JP2019510069A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019510069A5 JP2019510069A5 JP2018551785A JP2018551785A JP2019510069A5 JP 2019510069 A5 JP2019510069 A5 JP 2019510069A5 JP 2018551785 A JP2018551785 A JP 2018551785A JP 2018551785 A JP2018551785 A JP 2018551785A JP 2019510069 A5 JP2019510069 A5 JP 2019510069A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- group
- aryl
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 130
- 125000003118 aryl group Chemical group 0.000 claims description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims description 29
- 229910052801 chlorine Inorganic materials 0.000 claims description 21
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 18
- 229910052805 deuterium Inorganic materials 0.000 claims description 17
- 229910052731 fluorine Inorganic materials 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- 125000001072 heteroaryl group Chemical group 0.000 claims description 15
- 125000003545 alkoxy group Chemical group 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical class 0.000 claims description 9
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 9
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000005017 glioblastoma Diseases 0.000 claims 3
- 201000010536 head and neck cancer Diseases 0.000 claims 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 101150025421 ETS gene Proteins 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 102100039563 ETS translocation variant 1 Human genes 0.000 claims 1
- 102100039578 ETS translocation variant 4 Human genes 0.000 claims 1
- 102100030334 Friend leukemia integration 1 transcription factor Human genes 0.000 claims 1
- 101001077417 Gallus gallus Potassium voltage-gated channel subfamily H member 6 Proteins 0.000 claims 1
- 101000813729 Homo sapiens ETS translocation variant 1 Proteins 0.000 claims 1
- 101000813747 Homo sapiens ETS translocation variant 4 Proteins 0.000 claims 1
- 101001062996 Homo sapiens Friend leukemia integration 1 transcription factor Proteins 0.000 claims 1
- 101000893493 Homo sapiens Protein flightless-1 homolog Proteins 0.000 claims 1
- 101001010792 Homo sapiens Transcriptional regulator ERG Proteins 0.000 claims 1
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021053887A JP7269668B2 (ja) | 2016-03-31 | 2021-03-26 | インドール類似体及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662316156P | 2016-03-31 | 2016-03-31 | |
| US62/316,156 | 2016-03-31 | ||
| US201662417621P | 2016-11-04 | 2016-11-04 | |
| US62/417,621 | 2016-11-04 | ||
| PCT/US2017/022682 WO2017172368A1 (en) | 2016-03-31 | 2017-03-16 | Indoline analogs and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021053887A Division JP7269668B2 (ja) | 2016-03-31 | 2021-03-26 | インドール類似体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510069A JP2019510069A (ja) | 2019-04-11 |
| JP2019510069A5 true JP2019510069A5 (enExample) | 2020-04-09 |
| JP6864379B2 JP6864379B2 (ja) | 2021-04-28 |
Family
ID=59960688
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551785A Active JP6864379B2 (ja) | 2016-03-31 | 2017-03-16 | インドール類似体及びその使用 |
| JP2021053887A Active JP7269668B2 (ja) | 2016-03-31 | 2021-03-26 | インドール類似体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021053887A Active JP7269668B2 (ja) | 2016-03-31 | 2021-03-26 | インドール類似体及びその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9822122B2 (enExample) |
| EP (2) | EP3436434B1 (enExample) |
| JP (2) | JP6864379B2 (enExample) |
| KR (2) | KR102375929B1 (enExample) |
| CN (1) | CN109219594B (enExample) |
| AR (1) | AR108010A1 (enExample) |
| DK (1) | DK3436434T3 (enExample) |
| ES (1) | ES2823190T3 (enExample) |
