|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
CN105939767B
(zh)
|
2014-01-08 |
2018-04-06 |
弗洛设计声能学公司 |
具有双声电泳腔的声电泳装置
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
WO2017070632A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
AU2017308889B2
(en)
|
2016-08-09 |
2023-11-09 |
President And Fellows Of Harvard College |
Programmable Cas9-recombinase fusion proteins and uses thereof
|
|
IL264439B2
(en)
|
2016-08-17 |
2024-08-01 |
Factor Bioscience Inc |
non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
KR20190123328A
(ko)
|
2017-03-09 |
2019-10-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
암 백신
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
IL306092A
(en)
|
2017-03-23 |
2023-11-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
|
CN108690845B
(zh)
|
2017-04-10 |
2021-04-27 |
中国科学院动物研究所 |
基因组编辑系统和方法
|
|
JP2020517247A
(ja)
|
2017-04-18 |
2020-06-18 |
イエール ユニバーシティ |
Tリンパ球ゲノム操作のためのプラットフォームおよびそのインビボハイスループットスクリーニング法
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
EP3686275A4
(en)
*
|
2017-09-18 |
2021-09-29 |
Edigene Inc. |
GENE EDITING LYMPHOCYTE T AND RELATED USE
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
JP2021502077A
(ja)
*
|
2017-11-06 |
2021-01-28 |
エディタス・メディシン,インコーポレイテッド |
免疫療法のためのt細胞におけるcblbのcrispr−cas9編集のための方法、組成物および構成要素
|
|
SG11202004529XA
(en)
*
|
2017-11-16 |
2020-06-29 |
Mogam Inst Biomedical Res |
Transformed human cell and use thereof
|
|
AU2018383712B2
(en)
*
|
2017-12-11 |
2025-09-04 |
Editas Medicine, Inc. |
Cpf1-related methods and compositions for gene editing
|
|
CN114900773A
(zh)
|
2017-12-14 |
2022-08-12 |
弗洛设计声能学公司 |
声泳系统及其操作方法、控制声换能器及声学系统的方法
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019173942A1
(en)
*
|
2018-03-12 |
2019-09-19 |
Nanjing Bioheng Biotech Co., Ltd |
Engineered chimeric guide rna and uses thereof
|
|
CN112292139B
(zh)
|
2018-03-13 |
2024-03-08 |
明尼苏达大学董事会 |
使用Cas9碱基编辑器的淋巴造血改造
|
|
CA3096708A1
(en)
|
2018-04-18 |
2019-10-24 |
Yale University |
Compositions and methods for multiplexed tumor vaccination with endogenous gene activation
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US20210363206A1
(en)
*
|
2018-06-18 |
2021-11-25 |
The Regents Of The University Of California |
Proteins that inhibit cas12a (cpf1), a cripr-cas nuclease
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
US20210322473A1
(en)
*
|
2018-07-18 |
2021-10-21 |
The General Hospital Corporation |
Modified t cells and methods of their use
|
|
US20200080056A1
(en)
*
|
2018-09-06 |
2020-03-12 |
The Trustees Of The University Of Pennsylvania |
CRISPR-Cas9 Knock-out of SHP-1/2 to Reduce T cell Exhaustion in Adoptive Cell Therapy
|
|
AU2019341365A1
(en)
*
|
2018-09-21 |
2021-05-27 |
Crage Medical Co., Limited |
Method for gene editing of cell on the basis of CRISPR/Cas system
|
|
CA3116132A1
(en)
|
2018-10-16 |
2020-04-23 |
Intellia Therapeutics, Inc. |
Compositions and methods for immunotherapy
