JP2019503679A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019503679A5 JP2019503679A5 JP2018533140A JP2018533140A JP2019503679A5 JP 2019503679 A5 JP2019503679 A5 JP 2019503679A5 JP 2018533140 A JP2018533140 A JP 2018533140A JP 2018533140 A JP2018533140 A JP 2018533140A JP 2019503679 A5 JP2019503679 A5 JP 2019503679A5
- Authority
- JP
- Japan
- Prior art keywords
- cell population
- group
- signaling
- neural crest
- activators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022061883A JP2022095796A (ja) | 2015-12-23 | 2022-04-01 | ヒト腸神経堤系統由来多能性幹細胞によって可能にされるヒルシュスプルング病における細胞ベースの処置および薬物発見 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387468P | 2015-12-23 | 2015-12-23 | |
| US62/387,468 | 2015-12-23 | ||
| PCT/US2016/068430 WO2017112901A1 (en) | 2015-12-23 | 2016-12-22 | Cell-based treatment and drug discovery in hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022061883A Division JP2022095796A (ja) | 2015-12-23 | 2022-04-01 | ヒト腸神経堤系統由来多能性幹細胞によって可能にされるヒルシュスプルング病における細胞ベースの処置および薬物発見 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019503679A JP2019503679A (ja) | 2019-02-14 |
| JP2019503679A5 true JP2019503679A5 (https=) | 2020-02-06 |
| JP7549442B2 JP7549442B2 (ja) | 2024-09-11 |
Family
ID=59091237
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018533140A Active JP7549442B2 (ja) | 2015-12-23 | 2016-12-22 | ヒト腸神経堤系統由来多能性幹細胞によって可能にされるヒルシュスプルング病における細胞ベースの処置および薬物発見 |
| JP2022061883A Pending JP2022095796A (ja) | 2015-12-23 | 2022-04-01 | ヒト腸神経堤系統由来多能性幹細胞によって可能にされるヒルシュスプルング病における細胞ベースの処置および薬物発見 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022061883A Pending JP2022095796A (ja) | 2015-12-23 | 2022-04-01 | ヒト腸神経堤系統由来多能性幹細胞によって可能にされるヒルシュスプルング病における細胞ベースの処置および薬物発見 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12371662B2 (https=) |
| EP (1) | EP3414322A4 (https=) |
| JP (2) | JP7549442B2 (https=) |
| KR (1) | KR20180093063A (https=) |
| CN (1) | CN108699528A (https=) |
| AU (2) | AU2016377701B2 (https=) |
| CA (1) | CA3009509A1 (https=) |
| IL (1) | IL260214B2 (https=) |
| WO (1) | WO2017112901A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| KR20180105236A (ko) * | 2016-02-05 | 2018-09-27 | 메모리얼 슬로안-케터링 캔서 센터 | 줄기 세포-유래 외배엽 계통 전구체의 분화 방법 |
| CN109415685B (zh) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| JP7094567B2 (ja) * | 2017-04-27 | 2022-07-04 | 国立大学法人京都大学 | 神経堤細胞および交感神経細胞の製造方法 |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| CN108559726A (zh) * | 2017-12-28 | 2018-09-21 | 上海安集协康生物技术股份有限公司 | 一种对脑损伤类疾病有治疗作用的细胞亚群及其制备方法 |
| AU2019258575A1 (en) | 2018-04-27 | 2020-10-29 | Shionogi & Co., Ltd. | Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| WO2020040166A1 (ja) * | 2018-08-22 | 2020-02-27 | 国立大学法人京都大学 | 腸管神経前駆細胞の製造方法 |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| AU2019401518B2 (en) * | 2018-12-21 | 2026-02-26 | The Regents Of The University Of California | Method of producing enteric neurons and uses thereof |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| AU2020263484B2 (en) * | 2019-04-24 | 2026-04-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nociceptor differentiation from human pluripotent stem cells |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| CN110747276B (zh) * | 2019-11-22 | 2020-06-30 | 山东大学齐鲁医院 | Bace2作为胶质瘤预后/诊断/治疗标志物的应用 |
| CA3162011A1 (en) * | 2019-12-19 | 2021-06-24 | Rodolphe SORET | Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies |
| US20230126711A1 (en) * | 2020-03-25 | 2023-04-27 | The Regents Of The University Of California | Enteric nitrergic neurons and methods of using the same |
| WO2022046771A1 (en) * | 2020-08-24 | 2022-03-03 | The Johns Hopkins University | Juvenile protective factors to arrest and reverse aging in the enteric nervous system |
| WO2022199682A1 (zh) * | 2021-03-26 | 2022-09-29 | 广州市妇女儿童医疗中心 | 先天性巨结肠的诊断或早期诊断标志物及其应用 |
| US20240252545A1 (en) * | 2021-05-07 | 2024-08-01 | Children's Hospital Los Angeles | Methods for Making Stem Cell-Derived Enteric Neural Crest Cells and Their Use in Enteric Neuropathy Treatment |
| EP4355864A4 (en) * | 2021-06-18 | 2025-04-23 | Memorial Sloan Kettering Cancer Center | Methods of generating sacral neural crest lineages and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5649786B2 (ja) | 2006-03-07 | 2015-01-07 | ギータ シュロフ | ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法 |
| WO2008008266A2 (en) | 2006-07-07 | 2008-01-17 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Biohybrid elastomeric scaffolds and methods of use thereof |
