|
JPS5219208A
(en)
*
|
1975-08-04 |
1977-02-14 |
Sanyo Electric Co Ltd |
Slow starter circuit for motors
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US5019369A
(en)
|
1984-10-22 |
1991-05-28 |
Vestar, Inc. |
Method of targeting tumors in humans
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US4920016A
(en)
|
1986-12-24 |
1990-04-24 |
Linear Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5837258A
(en)
|
1991-08-30 |
1998-11-17 |
University Of South Florida |
Induction of tissue, bone or cartilage formation using connective tissue growth factor
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
NZ514348A
(en)
|
1999-05-04 |
2004-05-28 |
Exiqon As |
L-ribo-LNA analogues
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
KR100872437B1
(ko)
|
2000-12-01 |
2008-12-05 |
막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. |
Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자
|
|
US20050282188A1
(en)
|
2001-05-18 |
2005-12-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
|
US20080188430A1
(en)
|
2001-05-18 |
2008-08-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
|
WO2003020739A2
(en)
|
2001-09-04 |
2003-03-13 |
Exiqon A/S |
Novel lna compositions and uses thereof
|
|
US20040248835A1
(en)
|
2001-10-26 |
2004-12-09 |
Anja Krebs |
Use of a double-stranded ribonucleic acid for treating an infection with a positivestrand rna-virus
|
|
US20040138163A1
(en)
|
2002-05-29 |
2004-07-15 |
Mcswiggen James |
RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
KR100464261B1
(ko)
|
2002-01-24 |
2005-01-03 |
주식회사 파나진 |
Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
|
|
KR20030084444A
(ko)
|
2002-04-26 |
2003-11-01 |
주식회사 파나진 |
Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
ES2280826T5
(es)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Nuevas formas adicionales de moléculas de ARN de interferencia
|
|
JP2006507841A
(ja)
*
|
2002-11-14 |
2006-03-09 |
ダーマコン， インコーポレイテッド |
機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
WO2004080406A2
(en)
|
2003-03-07 |
2004-09-23 |
Alnylam Pharmaceuticals |
Therapeutic compositions
|
|
US20040198640A1
(en)
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
|
US7211668B2
(en)
|
2003-07-28 |
2007-05-01 |
Panagene, Inc. |
PNA monomer and precursor
|
|
US20050136437A1
(en)
|
2003-08-25 |
2005-06-23 |
Nastech Pharmaceutical Company Inc. |
Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
|
|
WO2005062937A2
(en)
|
2003-12-22 |
2005-07-14 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna
|
|
US20060134787A1
(en)
|
2004-12-22 |
2006-06-22 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
|
|
US20060069050A1
(en)
|
2004-02-17 |
2006-03-30 |
University Of Massachusetts |
Methods and compositions for mediating gene silencing
|
|
KR101246862B1
(ko)
|
2004-03-05 |
2013-03-27 |
베니텍 리미티드 |
ＲＮＡｉ 제제의 동시 전달을 위한 다중 프로모터 발현카세트
|
|
ES2423060T3
(es)
|
2004-03-12 |
2013-09-17 |
Alnylam Pharmaceuticals, Inc. |
Agentes iRNA que tienen como diana al VEGF
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
US20090170794A1
(en)
|
2004-09-10 |
2009-07-02 |
Somagenics Inc. |
Small interfering rnas that efficiently inhibit viral expression and methods of use thereof
|
|
NZ572403A
(en)
|
2004-09-24 |
2010-03-26 |
Alnylam Pharmaceuticals Inc |
Rnai modulation of apob and uses thereof
|
|
TWI386225B
(zh)
|
2004-12-23 |
2013-02-21 |
Alcon Inc |
用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術
|
|
US20060142228A1
(en)
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
AU2006235364A1
(en)
|
2005-04-08 |
2006-10-19 |
Marina Biotech, Inc. |
RNAi therapeutic for respiratory virus infection
|
|
WO2006125977A2
(en)
|
2005-05-25 |
2006-11-30 |
The University Of York |
Hybrid interfering rna
|
|
BRPI0611581B1
(pt)
|
2005-06-24 |
2021-08-03 |
Intervet International B.V. |
Flavivírus quimérico inativado, composição imunogênica, e, vacina
|
|
FR2890859B1
(fr)
|
2005-09-21 |
2012-12-21 |
Oreal |
Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase
|
|