| TW (2) | TWI786723B (enExample) |
| WO (1) | WO2017172368A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX388564B (es) | 2014-10-09 | 2025-03-20 | Oncternal Therapeutics Inc | Compuestos de indolinona y usos de los mismos. |
| EP3436434B1 (en) * | 2016-03-31 | 2020-07-08 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| MX395539B (es) | 2016-07-29 | 2025-03-25 | Oncternal Therapeutics Inc | Usos de compuestos de indolinona |
| TR202002324A2 (tr) * | 2020-02-17 | 2021-08-23 | Bahcesehir Ueniversitesi | Yeni̇ mouse double minute 2 (mdm2) i̇nhi̇bi̇törü olarak kullanmak i̇çi̇n drg-mdm2-3 |
| CN111518086B (zh) * | 2020-05-22 | 2021-08-06 | 广州医科大学 | 氧化吲哚-萘并呋喃衍生物及其制备方法、用途以及包含其的药物组合物、制剂 |
| WO2023178040A2 (en) * | 2022-03-13 | 2023-09-21 | University Of Virginia Patent Foundation | Inhibitors of ews-fli1 |
| CN115850151A (zh) * | 2022-11-25 | 2023-03-28 | 成都普康生物科技有限公司 | 一种席夫碱类似化合物及其合成方法、pi3k激酶抑制剂及其应用 |
| CN115993455A (zh) * | 2022-12-29 | 2023-04-21 | 南京医科大学康达学院 | Rna结合蛋白nova2作为非小细胞肺癌转移标志物的应用 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3435034A (en) | 1967-03-17 | 1969-03-25 | Sandoz Ag | Pyridazino(3,4-b)indoles |
| US3592813A (en) | 1967-04-18 | 1971-07-13 | Smith Kline French Lab | 3-phenyl-9h-pyridazino(3,4-b)indoles |
| US3631177A (en) | 1967-04-18 | 1971-12-28 | Smith Kline French Lab | 3-phenacyl-2-oxoindolines |
| US4376731A (en) | 1978-01-31 | 1983-03-15 | Boehringer Mannheim Gmbh | 1-Aziridine carboxylic acid derivatives with immunostimulant activity |
| CA1288436C (en) | 1983-07-22 | 1991-09-03 | David Paul Hesson | Phenylquinolinecarboxylic acids and derivatives as antitumor agents |
| US4935436A (en) | 1989-01-23 | 1990-06-19 | The Dow Chemical Company | Substituted triazoles and their use as fungicides |
| GB8909737D0 (en) | 1989-04-27 | 1989-06-14 | Shell Int Research | Thiazole derivatives |
| US5750542A (en) | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| EP0613890A1 (en) | 1993-02-28 | 1994-09-07 | Nihon Nohyaku Co., Ltd. | Novel triazole compound, process for preparing the same and antifungal agent containing the same |
| CA2190708A1 (en) | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
| KR20010006509A (ko) | 1997-04-16 | 2001-01-26 | 스티븐 에프. 웨인스톡 | 5,7-이치환된 4-아미노피리도[2,3-ｄ]피리미딘 화합물 및 아데노신 키나제 억제제로서의 이의 용도 |
| ATE285769T1 (de) | 1998-12-04 | 2005-01-15 | Neurosearch As | Verwendung von isatinderivaten als ionenkanalaktivierende mittel |
| CN1155572C (zh) | 2001-01-19 | 2004-06-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 吲哚类衍生物及其抗肿瘤用途 |
| US20030114666A1 (en) | 2001-06-19 | 2003-06-19 | Ellsworth Edmund Lee | Antibacterial agents |
| US20030157486A1 (en) | 2001-06-21 | 2003-08-21 | Graff Jonathan M. | Methods to identify signal sequences |
| GB0219687D0 (en) | 2002-08-23 | 2002-10-02 | Lilly Co Eli | Benzyl morpholine derivatives |
| EP3034510A1 (en) | 2004-04-30 | 2016-06-22 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a c5-modified pyrimidine |
| EP1753755A1 (en) | 2004-05-25 | 2007-02-21 | AstraZeneca AB | 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents |
| WO2005116022A1 (en) | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- `4- {6-substituted alkanoyl) pyridin-3-yl} -3-phenyl! -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents |
| KR101048535B1 (ko) | 2005-03-30 | 2011-07-11 | 주식회사 대웅제약 | 항진균성 트리아졸 유도체 |
| AR056317A1 (es) | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
| WO2006117414A1 (es) | 2005-04-29 | 2006-11-09 | Proyecto De Biomedicina Cima, S.L. | Modelo animal no humano de sarcoma |
