JP2019504030A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019504030A5 JP2019504030A5 JP2018532747A JP2018532747A JP2019504030A5 JP 2019504030 A5 JP2019504030 A5 JP 2019504030A5 JP 2018532747 A JP2018532747 A JP 2018532747A JP 2018532747 A JP2018532747 A JP 2018532747A JP 2019504030 A5 JP2019504030 A5 JP 2019504030A5
- Authority
- JP
- Japan
- Prior art keywords
- zika virus
- virus vaccine
- vaccine
- seq
- sucrose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000907316 Zika virus Species 0.000 claims description 18
- 241000700605 Viruses Species 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 239000012535 impurity Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000003306 harvesting Methods 0.000 claims description 5
- 229940124743 Zika virus vaccine Drugs 0.000 claims 23
- 229930006000 Sucrose Natural products 0.000 claims 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 11
- 239000005720 sucrose Substances 0.000 claims 11
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 9
- 230000002779 inactivation Effects 0.000 claims 8
- 102000007327 Protamines Human genes 0.000 claims 7
- 108010007568 Protamines Proteins 0.000 claims 7
- 239000002671 adjuvant Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 229940048914 protamine Drugs 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 229950008679 protamine sulfate Drugs 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108010076039 Polyproteins Proteins 0.000 claims 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 2
- 239000007857 degradation product Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- VGONTNSXDCQUGY-RRKCRQDMSA-N 2'-deoxyinosine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC2=O)=C2N=C1 VGONTNSXDCQUGY-RRKCRQDMSA-N 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 101710204837 Envelope small membrane protein Proteins 0.000 claims 1
- 101710145006 Lysis protein Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 claims 1
- 229940088679 drug related substance Drugs 0.000 claims 1
- 238000013467 fragmentation Methods 0.000 claims 1
- 238000006062 fragmentation reaction Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 238000011026 diafiltration Methods 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 238000009295 crossflow filtration Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 241000282994 Cervidae Species 0.000 description 1
- 229940124956 Ixiaro Drugs 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15202585 | 2015-12-23 | ||
| EP15202585.4 | 2015-12-23 | ||
| EP16161068.8 | 2016-03-18 | ||
| EP16161068 | 2016-03-18 | ||
| EP16176049.1 | 2016-06-23 | ||
| EP16176049 | 2016-06-23 | ||
| EP16176025.1 | 2016-06-23 | ||
| EP16176025 | 2016-06-23 | ||
| EP16182845 | 2016-08-04 | ||
| EP16182845.4 | 2016-08-04 | ||
| PCT/EP2016/082664 WO2017109225A1 (en) | 2015-12-23 | 2016-12-23 | Zika virus vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504030A JP2019504030A (ja) | 2019-02-14 |
| JP2019504030A5 true JP2019504030A5 (cg-RX-API-DMAC7.html) | 2019-12-26 |
| JP6949027B2 JP6949027B2 (ja) | 2021-10-20 |
Family
ID=57821924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532747A Active JP6949027B2 (ja) | 2015-12-23 | 2016-12-23 | ジカウイルスワクチン |
Country Status (19)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9895437B2 (en) | 2012-04-18 | 2018-02-20 | Valneva Austria Gmbh | Aluminum compounds for use in therapeutics and vaccines |
