JP2019509319A5

JP2019509319A5 -

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Publication number: JP2019509319A5
Authority: JP; Japan
Prior art keywords: carbonyl; hydroxy; dihydropyrimidin; pyrrolidine; dimethoxyphenyl
Prior art date: 2017-03-23
Legal status : Granted

Application number

JP2018549910A

Other languages

English (en)

Japanese (ja)

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JP2019509319A (ja

JP6716711B2 (ja

Filing date

2017-03-23

Publication date

2019-05-30

2017-03-23 Application filed filed Critical

2017-03-23 Priority claimed from PCT/US2017/023801 external-priority patent/WO2017165640A1/en

2019-04-04 Publication of JP2019509319A publication Critical patent/JP2019509319A/ja

2019-05-30 Publication of JP2019509319A5 publication Critical patent/JP2019509319A5/ja

2020-07-01 Application granted granted Critical

2020-07-01 Publication of JP6716711B2 publication Critical patent/JP6716711B2/ja

Status Active legal-status Critical Current

2037-03-23 Anticipated expiration legal-status Critical

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HYDQPFCBCDDQIQ-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC2=CC=C(C=C2C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC2=CC=C(C=C2C1)F)O)C1=C(C=CC=C1OC)OC HYDQPFCBCDDQIQ-UHFFFAOYSA-N 0.000 claims description 2
SBJWWZKLTQBWOA-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CCN(CC1)CC1=CC(=CC=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CCN(CC1)CC1=CC(=CC=C1)F)O)C1=C(C=CC=C1OC)OC SBJWWZKLTQBWOA-UHFFFAOYSA-N 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims 70
-1 2 -cyclopropyl Chemical group 0.000 claims 60
229910052801 chlorine Inorganic materials 0.000 claims 44
229910052731 fluorine Inorganic materials 0.000 claims 44
229910052739 hydrogen Inorganic materials 0.000 claims 38
229910052799 carbon Inorganic materials 0.000 claims 33
125000000623 heterocyclic group Chemical group 0.000 claims 31
229910052794 bromium Inorganic materials 0.000 claims 25
150000001875 compounds Chemical class 0.000 claims 25
150000003839 salts Chemical class 0.000 claims 25
229910052760 oxygen Inorganic materials 0.000 claims 17
125000004452 carbocyclyl group Chemical group 0.000 claims 15
KLIDCXVFHGNTTM-UHFFFAOYSA-N 2,6-dimethoxyphenol Chemical group COC1=CC=CC(OC)=C1O KLIDCXVFHGNTTM-UHFFFAOYSA-N 0.000 claims 14
229910004013 NO 2 Inorganic materials 0.000 claims 13
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
229910052757 nitrogen Inorganic materials 0.000 claims 11
125000004433 nitrogen atom Chemical group N* 0.000 claims 10
125000003118 aryl group Chemical group 0.000 claims 9
125000001072 heteroaryl group Chemical group 0.000 claims 9
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 7
125000003342 alkenyl group Chemical group 0.000 claims 7
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 7
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 6
229910052736 halogen Inorganic materials 0.000 claims 5
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
KMXXWKVCCAKXDY-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)C(F)(F)F)=O)COC(C)C Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)C(F)(F)F)=O)COC(C)C KMXXWKVCCAKXDY-UHFFFAOYSA-N 0.000 claims 3
OFVBATVGQKJOLU-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1)=O)COCC Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1)=O)COCC OFVBATVGQKJOLU-UHFFFAOYSA-N 0.000 claims 3
YXKAFEVCHZPZFL-CEISFSOZSA-N ClC=1C=CC(=NC=1)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)[C@@H](CC)C1=CC(=CC(=C1)F)F)C=1C=NN(C=1)C)=O Chemical compound ClC=1C=CC(=NC=1)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)[C@@H](CC)C1=CC(=CC(=C1)F)F)C=1C=NN(C=1)C)=O YXKAFEVCHZPZFL-CEISFSOZSA-N 0.000 claims 3
MYUXCFYUCBXCRA-YNNZGITBSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C=1C=NN(C=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C=1C=NN(C=1)C MYUXCFYUCBXCRA-YNNZGITBSA-N 0.000 claims 3
FTZGZTWBLHDPGA-XLDIYJRPSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1F)=O)C1=NN(C=C1)CC Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1F)=O)C1=NN(C=C1)CC FTZGZTWBLHDPGA-XLDIYJRPSA-N 0.000 claims 3
206010019280 Heart failures Diseases 0.000 claims 3
JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 3
125000004432 carbon atom Chemical group C* 0.000 claims 3
125000000753 cycloalkyl group Chemical group 0.000 claims 3
150000002367 halogens Chemical class 0.000 claims 3
125000005842 heteroatom Chemical group 0.000 claims 3
YTEOJTOREOIWOW-FQEVSTJZSA-N 2-but-3-enyl-6-hydroxy-3-(2-methoxy-6-methylphenyl)-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CC=C)C1=NC(=C(C(N1C1=C(C=CC=C1C)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O YTEOJTOREOIWOW-FQEVSTJZSA-N 0.000 claims 2
XFNHSEAVVHPURY-FXMQYSIJSA-N 2-butyl-3-[(1S)-1-(3,5-difluorophenyl)propyl]-5-[3-(3,5-difluoropyridin-2-yl)pyrrolidine-1-carbonyl]-6-hydroxypyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC(=CC(=C1)F)F)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O XFNHSEAVVHPURY-FXMQYSIJSA-N 0.000 claims 2