| NZ564696A (en) | 2005-06-10 | 2011-05-27 | Boehringer Ingelheim Int | Glucocorticoid, indazole, mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US20100016298A1 (en) | 2005-08-29 | 2010-01-21 | Housey Gerad M | Theramutein modulators |
| FR2903984B1 (fr) | 2006-07-24 | 2008-10-03 | Genfit Sa | Derives d'imidazolones substitues, preparation et utilisations |
| WO2008046083A2 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of oxindole compounds as therapeutic agents |
| EP2124910A4 (en) * | 2006-12-29 | 2012-02-15 | Univ Georgetown | ANTITUMOR THERAPY BY TARGETING EWS-FLI1 |
| US8232310B2 (en) | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| WO2008091681A2 (en) | 2007-01-23 | 2008-07-31 | Housey Gerard M | Theramutein modulators |
| US20120157434A1 (en) | 2007-03-02 | 2012-06-21 | CSO of MicuRx Pharmaceuticals, Inc. | Antimicrobial heterocyclic compounds for treatment of bacterial infections |
| JP5400032B2 (ja) | 2007-04-20 | 2014-01-29 | ザ リサーチ ファウンデーション オブ ザ ステイト ユニヴァーシティ オブ ニューヨーク | ベンズイミダゾール及びその医薬組成物 |
| US8377992B2 (en) | 2007-10-22 | 2013-02-19 | The Wistar Institute | TRBD-binding effectors and methods for using the same to modulate telomerase activity |
| LT2318006T (lt) | 2008-08-15 | 2017-01-10 | Nivalis Therapeutics, Inc. | Nauji s-nitrozoglutationo reduktazės pirolo inhibitoriai, kaip terapiniai agentai |
| CA2770302A1 (en) | 2008-09-17 | 2010-03-25 | Burnham Institute For Medical Research | Small molecule compounds for stem cell differentiation |
| JP6049260B2 (ja) | 2008-10-10 | 2016-12-21 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | プロアポトーシスｂａｘ及びｂｃｌ−２ポリペプチドの化学モジュレータ |
| EA024364B1 (ru) | 2008-10-21 | 2016-09-30 | Оникс Терапьютикс, Инк. | Способ лечения множественной миеломы |
| US8710068B2 (en) * | 2009-01-19 | 2014-04-29 | The Trustees Of The University Of Pennsylvania | Method of treating cancer using a survivin inhibitor |
| KR101149529B1 (ko) | 2009-09-11 | 2012-05-25 | 한국화학연구원 | 인덴온 유도체 및 이를 포함하는 약학적 조성물 |
| WO2012003418A2 (en) | 2010-07-02 | 2012-01-05 | The University Of North Carolina At Chapel Hill | Functionally selective ligands of dopamine d2 receptors |
| WO2012021467A1 (en) | 2010-08-10 | 2012-02-16 | Metabolic Solutions Development Company, Llc | Synthesis for thiazolidinedione compounds |
| WO2012078519A2 (en) | 2010-12-06 | 2012-06-14 | Numerate, Inc. | 3-acylidene-2-oxoindole derivatives for inhibition of transglutaminase 2 |
| WO2012177603A2 (en) | 2011-06-19 | 2012-12-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| CN102516152B (zh) | 2011-12-12 | 2014-12-10 | 华东师范大学 | 一种α-二氟羰基取代的手性叔醇类化合物及其合成方法和应用 |
| WO2013091096A1 (en) | 2011-12-20 | 2013-06-27 | Boehringer Ingelheim International Gmbh | Condensed triclyclic compounds as inhibitors of hiv replication |
| WO2013144224A1 (en) | 2012-03-27 | 2013-10-03 | Syngenta Participations Ag | Acetylenic microbiocides |
| US20130259927A1 (en) | 2012-04-02 | 2013-10-03 | Gradalis, Inc. | Ewing's Sarcoma Bifunctional shRNA Design |
| KR102145835B1 (ko) * | 2012-04-12 | 2020-08-20 | 조지타운 유니버시티 | 유잉육종계 종양을 치료하기 위한 조성물 |
| WO2014015153A2 (en) * | 2012-07-20 | 2014-01-23 | Star Biotechnology, Llc | Compositions and methods for treating ewing's sarcoma and other disorders related to ews-fli1 |
| BR112015003376A8 (pt) | 2012-08-23 | 2018-01-23 | Alios Biopharma Inc | composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e usos de quantidade eficiente de composto ou sal farmaceuticamente aceitável do mesmo ou composição farmacêutica |
| TWI687220B (zh) | 2013-03-01 | 2020-03-11 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| RU2015144155A (ru) | 2013-03-15 | 2017-04-24 | Акадиа Фармасьютикалз Инк. | Мускариновые агонисты |
