JP2015511599A5 - - Google Patents
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- Publication number
- JP2015511599A5 JP2015511599A5 JP2014561543A JP2014561543A JP2015511599A5 JP 2015511599 A5 JP2015511599 A5 JP 2015511599A5 JP 2014561543 A JP2014561543 A JP 2014561543A JP 2014561543 A JP2014561543 A JP 2014561543A JP 2015511599 A5 JP2015511599 A5 JP 2015511599A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- seq
- polypeptide
- soluble
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 50
- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 101150096839 Fcmr gene Proteins 0.000 claims 23
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 239000000178 monomer Substances 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 101000878510 Homo sapiens Fas apoptotic inhibitory molecule 3 Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 102000051981 human FCMR Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000003352 Hyper-IgM Immunodeficiency Syndrome Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029379 Neutrophilia Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010066130 hyper-IgM syndrome Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261612183P | 2012-03-16 | 2012-03-16 | |
| US61/612,183 | 2012-03-16 | ||
| US201261646143P | 2012-05-11 | 2012-05-11 | |
| US61/646,143 | 2012-05-11 | ||
| US201261731428P | 2012-11-29 | 2012-11-29 | |
| US61/731,428 | 2012-11-29 | ||
| PCT/IB2013/001179 WO2013136193A2 (en) | 2012-03-16 | 2013-03-14 | Methods and compositions for modulating toso activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017162409A Division JP6462800B2 (ja) | 2012-03-16 | 2017-08-25 | Ｔｏｓｏ活性を調節するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511599A JP2015511599A (ja) | 2015-04-20 |
| JP2015511599A5 true JP2015511599A5 (https=) | 2016-04-21 |
| JP6200437B2 JP6200437B2 (ja) | 2017-09-20 |
Family
ID=48747619
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561543A Expired - Fee Related JP6200437B2 (ja) | 2012-03-16 | 2013-03-14 | Ｔｏｓｏ活性を調節するための方法および組成物 |
| JP2017162409A Expired - Fee Related JP6462800B2 (ja) | 2012-03-16 | 2017-08-25 | Ｔｏｓｏ活性を調節するための方法および組成物 |
| JP2018244907A Expired - Fee Related JP6744391B2 (ja) | 2012-03-16 | 2018-12-27 | Ｔｏｓｏ活性を調節するための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017162409A Expired - Fee Related JP6462800B2 (ja) | 2012-03-16 | 2017-08-25 | Ｔｏｓｏ活性を調節するための方法および組成物 |
| JP2018244907A Expired - Fee Related JP6744391B2 (ja) | 2012-03-16 | 2018-12-27 | Ｔｏｓｏ活性を調節するための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9228006B2 (https=) |
| EP (2) | EP2825191B1 (https=) |
| JP (3) | JP6200437B2 (https=) |
| KR (1) | KR102143887B1 (https=) |
| CN (1) | CN104394880B (https=) |
| AU (3) | AU2013234046B2 (https=) |
| CA (1) | CA2867444C (https=) |
| IL (1) | IL234683B (https=) |
| WO (1) | WO2013136193A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2867444C (en) | 2012-03-16 | 2021-04-13 | University Health Network | Compositions containing soluble toso protein and uses thereof |
| US9493561B2 (en) | 2013-07-03 | 2016-11-15 | University Health Network | Antibodies to Toso |
| ES2795727T3 (es) * | 2014-01-15 | 2020-11-24 | Medimmune Llc | Anticuerpos específicos del vrs y partes funcionales de los mismos |
| AU2015225867B2 (en) * | 2014-03-07 | 2020-02-06 | University Health Network | Methods and compositions for modifying the immune response |
| EP3009841A1 (en) * | 2014-10-14 | 2016-04-20 | Bernhard-Nocht-Institut für Tropenmedizin | Detection of IgM Antibodies using an immune complex (IC) ELISA |
| ES2754432T3 (es) | 2015-05-04 | 2020-04-17 | Apogenix Ag | Proteínas agonistas de receptor CD40 de cadena sencilla |
| ES2690420T3 (es) * | 2015-05-28 | 2018-11-20 | Universität Zu Köln | Receptor de antígeno quimérico anti-toso y su uso |
| CA3126295A1 (en) | 2019-01-18 | 2020-07-23 | University Health Network | Lilrb3-binding molecules and uses therefor |
| MX2021009767A (es) * | 2019-02-15 | 2021-11-17 | Univ Health Network | Moleculas de union de fmcr y usos de las mismas. |
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| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
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| ES2100892T3 (es) * | 1989-09-15 | 1997-07-01 | Tanox Biosystems Inc | Tratamiento de enfermedades autoinmunitarias. |
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| US5686073A (en) | 1990-05-23 | 1997-11-11 | The University Of Iowa Research Foundation | Polyclonal and monoclonal antibodies against a 43 KDA dystrophin associated protein |
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| JPH07501694A (ja) * | 1991-11-18 | 1995-02-23 | タノックス バイオシステムズ インコーポレイテッド | 免疫グロブリン生産のアイソタイプ特異的抑制のためのアンチセンスオリゴヌクレオチド |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
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| US6727350B2 (en) * | 1997-11-17 | 2004-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Toso |
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| US20120148581A1 (en) | 2009-08-17 | 2012-06-14 | The Regents Of The University Of California | Use of nkg2d inhibitors for treating cardiovascular and metabolic diseases, such as type 2 diabetes |
| CA2867444C (en) | 2012-03-16 | 2021-04-13 | University Health Network | Compositions containing soluble toso protein and uses thereof |
| US11392902B2 (en) | 2017-06-06 | 2022-07-19 | United Parcel Service Of America, Inc. | Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery |
-
2013
- 2013-03-14 CA CA2867444A patent/CA2867444C/en not_active Expired - Fee Related
- 2013-03-14 EP EP13734483.4A patent/EP2825191B1/en active Active
- 2013-03-14 CN CN201380023772.0A patent/CN104394880B/zh not_active Expired - Fee Related
- 2013-03-14 US US13/831,031 patent/US9228006B2/en not_active Expired - Fee Related
- 2013-03-14 WO PCT/IB2013/001179 patent/WO2013136193A2/en not_active Ceased
- 2013-03-14 JP JP2014561543A patent/JP6200437B2/ja not_active Expired - Fee Related
- 2013-03-14 AU AU2013234046A patent/AU2013234046B2/en not_active Ceased
- 2013-03-14 EP EP19186831.4A patent/EP3626254A1/en not_active Withdrawn
- 2013-03-14 KR KR1020147028977A patent/KR102143887B1/ko not_active Expired - Fee Related
-
2014
- 2014-09-16 IL IL234683A patent/IL234683B/en active IP Right Grant
- 2014-11-12 US US14/539,879 patent/US9670265B2/en not_active Expired - Fee Related
- 2014-11-12 US US14/539,872 patent/US9321824B2/en not_active Expired - Fee Related
- 2014-11-12 US US14/539,884 patent/US9624289B2/en not_active Expired - Fee Related
-
2017
- 2017-05-01 US US15/583,788 patent/US10822388B2/en not_active Expired - Fee Related
- 2017-08-25 JP JP2017162409A patent/JP6462800B2/ja not_active Expired - Fee Related
- 2017-12-05 AU AU2017272172A patent/AU2017272172B2/en not_active Ceased
-
2018
- 2018-12-27 JP JP2018244907A patent/JP6744391B2/ja not_active Expired - Fee Related
-
2019
- 2019-06-28 AU AU2019204594A patent/AU2019204594B2/en not_active Expired - Fee Related
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