GWOISGGMOJDLOR-AKRCKQFNSA-N 2-butyl-5-[3-(2-fluorophenyl)pyrrolidine-1-carbonyl]-6-hydroxy-3-[(1S)-1-phenylpropyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC=CC=C1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)O GWOISGGMOJDLOR-AKRCKQFNSA-N 0.000 claims 2
NQJTYSNXVAXUEU-ZYZRXSCRSA-N 2-butyl-5-[3-(3,5-difluoropyridin-2-yl)pyrrolidine-1-carbonyl]-6-hydroxy-3-[(1S)-1-phenylpropyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC=CC=C1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O NQJTYSNXVAXUEU-ZYZRXSCRSA-N 0.000 claims 2
OVTSAJGGBMKROF-YANBTOMASA-N 2-butyl-5-[3-(3-fluorophenyl)pyrrolidine-1-carbonyl]-6-hydroxy-3-[(1S)-1-phenylpropyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC=CC=C1)=O)C(=O)N1CC(CC1)C1=CC(=CC=C1)F)O OVTSAJGGBMKROF-YANBTOMASA-N 0.000 claims 2
MDHWTKHTNVRHQF-FXMQYSIJSA-N 2-butyl-5-[3-(5-chloro-3-fluoropyridin-2-yl)pyrrolidine-1-carbonyl]-3-[(1S)-1-(3,5-difluorophenyl)propyl]-6-hydroxypyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC(=CC(=C1)F)F)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)Cl)O MDHWTKHTNVRHQF-FXMQYSIJSA-N 0.000 claims 2
SBJALXICERGMIS-ZYZRXSCRSA-N 2-butyl-5-[3-(5-chloro-3-fluoropyridin-2-yl)pyrrolidine-1-carbonyl]-6-hydroxy-3-[(1R)-2-methoxy-1-phenylethyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](COC)C1=CC=CC=C1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)Cl)O SBJALXICERGMIS-ZYZRXSCRSA-N 0.000 claims 2
IWDWCKWANCTNRN-ZYZRXSCRSA-N 2-butyl-5-[3-(5-chloro-3-fluoropyridin-2-yl)pyrrolidine-1-carbonyl]-6-hydroxy-3-[(1S)-1-phenylpropyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC=CC=C1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)Cl)O IWDWCKWANCTNRN-ZYZRXSCRSA-N 0.000 claims 2
125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 2
125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 2
JYSMTRKHZIFCLN-BPARTEKVSA-N 3-[(1S)-1-[2-butyl-5-[3-(3,5-difluoropyridin-2-yl)pyrrolidine-1-carbonyl]-4-hydroxy-6-oxopyrimidin-1-yl]propyl]benzonitrile Chemical compound C(CCC)C=1N(C(C(=C(N=1)O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)[C@@H](CC)C=1C=C(C#N)C=CC=1 JYSMTRKHZIFCLN-BPARTEKVSA-N 0.000 claims 2
POQUQFBFMBBEHV-UQTORGHUSA-N 3-[(S)-[2-butyl-5-[3-(5-chloropyridin-2-yl)pyrrolidine-1-carbonyl]-4-hydroxy-6-oxopyrimidin-1-yl]-cyclopropylmethyl]benzonitrile Chemical compound C(CCC)C=1N(C(C(=C(N=1)O)C(=O)N1CC(CC1)C1=NC=C(C=C1)Cl)=O)[C@H](C=1C=C(C#N)C=CC=1)C1CC1 POQUQFBFMBBEHV-UQTORGHUSA-N 0.000 claims 2
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
JPRJFZZBPUGYCB-UHFFFAOYSA-N C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)O)C1=C(C=CC=C1OC)OC Chemical compound C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)O)C1=C(C=CC=C1OC)OC JPRJFZZBPUGYCB-UHFFFAOYSA-N 0.000 claims 2
DGVLFASAPIUBMI-UHFFFAOYSA-N C(C)C1=C(C(=CC=C1)CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NN(C=C1)C Chemical compound C(C)C1=C(C(=CC=C1)CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NN(C=C1)C DGVLFASAPIUBMI-UHFFFAOYSA-N 0.000 claims 2
PUALTDQVGGYXCD-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)O)C1=C(C=CC=C1OC)OC PUALTDQVGGYXCD-UHFFFAOYSA-N 0.000 claims 2
MHLWFUDLXMXXBP-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)O)C1=C(C=CC=C1OC)OC MHLWFUDLXMXXBP-UHFFFAOYSA-N 0.000 claims 2
KQIHNPUEKPNRRI-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)Cl)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)Cl)O)C1=C(C=CC=C1OC)OC KQIHNPUEKPNRRI-UHFFFAOYSA-N 0.000 claims 2
KCWZFHBIOKEJSH-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC KCWZFHBIOKEJSH-UHFFFAOYSA-N 0.000 claims 2
UYALXHDMGGCLAX-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=NC=C1)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=NC=C1)O)C1=C(C=CC=C1OC)OC UYALXHDMGGCLAX-UHFFFAOYSA-N 0.000 claims 2
KSQCOKRJNWPXJJ-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1)Cl)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1)Cl)O)C1=C(C=CC=C1OC)OC KSQCOKRJNWPXJJ-UHFFFAOYSA-N 0.000 claims 2
VVGSXIQDWIXKIA-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC VVGSXIQDWIXKIA-UHFFFAOYSA-N 0.000 claims 2
DLZMBKPZRKNVHA-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)Cl)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)Cl)O)C1=C(C=CC=C1OC)OC DLZMBKPZRKNVHA-UHFFFAOYSA-N 0.000 claims 2
ZCYVIKDZVPTGBA-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O)C1=C(C=CC=C1OC)OC ZCYVIKDZVPTGBA-UHFFFAOYSA-N 0.000 claims 2
ATBDLSRTTBGEPS-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=CC=C1)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=CC=C1)O)C1=C(C=CC=C1OC)OC ATBDLSRTTBGEPS-UHFFFAOYSA-N 0.000 claims 2
KJWWUJYVHSWKRR-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=CC=C1F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=CC=C1F)O)C1=C(C=CC=C1OC)OC KJWWUJYVHSWKRR-UHFFFAOYSA-N 0.000 claims 2