| EA035921B1 (ru) * | 2015-07-16 | 2020-08-31 | Бхарат Байотек Интернэшнл Лимитед | Вакцинные композиции для профилактики арбовирусных инфекций |
| US10537630B2 (en) | 2015-12-23 | 2020-01-21 | Valneva Se | Virus purification |
| BR112018077540A2 (pt) * | 2016-07-08 | 2019-10-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | vírus quimérico da dengue/zika como vacinas de zika vírus vivo atenuado |
| CN118662621A (zh) | 2017-09-21 | 2024-09-20 | 瓦尔尼瓦公司 | 包含免疫原性屈公病毒chikv-delta5nsp3的医药组成物的制备方法 |
| CN111526885A (zh) * | 2017-11-03 | 2020-08-11 | 武田疫苗股份有限公司 | 寨卡疫苗和免疫原性组合物及其使用方法 |
| CN107988239B (zh) * | 2017-11-29 | 2021-03-19 | 南方医科大学 | 一种寨卡病毒的重组基因及其制备方法和应用 |
| CA3084605A1 (en) * | 2017-11-30 | 2019-06-06 | Takeda Vaccines, Inc. | Method for inactivating zika virus and related methods |
| CN107904215B (zh) * | 2017-12-27 | 2021-07-27 | 华农（肇庆）生物产业技术研究院有限公司 | 一种禽流感病毒的全悬浮培养方法 |
| TWI658848B (zh) * | 2018-02-13 | 2019-05-11 | National Tsing Hua University | 茲卡病毒疫苗組合物及其應用 |
| CN110156880B (zh) * | 2018-02-13 | 2022-12-16 | 吴夙钦 | 兹卡病毒疫苗组合物及其应用 |
| MX420109B (es) * | 2018-03-26 | 2025-02-10 | Boehringer Ingelheim Animal Health Usa Inc | Metodo para producir una composicion inmunogenica |
| CN108676780B (zh) * | 2018-07-24 | 2021-08-10 | 华中农业大学 | 一种高效分离猪肠道冠状病毒的方法 |
| CN109337876A (zh) * | 2018-10-15 | 2019-02-15 | 北京世纪元亨动物防疫技术有限公司 | 一种猪流行性腹泻病毒的纯化方法 |
| WO2020106358A1 (en) | 2018-11-20 | 2020-05-28 | Takeda Vaccines, Inc. | Novel anti-zika virus antibodies and uses thereof |
| CN109627297B (zh) * | 2018-12-29 | 2022-06-14 | 复旦大学 | 来自寨卡病毒e蛋白的中和表位及其应用 |
| EP3914067A4 (en) * | 2019-01-22 | 2022-11-02 | 2seventy bio, Inc. | METHODS AND SYSTEMS FOR MAKING VIRAL VECTORS |
| MX2021011913A (es) * | 2019-05-08 | 2021-12-15 | Takeda Vaccines Inc | Composiciones de virus inactivado y formulaciones de vacunas contra el zika. |
| AU2020327602A1 (en) | 2019-08-09 | 2022-01-27 | Valneva Se | Chikungunya vaccine formulations |
| PH12021553187A1 (en) | 2019-08-09 | 2022-11-07 | Valneva Se | Single shot chikungunya virus vaccine |
| EP4028511A1 (en) * | 2019-09-09 | 2022-07-20 | Valneva Austria GmbH | Inactivation process for viruses |
| KR102243295B1 (ko) * | 2019-11-15 | 2021-04-23 | 강원대학교산학협력단 | 지카바이러스의 외피 단백질을 포함하는 재조합 백신 조성물 |
| KR102365464B1 (ko) * | 2019-12-24 | 2022-02-22 | 강원대학교산학협력단 | 지카바이러스 재조합 서브유닛 백신의 개발 및 이의 제조방법 |
| US20230065376A1 (en) * | 2020-02-05 | 2023-03-02 | New York Blood Center, Inc. | Zika virus immunogenic compositions |
| EP3895729A1 (en) | 2020-03-01 | 2021-10-20 | Valneva Austria GmbH | Cpg-adjuvanted sars-cov-2 virus vaccine |
| WO2021176434A1 (en) | 2020-03-01 | 2021-09-10 | Valneva Austria Gmbh | Cpg-adjuvanted sars-cov-2 virus vaccine |
| US20230110516A1 (en) | 2020-03-01 | 2023-04-13 | Dynavax Technologies Corporation | Coronavirus vaccines comprising a tlr9 agonist |
| US20240189412A1 (en) * | 2020-03-03 | 2024-06-13 | Mayo Foundation For Medical Education And Research | Zika Virus Polypeptides |
| WO2021204825A2 (en) | 2020-04-06 | 2021-10-14 | Valneva Austria Gmbh | INACTIVATED SARS-CoV-2 VIRUS VACCINE |
| EP4153222A1 (en) | 2020-05-20 | 2023-03-29 | Takeda Vaccines, Inc. | Method for detection of zika virus specific antibodies |
| EP4154003A1 (en) | 2020-05-20 | 2023-03-29 | Takeda Vaccines, Inc. | Method for determining the potency of antigens |
| WO2021236225A1 (en) | 2020-05-20 | 2021-11-25 | Takeda Vaccines, Inc. | Method for detection of zika virus specific antibodies |
| WO2023148256A1 (en) | 2022-02-02 | 2023-08-10 | Valneva Austria Gmbh | Inactivated sars-cov-2 virus vaccine |
