JP2018533375A5 - - Google Patents
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- Publication number
- JP2018533375A5 JP2018533375A5 JP2018542995A JP2018542995A JP2018533375A5 JP 2018533375 A5 JP2018533375 A5 JP 2018533375A5 JP 2018542995 A JP2018542995 A JP 2018542995A JP 2018542995 A JP2018542995 A JP 2018542995A JP 2018533375 A5 JP2018533375 A5 JP 2018533375A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide sequence
- cas9 molecule
- targeting domain
- gene
- hsv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 206
- 125000003729 nucleotide group Chemical group 0.000 claims 206
- 108091033409 CRISPR Proteins 0.000 claims 159
- 230000008685 targeting Effects 0.000 claims 116
- 108020005004 Guide RNA Proteins 0.000 claims 50
- 238000010362 genome editing Methods 0.000 claims 47
- 230000000295 complement effect Effects 0.000 claims 43
- 241000193996 Streptococcus pyogenes Species 0.000 claims 38
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 30
- 241000700584 Simplexvirus Species 0.000 claims 28
- 101150087673 RL2 gene Proteins 0.000 claims 25
- 101150084777 RS1 gene Proteins 0.000 claims 25
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 20
- 101150086595 lat gene Proteins 0.000 claims 15
- 239000013598 vector Substances 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 108700023549 Human herpesvirus 2 LAT Proteins 0.000 claims 10
- 108700005077 Viral Genes Proteins 0.000 claims 10
- 238000003776 cleavage reaction Methods 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000007017 scission Effects 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 2
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 2
- 108091092724 Noncoding DNA Proteins 0.000 claims 2
- 230000005783 single-strand break Effects 0.000 claims 2
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000004075 alteration Effects 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000003061 neural cell Anatomy 0.000 claims 1
- 108091008695 photoreceptors Proteins 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022007688A JP2022068156A (ja) | 2015-10-30 | 2022-01-21 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
| JP2023206552A JP2024055867A (ja) | 2015-10-30 | 2023-12-07 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562249159P | 2015-10-30 | 2015-10-30 | |
| US201562249071P | 2015-10-30 | 2015-10-30 | |
| US62/249,071 | 2015-10-30 | ||
| US62/249,159 | 2015-10-30 | ||
| PCT/US2016/059502 WO2017075475A1 (en) | 2015-10-30 | 2016-10-28 | Crispr/cas-related methods and compositions for treating herpes simplex virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022007688A Division JP2022068156A (ja) | 2015-10-30 | 2022-01-21 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533375A JP2018533375A (ja) | 2018-11-15 |
| JP2018533375A5 true JP2018533375A5 (https=) | 2019-12-05 |
| JP7408284B2 JP7408284B2 (ja) | 2024-01-05 |
Family
ID=57321423
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542995A Active JP7408284B2 (ja) | 2015-10-30 | 2016-10-28 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
| JP2022007688A Withdrawn JP2022068156A (ja) | 2015-10-30 | 2022-01-21 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
| JP2023206552A Pending JP2024055867A (ja) | 2015-10-30 | 2023-12-07 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022007688A Withdrawn JP2022068156A (ja) | 2015-10-30 | 2022-01-21 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
| JP2023206552A Pending JP2024055867A (ja) | 2015-10-30 | 2023-12-07 | 単純ヘルペスウイルスを治療するためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11001844B2 (https=) |
| EP (1) | EP3368670A1 (https=) |
| JP (3) | JP7408284B2 (https=) |
| CN (2) | CN115491373A (https=) |
| AU (3) | AU2016343991B2 (https=) |
| CA (1) | CA3001711A1 (https=) |
| WO (1) | WO2017075475A1 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| MA41349A (fr) * | 2015-01-14 | 2017-11-21 | Univ Temple | Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018081504A1 (en) * | 2016-10-28 | 2018-05-03 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3746554A1 (en) * | 2018-01-30 | 2020-12-09 | Editas Medicine, Inc. | Systems and methods for modulating chromosomal rearrangements |
| WO2019152868A1 (en) * | 2018-02-01 | 2019-08-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus (hsv) related keratitis |
| WO2019178427A1 (en) | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020055941A1 (en) * | 2018-09-13 | 2020-03-19 | Excision Biotherapeutics, Inc. | Compositions and methods for excision with single grna |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3918071A1 (en) * | 2019-02-01 | 2021-12-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions targeting virus genomes |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN115379850A (zh) | 2019-12-24 | 2022-11-22 | 裘美娜治疗公司 | 再生性多肽及其用途 |