| DK3578988T3 (da) * | 2010-05-25 | 2025-02-24 | Memorial Sloan Kettering Cancer Center | Fremgangsmåde til nociceptordifferentiering af humane embryonale stamceller og anvendelse heraf |
| US20110296542A1 (en) | 2010-05-28 | 2011-12-01 | Kevin Ka-Wang Wang | Exogenous matrix-supported topical application of stem cells to organ surface |
| US20120053121A1 (en) * | 2010-08-31 | 2012-03-01 | Nationwide Children's Hospital, Inc. | Administration of HB-EGF for the Protection of Enteric Neurons |
| WO2013188744A1 (en) | 2012-06-15 | 2013-12-19 | Baylor College Of Medicine | Perineurium derived adult stem cells and methods of use |
| RU2519692C1 (ru) * | 2012-11-12 | 2014-06-20 | Закрытое Акционерное Общество "Твин Трейдинг Компани" | Способ извлечения редкоземельных элементов из твердых материалов, содержащих редкоземельные элементы |
| AU2014352773B2 (en) | 2013-11-21 | 2021-04-29 | Memorial Sloan-Kettering Cancer Center | Specification of functional cranial placode derivatives from human pluripotent stem cells |
| US10024870B2 (en) * | 2014-04-02 | 2018-07-17 | Wisconsin Alumni Research Foundation | Therapeutic and diagnostic methods and compositions for neurodegenerative diseases |
| CN104073468B (zh) * | 2014-07-16 | 2016-04-27 | 栾佐 | 获得人源OPCs的方法和OPCs培养基 |
| CN104474537B (zh) * | 2014-12-17 | 2017-05-10 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Nedl2蛋白及其编码基因在治疗先天性巨结肠疾病中的应用 |
-
2016
- 2016-12-22 EP EP16880120.7A patent/EP3414322A4/en active Pending
- 2016-12-22 JP JP2018533140A patent/JP7549442B2/ja active Active
- 2016-12-22 KR KR1020187020591A patent/KR20180093063A/ko not_active Ceased
- 2016-12-22 AU AU2016377701A patent/AU2016377701B2/en active Active
- 2016-12-22 CA CA3009509A patent/CA3009509A1/en active Pending
- 2016-12-22 CN CN201680082392.8A patent/CN108699528A/zh active Pending
- 2016-12-22 IL IL260214A patent/IL260214B2/en unknown
- 2016-12-22 WO PCT/US2016/068430 patent/WO2017112901A1/en not_active Ceased
-
2018
- 2018-06-22 US US16/015,748 patent/US12371662B2/en active Active
-
2022
- 2022-04-01 JP JP2022061883A patent/JP2022095796A/ja active Pending
-
2023
- 2023-07-06 AU AU2023204373A patent/AU2023204373A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019503679A5 (https=) | ||
| Conti et al. | Neural stem cell systems: physiological players or in vitro entities? | |
| Kumamaru et al. | Generation and post-injury integration of human spinal cord neural stem cells | |
| Shimozaki et al. | Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures | |
| EP2464723B1 (en) | Method for inducing differentiation of pluripotent stem cells into neural precursor cells | |
| Ebert et al. | EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs | |
| AU2013251749B2 (en) | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells | |
| JP2021118718A (ja) | 多能性幹細胞由来の機能性オリゴデンドロサイト、ならびにその作製方法及び使用方法 | |
| Gorris et al. | Pluripotent stem cell‐derived radial glia‐like cells as stable intermediate for efficient generation of human oligodendrocytes | |
| Gökhan et al. | Basic and clinical neuroscience applications of embryonic stem cells | |
| Petros et al. | Pluripotent stem cells for the study of CNS development | |
| Gale et al. | Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells | |
| Sato et al. | Microfabric vessels for embryoid body formation and rapid differentiation of pluripotent stem cells | |
| Zhao et al. | Neurogenesis potential of oligodendrocyte precursor cells from oligospheres and injured spinal cord | |
| KR20130085767A (ko) | 유전자 도입 없이 직접적 역분화를 통해 체세포로부터 신경상피세포 및 신경줄기세포를 유도하는 방법 | |
| JPWO2021045217A5 (https=) | ||
| Yang et al. | High glucose suppresses embryonic stem cell differentiation into neural lineage cells | |
| Shimada et al. | Differentiation of dopaminergic neurons from human embryonic stem cells: modulation of differentiation by FGF-20 | |
| Mirakhori et al. | Induction of neural progenitor-like cells from human fibroblasts via a genetic material-free approach | |
| Dandapat et al. | Expression of the human FSHD-linked DUX4 gene induces neurogenesis during differentiation of murine embryonic stem cells | |
| US20160108362A1 (en) | Culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells | |
| Nat et al. | Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development | |
| Chen et al. | Prerequisite OCT4 maintenance potentiates the neural induction of differentiating human embryonic stem cells and induced pluripotent stem cells | |
| CN101294146B (zh) | 诱导神经干细胞分化的系统及诱导方法 | |
| Giadrossi et al. | Chromatin organization and differentiation in embryonic stem cell models |