US7825099B2
(en)
|
2006-01-20 |
2010-11-02 |
Quark Pharmaceuticals, Inc. |
Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
|
|
CA2638906A1
(en)
|
2006-01-26 |
2007-08-16 |
University Of Massachusetts |
Rna interference agents for therapeutic use
|
|
CA2640423C
(en)
|
2006-01-27 |
2016-03-15 |
Biogen Idec Ma Inc. |
Nogo receptor antagonists
|
|
US20070218495A1
(en)
|
2006-03-16 |
2007-09-20 |
Dharmacon, Inc. |
Methods, libraries and computer program products for gene silencing with reduced off-target effects
|
|
US7700541B2
(en)
|
2006-04-06 |
2010-04-20 |
Nitto Denko Corporation |
Biodegradable cationic polymers
|
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
|
WO2008109377A1
(en)
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting vegf family gene expression and uses thereof
|
|
US20100105134A1
(en)
|
2007-03-02 |
2010-04-29 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting gene expression and uses thereof
|
|
WO2008150897A2
(en)
|
2007-05-31 |
2008-12-11 |
University Of Iowa Research Foundation |
Reduction of off-target rna interference toxicity
|
|
US20090004668A1
(en)
|
2007-06-22 |
2009-01-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Pre-miRNA loop-modulated target regulation
|
|
CA2693742A1
(en)
|
2007-07-12 |
2009-01-15 |
Prosensa Technologies B.V. |
Molecules for targeting compounds to various selected organs, tissues or tumor cells
|
|
WO2009020344A2
(en)
|
2007-08-06 |
2009-02-12 |
Postech Acad Ind Found |
Small interfering rnas (sirnas) controlling multiple target genes and method for preparing the same
|
|
EP2193140B1
(en)
|
2007-08-27 |
2016-11-02 |
1Globe Health Institute LLC |
Compositions of asymmetric interfering rna and uses thereof
|
|
CN101849008A
(zh)
|
2007-09-19 |
2010-09-29 |
应用生物系统有限公司 |
用于减少RNAi中的脱靶表型效应的siRNA的不依赖于序列的修饰形式和其稳定形式
|
|
CN103898110A
(zh)
|
2007-10-03 |
2014-07-02 |
夸克制药公司 |
新siRNA结构
|
|
AR069328A1
(es)
|
2007-11-15 |
2010-01-13 |
Alcon Mfg Ltd |
Liberacion de rna interferente corto o sirna, intermediada por receptor de lipoproteina de baja densidad
|
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
|
KR100949791B1
(ko)
|
2007-12-18 |
2010-03-30 |
이동기 |
오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도
|
|
JP2011518116A
(ja)
|
2008-02-21 |
2011-06-23 |
ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション |
トール様受容体３拮抗薬としての超小型ｒｎａ
|
|
US8324366B2
(en)
|
2008-04-29 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for delivering RNAI using lipoproteins
|
|
EP2318528A1
(en)
|
2008-07-24 |
2011-05-11 |
Rxi Pharmaceuticals Corporation |
Rnai constructs and uses therof
|
|
WO2010026660A1
(ja)
|
2008-09-08 |
2010-03-11 |
学校法人福岡大学 |
Ｚｆａｔ遺伝子発現抑制ｒｎａ
|
|
EP2340309A2
(en)
|
2008-09-22 |
2011-07-06 |
Rxi Pharmaceuticals Corporation |
Neutral nanotransporters
|
|
US20100227920A1
(en)
|
2008-09-29 |
2010-09-09 |
The Regents Of The University Of California |
Aldehyde dehydrogenase inhibitors as novel depigmenting agents
|
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
JP2012517815A
(ja)
|
2009-02-18 |
2012-08-09 |
サイレンス・セラピューティクス・アーゲー |
Ａｎｇ２の発現を阻害するための手段
|
|
JP2012520683A
(ja)
|
2009-03-19 |
2012-09-10 |
メルク・シャープ・エンド・ドーム・コーポレイション |
低分子干渉核酸（ｓｉＮＡ）を用いた結合組織増殖因子（ＣＴＧＦ）遺伝子発現のＲＮＡ干渉媒介性阻害
|
|
ES2628144T3
(es)
|
2009-04-03 |
2017-08-01 |
Dicerna Pharmaceuticals, Inc. |
Métodos y composiciones para la inhibición específica de KRAS por RNA bicatenario asimétrico
|
|
US8472766B2
(en)
|
2009-08-14 |
2013-06-25 |
Massachusetts Institute Of Technology |
Waveguide coupler having continuous three-dimensional tapering
|
|
KR101207561B1
(ko)
|
2009-12-15 |
2012-12-04 |
주식회사 코리아나화장품 |
티로시나제의 발현을 저해하는 ｓｉＲＮＡ 올리고뉴클레오타이드 및 이를 함유하는 화장료 조성물
|
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
|
EP3023495B1
(en)
|
2010-02-24 |
2019-05-08 |
Arrowhead Pharmaceuticals, Inc. |
Compositions for targeted delivery of sirna
|
|
CN106074591B
(zh)
|
2010-03-24 |
2020-01-14 |
菲奥医药公司 |
眼部症候中的rna干扰
|
|
US20130115613A1
(en)
|
2010-05-12 |
2013-05-09 |
Val-Chum, Limited Partnership |