DZWWONYTHLSMAF-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C=1C=NC=CC=1)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C=1C=NC=CC=1)O)C1=C(C=CC=C1OC)OC DZWWONYTHLSMAF-UHFFFAOYSA-N 0.000 claims 2
GOTTUBKXURKFIG-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CCC(CC1)OC1=C(C(=CC=C1)F)Cl)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CCC(CC1)OC1=C(C(=CC=C1)F)Cl)O)C1=C(C=CC=C1OC)OC GOTTUBKXURKFIG-UHFFFAOYSA-N 0.000 claims 2
VTVMLXBRPFXGQN-UHFFFAOYSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CCN(CC1)CC1=C(C(=CC=C1)F)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1CCN(CC1)CC1=C(C(=CC=C1)F)F)O)C1=C(C=CC=C1OC)OC VTVMLXBRPFXGQN-UHFFFAOYSA-N 0.000 claims 2
BDLQPIGUKDQSBV-UHFFFAOYSA-N C1(CC1)CCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C1(CC1)CCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC BDLQPIGUKDQSBV-UHFFFAOYSA-N 0.000 claims 2
QSOSWPJPTNXYMW-UHFFFAOYSA-N C1(CC1)CCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O)C1=C(C=CC=C1OC)OC Chemical compound C1(CC1)CCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O)C1=C(C=CC=C1OC)OC QSOSWPJPTNXYMW-UHFFFAOYSA-N 0.000 claims 2
WLVNHWHICLVJSF-UHFFFAOYSA-N C1(CC1)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C1(CC1)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)O)C1=C(C=CC=C1OC)OC WLVNHWHICLVJSF-UHFFFAOYSA-N 0.000 claims 2
NPWFJSVUWOJMNF-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(C1)C1=CC=C(C=C1)C)=O)COC(C)C Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(C1)C1=CC=C(C=C1)C)=O)COC(C)C NPWFJSVUWOJMNF-UHFFFAOYSA-N 0.000 claims 2
IFDAJTGDMJSTBG-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)=O)COC(C)C Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)=O)COC(C)C IFDAJTGDMJSTBG-UHFFFAOYSA-N 0.000 claims 2
BKCCKSROPMYQRA-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)=O)COCC Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C#N)C=CC=C1)=O)COCC BKCCKSROPMYQRA-UHFFFAOYSA-N 0.000 claims 2
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OOPHWTDKOCYMNM-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=CC=C(C#N)C=C1)=O)COC(C)C Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=CC=C(C#N)C=C1)=O)COC(C)C OOPHWTDKOCYMNM-UHFFFAOYSA-N 0.000 claims 2
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MLKREUKUQXKSKJ-UHFFFAOYSA-N FC1=C(C=CC(=C1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)COC(C)C)=O Chemical compound FC1=C(C=CC(=C1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)COC(C)C)=O MLKREUKUQXKSKJ-UHFFFAOYSA-N 0.000 claims 2
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GMLIMNFXHKHSGC-CEISFSOZSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)=O)C=1C=NN(C=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)=O)C=1C=NN(C=1)C GMLIMNFXHKHSGC-CEISFSOZSA-N 0.000 claims 2
SDCDGWXARNMVNN-CEISFSOZSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C1=NN(C=C1)CC Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C1=NN(C=C1)CC SDCDGWXARNMVNN-CEISFSOZSA-N 0.000 claims 2
FRASOWUACCDYTP-FXMQYSIJSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1F)=O)C1=NN(C=C1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1F)=O)C1=NN(C=C1)C FRASOWUACCDYTP-FXMQYSIJSA-N 0.000 claims 2
206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
125000004122 cyclic group Chemical group 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 2
125000005843 halogen group Chemical group 0.000 claims 2
230000002107 myocardial effect Effects 0.000 claims 2
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238000007634 remodeling Methods 0.000 claims 2
229910052717 sulfur Inorganic materials 0.000 claims 2
229940124597 therapeutic agent Drugs 0.000 claims 2
125000006706 (C3-C6) carbocyclyl group Chemical group 0.000 claims 1
125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
MFJBSCLACUMXCV-IBGZPJMESA-N 2-(cyclobutyloxymethyl)-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C1(CCC1)OCC1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O MFJBSCLACUMXCV-IBGZPJMESA-N 0.000 claims 1
AVOKSOPYZNSZEI-IBGZPJMESA-N 2-(cyclopropylmethyl)-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C1(CC1)CC1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O AVOKSOPYZNSZEI-IBGZPJMESA-N 0.000 claims 1
AVOKSOPYZNSZEI-LJQANCHMSA-N 2-(cyclopropylmethyl)-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C1(CC1)CC1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O AVOKSOPYZNSZEI-LJQANCHMSA-N 0.000 claims 1
UKMJDWVNHIGHIU-SFHVURJKSA-N 2-(cyclopropyloxymethyl)-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C1(CC1)OCC1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O UKMJDWVNHIGHIU-SFHVURJKSA-N 0.000 claims 1
NXFFJDQHYLNEJK-UHFFFAOYSA-N 2-[4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1h-cyclopenta[b]indol-3-yl]acetic acid Chemical compound C1=2C(S(=O)(=O)C)=CC(F)=CC=2C=2CCC(CC(O)=O)C=2N1CC1=CC=C(Cl)C=C1 NXFFJDQHYLNEJK-UHFFFAOYSA-N 0.000 claims 1
YZDPLOBKKCWWJI-IBGZPJMESA-N 2-but-3-enyl-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CC=C)C1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O YZDPLOBKKCWWJI-IBGZPJMESA-N 0.000 claims 1
