DK1285080T3 - Fremgangsmåde til oprensning af alphavirusreplikonpartikler - Google Patents
Fremgangsmåde til oprensning af alphavirusreplikonpartiklerInfo
- Publication number
- DK1285080T3 DK1285080T3 DK01941874T DK01941874T DK1285080T3 DK 1285080 T3 DK1285080 T3 DK 1285080T3 DK 01941874 T DK01941874 T DK 01941874T DK 01941874 T DK01941874 T DK 01941874T DK 1285080 T3 DK1285080 T3 DK 1285080T3
- Authority
- DK
- Denmark
- Prior art keywords
- purification
- alphavirus replicon
- methods
- replicon particles
- disclosed
- Prior art date
Links
- 241000710929 Alphavirus Species 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36151—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Powder Metallurgy (AREA)
- Disintegrating Or Milling (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20837600P | 2000-05-31 | 2000-05-31 | |
| PCT/US2001/018021 WO2001092552A2 (en) | 2000-05-31 | 2001-05-31 | Method for the purification of alphavirus replicon particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1285080T3 true DK1285080T3 (da) | 2008-12-01 |
Family
ID=22774372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01941874T DK1285080T3 (da) | 2000-05-31 | 2001-05-31 | Fremgangsmåde til oprensning af alphavirusreplikonpartikler |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6767699B2 (da) |
| EP (1) | EP1285080B1 (da) |
| AT (1) | ATE409749T1 (da) |
| AU (1) | AU2001275191A1 (da) |
| CA (1) | CA2410948C (da) |
| DE (1) | DE60135983D1 (da) |
| DK (1) | DK1285080T3 (da) |
| ES (1) | ES2312447T3 (da) |
| WO (1) | WO2001092552A2 (da) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| AU2002303330B2 (en) | 2001-05-31 | 2008-07-24 | Novartis Vaccines And Diagnostics, Inc. | Chimeric alphavirus replicon particles |
| JP4790984B2 (ja) * | 2001-09-06 | 2011-10-12 | アルファヴァックス，インコーポレイテッド | アルファウイルスレプリコンベクター系 |
| US7195905B2 (en) * | 2001-12-10 | 2007-03-27 | Baxter Healthcare S.A. | Enveloped virus vaccine and method for production |
| ATE427990T1 (de) | 2002-04-30 | 2009-04-15 | Oncolytics Biotech Inc | Verbesserte reinigungsmethode fur viren |
| WO2004030631A2 (en) | 2002-10-01 | 2004-04-15 | Chiron Corporation | Anti-cancer and anti-infectious disease compositions and methods for using same |
| ES2618309T3 (es) | 2002-12-13 | 2017-06-21 | Alphavax, Inc. | Partículas de replicón de alfavirus multi-antigénico y métodos |
| DK2290054T3 (da) * | 2002-12-13 | 2017-07-03 | Alphavax Inc | Alfavirus-partikler og fremgangsmåder til fremstilling deraf |
| KR101454842B1 (ko) * | 2003-03-20 | 2014-11-04 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
| US7419674B2 (en) * | 2003-07-11 | 2008-09-02 | Alpha Vax, Inc. | Alpha virus-based cytomegalovirus vaccines |
| CA2567254C (en) * | 2004-05-18 | 2012-03-13 | Alphavax, Inc. | Tc-83-derived alphavirus vectors, particles and methods |
| JP4896021B2 (ja) | 2004-05-21 | 2012-03-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド | 呼吸器系病原体ワクチンのためのアルファウイルスベクター |
| US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| KR100760525B1 (ko) * | 2006-04-13 | 2007-10-04 | 김재만 | 병원성 미생물의 무증폭 다중 정량 검출킷트 및 검출방법 |
| EP2061508B1 (en) * | 2006-09-12 | 2014-10-15 | Alphavax, Inc. | Alphavirus replicon particles matched to protein antigens as immunological adjuvants |
| WO2008085557A2 (en) | 2006-09-12 | 2008-07-17 | Alphavax, Inc. | Alphavirus replicon particles encoding il- 12 as immunological adjuvants |
| DK2099485T3 (da) * | 2006-11-03 | 2018-05-22 | Alphavax Inc | Alfavirus- og alfavirusreplikonpartikelformuleringer samt tilhørende fremgangsmåder |
| AU2008266807B2 (en) * | 2007-06-21 | 2012-08-16 | Alphavax, Inc. | Promoterless cassettes for expression of alphavirus structural proteins |
| US8680258B2 (en) | 2008-12-01 | 2014-03-25 | Alphavax, Inc. | Use of microRNAs to control virus helper nucleic acids |
| CN105056229A (zh) | 2009-01-05 | 2015-11-18 | 埃皮托吉尼西斯股份有限公司 | 佐剂组合物及使用方法 |
| US10072307B1 (en) | 2009-01-23 | 2018-09-11 | Colorado State University Research Foundation | Isolation of viruses using anionic resin beads |
| AU2010234362B2 (en) | 2009-04-08 | 2015-11-26 | Alphavax, Inc. | Alphavirus replicon particles expressing TRP2 |
| KR20150023923A (ko) | 2010-07-30 | 2015-03-05 | 이엠디 밀리포어 코포레이션 | 크로마토그래피 매질 및 방법 |
| US8895291B2 (en) | 2010-10-08 | 2014-11-25 | Terumo Bct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| US10561720B2 (en) | 2011-06-24 | 2020-02-18 | EpitoGenesis, Inc. | Pharmaceutical compositions, comprising a combination of select carriers, vitamins, tannins and flavonoids as antigen-specific immuno-modulators |