| WO2023154043A1 (en) * | 2022-02-09 | 2023-08-17 | Takeda Vaccines, Inc. | Zika vaccines and immunogenic compositions, and methods of using the same |
| WO2025099278A2 (en) * | 2023-11-08 | 2025-05-15 | Valneva Austria Gmbh | Immunogenic zika virus compositions and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US86061A (en) * | 1869-01-19 | Improved horse-power | ||
| DE122009000037I2 (de) * | 1997-08-28 | 2011-06-16 | Cheil Jedang Corp | Ein an vero-zellen angepasstes abgeschwächtes japanisches enzephalitis virus und ein impfstoff gegen japanische enzephalitis |
| CA2341354C (en) * | 1998-09-02 | 2009-10-20 | The Government Of The United States Of America | Dengue viruses that are replication defective in mosquitos for use as vaccines |
| DK1285080T3 (da) | 2000-05-31 | 2008-12-01 | Novartis Vaccines & Diagnostic | Fremgangsmåde til oprensning af alphavirusreplikonpartikler |
| WO2002074963A1 (en) * | 2001-03-16 | 2002-09-26 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Healt | Dengue viruses that are replication defective in mosquitos for use as vaccines |
| WO2002089840A1 (en) * | 2001-05-10 | 2002-11-14 | The Regents Of The University Of California | Recombinant bicistronic flaviviruses and methods of use thereof |
| DE602004029657D1 (de) | 2003-03-24 | 2010-12-02 | Intercell Ag | Verbesserte impfstoffe |
| WO2008026225A2 (en) * | 2006-09-01 | 2008-03-06 | Bharat Biotech International Limited | A vaccine for chikungunya virus infection |
| WO2009048633A2 (en) | 2007-10-11 | 2009-04-16 | The Board Of Regents Of The University Of Texas System | Chimeric chikungunya virus and uses thereof |
| AU2009240738B2 (en) * | 2008-04-21 | 2014-09-11 | Tissue Regeneration Therapeutics, Inc. | Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents |
| CN102317308A (zh) * | 2008-11-26 | 2012-01-11 | 美国国有健康与人类服务部 | 类病毒组合物颗粒及其使用方法 |
| WO2010085358A2 (en) * | 2009-01-23 | 2010-07-29 | The Board Of Regents Of The University Of Texas System | Flaviviruses expressing the prm, e, and ns1 proteins of other flaviviruses and uses thereof |
| US8765148B2 (en) | 2010-02-19 | 2014-07-01 | Valneva Austria Gmbh | 1C31 nanoparticles |
| PL3106176T3 (pl) | 2011-12-06 | 2018-03-30 | Valneva Austria Gmbh | Związki glinu do stosowania w terapeutykach i szczepionkach |
| US9895437B2 (en) | 2012-04-18 | 2018-02-20 | Valneva Austria Gmbh | Aluminum compounds for use in therapeutics and vaccines |
| WO2016145149A1 (en) * | 2015-03-11 | 2016-09-15 | The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of The Walter Reed Army Institute Of Research | Combination purified inactivated vaccine for flaviviruses |
| EA035921B1 (ru) * | 2015-07-16 | 2020-08-31 | Бхарат Байотек Интернэшнл Лимитед | Вакцинные композиции для профилактики арбовирусных инфекций |
| US10537630B2 (en) | 2015-12-23 | 2020-01-21 | Valneva Se | Virus purification |
| CN105749268B (zh) | 2016-04-11 | 2020-09-11 | 北京科兴中维生物技术有限公司 | 一种灭活的寨卡病毒疫苗 |
| CN118662621A (zh) | 2017-09-21 | 2024-09-20 | 瓦尔尼瓦公司 | 包含免疫原性屈公病毒chikv-delta5nsp3的医药组成物的制备方法 |
-
2016
- 2016-12-23 US US16/062,245 patent/US10537630B2/en active Active
- 2016-12-23 ES ES16826741T patent/ES2950887T3/es active Active
- 2016-12-23 SG SG11201805120YA patent/SG11201805120YA/en unknown
- 2016-12-23 DK DK16828746.4T patent/DK3393510T5/da active
- 2016-12-23 AU AU2016375338A patent/AU2016375338B2/en active Active
- 2016-12-23 KR KR1020187017319A patent/KR20180097558A/ko active Pending
