|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
WO2015105955A1
(en)
|
2014-01-08 |
2015-07-16 |
Flodesign Sonics, Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
JP6816133B2
(ja)
*
|
2015-10-05 |
2021-01-20 |
プレシジョン バイオサイエンシズ，インク． |
改変ヒトｔ細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞
|
|
EP3359660B1
(en)
|
2015-10-05 |
2019-12-04 |
Precision Biosciences, Inc. |
Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene
|
|
EP3433269B1
(en)
|
2016-03-23 |
2023-09-27 |
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Fusion proteins of pd-1 and 4-1bb
|
|
US20190161530A1
(en)
*
|
2016-04-07 |
2019-05-30 |
Bluebird Bio, Inc. |
Chimeric antigen receptor t cell compositions
|
|
EP4628587A3
(en)
|
2016-04-15 |
2026-02-25 |
Memorial Sloan Kettering Cancer Center |
Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
KR102451510B1
(ko)
*
|
2016-09-08 |
2022-10-07 |
2세븐티 바이오, 인코포레이티드 |
Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법
|
|
AU2017347854B2
(en)
*
|
2016-10-27 |
2022-12-08 |
Intima Bioscience, Inc. |
Viral methods of T cell therapy
|
|
EP3583203B1
(en)
|
2017-02-15 |
2023-11-01 |
2seventy bio, Inc. |
Donor repair templates multiplex genome editing
|
|
EP4029943A1
(en)
*
|
2017-05-08 |
2022-07-20 |
Precision Biosciences, Inc. |
Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
|
|
US11166985B2
(en)
|
2017-05-12 |
2021-11-09 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
|
MX2019013514A
(es)
|
2017-05-12 |
2020-01-20 |
Crispr Therapeutics Ag |
Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia.
|
|
WO2018232356A1
(en)
|
2017-06-15 |
2018-12-20 |
The Regents Of The University Of California |
Targeted non-viral dna insertions
|
|
EP3645038B1
(en)
|
2017-06-30 |
2026-02-18 |
Precision Biosciences, Inc. |
Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene
|
|
US12023353B2
(en)
*
|
2017-10-18 |
2024-07-02 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
Methods and compounds for improved immune cell therapy
|
|
JP7101419B2
(ja)
*
|
2017-10-27 |
2022-07-15 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
内因性ｔ細胞受容体の標的置換
|
|
SG11202004026QA
(en)
|
2017-10-30 |
2020-05-28 |
Pact Pharma Inc |
Primary cell gene editing
|
|
KR102439221B1
(ko)
|
2017-12-14 |
2022-09-01 |
프로디자인 소닉스, 인크. |
음향 트랜스듀서 구동기 및 제어기
|
|
CN110221068B
(zh)
*
|
2018-03-02 |
2020-09-18 |
中国医学科学院基础医学研究所 |
检测Kyn含量的试剂的应用
|
|
US20190284553A1
(en)
|
2018-03-15 |
2019-09-19 |
KSQ Therapeutics, Inc. |
Gene-regulating compositions and methods for improved immunotherapy
|
|
IL277722B2
(en)
|
2018-04-02 |
2025-12-01 |
Pact Pharma Inc |
Peptide-mhc compacts
|
|
US11786554B2
(en)
|
2018-04-12 |
2023-10-17 |
Precision Biosciences, Inc. |
Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene
|
|
MX2020012028A
(es)
|
2018-05-11 |
2021-03-29 |
Crispr Therapeutics Ag |
Metodos y composiciones para tratar el cancer.
|
|
CN112384230A
(zh)
*
|
2018-05-14 |
2021-02-19 |
瑟姆巴股份有限公司 |
用于自身免疫障碍的基因编辑
|
|
US20210207174A1
(en)
*
|
2018-05-25 |
2021-07-08 |
The Regents Of The University Of California |
Genetic engineering of endogenous proteins
|
|
US12497611B2
(en)
|
2018-08-17 |
2025-12-16 |
Yale University |
Compositions and methods for high-throughput activation screening to boost T cell effector function
|
|
JP7470119B2
(ja)
|
2018-08-24 |
2024-04-17 |
シーエスエル ベーリング ジーン セラピー インコーポレイテッド |
無血清培地におけるベクター産生
|
|
US20210213119A1
(en)
*
|
2018-08-28 |
2021-07-15 |
Immunotech Biopharm Co., Ltd. |
Improved therapeutic t cell
|
|
SG11202102012SA
(en)
*
|
2018-08-28 |
2021-04-29 |
Pharos Vaccine Inc |
Improved lentiviral vector
|
|
WO2020092057A1
(en)
*
|
2018-10-30 |
2020-05-07 |
Yale University |
Compositions and methods for rapid and modular generation of chimeric antigen receptor t cells
|
|
IL283724B1
(en)
|
2018-12-10 |
2026-02-01 |
Genetix Biotherapeutics Inc |
pdcd-1 homing endonuclease variants
|
|
JP2022513750A
(ja)
|
2018-12-10 |
2022-02-09 |
２セブンティ バイオ インコーポレイテッド |
ホーミングエンドヌクレアーゼバリアント
|
|
KR20210104772A
(ko)
*
|
2018-12-14 |
2021-08-25 |
블루버드 바이오, 인코포레이티드. |
이량체화제로 조절된 면역수용체 복합체
|
|
IL285534B2
(en)
|
2019-02-12 |
2025-04-01 |
Pact Pharma Inc |
Preparations and methods for identifying antigen-specific T cells
|
|
AU2020262409A1
(en)
*
|
2019-04-24 |
2021-12-23 |
Seattle Children's Hospital D/B/A Seattle Children's Research Institute |
Wiskott-Aldrich syndrome gene homing endonuclease variants, compositions, and methods of use
|
|
SG11202111031RA
(en)
*
|
2019-04-26 |
2021-11-29 |
Allogene Therapeutics Inc |
Rituximab-resistant chimeric antigen receptors and uses thereof
|
|
MX2021013359A
(es)
|
2019-04-30 |
2022-01-31 |
Crispr Therapeutics Ag |
Terapia de celulas alogénicas de neoplasias malignas de células b usando células t modificadas genéticamente dirigidas a cd19.
