JP2019508714A5 - - Google Patents
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- JP2019508714A5 JP2019508714A5 JP2018555442A JP2018555442A JP2019508714A5 JP 2019508714 A5 JP2019508714 A5 JP 2019508714A5 JP 2018555442 A JP2018555442 A JP 2018555442A JP 2018555442 A JP2018555442 A JP 2018555442A JP 2019508714 A5 JP2019508714 A5 JP 2019508714A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- amount
- bcma polypeptide
- subject
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 68
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 66
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 66
- 239000012634 fragment Substances 0.000 claims description 64
- 229920001184 polypeptide Polymers 0.000 claims description 62
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 62
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 62
- 238000000034 method Methods 0.000 claims description 37
- 239000012472 biological sample Substances 0.000 claims description 30
- 238000003556 assay Methods 0.000 claims description 25
- 239000000523 sample Substances 0.000 claims description 24
- 210000002966 serum Anatomy 0.000 claims description 24
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 10
- 210000001185 bone marrow Anatomy 0.000 claims description 10
- 210000005087 mononuclear cell Anatomy 0.000 claims description 10
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- 206010061598 Immunodeficiency Diseases 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 230000007813 immunodeficiency Effects 0.000 claims description 8
- 238000003127 radioimmunoassay Methods 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 210000000987 immune system Anatomy 0.000 claims description 6
- 238000003018 immunoassay Methods 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 6
- 201000010717 Bruton-type agammaglobulinemia Diseases 0.000 claims description 5
- 208000016349 X-linked agammaglobulinemia Diseases 0.000 claims description 5
- 208000030507 AIDS Diseases 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 4
- 238000012286 ELISA Assay Methods 0.000 claims description 4
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims description 4
- 208000009388 Job Syndrome Diseases 0.000 claims description 4
- 230000001010 compromised effect Effects 0.000 claims description 4
- 208000014796 hyper-IgE recurrent infection syndrome 1 Diseases 0.000 claims description 4
- 206010051040 hyper-IgE syndrome Diseases 0.000 claims description 4
- 208000012116 immunodeficiency-related disease Diseases 0.000 claims description 4
- 208000011580 syndromic disease Diseases 0.000 claims description 4
- 208000010543 22q11.2 deletion syndrome Diseases 0.000 claims description 2
- 208000008190 Agammaglobulinemia Diseases 0.000 claims description 2
- 206010003594 Ataxia telangiectasia Diseases 0.000 claims description 2
- 208000033241 Autosomal dominant hyper-IgE syndrome Diseases 0.000 claims description 2
- 208000031879 Chédiak-Higashi syndrome Diseases 0.000 claims description 2
- 206010010099 Combined immunodeficiency Diseases 0.000 claims description 2
- 201000003874 Common Variable Immunodeficiency Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000000398 DiGeorge Syndrome Diseases 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108010044091 Globulins Proteins 0.000 claims description 2
- 102000006395 Globulins Human genes 0.000 claims description 2
- 208000028523 Hereditary Complement Deficiency disease Diseases 0.000 claims description 2
- 208000003352 Hyper-IgM Immunodeficiency Syndrome Diseases 0.000 claims description 2
- 208000007924 IgA Deficiency Diseases 0.000 claims description 2
- 101150105931 LRBA gene Proteins 0.000 claims description 2
- 201000001779 Leukocyte adhesion deficiency Diseases 0.000 claims description 2
- 206010039915 Selective IgA immunodeficiency Diseases 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 201000002388 complement deficiency Diseases 0.000 claims description 2
- 206010066130 hyper-IgM syndrome Diseases 0.000 claims description 2
- 230000000521 hyperimmunizing effect Effects 0.000 claims description 2
- 201000007156 immunoglobulin alpha deficiency Diseases 0.000 claims description 2
- 238000003364 immunohistochemistry Methods 0.000 claims description 2
- 230000001771 impaired effect Effects 0.000 claims description 2
- 208000029138 selective IgA deficiency disease Diseases 0.000 claims description 2
- 208000002491 severe combined immunodeficiency Diseases 0.000 claims description 2
- 208000008732 thymoma Diseases 0.000 claims description 2
- 208000023706 Bruton agammaglobulinaemia Diseases 0.000 claims 1
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 208000029192 congenital agammaglobulinemia Diseases 0.000 claims 1
- 208000019758 Hypergammaglobulinemia Diseases 0.000 description 1
- 208000035623 congenital anemia Diseases 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022004416A JP2022058619A (ja) | 2016-01-12 | 2022-01-14 | 被験体の免疫状態をモニタリングするための改善された方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662277801P | 2016-01-12 | 2016-01-12 | |
| US62/277,801 | 2016-01-12 | ||
| US201662300708P | 2016-02-26 | 2016-02-26 | |
| US62/300,708 | 2016-02-26 | ||
| PCT/US2017/013169 WO2017123741A1 (en) | 2016-01-12 | 2017-01-12 | Improved methods for monitoring immune status of a subject |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022004416A Division JP2022058619A (ja) | 2016-01-12 | 2022-01-14 | 被験体の免疫状態をモニタリングするための改善された方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019508714A JP2019508714A (ja) | 2019-03-28 |
