ES2983639T3 - Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística - Google Patents

Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística Download PDF

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Publication number
ES2983639T3
ES2983639T3 ES17779973T ES17779973T ES2983639T3 ES 2983639 T3 ES2983639 T3 ES 2983639T3 ES 17779973 T ES17779973 T ES 17779973T ES 17779973 T ES17779973 T ES 17779973T ES 2983639 T3 ES2983639 T3 ES 2983639T3
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ES
Spain
Prior art keywords
certain embodiments
molar ratio
amb
asl
cholesterol
Prior art date
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Active
Application number
ES17779973T
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English (en)
Spanish (es)
Inventor
Martin Burke
Katrina Muraglia
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University of Illinois System
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University of Illinois System
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Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
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Publication of ES2983639T3 publication Critical patent/ES2983639T3/es
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/10Expectorants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
ES17779973T 2016-04-08 2017-04-10 Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística Active ES2983639T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662320111P 2016-04-08 2016-04-08
US201662320795P 2016-04-11 2016-04-11
PCT/US2017/026806 WO2017177228A1 (en) 2016-04-08 2017-04-10 Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia

Publications (1)

Publication Number Publication Date
ES2983639T3 true ES2983639T3 (es) 2024-10-24

Family

ID=60001496

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17779973T Active ES2983639T3 (es) 2016-04-08 2017-04-10 Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística

Country Status (9)

Country Link
US (2) US20190083517A1 (enExample)
EP (1) EP3439668B1 (enExample)
JP (1) JP7041961B2 (enExample)
AU (1) AU2017248394B2 (enExample)
DK (1) DK3439668T3 (enExample)
ES (1) ES2983639T3 (enExample)
FI (1) FI3439668T3 (enExample)
PT (1) PT3439668T (enExample)
WO (1) WO2017177228A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2983639T3 (es) 2016-04-08 2024-10-24 The Board Of Trustees Of The Univ Illinois Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística
DK3694526T3 (da) * 2017-10-11 2025-02-03 Univ Illinois Genotype-agnostisk redning af cystisk fibrose med småmolekylære bicarbonatkanaler
CA3250825A1 (en) 2022-03-21 2023-09-28 Cystetic Medicines Inc PROSTHETIC COMPOSITIONS WITH ION CHANNELS COMPRISING AMPHOTEROTIN B LIPID-COATED CRYSTALS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
JP3507486B2 (ja) 1991-03-15 2004-03-15 アムジエン・インコーポレーテツド 顆粒球コロニー刺激因子の肺内投与
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
CA2194049A1 (en) 1994-06-28 1996-01-11 Georgi Stankov Novel clinical uses of polyene macrolides
TWI249408B (en) * 2003-12-10 2006-02-21 Ind Tech Res Inst New antifungal formulation and manufacturing method thereof
AU2005251745A1 (en) 2004-06-04 2005-12-22 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
HUE031951T2 (en) * 2006-10-10 2017-08-28 Jina Pharmaceuticals Inc Aqueous systems for lipid-based drug compounds; preparations, processes and their use
WO2009006311A2 (en) * 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
RU2481100C2 (ru) * 2009-10-16 2013-05-10 Лайфкеа Инновейшнз Пвт. Лтд. Новая лекарственная форма для лечения грибковой инфекции
CN105848721B (zh) * 2013-10-07 2019-08-23 伊利诺伊大学评议会 具有提高的治疗指数的两性霉素b衍生物
US20180015115A1 (en) * 2014-11-04 2018-01-18 The Board Of Trustees Of The University Of Illinois Restoring physiology with small molecule mimics of missing proteins
ES2983639T3 (es) 2016-04-08 2024-10-24 The Board Of Trustees Of The Univ Illinois Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística

Also Published As

Publication number Publication date
AU2017248394A1 (en) 2018-11-22
US20190083517A1 (en) 2019-03-21
US11850256B2 (en) 2023-12-26
EP3439668B1 (en) 2024-06-19
JP7041961B2 (ja) 2022-03-25
FI3439668T3 (fi) 2024-09-05
AU2017248394B2 (en) 2023-02-23
WO2017177228A1 (en) 2017-10-12
EP3439668A4 (en) 2019-12-18
PT3439668T (pt) 2024-08-12
DK3439668T3 (da) 2024-09-02
US20210393661A1 (en) 2021-12-23
EP3439668A1 (en) 2019-02-13
JP2019510788A (ja) 2019-04-18

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