YZDPLOBKKCWWJI-LJQANCHMSA-N 2-but-3-enyl-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CC=C)C1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O YZDPLOBKKCWWJI-LJQANCHMSA-N 0.000 claims 1
OVGUUSBHAPPKQU-UHFFFAOYSA-N 2-butyl-3-(2,6-diethylphenyl)-5-[3-(4-fluorophenyl)pyrrolidine-1-carbonyl]-6-hydroxypyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C1=C(C=CC=C1CC)CC)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)O OVGUUSBHAPPKQU-UHFFFAOYSA-N 0.000 claims 1
GDXIQEVIBIVXGF-QHCPKHFHSA-N 2-butyl-3-(2,6-diethylphenyl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C1=C(C=CC=C1CC)CC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O GDXIQEVIBIVXGF-QHCPKHFHSA-N 0.000 claims 1
GDXIQEVIBIVXGF-HSZRJFAPSA-N 2-butyl-3-(2,6-diethylphenyl)-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C1=C(C=CC=C1CC)CC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O GDXIQEVIBIVXGF-HSZRJFAPSA-N 0.000 claims 1
QRJSCLOMWHJDGT-UHFFFAOYSA-N 2-butyl-3-(2,6-dimethoxyphenyl)-5-[3-(4-fluorophenyl)pyrrolidine-1-carbonyl]-6-hydroxypyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)O QRJSCLOMWHJDGT-UHFFFAOYSA-N 0.000 claims 1
ZUZXUICJVLFZQL-LJQANCHMSA-N 2-butyl-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O ZUZXUICJVLFZQL-LJQANCHMSA-N 0.000 claims 1
ZZDVWNBKRXZMTP-KRWDZBQOSA-N 2-butyl-3-(4,6-dimethoxypyrimidin-5-yl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C=1C(=NC=NC=1OC)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O ZZDVWNBKRXZMTP-KRWDZBQOSA-N 0.000 claims 1
ZZDVWNBKRXZMTP-QGZVFWFLSA-N 2-butyl-3-(4,6-dimethoxypyrimidin-5-yl)-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C=1C(=NC=NC=1OC)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O ZZDVWNBKRXZMTP-QGZVFWFLSA-N 0.000 claims 1
LXVZLHUZAMFUCO-APWZRJJASA-N 2-butyl-3-[(1R)-1-cyclopropylethyl]-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](C)C1CC1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O LXVZLHUZAMFUCO-APWZRJJASA-N 0.000 claims 1
LXVZLHUZAMFUCO-VQIMIIECSA-N 2-butyl-3-[(1R)-1-cyclopropylethyl]-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](C)C1CC1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O LXVZLHUZAMFUCO-VQIMIIECSA-N 0.000 claims 1
ZPMRRHBAJDABRN-JTHBVZDNSA-N 2-butyl-3-[(1R)-2,3-dihydro-1H-inden-1-yl]-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H]1CCC2=CC=CC=C12)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O ZPMRRHBAJDABRN-JTHBVZDNSA-N 0.000 claims 1
ZPMRRHBAJDABRN-FYYLOGMGSA-N 2-butyl-3-[(1R)-2,3-dihydro-1H-inden-1-yl]-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H]1CCC2=CC=CC=C12)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O ZPMRRHBAJDABRN-FYYLOGMGSA-N 0.000 claims 1
UNIPHJZGDABKIO-RXVVDRJESA-N 2-butyl-3-[(1S)-1-(4-fluorophenyl)ethyl]-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1=CC=C(C=C1)F)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O UNIPHJZGDABKIO-RXVVDRJESA-N 0.000 claims 1
UNIPHJZGDABKIO-GHTZIAJQSA-N 2-butyl-3-[(1S)-1-(4-fluorophenyl)ethyl]-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1=CC=C(C=C1)F)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O UNIPHJZGDABKIO-GHTZIAJQSA-N 0.000 claims 1
LXVZLHUZAMFUCO-LPHOPBHVSA-N 2-butyl-3-[(1S)-1-cyclopropylethyl]-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1CC1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O LXVZLHUZAMFUCO-LPHOPBHVSA-N 0.000 claims 1
LXVZLHUZAMFUCO-QFBILLFUSA-N 2-butyl-3-[(1S)-1-cyclopropylethyl]-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1CC1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O LXVZLHUZAMFUCO-QFBILLFUSA-N 0.000 claims 1
FUHSSDMGLSAQOD-IJHRGXPZSA-N 2-butyl-3-[1-(2-chlorophenyl)ethyl]-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C1=C(C=CC=C1)Cl)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O FUHSSDMGLSAQOD-IJHRGXPZSA-N 0.000 claims 1
FUHSSDMGLSAQOD-ROPPNANJSA-N 2-butyl-3-[1-(2-chlorophenyl)ethyl]-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C1=C(C=CC=C1)Cl)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O FUHSSDMGLSAQOD-ROPPNANJSA-N 0.000 claims 1
JKVTVQQSCHQVIE-ZYZRXSCRSA-N 2-butyl-5-[3-(3,5-difluoropyridin-2-yl)pyrrolidine-1-carbonyl]-6-hydroxy-3-[(1R)-2-methoxy-1-phenylethyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](COC)C1=CC=CC=C1)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O JKVTVQQSCHQVIE-ZYZRXSCRSA-N 0.000 claims 1
XZKLWCYQVWSPHV-YSYXNDDBSA-N 2-butyl-5-[3-(3,5-difluoropyridin-2-yl)pyrrolidine-1-carbonyl]-6-hydroxy-3-[(1S)-1-(3-methoxyphenyl)propyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC(=CC=C1)OC)=O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)O XZKLWCYQVWSPHV-YSYXNDDBSA-N 0.000 claims 1
LLUVESSPUREZHP-UHFFFAOYSA-N 2-butyl-5-[3-(3-chlorophenyl)azetidine-1-carbonyl]-3-(2,6-dimethoxyphenyl)-6-hydroxypyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1CC(C1)C1=CC(=CC=C1)Cl)O LLUVESSPUREZHP-UHFFFAOYSA-N 0.000 claims 1