| US9593113B2 (en) | 2013-08-22 | 2017-03-14 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
| CN103435606A (zh) | 2013-08-22 | 2013-12-11 | 中国药科大学 | CDK2与GSK3β双重抑制剂及用途 |
| MX2016004678A (es) | 2013-10-24 | 2017-03-10 | Univ Georgetown | Composiciones para el tratamiento del cancer. |
| JP2016538310A (ja) | 2013-11-27 | 2016-12-08 | オンコエシックス ゲーエムベーハー | チエノトリアゾロジアゼピン化合物を含む医薬製剤を用いる白血病の治療方法 |
| CN105793251B (zh) | 2013-12-05 | 2018-10-12 | 豪夫迈·罗氏有限公司 | 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物 |
| MX2016011105A (es) | 2014-03-07 | 2016-12-12 | Bristol Myers Squibb Co | Inhibidores de monoacilglicerol aciltransferasa 2 (mgat2) de dihidropiridinona para usarse en el tratamiento de trastornos metabolicos. |
| WO2015160868A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| WO2016044067A1 (en) | 2014-09-15 | 2016-03-24 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| MX388564B (es) * | 2014-10-09 | 2025-03-20 | Oncternal Therapeutics Inc | Compuestos de indolinona y usos de los mismos. |
| EP3436434B1 (en) * | 2016-03-31 | 2020-07-08 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| MX395539B (es) | 2016-07-29 | 2025-03-25 | Oncternal Therapeutics Inc | Usos de compuestos de indolinona |
-
2017
- 2017-03-16 EP EP17776297.8A patent/EP3436434B1/en active Active
- 2017-03-16 KR KR1020187031059A patent/KR102375929B1/ko active Active
- 2017-03-16 EP EP20184572.4A patent/EP3795563B1/en active Active
- 2017-03-16 CN CN201780034085.7A patent/CN109219594B/zh active Active
- 2017-03-16 JP JP2018551785A patent/JP6864379B2/ja active Active
- 2017-03-16 ES ES17776297T patent/ES2823190T3/es active Active
- 2017-03-16 DK DK17776297.8T patent/DK3436434T3/da active
- 2017-03-16 US US15/461,327 patent/US9822122B2/en active Active
- 2017-03-16 WO PCT/US2017/022682 patent/WO2017172368A1/en not_active Ceased
- 2017-03-16 KR KR1020227008510A patent/KR102514814B1/ko active Active
- 2017-03-30 TW TW110125866A patent/TWI786723B/zh active
- 2017-03-30 TW TW106110666A patent/TWI793070B/zh active
- 2017-03-30 AR ARP170100787A patent/AR108010A1/es unknown
- 2017-08-18 US US15/680,905 patent/US10351569B2/en active Active
-
2019
- 2019-06-03 US US16/430,234 patent/US10711008B2/en active Active
-
2021
- 2021-03-26 JP JP2021053887A patent/JP7269668B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019510069A5 (enExample) | ||
| RU2477723C2 (ru) | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе | |
| IL268030B2 (en) | Bicyclic compounds as allosteric shp2 inhibitors | |
| JP2008535902A5 (enExample) | ||
| KR930702292A (ko) | 종양 치료 활성을 증대시키기 위한 퀴나졸린 유도체 | |
| JP2019514863A5 (enExample) | ||
| JP2008535903A5 (enExample) | ||
| KR20010102519A (ko) | 항 종양 활성을 갖는 캠토테신 유도체 | |
| JP2015512943A5 (enExample) | ||
| JP2012526766A5 (enExample) | ||
| CA2485430A1 (en) | Process for the preparation of a hydrate of an anthranilic acid derivative | |
| CN110770234B (zh) | 取代芳基醚类化合物、其制备方法、药用组合物及其应用 | |
| RU2017120030A (ru) | Новый тип производного цитидина и его применение | |
| WO2013178021A1 (zh) | 吡咯并[2，1—f][1，2，4]三嗪衍生物及其抗肿瘤用途 | |
| CA2958741C (en) | Quinazoline derivatives | |
| JP4876070B2 (ja) | エピポドフィロトキシンの（ポリ）アミノアルキルアミノアセトアミド誘導体、その調製方法及び諸療法における抗癌剤としてのその応用 | |
| CN113087712A (zh) | L-氨基酸-6-胶霉毒素酯三氟乙酸盐及其制备方法 | |
| JP2007532628A5 (enExample) | ||
| JP2020517676A5 (enExample) | ||
| JP2009520692A5 (enExample) | ||
| US8133888B2 (en) | Hydrazide containing taxane conjugates | |
| JP2012526054A (ja) | 複素環置換のジフェニル尿素類誘導体及びその用途 | |
| JP2004536132A (ja) | 新規なｅｔ−７４３の抗腫瘍性誘導体 | |
| JP2012526767A5 (enExample) | ||
| TWI293302B (en) | New derivatives of mikanolide, their preparation and their therapeutic uses |