| CN105992816B (zh) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | 生物反应器中的细胞扩增 |
| EP3613841B1 (en) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passive replacement of media |
| CN106794389A (zh) | 2014-09-02 | 2017-05-31 | Emd密理博公司 | 具有纳米原纤化表面特征的高表面积纤维介质 |
| JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
| SG11201703399QA (en) | 2014-12-08 | 2017-05-30 | Emd Millipore Corp | Mixed bed ion exchange adsorber |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| EP3393507B1 (en) | 2015-12-23 | 2024-02-07 | Valneva Austria GmbH | Zika virus purification |
| WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| NZ761619A (en) | 2017-09-21 | 2024-03-22 | Valneva Se | Method of producing pharmaceutical compositions comprising immunogenic chikungunya virus chikv-delta5nsp3 |
| NL2022538B1 (en) | 2019-02-08 | 2020-08-19 | Academisch Ziekenhuis Groningen | Methods for providing purified viral particles of Semliki Forest Virus (SFV), preparations obtainable thereby, and uses thereof. |
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| US5466788A (en) * | 1985-03-07 | 1995-11-14 | Mycogen Plant Science, Inc. | Subgenomic promoter |
| ES8800988A1 (es) | 1985-04-05 | 1987-12-16 | Meloy Lab | Procedimiento de producir interferona humana. |
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| WO1988000472A1 (en) | 1986-07-23 | 1988-01-28 | Aphton Corporation | Immunogens and improved methods of making immunogens |
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| US5843712A (en) | 1996-06-06 | 1998-12-01 | The Trustees Of Columbia University In The City Of New York | Sindbis virus expression system for recombinant antibody production |
| WO1998013511A1 (en) | 1996-09-25 | 1998-04-02 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Retroviral packaging cassettes amplified in the cytoplasm by autocatalytic togavirus vectors |
| EP0932693A1 (en) | 1996-10-10 | 1999-08-04 | Henrik Garoff | Alphavirus-retrovirus vectors |
| AU7637796A (en) | 1996-12-09 | 1998-07-03 | James Edwin Bailey | Expression of active interferon beta 1 using recombinant rna replicons |
| US6261823B1 (en) * | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| US5811407A (en) * | 1997-02-19 | 1998-09-22 | The University Of North Carolina At Chapel Hill | System for the in vivo delivery and expression of heterologous genes in the bone marrow |
| US6261570B1 (en) | 1997-05-20 | 2001-07-17 | The United States Of America As Represented By The Secretary Of The Army | Live attenuated virus vaccines for western equine encephalitis virus, eastern equine encephalitis virus, and venezuelan equine encephalitis virus IE and IIIA variants |
| EP0996737A1 (en) | 1997-08-15 | 2000-05-03 | Inex Pharmaceuticals Corp. | Semliki forest virus vectors for gene transfer into non-endothelial cardiovascular cells |
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| EP1034289A1 (en) | 1997-11-14 | 2000-09-13 | Connaught Laboratories Limited | Alphavirus vectors for paramyxovirus vaccines |
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-
2001
- 2001-05-31 DK DK01941874T patent/DK1285080T3/da active
- 2001-05-31 ES ES01941874T patent/ES2312447T3/es not_active Expired - Lifetime
- 2001-05-31 AT AT01941874T patent/ATE409749T1/de active
- 2001-05-31 DE DE60135983T patent/DE60135983D1/de not_active Expired - Lifetime
- 2001-05-31 AU AU2001275191A patent/AU2001275191A1/en not_active Abandoned
- 2001-05-31 US US09/872,086 patent/US6767699B2/en not_active Expired - Fee Related
- 2001-05-31 CA CA2410948A patent/CA2410948C/en not_active Expired - Fee Related
- 2001-05-31 WO PCT/US2001/018021 patent/WO2001092552A2/en active Application Filing
- 2001-05-31 EP EP01941874A patent/EP1285080B1/en not_active Expired - Lifetime
-
2004
- 2004-06-29 US US10/881,575 patent/US20050112752A1/en not_active Abandoned
-
2008
- 2008-09-18 US US12/212,978 patent/US20100055128A1/en not_active Abandoned
-
2012
- 2012-03-27 US US13/430,920 patent/US20120231526A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001275191A1 (en) | 2001-12-11 |
| WO2001092552A3 (en) | 2002-05-23 |
| ES2312447T3 (es) | 2009-03-01 |
| US6767699B2 (en) | 2004-07-27 |
| DE60135983D1 (de) | 2008-11-13 |
| CA2410948A1 (en) | 2001-12-06 |
| WO2001092552A2 (en) | 2001-12-06 |
| US20020015945A1 (en) | 2002-02-07 |
| US20050112752A1 (en) | 2005-05-26 |
| EP1285080A2 (en) | 2003-02-26 |
| US20120231526A1 (en) | 2012-09-13 |
| EP1285080B1 (en) | 2008-10-01 |
| CA2410948C (en) | 2012-07-17 |
| ATE409749T1 (de) | 2008-10-15 |
| US20100055128A1 (en) | 2010-03-04 |
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