Screening assays based on mag and/or abhd6 for selecting insulin secretion promoting agent
|
|
CA2812046A1
(en)
|
2010-09-15 |
2012-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified irna agents
|
|
EP2631291B1
(en)
*
|
2010-10-22 |
2019-05-15 |
OliX Pharmaceuticals, Inc. |
Nucleic acid molecules inducing rna interference, and uses thereof
|
|
US20130324591A1
(en)
|
2010-12-06 |
2013-12-05 |
Quark Pharmaceuticals, Inc. |
Double stranded oligonucleotide compounds comprising positional modifications
|
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
|
ES2605990T3
(es)
|
2010-12-29 |
2017-03-17 |
F. Hoffmann-La Roche Ag |
Conjugados de molécula pequeña para la administración intracelular de ácidos nucleicos
|
|
WO2012118911A1
(en)
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide modulators of the toll-like receptor pathway
|
|
CN102719432B
(zh)
|
2011-03-29 |
2013-10-23 |
南京大学 |
特异性抑制肿瘤凋亡抑制基因Bcl2的双链不对称小核酸干扰分子asiRNA及其应用
|
|
KR101590586B1
(ko)
|
2011-05-30 |
2016-02-01 |
성균관대학교산학협력단 |
표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 ｒｎａ
|
|
ES2907620T3
(es)
|
2011-07-18 |
2022-04-25 |
Univ Kentucky Res Found |
Protección de células de la degeneración inducida por ARN Alu e inhibidores para proteger células
|
|
US9707235B1
(en)
|
2012-01-13 |
2017-07-18 |
University Of Kentucky Research Foundation |
Protection of cells from degeneration and treatment of geographic atrophy
|
|
CN118581086A
(zh)
|
2012-01-27 |
2024-09-03 |
比奥马林技术公司 |
用于治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
|
|
DK2853597T3
(en)
|
2012-05-22 |
2019-04-08 |
Olix Pharmaceuticals Inc |
RNA INTERFERENCE-INducing NUCLEIC ACID MOLECULES WITH CELL PENETENING EQUIPMENT AND USE THEREOF
|
|
US9611473B2
(en)
|
2012-09-12 |
2017-04-04 |
Quark Pharmaceuticals, Inc. |
Double-stranded nucleic acid compounds
|
|
EP3591053A1
(en)
|
2013-07-05 |
2020-01-08 |
Bioneer Corporation |
Respiratory disease-related gene specific sirna, double-helical oligo rna structure containing sirna, compositon containing same for preventing or treating respiratory disease
|
|
EP3027223A1
(en)
|
2013-07-31 |
2016-06-08 |
QBI Enterprises Ltd. |
Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
|
|
US9790506B2
(en)
*
|
2013-10-02 |
2017-10-17 |
The Regents Of The University Of California |
Diagnostic and screening methods for atopic dermatitis
|
|
US8980273B1
(en)
*
|
2014-07-15 |
2015-03-17 |
Kymab Limited |
Method of treating atopic dermatitis or asthma using antibody to IL4RA
|
|
WO2015171641A1
(en)
|
2014-05-05 |
2015-11-12 |
Brigham And Women's Hospital, Inc. |
Coordinate control of pathogenic signaling by the mir-130/301 family in pulmonary hypertension and fibroproliferative diseases
|
|
US9139648B1
(en)
|
2014-07-15 |
2015-09-22 |
Kymab Limited |
Precision medicine by targeting human NAV1.9 variants for treatment of pain
|
|
WO2016161388A1
(en)
*
|
2015-04-03 |
2016-10-06 |
University Of Massachusetts |
Fully stabilized asymmetric sirna
|
|
CA3022872C
(en)
|
2015-07-27 |
2024-01-09 |
Olix Pharmaceuticals, Inc. |
Rna complexes that inhibit melanin production
|
|
EP3377630A4
(en)
|
2015-11-16 |
2020-01-01 |
Olix Pharmaceuticals, Inc. |
Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3
|
|
EP3411481A4
(en)
|
2016-02-02 |
2020-02-26 |
Olix Pharmaceuticals, Inc. |
TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENESIS USING ANGPT2 AND PDGFB TARGETED RNA COMPLEXES
|
|
JP6944942B2
(ja)
|
2016-02-02 |
2021-10-06 |
オリックス ファーマシューティカルズ，インコーポレーテッド |
ＩＬ４Ｒα、ＴＲＰＡ１、またはＦ２ＲＬ１を標的とするＲＮＡ複合体を用いたアトピー性皮膚炎および喘息の治療
|
|
WO2017178883A2
(en)
|
2016-04-11 |
2017-10-19 |
Olix Pharmaceuticals, Inc. |
Treatment of idiopathic pulmonary fibrosis using rna complexes that target connective tissue growth factor
|
|
KR101916652B1
(ko)
|
2016-06-29 |
2018-11-08 |
올릭스 주식회사 |
작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
|
|
EP3580339A4
(en)
|
2017-02-10 |
2020-12-23 |
Research & Business Foundation Sungkyunkwan University |
LONG DOUBLE STRAND RNA FOR RNA INTERFERENCE
|