JFWKQRKFFSUZPV-BPARTEKVSA-N 2-butyl-6-hydroxy-3-(1-phenylethyl)-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O JFWKQRKFFSUZPV-BPARTEKVSA-N 0.000 claims 1
JFWKQRKFFSUZPV-AVKWCDSFSA-N 2-butyl-6-hydroxy-3-(1-phenylethyl)-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O JFWKQRKFFSUZPV-AVKWCDSFSA-N 0.000 claims 1
BTZZLEWEPNHEHR-ZZHFZYNASA-N 2-butyl-6-hydroxy-3-(2-methyl-1-phenylpropyl)-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C(C)C)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O BTZZLEWEPNHEHR-ZZHFZYNASA-N 0.000 claims 1
SJSFFCXZHPUWDH-CTNGQTDRSA-N 2-butyl-6-hydroxy-3-[(1R)-1-(2-methoxyphenyl)ethyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](C)C1=C(C=CC=C1)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O SJSFFCXZHPUWDH-CTNGQTDRSA-N 0.000 claims 1
SJSFFCXZHPUWDH-TZIWHRDSSA-N 2-butyl-6-hydroxy-3-[(1R)-1-(2-methoxyphenyl)ethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](C)C1=C(C=CC=C1)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O SJSFFCXZHPUWDH-TZIWHRDSSA-N 0.000 claims 1
JFWKQRKFFSUZPV-KNQAVFIVSA-N 2-butyl-6-hydroxy-3-[(1R)-1-phenylethyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](C)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O JFWKQRKFFSUZPV-KNQAVFIVSA-N 0.000 claims 1
JFWKQRKFFSUZPV-DENIHFKCSA-N 2-butyl-6-hydroxy-3-[(1R)-1-phenylethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](C)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O JFWKQRKFFSUZPV-DENIHFKCSA-N 0.000 claims 1
OPTCGNNKTWEHIE-XZOQPEGZSA-N 2-butyl-6-hydroxy-3-[(1R)-1-phenylpropyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](CC)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O OPTCGNNKTWEHIE-XZOQPEGZSA-N 0.000 claims 1
OPTCGNNKTWEHIE-DHIUTWEWSA-N 2-butyl-6-hydroxy-3-[(1R)-1-phenylpropyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](CC)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O OPTCGNNKTWEHIE-DHIUTWEWSA-N 0.000 claims 1
JBMUARNSQGXMNO-GOTSBHOMSA-N 2-butyl-6-hydroxy-3-[(1R)-2-methoxy-1-phenylethyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](COC)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O JBMUARNSQGXMNO-GOTSBHOMSA-N 0.000 claims 1
JBMUARNSQGXMNO-PKTZIBPZSA-N 2-butyl-6-hydroxy-3-[(1R)-2-methoxy-1-phenylethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](COC)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O JBMUARNSQGXMNO-PKTZIBPZSA-N 0.000 claims 1
SJSFFCXZHPUWDH-PZJWPPBQSA-N 2-butyl-6-hydroxy-3-[(1S)-1-(2-methoxyphenyl)ethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1=C(C=CC=C1)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O SJSFFCXZHPUWDH-PZJWPPBQSA-N 0.000 claims 1
MPNYDTBILOXJOW-UGKGYDQZSA-N 2-butyl-6-hydroxy-3-[(1S)-1-(3-methoxyphenyl)ethyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1=CC(=CC=C1)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O MPNYDTBILOXJOW-UGKGYDQZSA-N 0.000 claims 1
MPNYDTBILOXJOW-SIKLNZKXSA-N 2-butyl-6-hydroxy-3-[(1S)-1-(3-methoxyphenyl)ethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1=CC(=CC=C1)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O MPNYDTBILOXJOW-SIKLNZKXSA-N 0.000 claims 1
OAFNZMIDPBYGLZ-ZEQRLZLVSA-N 2-butyl-6-hydroxy-3-[(1S)-1-phenylbutyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CCC)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O OAFNZMIDPBYGLZ-ZEQRLZLVSA-N 0.000 claims 1
OAFNZMIDPBYGLZ-RPWUZVMVSA-N 2-butyl-6-hydroxy-3-[(1S)-1-phenylbutyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CCC)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O OAFNZMIDPBYGLZ-RPWUZVMVSA-N 0.000 claims 1
JFWKQRKFFSUZPV-UGKGYDQZSA-N 2-butyl-6-hydroxy-3-[(1S)-1-phenylethyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O JFWKQRKFFSUZPV-UGKGYDQZSA-N 0.000 claims 1
JFWKQRKFFSUZPV-SIKLNZKXSA-N 2-butyl-6-hydroxy-3-[(1S)-1-phenylethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](C)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O JFWKQRKFFSUZPV-SIKLNZKXSA-N 0.000 claims 1
OPTCGNNKTWEHIE-GOTSBHOMSA-N 2-butyl-6-hydroxy-3-[(1S)-1-phenylpropyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O OPTCGNNKTWEHIE-GOTSBHOMSA-N 0.000 claims 1
OPTCGNNKTWEHIE-PKTZIBPZSA-N 2-butyl-6-hydroxy-3-[(1S)-1-phenylpropyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@@H](CC)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O OPTCGNNKTWEHIE-PKTZIBPZSA-N 0.000 claims 1
JBMUARNSQGXMNO-XZOQPEGZSA-N 2-butyl-6-hydroxy-3-[(1S)-2-methoxy-1-phenylethyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](COC)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O JBMUARNSQGXMNO-XZOQPEGZSA-N 0.000 claims 1
JBMUARNSQGXMNO-DHIUTWEWSA-N 2-butyl-6-hydroxy-3-[(1S)-2-methoxy-1-phenylethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H](COC)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O JBMUARNSQGXMNO-DHIUTWEWSA-N 0.000 claims 1
QYPVCSZUHUCCMH-ZYZRXSCRSA-N 2-butyl-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]-3-(1-pyridin-3-ylethyl)pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C=1C=NC=CC=1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O QYPVCSZUHUCCMH-ZYZRXSCRSA-N 0.000 claims 1