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
CN121759517A
(zh)
*
|
2019-01-04 |
2026-03-31 |
赋生元公司 |
使用单链环状dna靶向修饰基因组
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US12600971B2
(en)
|
2019-02-13 |
2026-04-14 |
Beam Therapeutics Inc. |
Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
|
|
US10913941B2
(en)
|
2019-02-14 |
2021-02-09 |
Metagenomi Ip Technologies, Llc |
Enzymes with RuvC domains
|
|
BR112021016046A2
(pt)
|
2019-02-15 |
2021-11-09 |
Editas Medicine Inc |
Células assassinas naturais modificadas (nk) para imunoterapia
|
|
KR20210137085A
(ko)
|
2019-03-05 |
2021-11-17 |
엔카르타, 인크. |
Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
|
|
WO2020191241A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
WO2020190925A1
(en)
|
2019-03-19 |
2020-09-24 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Methods and compositions for engineering cd4-deficient car t cells and anti-cd4 car t cells and uses thereof
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN114174325A
(zh)
*
|
2019-06-04 |
2022-03-11 |
恩卡尔塔公司 |
用于免疫疗法的工程化自然杀伤细胞和工程化t细胞的组合
|
|
WO2020264117A1
(en)
*
|
2019-06-26 |
2020-12-30 |
Integrated Dna Technologies, Inc. |
Compositions and methods for improved detection of genomic editing events
|
|
CA3145425A1
(en)
|
2019-07-03 |
2021-01-07 |
Factor Bioscience Inc. |
Cationic lipids and uses thereof
|
|
US10501404B1
(en)
|
2019-07-30 |
2019-12-10 |
Factor Bioscience Inc. |
Cationic lipids and transfection methods
|
|
AU2020324386B2
(en)
*
|
2019-08-02 |
2026-04-23 |
Monsanto Technology Llc |
Methods and compositions to promote targeted genome modifications using HUH endonucleases
|
|
US20220340966A1
(en)
*
|
2019-09-09 |
2022-10-27 |
Oregon Health & Science University |
Crispr-mediated capture of nucleic acids
|
|
WO2021062267A1
(en)
*
|
2019-09-26 |
2021-04-01 |
Nantbio, Inc. |
Primary t-cell expansion
|
|
US12594301B2
(en)
|
2019-09-27 |
2026-04-07 |
Beam Therapeutics Inc. |
Compositions and methods for treatment of liquid cancers
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN110904239B
(zh)
*
|
2019-12-25 |
2020-11-10 |
武汉博杰生物医学科技有限公司 |
肺癌相关分子标志物基因突变的检测试剂盒与检测方法
|
|
AU2021216418A1
(en)
*
|
2020-02-05 |
2022-09-01 |
Danmarks Tekniske Universitet |
Compositions and methods for targeting, editing or modifying human genes
|
|
CN116096892A
(zh)
*
|
2020-05-08 |
2023-05-09 |
宏基因组学公司 |
具有RuvC结构域的酶
|
|
CA3177481A1
(en)
|
2020-05-08 |
2021-11-11 |
David R. Liu |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
JP2023525579A
(ja)
*
|
2020-05-15 |
2023-06-16 |
アールエックスセル インコーポレーテッド |
低免疫原性の細胞および免疫応答におけるそれらの使用
|
|
JP2023527145A
(ja)
*
|
2020-05-20 |
2023-06-27 |
ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド |
試料中の病原体を検出するcrisprベースアッセイ
|
|
MX2022015586A
(es)
|
2020-06-12 |
2023-03-15 |
Nkarta Inc |
Linfocitos citolíticos naturales modificados genéticamente para inmunoterapia de cáncer dirigida a cd70.