| JP2019508714A5 true JP2019508714A5 (https=) | 2020-02-27 |
| JP7011600B2 JP7011600B2 (ja) | 2022-01-26 |
Family
ID=59312140
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555442A Active JP7011600B2 (ja) | 2016-01-12 | 2017-01-12 | 被験体の免疫状態をモニタリングするための改善された方法 |
| JP2022004416A Pending JP2022058619A (ja) | 2016-01-12 | 2022-01-14 | 被験体の免疫状態をモニタリングするための改善された方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022004416A Pending JP2022058619A (ja) | 2016-01-12 | 2022-01-14 | 被験体の免疫状態をモニタリングするための改善された方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11698369B2 (https=) |
| EP (2) | EP3402515B8 (https=) |
| JP (2) | JP7011600B2 (https=) |
| DK (1) | DK3402515T3 (https=) |
| ES (1) | ES2898329T3 (https=) |
| WO (1) | WO2017123741A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014124280A1 (en) | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
| ES2898329T3 (es) | 2016-01-12 | 2022-03-07 | Oncotracker Inc | Métodos mejorados para supervisar el estado inmunitario de un sujeto |
| US11635435B2 (en) | 2017-06-13 | 2023-04-25 | Oncotracker, Inc. | Diagnostic, prognostic, and monitoring methods for solid tumor cancers |
| MA53732A (fr) * | 2018-09-28 | 2022-01-05 | Amgen Inc | Anticorps dirigés contre bcma soluble |
| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
| CN118206620A (zh) * | 2022-12-09 | 2024-06-18 | 上海细胞治疗集团股份有限公司 | 一种多肽标签及其应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4493795A (en) | 1983-10-17 | 1985-01-15 | Syntex (U.S.A.) Inc. | Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| WO1998001151A1 (en) | 1996-07-10 | 1998-01-15 | Meiji Milk Products Co., Ltd. | Novel use of mk family as hematopoietic factor |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6355623B2 (en) | 1998-09-24 | 2002-03-12 | Hopital-Sainte-Justine | Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| US7320991B2 (en) | 2001-02-27 | 2008-01-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Analogs of thalidomide as potential angiogenesis inhibitors |
| WO2003022877A1 (en) | 2001-09-06 | 2003-03-20 | Biogen Idec Ma Inc. | Crystal structure of baff, and use thereof in drug design |
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| JP5570681B2 (ja) | 2004-08-31 | 2014-08-13 | 興和株式会社 | 抗ヒトｂａｆｆ抗体 |
| EP2332563A3 (en) | 2004-10-13 | 2013-03-13 | The Washington University | Use of BAFF to treat sepsis |
| US7947805B2 (en) | 2004-12-23 | 2011-05-24 | Merck Serono S.A. | BCMA polypeptides and uses thereof |
| WO2007053732A2 (en) | 2005-11-01 | 2007-05-10 | Mayo Foundation For Medical Education And Research | Promoter polymorphisms of the blys gene and use in diagnostic methods |
| US8202698B2 (en) | 2005-11-08 | 2012-06-19 | Biogen Idec Ma Inc. | Methods of evaluating BAFF |
| ES2618543T3 (es) | 2005-11-23 | 2017-06-21 | Genentech, Inc. | Métodos y composiciones relacionados con ensayos de linfocitos B |
| SG10202003901UA (en) | 2005-12-13 | 2020-05-28 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
| CA2644136A1 (en) | 2006-02-27 | 2007-09-07 | The Johns Hopkins University | Cancer treatment with gamma-secretase inhibitors |
| CA2651174A1 (en) | 2006-05-03 | 2007-11-15 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Chimeric t cell receptors and related materials and methods of use |
| KR20150036210A (ko) | 2007-06-13 | 2015-04-07 | 인사이트 코포레이션 | 야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염 |
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| WO2014068079A1 (en) | 2012-11-01 | 2014-05-08 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
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| WO2014124280A1 (en) | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
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| ES2898329T3 (es) | 2016-01-12 | 2022-03-07 | Oncotracker Inc | Métodos mejorados para supervisar el estado inmunitario de un sujeto |
| WO2017201040A1 (en) | 2016-05-16 | 2017-11-23 | Berenson James Richard | Improved methods for monitoring immune status of a subject |
| BR112019002035A2 (pt) | 2016-08-01 | 2019-05-14 | Novartis Ag | tratamento de câncer usando um receptor de antígeno quimérico em combinação com um inibidor de uma molécula pró-macrófago m2 |
| WO2018085363A2 (en) | 2016-11-02 | 2018-05-11 | Berenson James Richard | Cd147 detection in diagnostic, prognostic and monitoring methods for multiple myeloma |
| US11635435B2 (en) | 2017-06-13 | 2023-04-25 | Oncotracker, Inc. | Diagnostic, prognostic, and monitoring methods for solid tumor cancers |
| JP2020528885A (ja) | 2017-07-19 | 2020-10-01 | フェイト セラピューティクス，インコーポレイテッド | 養子免疫療法における免疫細胞調節のための組成物および方法 |
| US20220000872A1 (en) | 2018-10-31 | 2022-01-06 | Oncotracker, Inc. | Method of enhancing immune-based therapy |
-
2017
- 2017-01-12 ES ES17738918T patent/ES2898329T3/es active Active
- 2017-01-12 DK DK17738918.6T patent/DK3402515T3/da active
- 2017-01-12 WO PCT/US2017/013169 patent/WO2017123741A1/en not_active Ceased
- 2017-01-12 US US16/068,831 patent/US11698369B2/en active Active
- 2017-01-12 EP EP17738918.6A patent/EP3402515B8/en active Active
- 2017-01-12 JP JP2018555442A patent/JP7011600B2/ja active Active
- 2017-01-12 EP EP21190326.5A patent/EP4079320A1/en active Pending
-
2022
- 2022-01-14 JP JP2022004416A patent/JP2022058619A/ja active Pending
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