NXINJULQQULGIQ-ZYZRXSCRSA-N 2-butyl-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]-3-(1-pyridin-4-ylethyl)pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C1=CC=NC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O NXINJULQQULGIQ-ZYZRXSCRSA-N 0.000 claims 1
ATEPUDXFDCVEPZ-UPVQGACJSA-N 2-butyl-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H]1CCCC2=CC=CC=C12)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O ATEPUDXFDCVEPZ-UPVQGACJSA-N 0.000 claims 1
GZPLRKKFTSWWLM-KRWDZBQOSA-N 2-butyl-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]-3-propan-2-ylpyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O GZPLRKKFTSWWLM-KRWDZBQOSA-N 0.000 claims 1
QYPVCSZUHUCCMH-BDPMCISCSA-N 2-butyl-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]-3-(1-pyridin-3-ylethyl)pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C=1C=NC=CC=1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O QYPVCSZUHUCCMH-BDPMCISCSA-N 0.000 claims 1
ATEPUDXFDCVEPZ-VWNXMTODSA-N 2-butyl-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1[C@H]1CCCC2=CC=CC=C12)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O ATEPUDXFDCVEPZ-VWNXMTODSA-N 0.000 claims 1
GZPLRKKFTSWWLM-QGZVFWFLSA-N 2-butyl-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]-3-propan-2-ylpyrimidin-4-one Chemical compound C(CCC)C1=NC(=C(C(N1C(C)C)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O GZPLRKKFTSWWLM-QGZVFWFLSA-N 0.000 claims 1
OBAVYJUIHLXDRV-FQEVSTJZSA-N 2-cyclopentyl-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C1(CCCC1)C1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O OBAVYJUIHLXDRV-FQEVSTJZSA-N 0.000 claims 1
OBAVYJUIHLXDRV-HXUWFJFHSA-N 2-cyclopentyl-3-(2,6-dimethoxyphenyl)-6-hydroxy-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-4-one Chemical compound C1(CCCC1)C1=NC(=C(C(N1C1=C(C=CC=C1OC)OC)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)O OBAVYJUIHLXDRV-HXUWFJFHSA-N 0.000 claims 1
JBCWMYZVSLWKOV-QHCPKHFHSA-N 3-(2,6-diethylphenyl)-6-hydroxy-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]-2-(propan-2-yloxymethyl)pyrimidin-4-one Chemical compound C(C)C1=C(C(=CC=C1)CC)N1C(=NC(=C(C1=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O)COC(C)C JBCWMYZVSLWKOV-QHCPKHFHSA-N 0.000 claims 1
UBRYGZKVZFHKJT-CVDCTZTESA-N 3-[(1S)-1-[2-butyl-4-hydroxy-6-oxo-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-1-yl]ethyl]benzonitrile Chemical compound C(CCC)C=1N(C(C(=C(N=1)O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)=O)[C@@H](C)C=1C=C(C#N)C=CC=1 UBRYGZKVZFHKJT-CVDCTZTESA-N 0.000 claims 1
UBRYGZKVZFHKJT-WMZHIEFXSA-N 3-[(1S)-1-[2-butyl-4-hydroxy-6-oxo-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]pyrimidin-1-yl]ethyl]benzonitrile Chemical compound C(CCC)C=1N(C(C(=C(N=1)O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)=O)[C@@H](C)C=1C=C(C#N)C=CC=1 UBRYGZKVZFHKJT-WMZHIEFXSA-N 0.000 claims 1
INPKGHONUSXLHG-BPARTEKVSA-N 3-[(1S)-1-[2-butyl-5-[3-(5-chloro-3-fluoropyridin-2-yl)pyrrolidine-1-carbonyl]-4-hydroxy-6-oxopyrimidin-1-yl]propyl]benzonitrile Chemical compound C(CCC)C=1N(C(C(=C(N=1)O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)Cl)=O)[C@@H](CC)C=1C=C(C#N)C=CC=1 INPKGHONUSXLHG-BPARTEKVSA-N 0.000 claims 1
RFTYGENCWMDDIN-AKRCKQFNSA-N 3-[(1S)-1-[2-butyl-5-[3-(5-fluoropyridin-2-yl)pyrrolidine-1-carbonyl]-4-hydroxy-6-oxopyrimidin-1-yl]propyl]benzonitrile Chemical compound C(CCC)C=1N(C(C(=C(N=1)O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)=O)[C@@H](CC)C=1C=C(C#N)C=CC=1 RFTYGENCWMDDIN-AKRCKQFNSA-N 0.000 claims 1
QQFJGMNZUQQFEW-ZEQRLZLVSA-N 3-[(1S)-1-[4-hydroxy-6-oxo-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]-2-(propan-2-yloxymethyl)pyrimidin-1-yl]propyl]benzonitrile Chemical compound OC=1N=C(N(C(C=1C(=O)N1C[C@H](CC1)C1=CC=CC=C1)=O)[C@@H](CC)C=1C=C(C#N)C=CC=1)COC(C)C QQFJGMNZUQQFEW-ZEQRLZLVSA-N 0.000 claims 1
DBFWYSZWFRMJCO-GHZUAHJPSA-N 3-[(S)-[2-butyl-5-[3-(3,5-difluoropyridin-2-yl)pyrrolidine-1-carbonyl]-4-hydroxy-6-oxopyrimidin-1-yl]-cyclopropylmethyl]benzonitrile Chemical compound C(CCC)C=1N(C(C(=C(N=1)O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)[C@H](C=1C=C(C#N)C=CC=1)C1CC1 DBFWYSZWFRMJCO-GHZUAHJPSA-N 0.000 claims 1
125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
SWPVNSNRMYFXFL-UHFFFAOYSA-N 5-[4-(6-chloropyridin-3-yl)piperidine-1-carbonyl]-3-(2,6-diethylphenyl)-6-hydroxy-2-(propan-2-yloxymethyl)pyrimidin-4-one Chemical compound ClC1=CC=C(C=N1)C1CCN(CC1)C(=O)C=1C(N(C(=NC=1O)COC(C)C)C1=C(C=CC=C1CC)CC)=O SWPVNSNRMYFXFL-UHFFFAOYSA-N 0.000 claims 1
JMRVEVDLWJYYSN-VXKWHMMOSA-N 6-hydroxy-3-[(1R)-2-methoxy-1-phenylethyl]-5-[(3R)-3-phenylpyrrolidine-1-carbonyl]-2-propylpyrimidin-4-one Chemical compound OC1=C(C(N(C(=N1)CCC)[C@@H](COC)C1=CC=CC=C1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1 JMRVEVDLWJYYSN-VXKWHMMOSA-N 0.000 claims 1