- 2016-12-23 HU HUE16828746A patent/HUE061679T2/hu unknown
- 2016-12-23 EP EP16828746.4A patent/EP3393510B1/en active Active
- 2016-12-23 EP EP23219512.3A patent/EP4357355A3/en active Pending
- 2016-12-23 CN CN201680074939.XA patent/CN108697785B/zh active Active
- 2016-12-23 ES ES16828746T patent/ES2941967T3/es active Active
- 2016-12-23 BR BR112018012873-2A patent/BR112018012873A2/pt active Search and Examination
- 2016-12-23 SI SI201631676T patent/SI3393510T1/sl unknown
- 2016-12-23 EP EP16826739.1A patent/EP3393506B1/en active Active
- 2016-12-23 US US16/060,054 patent/US11331382B2/en active Active
- 2016-12-23 US US16/063,007 patent/US10639365B2/en active Active
- 2016-12-23 EP EP16826741.7A patent/EP3393508B9/en active Active
- 2016-12-23 WO PCT/EP2016/082664 patent/WO2017109225A1/en not_active Ceased
- 2016-12-23 EP EP16828745.6A patent/EP3393509B1/en active Active
- 2016-12-23 CN CN202210678575.3A patent/CN115381934A/zh active Pending
- 2016-12-23 EP EP23152481.0A patent/EP4218807A3/en active Pending
- 2016-12-23 CA CA3009278A patent/CA3009278A1/en active Pending
- 2016-12-23 EP EP23175136.3A patent/EP4253403A3/en active Pending
- 2016-12-23 EP EP24159155.1A patent/EP4393938A3/en active Pending
- 2016-12-23 US US15/781,825 patent/US10744194B2/en active Active
- 2016-12-23 EP EP16826740.9A patent/EP3393507B1/en active Active
- 2016-12-23 ES ES16826739T patent/ES2976311T3/es active Active
- 2016-12-23 WO PCT/EP2016/082667 patent/WO2017109228A1/en not_active Ceased
- 2016-12-23 US US15/781,959 patent/US10660950B2/en active Active
- 2016-12-23 WO PCT/EP2016/082666 patent/WO2017109227A1/en not_active Ceased
- 2016-12-23 HR HRP20230273TT patent/HRP20230273T1/hr unknown
- 2016-12-23 MX MX2018007627A patent/MX2018007627A/es unknown
- 2016-12-23 FI FIEP16828746.4T patent/FI3393510T3/fi active
- 2016-12-23 WO PCT/EP2016/082662 patent/WO2017109223A1/en not_active Ceased
- 2016-12-23 PL PL16828746.4T patent/PL3393510T3/pl unknown
- 2016-12-23 WO PCT/EP2016/082668 patent/WO2017109229A1/en not_active Ceased
- 2016-12-23 WO PCT/EP2016/082663 patent/WO2017109224A1/en not_active Ceased
- 2016-12-23 JP JP2018532747A patent/JP6949027B2/ja active Active
- 2016-12-23 LT LTEPPCT/EP2016/082664T patent/LT3393510T/lt unknown
- 2016-12-23 ES ES16828745T patent/ES2973267T3/es active Active
-
2019
- 2019-12-04 US US16/702,764 patent/US11207397B2/en active Active
-
2020
- 2020-03-10 US US16/813,862 patent/US11219681B2/en active Active
- 2020-04-06 US US16/840,760 patent/US11406700B2/en active Active
- 2020-07-13 US US16/927,086 patent/US11524064B2/en active Active
-
2021
- 2021-12-13 US US17/548,721 patent/US12005111B2/en active Active
-
2022
- 2022-07-06 US US17/811,059 patent/US12214033B2/en active Active
-
2023
- 2023-03-06 US US18/178,638 patent/US11951163B2/en active Active
- 2023-06-14 US US18/334,497 patent/US12102673B2/en active Active
-
2024
- 2024-08-09 US US18/799,291 patent/US20250018023A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019504030A5 (cg-RX-API-DMAC7.html) | ||
| US11207397B2 (en) | Virus purification | |
| JP5129805B2 (ja) | 細胞培養物から精製水疱性口内炎ウイルスを単離するための精製プロセス | |
| TW202203967A (zh) | 不活化ＳＡＲＳ—ＣｏＶ—２病毒疫苗 | |
| US20240293531A1 (en) | Inactivated sars-cov-2 virus vaccine | |
| HK40103263A (en) | Virus purification | |
| HK1261326B (en) | Virus purification | |
| HK1261326A1 (en) | Virus purification | |
| HK1261562B (en) | Virus purification | |
| HK1261562A1 (en) | Virus purification | |
| AU2007221746A1 (en) | Improvements in virus production |