CN109311984A - 基因组编辑的免疫效应细胞 - Google Patents

基因组编辑的免疫效应细胞 Download PDF

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Publication number
CN109311984A
CN109311984A CN201780027741.0A CN201780027741A CN109311984A CN 109311984 A CN109311984 A CN 109311984A CN 201780027741 A CN201780027741 A CN 201780027741A CN 109311984 A CN109311984 A CN 109311984A
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cell
receptor
domain
group
tcr
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乔丹·贾儒尔
亚历山大·阿斯特拉罕
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2 Savinti Biology
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Bluebird Bio Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C12Y307/01—Hydrolases acting on carbon-carbon bonds (3.7) in ketonic substances (3.7.1)
    • C12Y307/01003—Kynureninase (3.7.1.3)
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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CN201780027741.0A 2016-03-11 2017-03-10 基因组编辑的免疫效应细胞 Pending CN109311984A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662307245P 2016-03-11 2016-03-11
US62/307,245 2016-03-11
US201662322604P 2016-04-14 2016-04-14
US62/322,604 2016-04-14
PCT/US2017/021951 WO2017156484A1 (en) 2016-03-11 2017-03-10 Genome edited immune effector cells

Publications (1)

Publication Number Publication Date
CN109311984A true CN109311984A (zh) 2019-02-05

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US (1) US20190241910A1 (https=)
EP (1) EP3426690A4 (https=)
JP (1) JP2019509738A (https=)
KR (2) KR102386029B1 (https=)
CN (1) CN109311984A (https=)
AU (1) AU2017230011A1 (https=)
BR (1) BR112018068354A2 (https=)
CA (1) CA3017213A1 (https=)
IL (1) IL261621A (https=)
MX (1) MX2018010924A (https=)
RU (1) RU2018135819A (https=)
SG (1) SG11201807820PA (https=)
WO (1) WO2017156484A1 (https=)

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CN109415687A (zh) * 2016-04-07 2019-03-01 蓝鸟生物公司 嵌合抗原受体t细胞组合物
CN110938656A (zh) * 2019-12-24 2020-03-31 中国大熊猫保护研究中心 重组表达大熊猫促卵泡生成素的载体、表达系统及制备方法
WO2021057906A1 (zh) * 2019-09-25 2021-04-01 科济生物医药（上海）有限公司 表达il-15的免疫效应细胞
WO2021109977A1 (zh) * 2019-12-02 2021-06-10 河北森朗生物科技有限公司 一种能高效制备且应用安全的嵌合抗原受体t细胞及其制备方法与应用
CN113481184A (zh) * 2021-08-06 2021-10-08 北京大学 融合蛋白以及其使用方法
CN114207126A (zh) * 2019-04-24 2022-03-18 西雅图儿童医院d/b/a西雅图儿童研究所 维斯科特-奥尔德里奇综合征基因归巢内切核酸酶变体、组合物和使用方法
CN114206928A (zh) * 2019-05-08 2022-03-18 印希彼有限公司 Cd33靶向免疫疗法
CN115003314A (zh) * 2019-11-27 2022-09-02 得克萨斯大学体系董事会 B细胞的大规模组合car转导和crispr基因编辑
WO2024165053A1 (zh) * 2023-02-10 2024-08-15 南京北恒生物科技有限公司 功能增强的细胞疗法

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