JMRVEVDLWJYYSN-YADHBBJMSA-N 6-hydroxy-3-[(1R)-2-methoxy-1-phenylethyl]-5-[(3S)-3-phenylpyrrolidine-1-carbonyl]-2-propylpyrimidin-4-one Chemical compound OC1=C(C(N(C(=N1)CCC)[C@@H](COC)C1=CC=CC=C1)=O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1 JMRVEVDLWJYYSN-YADHBBJMSA-N 0.000 claims 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
KJZKRYJVMIRYDN-UHFFFAOYSA-N C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)Cl)O)C1=C(C=CC=C1OC)OC Chemical compound C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)Cl)O)C1=C(C=CC=C1OC)OC KJZKRYJVMIRYDN-UHFFFAOYSA-N 0.000 claims 1
UKLITGJJJKCNSY-UHFFFAOYSA-N C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)O)C1=C(C=CC=C1OC)OC UKLITGJJJKCNSY-UHFFFAOYSA-N 0.000 claims 1
PQLKHUNPNPCJBW-UHFFFAOYSA-N C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC Chemical compound C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)O)C1=C(C=CC=C1OC)OC PQLKHUNPNPCJBW-UHFFFAOYSA-N 0.000 claims 1
CNCRLSNNLWARSD-IBGZPJMESA-N C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O)C1=C(C=CC=C1OC)OC Chemical compound C(C)(C)(C)OCC=1N(C(=C(C(N=1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O)C1=C(C=CC=C1OC)OC CNCRLSNNLWARSD-IBGZPJMESA-N 0.000 claims 1
RGEVCSHXMLPNRM-UHFFFAOYSA-N C(C)C1=C(C(=CC=C1)CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NN(C=C1)C(C)C Chemical compound C(C)C1=C(C(=CC=C1)CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NN(C=C1)C(C)C RGEVCSHXMLPNRM-UHFFFAOYSA-N 0.000 claims 1
QFAUPZJGCZDRGG-UHFFFAOYSA-N C(C)C1=C(C(=CC=C1)CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C=1C=NN(C=1)CC Chemical compound C(C)C1=C(C(=CC=C1)CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C=1C=NN(C=1)CC QFAUPZJGCZDRGG-UHFFFAOYSA-N 0.000 claims 1
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ASJAZUDLKHVIOA-QHCPKHFHSA-N C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O)C1=C(C=CC=C1C1CC1)C1CC1 Chemical compound C(CCC)C=1N(C(=C(C(N=1)=O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)O)C1=C(C=CC=C1C1CC1)C1CC1 ASJAZUDLKHVIOA-QHCPKHFHSA-N 0.000 claims 1
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KLXPBZJTSAPLSN-RGHXLCRISA-N C(OC1=C(C(=CC=C1)OC([2H])([2H])[2H])N1C(=NC(C(=C1O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)=O)CCCC)([2H])([2H])[2H] Chemical compound C(OC1=C(C(=CC=C1)OC([2H])([2H])[2H])N1C(=NC(C(=C1O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)=O)CCCC)([2H])([2H])[2H] KLXPBZJTSAPLSN-RGHXLCRISA-N 0.000 claims 1
KKVOZQKVYSKADL-FAQKSFSJSA-N C(OC1=C(C(=CC=C1)OC([2H])([2H])[2H])N1C(=NC(C(=C1O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)=O)COCC)([2H])([2H])[2H] Chemical compound C(OC1=C(C(=CC=C1)OC([2H])([2H])[2H])N1C(=NC(C(=C1O)C(=O)N1C[C@@H](CC1)C1=CC=CC=C1)=O)COCC)([2H])([2H])[2H] KKVOZQKVYSKADL-FAQKSFSJSA-N 0.000 claims 1
KKVOZQKVYSKADL-MIIFTPDFSA-N C(OC1=C(C(=CC=C1)OC([2H])([2H])[2H])N1C(=NC(C(=C1O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)=O)COCC)([2H])([2H])[2H] Chemical compound C(OC1=C(C(=CC=C1)OC([2H])([2H])[2H])N1C(=NC(C(=C1O)C(=O)N1C[C@H](CC1)C1=CC=CC=C1)=O)COCC)([2H])([2H])[2H] KKVOZQKVYSKADL-MIIFTPDFSA-N 0.000 claims 1
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SRAPBYCCIBVCFB-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(C1)C1=CC=CC=C1)=O)COC(C)C Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(C1)C1=CC=CC=C1)=O)COC(C)C SRAPBYCCIBVCFB-UHFFFAOYSA-N 0.000 claims 1
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LPALMFBFJGEADD-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NC(=CC=C1)C Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NC(=CC=C1)C LPALMFBFJGEADD-UHFFFAOYSA-N 0.000 claims 1
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COIILOBUXHKWBO-UHFFFAOYSA-N COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C=1C=NC=C(C=1)C Chemical compound COC1=C(C(=CC=C1)OC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C=1C=NC=C(C=1)C COIILOBUXHKWBO-UHFFFAOYSA-N 0.000 claims 1
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HAOMEDJFLJVBCF-UHFFFAOYSA-N FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)C1=CC(=CC=C1)C)=O Chemical compound FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)C1=CC(=CC=C1)C)=O HAOMEDJFLJVBCF-UHFFFAOYSA-N 0.000 claims 1
NDQSSUFVZJSICZ-UHFFFAOYSA-N FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)C1=CC(=CC=C1)OC)=O Chemical compound FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)C1=CC(=CC=C1)OC)=O NDQSSUFVZJSICZ-UHFFFAOYSA-N 0.000 claims 1
BEUXJFVEOFLVOD-UHFFFAOYSA-N FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)C1=NC(=CC=C1)C)=O Chemical compound FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)C1=C(C=CC=C1OC)OC)C1=NC(=CC=C1)C)=O BEUXJFVEOFLVOD-UHFFFAOYSA-N 0.000 claims 1
AKZADDCANKYRKO-OZBJMMHXSA-N FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)[C@@H](CC)C1=CC=CC=C1)C=1SC=C(N=1)C)=O Chemical compound FC=1C(=NC=C(C=1)F)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)[C@@H](CC)C1=CC=CC=C1)C=1SC=C(N=1)C)=O AKZADDCANKYRKO-OZBJMMHXSA-N 0.000 claims 1
