017177761A Active JP6636486B2 (ja) 2014-05-30 2017-09-15 ヒト化ジペプチジルペプチダーゼｉｖ（ｄｐｐ４）動物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016566982A Active JP6212659B2 (ja) 2014-05-30 2015-05-28 ヒト化ジペプチジルペプチダーゼｉｖ（ｄｐｐ４）動物

Country Status (16)

Country Link
US (5) US9497945B2 (OSRAM)
EP (2) EP2993977B1 (OSRAM)
JP (2) JP6212659B2 (OSRAM)
KR (1) KR101737432B1 (OSRAM)
CN (2) CN111118047B (OSRAM)
AU (1) AU2015266841C1 (OSRAM)
BR (1) BR112016026245A2 (OSRAM)
CA (1) CA2947899C (OSRAM)
ES (2) ES2877275T3 (OSRAM)
IL (1) IL248702B (OSRAM)
MX (2) MX387036B (OSRAM)
NZ (1) NZ726355A (OSRAM)
PH (1) PH12016502170A1 (OSRAM)
RU (1) RU2648166C1 (OSRAM)
SG (1) SG11201609154TA (OSRAM)
WO (1) WO2015184164A1 (OSRAM)

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Publication number Priority date Publication date Assignee Title
JO3701B1 (ar) * 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
US9497945B2 (en) 2014-05-30 2016-11-22 Regeneron Pharmaceuticals, Inc. Humanized dipeptidyl peptidase IV (DPP4) animals
EP3585162B1 (en) * 2017-09-29 2023-08-30 Regeneron Pharmaceuticals, Inc. Rodents comprising a humanized ttr locus and methods of use
CN109022489B (zh) * 2018-08-09 2023-03-31 中国食品药品检定研究院 人dpp4基因敲入的小鼠模型、其产生方法和用途
US11464217B2 (en) 2019-02-22 2022-10-11 Regeneron Pharmaceuticals, Inc. Rodents having genetically modified sodium channels and methods of use thereof
WO2021154791A1 (en) * 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
KR102207249B1 (ko) * 2020-02-28 2021-01-25 대한민국(관리청: 특허청장, 승계청: 질병관리청장) 한국형 중동호흡기증후군 코로나바이러스 감염에 감수성을 가지는 인간 dpp4 유전자를 전신에 발현하는 형질전환마우스와 이의 용도
KR102243416B1 (ko) * 2020-02-28 2021-04-22 대한민국(질병관리청장) 한국형 중동호흡기증후군 코로나바이러스 감염에 감수성을 가지는 인간 dpp4 유전자를 폐 조직 특이적으로 발현하는 형질전환마우스와 이의 용도
CN113355325B (zh) * 2020-03-06 2023-07-14 中国科学院广州生物医药与健康研究院 人源化ace2基因改造小鼠胚胎干细胞模型制备方法及应用
US20230232796A1 (en) * 2020-06-26 2023-07-27 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ace2 locus
WO2024124111A1 (en) * 2022-12-08 2024-06-13 The Regents Of The University Of California Multimeric protein complexes for neutralization of viral pathogens in diagnostic, prophylactic, and therapeutic applications

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US6368604B1 (en) * 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
AU2002222951A1 (en) 2000-07-18 2002-01-30 Geoff D. Koch Apparatus and method for maintaining control of a drilling machine
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
EP1631680A2 (en) * 2003-05-21 2006-03-08 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
PL2767161T3 (pl) 2004-10-19 2018-09-28 Regeneron Pharmaceuticals, Inc. Sposób wytwarzania zwierzęcia homozygotycznego pod względem modyfikacji genetycznej
WO2006128163A2 (en) 2005-05-27 2006-11-30 Memory Pharmaceuticals Corp. Transgenic alzheimer's mouse model vectors and uses thereof
EP2099920B1 (en) * 2006-12-22 2014-06-25 Genentech, Inc. Transgenic mice expressing humanized vegf
WO2010110914A2 (en) 2009-03-27 2010-09-30 Zirus, Inc. Mammalian genes involved in infection
JP5595517B2 (ja) 2009-12-21 2014-09-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ＦｃγＲマウス
CN103348012B (zh) * 2010-11-27 2016-06-08 朱坚 一种人源化的转基因动物
KR102714361B1 (ko) * 2011-02-15 2024-10-11 리제너론 파마슈티칼스 인코포레이티드 인간화된 ｍ－ｃｓｆ 마우스
PL2663575T3 (pl) * 2011-10-28 2015-03-31 Regeneron Pharma Humanizowane IL-6 i receptor IL-6
WO2014045254A2 (en) * 2012-09-23 2014-03-27 Erasmus University Medical Center Rotterdam Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor
CN109913495B (zh) 2013-02-20 2022-11-25 瑞泽恩制药公司 大鼠的遗传修饰
SG10201808935WA (en) 2013-04-16 2018-11-29 Regeneron Pharma Targeted modification of rat genome
CN103554235B (zh) * 2013-06-17 2015-06-24 清华大学 MERS-CoV病毒膜蛋白中的RBD片段及其编码基因和应用
CN103724406A (zh) * 2013-11-20 2014-04-16 中国疾病预防控制中心病毒病预防控制所 一种具有中和活性的MERS-CoV合成肽疫苗及其应用
JP6174811B2 (ja) * 2013-12-11 2017-08-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ゲノムの標的改変のための方法及び組成物
US9497945B2 (en) 2014-05-30 2016-11-22 Regeneron Pharmaceuticals, Inc. Humanized dipeptidyl peptidase IV (DPP4) animals

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