|
|
AU2021347359A1
(en)
|
2020-09-25 |
2023-05-18 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
CA3198905A1
(en)
*
|
2020-10-19 |
2022-04-28 |
Caribou Biosciences, Inc. |
Dna-containing polynucleotides and guides for crispr type v systems, and methods of making and using the same
|
|
KR20230093328A
(ko)
*
|
2020-10-30 |
2023-06-27 |
아버 바이오테크놀로지스, 인크. |
B2m을 표적화하는 rna 가이드를 포함하는 조성물 및 이의 용도
|
|
AU2021368740A1
(en)
*
|
2020-10-30 |
2023-06-01 |
Arbor Biotechnologies, Inc. |
Compositions comprising an rna guide targeting trac and uses thereof
|
|
CN113881652B
(zh)
*
|
2020-11-11 |
2022-11-22 |
山东舜丰生物科技有限公司 |
新型Cas酶和系统以及应用
|
|
US11459372B2
(en)
|
2020-11-30 |
2022-10-04 |
Crispr Therapeutics Ag |
Gene-edited natural killer cells
|
|
IL303269A
(en)
|
2020-12-03 |
2023-07-01 |
Century Therapeutics Inc |
Genetically engineered cells and uses thereof
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
EP4255453A4
(en)
*
|
2020-12-03 |
2025-03-26 |
Nkarta, Inc. |
Methods for manipulating immune cells for increased potency and persistence, as well as uses of engineered cells in immunotherapy
|
|
CN116848241A
(zh)
*
|
2020-12-17 |
2023-10-03 |
孟山都技术公司 |
工程化无ssDNA酶的CRISPR核酸内切酶
|
|
TW202241935A
(zh)
|
2020-12-18 |
2022-11-01 |
美商世紀治療股份有限公司 |
具有可調適受體專一性之嵌合抗原受體系統
|
|
EP4271798A1
(en)
|
2020-12-30 |
2023-11-08 |
CRISPR Therapeutics AG |
Compositions and methods for differentiating stem cells into nk cells
|
|
JP7877351B2
(ja)
*
|
2021-03-19 |
2026-06-22 |
メタゲノミ セラピューティクス,インク. |
Cas酵素を用いたマルチプレックス編集
|
|
KR102428773B1
(ko)
*
|
2021-04-21 |
2022-08-05 |
(주)지플러스생명과학 |
분리형 crRNA 및 이를 이용한 CRISPR-Cas 시스템
|
|
MX2023014356A
(es)
*
|
2021-06-02 |
2024-02-15 |
Metagenomi Inc |
Sistemas crispr de clase ii, tipo v.
|
|
WO2022272292A2
(en)
|
2021-06-23 |
2022-12-29 |
Editas Medicine, Inc. |
Engineered cells for therapy
|
|
KR20240051112A
(ko)
|
2021-07-01 |
2024-04-19 |
인답타 세라뷰틱스 인코포레이티드 |
조작된 자연 살해(nk) 세포 및 관련 방법
|
|
CN119452085A
(zh)
*
|
2021-08-27 |
2025-02-14 |
宏基因组学公司 |
具有ruvc结构域的酶
|
|
KR20240110603A
(ko)
|
2021-11-24 |
2024-07-15 |
메타지노미, 인크. |
엔도뉴클레아제 시스템
|
|
TWI870769B
(zh)
*
|
2022-01-24 |
2025-01-21 |
美洛生物科技股份有限公司 |
合成rna片段及其用於rna依賴擴增之用途
|
|
JP2023107748A
(ja)
*
|
2022-01-24 |
2023-08-03 |
美洛生物科技股▲ふん▼有限公司 |
合成rna断片及びrna依存性増幅のためのその使用
|
|
WO2023164625A2
(en)
*
|
2022-02-25 |
2023-08-31 |
Georgia Tech Research Corporation |
Modified plant virus system for delivery of nucleic acids into mammalian cells
|
|
US20250375524A1
(en)
|
2022-06-30 |
2025-12-11 |
Indapta Therapeutics, Inc. |
Combination of engineered natural killer (nk) cells and antibody therapy and related methods
|
|
WO2024263564A2
(en)
*
|
2023-06-21 |
2024-12-26 |
Lonza Cologne Gmbh |
Multi-chambered electroporation cartridge and methods of use
|
|
WO2025213127A1
(en)
|
2024-04-05 |
2025-10-09 |
Indapta Therapeutics, Inc. |
Treatment of autoimmune diseases or conditions with natural killer cells
|
|
WO2025245399A1
(en)
|
2024-05-23 |
2025-11-27 |
Indapta Therapeutics, Inc. |
Method of treating cancer with natural killer cells
|
|
KR102955030B1
(ko)
*
|
2025-11-04 |
2026-04-23 |
대한민국 |
신규한 가이드 rna 및 이의 용도
|