JP2019510788A5 - - Google Patents

Info

Publication number

JP2019510788A5

JP2019510788A5 JP2018552659A JP2018552659A JP2019510788A5 JP 2019510788 A5 JP2019510788 A5 JP 2019510788A5 JP 2018552659 A JP2018552659 A JP 2018552659A JP 2018552659 A JP2018552659 A JP 2018552659A JP 2019510788 A5 JP2019510788 A5 JP 2019510788A5

Authority

JP

Japan

Prior art keywords

composition

amb

cholesterol

hydrate

acceptable salt

Prior art date

2017-04-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 76
• 239000000203 mixture Substances 0.000 claims description 60
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims description 41
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 41
• 229960003942 amphotericin b Drugs 0.000 claims description 41
• 235000012000 cholesterol Nutrition 0.000 claims description 38
• 201000003883 Cystic fibrosis Diseases 0.000 claims description 25
• 150000003839 salts Chemical class 0.000 claims description 20
• 239000012530 fluid Substances 0.000 claims description 11
• 239000000443 aerosol Substances 0.000 claims description 8
• 210000002345 respiratory system Anatomy 0.000 claims description 8
• BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 3
• 238000001990 intravenous administration Methods 0.000 claims description 3
• 238000007910 systemic administration Methods 0.000 claims description 3
• 108010039491 Ricin Proteins 0.000 claims 1
• 238000000034 method Methods 0.000 description 56
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 238000009472 formulation Methods 0.000 description 1