JP2019503998A5 - - Google Patents

Info

Publication number

JP2019503998A5

JP2019503998A5 JP2018529102A JP2018529102A JP2019503998A5 JP 2019503998 A5 JP2019503998 A5 JP 2019503998A5 JP 2018529102 A JP2018529102 A JP 2018529102A JP 2018529102 A JP2018529102 A JP 2018529102A JP 2019503998 A5 JP2019503998 A5 JP 2019503998A5

Authority

JP

Japan

Prior art keywords

c6orf106

compound

protein activity

polynucleotide

subject

Prior art date

2016-12-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 18
• 101000998434 Homo sapiens Protein ILRUN Proteins 0.000 claims 16
• 102100033275 Protein ILRUN Human genes 0.000 claims 15
• 239000000203 mixture Substances 0.000 claims 14
• 230000004952 protein activity Effects 0.000 claims 11
• 108091033319 polynucleotide Proteins 0.000 claims 9
• 102000040430 polynucleotide Human genes 0.000 claims 9
• 239000002157 polynucleotide Substances 0.000 claims 9
• 229920001184 polypeptide Polymers 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 101001011382 Homo sapiens Interferon regulatory factor 3 Proteins 0.000 claims 5
• 102100029843 Interferon regulatory factor 3 Human genes 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 230000028993 immune response Effects 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 102000004127 Cytokines Human genes 0.000 claims 4
• 108090000695 Cytokines Proteins 0.000 claims 4
• 230000016396 cytokine production Effects 0.000 claims 4
• 230000007423 decrease Effects 0.000 claims 4
• 208000023275 Autoimmune disease Diseases 0.000 claims 3
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• 238000013518 transcription Methods 0.000 claims 3
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• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
• 208000036142 Viral infection Diseases 0.000 claims 2
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• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
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• 108091008102 DNA aptamers Proteins 0.000 claims 1
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• 206010061598 Immunodeficiency Diseases 0.000 claims 1
• 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
• 102100026720 Interferon beta Human genes 0.000 claims 1
• 108010047761 Interferon-alpha Proteins 0.000 claims 1
• 102000006992 Interferon-alpha Human genes 0.000 claims 1
• 108090000467 Interferon-beta Proteins 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
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• 108091008103 RNA aptamers Proteins 0.000 claims 1
• 108700019146 Transgenes Proteins 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
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• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 1
• 208000030428 polyarticular arthritis Diseases 0.000 claims 1
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