| BR112022017713A2 (pt) * | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN116209751A (zh) * | 2020-07-07 | 2023-06-02 | 北京奥源和力生物技术有限公司 | 用于hsv-1基因编辑的指导rna及其方法 |
| EP4221740A4 (en) * | 2020-10-02 | 2024-10-30 | Temple University of the Commonwealth System of Higher Education | RNA-GUIDED ERADICATION OF HERPES SIMPLEX TYPE I AND OTHER RELATED HUMAN HERPESVIRUSES |
| US12171813B2 (en) | 2021-02-05 | 2024-12-24 | Christiana Care Gene Editing Institute, Inc. | Methods of and compositions for reducing gene expression and/or activity |
| WO2022271466A1 (en) * | 2021-06-21 | 2022-12-29 | Juvena Therapeutics, Inc. | Regenerative polypeptides and uses thereof |
| WO2024113302A1 (zh) * | 2022-12-01 | 2024-06-06 | 深圳先进技术研究院 | 靶向HSV必需基因的gRNA、CRISPR/Cas基因编辑系统、递送系统及应用 |
| CN116121271B (zh) * | 2022-12-21 | 2025-05-09 | 四川农业大学 | 多杀性巴氏杆菌arcA基因及其应用 |
| US12227748B1 (en) * | 2024-04-25 | 2025-02-18 | King Saud University | Aptamers for binding to a membrane-based lipid |
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| GB9102126D0 (en) * | 1991-01-31 | 1991-03-13 | Smithkline Beecham Biolog | Novel vaccine |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5725493A (en) | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
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| CA2383499C (en) | 1999-10-21 | 2009-11-24 | Alcon Universal Ltd. | Drug delivery device |
| US7074596B2 (en) | 2002-03-25 | 2006-07-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse mRNA cap analogues |
| US7795419B2 (en) * | 2004-05-26 | 2010-09-14 | Rosetta Genomics Ltd. | Viral and viral associated miRNAs and uses thereof |
| US8304529B2 (en) | 2006-07-28 | 2012-11-06 | Life Technologies Corporation | Dinucleotide MRNA cap analogs |
| WO2009024834A2 (en) * | 2006-12-05 | 2009-02-26 | Rosetta Genomics Ltd | Nucleic acids involved in viral infection |
| CN104072561B (zh) | 2007-06-19 | 2017-12-22 | 路易斯安那州州立大学及农业机械学院管理委员会 | 信使rna帽的抗‑反向硫代磷酸类似物的合成和用途 |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| WO2013059475A1 (en) | 2011-10-18 | 2013-04-25 | Life Technologies Corporation | Alkynyl-derivatized cap analogs, preparation and uses thereof |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| SG10201804975PA (en) | 2013-12-12 | 2018-07-30 | Broad Inst Inc | Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders |
| US10286084B2 (en) | 2014-02-18 | 2019-05-14 | Duke University | Compositions for the inactivation of virus replication and methods of making and using the same |
| WO2015148670A1 (en) * | 2014-03-25 | 2015-10-01 | Editas Medicine Inc. | Crispr/cas-related methods and compositions for treating hiv infection and aids |
| WO2015153791A1 (en) * | 2014-04-01 | 2015-10-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2) |
| WO2015153789A1 (en) * | 2014-04-01 | 2015-10-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1) |
| WO2015153889A2 (en) * | 2014-04-02 | 2015-10-08 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| WO2015161276A2 (en) * | 2014-04-18 | 2015-10-22 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| CA2954791C (en) | 2014-07-14 | 2025-11-18 | The Regents Of The University Of California | CRISPR/CAS TRANSCRIPTIONAL MODULATION |
| US10071098B2 (en) * | 2014-09-26 | 2018-09-11 | Drexel University | Compositions useful for treating herpes simplex labialis and/or herpes esophagitis, and methods using same |
| MA41349A (fr) * | 2015-01-14 | 2017-11-21 | Univ Temple | Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn |
| EP3748004A1 (en) | 2015-04-01 | 2020-12-09 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy |
| CN110168084A (zh) * | 2016-12-05 | 2019-08-23 | 爱迪塔斯医药公司 | 用于内源和来源DNA的单发指导RNA(ogRNA)靶向的系统和方法 |
-
2016
- 2016-10-28 CN CN202211088995.2A patent/CN115491373A/zh active Pending
- 2016-10-28 CN CN201680074667.3A patent/CN109312338B/zh active Active
- 2016-10-28 AU AU2016343991A patent/AU2016343991B2/en active Active
- 2016-10-28 WO PCT/US2016/059502 patent/WO2017075475A1/en not_active Ceased
- 2016-10-28 EP EP16795487.4A patent/EP3368670A1/en active Pending
- 2016-10-28 CA CA3001711A patent/CA3001711A1/en active Pending
- 2016-10-28 JP JP2018542995A patent/JP7408284B2/ja active Active
-
2018
- 2018-04-30 US US15/966,897 patent/US11001844B2/en active Active
-
2021
- 2021-04-19 US US17/234,145 patent/US11834649B2/en active Active
-
2022
- 2022-01-21 JP JP2022007688A patent/JP2022068156A/ja not_active Withdrawn
- 2022-11-14 AU AU2022271376A patent/AU2022271376B9/en active Active
-
2023
- 2023-12-07 JP JP2023206552A patent/JP2024055867A/ja active Pending
-
2025
- 2025-12-09 AU AU2025279635A patent/AU2025279635A1/en active Pending
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