|
|
US12552855B2
(en)
*
|
2019-05-08 |
2026-02-17 |
Regeneron Pharmaceuticals, Inc. |
CD33 targeted immunotherapies
|
|
WO2021057906A1
(zh)
*
|
2019-09-25 |
2021-04-01 |
科济生物医药（上海）有限公司 |
表达il-15的免疫效应细胞
|
|
EP4061947A4
(en)
*
|
2019-11-22 |
2024-04-24 |
California Institute of Technology |
METHODS FOR ROBUST CONTROL OF GENE EXPRESSION
|
|
CN115003314A
(zh)
*
|
2019-11-27 |
2022-09-02 |
得克萨斯大学体系董事会 |
B细胞的大规模组合car转导和crispr基因编辑
|
|
CN112980886B
(zh)
*
|
2019-12-02 |
2022-02-22 |
河北森朗生物科技有限公司 |
一种能高效制备且应用安全的嵌合抗原受体t细胞及其制备方法与应用
|
|
CN115052887B
(zh)
|
2019-12-11 |
2026-03-31 |
A2生物治疗公司 |
基于lilrb1的嵌合抗原受体
|
|
CN110938656B
(zh)
*
|
2019-12-24 |
2021-12-28 |
中国大熊猫保护研究中心 |
重组表达大熊猫促卵泡生成素的载体、表达系统及制备方法
|
|
US20230133554A1
(en)
*
|
2020-04-09 |
2023-05-04 |
Autolus Limited |
Molecule
|
|
WO2022040444A1
(en)
|
2020-08-20 |
2022-02-24 |
A2 Biotherapeutics, Inc. |
Compositions and methods for treating egfr positive cancers
|
|
IL300500A
(en)
|
2020-08-20 |
2023-04-01 |
A2 Biotherapeutics Inc |
Preparations and methods for the treatment of mesothelin positive cancer
|
|
CA3188867A1
(en)
|
2020-08-20 |
2022-02-24 |
Xueyin Wang |
Compositions and methods for treating ceacam positive cancers
|
|
WO2022104344A2
(en)
*
|
2020-11-10 |
2022-05-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Knock-in of large dna for long-term high genomic expression
|
|
JP2024503249A
(ja)
*
|
2020-12-21 |
2024-01-25 |
２セブンティ バイオ インコーポレイテッド |
部位特異的変異導入のための組成物及び方法
|
|
CN117321215A
(zh)
*
|
2021-04-30 |
2023-12-29 |
逻辑生物治疗公司 |
病毒载体组合物和其使用方法
|
|
KR20240021179A
(ko)
*
|
2021-05-14 |
2024-02-16 |
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 |
키메라 폴리펩티드 및 사용 방법
|
|
WO2022272259A1
(en)
*
|
2021-06-23 |
2022-12-29 |
H. Lee Moffitt Cancer Center And Research Institute Inc. |
Car-t cell therapy for triple negative breast cancer
|
|
CN113481184A
(zh)
*
|
2021-08-06 |
2021-10-08 |
北京大学 |
融合蛋白以及其使用方法
|
|
JP2024537991A
(ja)
|
2021-10-14 |
2024-10-18 |
アーセナル バイオサイエンシズ インコーポレイテッド |
共発現されるｓｈＲＮＡと論理ゲートシステムとを有する免疫細胞
|
|
CN117624375A
(zh)
*
|
2022-08-30 |
2024-03-01 |
北京卡替医疗技术有限公司 |
增强受体、表达增强受体的免疫细胞及其用途
|
|
KR20250166108A
(ko)
*
|
2023-02-10 |
2025-11-27 |
난징 바이오흐엥 바이오테크 씨오., 엘티디 |
기능이 향상된 세포 치료법
|
|
AU2024372734A1
(en)
*
|
2023-10-30 |
2026-04-16 |
Allogene Therapeutics, Inc. |
Engineered cells
|
|
WO2025096594A2
(en)
*
|
2023-10-30 |
2025-05-08 |
Allogene Therapeutics, Inc. |
Cells expressing anti-cd19 chimeric antigen receptors and methods of use thereof
|