QNAUVNNXKFNLBI-JIKORUOASA-N FC=1C=C(C=C(C=1)F)[C@H](C(C)C)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C1=NN(C=C1)CC Chemical compound FC=1C=C(C=C(C=1)F)[C@H](C(C)C)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C1=NN(C=C1)CC QNAUVNNXKFNLBI-JIKORUOASA-N 0.000 claims 1
SCSAYYMIBRIFBX-KESSSICBSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NN(C=C1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C1=NN(C=C1)C SCSAYYMIBRIFBX-KESSSICBSA-N 0.000 claims 1
ZSSGMFSCDUMERQ-KESSSICBSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C=1C=NN(C=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)F)=O)C=1C=NN(C=1)C ZSSGMFSCDUMERQ-KESSSICBSA-N 0.000 claims 1
RTELFLCYUTVHLF-VXLWULRPSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)OC)=O)C1=NN(C=C1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)OC)=O)C1=NN(C=C1)C RTELFLCYUTVHLF-VXLWULRPSA-N 0.000 claims 1
MEQJVSBHKXVEJM-VXLWULRPSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)OC)=O)C=1C=NN(C=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=C(C=CC=C1)OC)=O)C=1C=NN(C=1)C MEQJVSBHKXVEJM-VXLWULRPSA-N 0.000 claims 1
WNMVCFQFJCBMHZ-VXLWULRPSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)=O)C1=NN(C=C1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)=O)C1=NN(C=C1)C WNMVCFQFJCBMHZ-VXLWULRPSA-N 0.000 claims 1
WEEWWLRDDNREKP-VXLWULRPSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)=O)C=1C=NN(C=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=CC=C(C=C1)F)=O)C=1C=NN(C=1)C WEEWWLRDDNREKP-VXLWULRPSA-N 0.000 claims 1
YTKDBAOFVPEASY-CEISFSOZSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)=O)C1=NN(C=C1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)=O)C1=NN(C=C1)C YTKDBAOFVPEASY-CEISFSOZSA-N 0.000 claims 1
CQHLQYGBLHLTPL-FXMQYSIJSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)=O)C=1SC=C(N=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1)F)=O)C=1SC=C(N=1)C CQHLQYGBLHLTPL-FXMQYSIJSA-N 0.000 claims 1
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DQJGTYBQOAMOCA-LGTGAQBVSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C=1SC=C(N=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=C(C=C1F)F)=O)C=1SC=C(N=1)C DQJGTYBQOAMOCA-LGTGAQBVSA-N 0.000 claims 1
ZBGCOISLEVAWGX-CEISFSOZSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC(=C1)F)=O)C1=NN(C=C1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC(=C1)F)=O)C1=NN(C=C1)C ZBGCOISLEVAWGX-CEISFSOZSA-N 0.000 claims 1
BUKFEWMTMFXLPG-CEISFSOZSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC(=C1)F)=O)C=1C=NN(C=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC(=C1)F)=O)C=1C=NN(C=1)C BUKFEWMTMFXLPG-CEISFSOZSA-N 0.000 claims 1
BANKFPPGUYAAEK-FXMQYSIJSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC(=C1)F)=O)C=1SC=C(N=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC(=C1)F)=O)C=1SC=C(N=1)C BANKFPPGUYAAEK-FXMQYSIJSA-N 0.000 claims 1
SVZZZAWDSHWMEN-MBABXSBOSA-N FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1F)=O)C=1SC=C(N=1)C Chemical compound FC=1C=C(C=C(C=1)F)[C@H](CC)N1C(=NC(C(=C1O)C(=O)N1CC(CC1)C1=NC=CC=C1F)=O)C=1SC=C(N=1)C SVZZZAWDSHWMEN-MBABXSBOSA-N 0.000 claims 1
QEMUXOSDHFVCMV-ZYZRXSCRSA-N FC=1C=CC(=NC=1)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)[C@@H](CC)C1=CC=CC=C1)C=1SC=C(N=1)C)=O Chemical compound FC=1C=CC(=NC=1)C1CN(CC1)C(=O)C=1C(N=C(N(C=1O)[C@@H](CC)C1=CC=CC=C1)C=1SC=C(N=1)C)=O QEMUXOSDHFVCMV-ZYZRXSCRSA-N 0.000 claims 1
206010061216 Infarction Diseases 0.000 claims 1
208000006011 Stroke Diseases 0.000 claims 1
208000008253 Systolic Heart Failure Diseases 0.000 claims 1
125000002947 alkylene group Chemical group 0.000 claims 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
238000007675 cardiac surgery Methods 0.000 claims 1
208000029078 coronary artery disease Diseases 0.000 claims 1
125000000392 cycloalkenyl group Chemical group 0.000 claims 1
206010012601 diabetes mellitus Diseases 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
208000018578 heart valve disease Diseases 0.000 claims 1
230000007574 infarction Effects 0.000 claims 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
125000000714 pyrimidinyl group Chemical group 0.000 claims 1
125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
238000006467 substitution reaction Methods 0.000 claims 1
238000002560 therapeutic procedure Methods 0.000 claims 1
125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 claims 1
IFVBDTXUZRICAR-QHCPKHFHSA-N CCCCC(N(c1c(CC)cccc1CC)C(O)=C1C(N(CC2)C[C@H]2c2ccccc2)=O)=NC1=O Chemical compound CCCCC(N(c1c(CC)cccc1CC)C(O)=C1C(N(CC2)C[C@H]2c2ccccc2)=O)=NC1=O IFVBDTXUZRICAR-QHCPKHFHSA-N 0.000 description 1
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AVFZOVWCLRSYKC-UHFFFAOYSA-N CN1CCCC1 Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 description 1
PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1

JP2018549910A 2016-03-24 2017-03-23 Ａｐｊアゴニストとしての６−ヒドロキシ−４−オキソ−１，４−ジヒドロピリミジン−５−カルボキシアミド Active JP6716711B2 (ja)