CN108779463B - 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘 - Google Patents

使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘 Download PDF

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CN108779463B
CN108779463B CN201780015898.1A CN201780015898A CN108779463B CN 108779463 B CN108779463 B CN 108779463B CN 201780015898 A CN201780015898 A CN 201780015898A CN 108779463 B CN108779463 B CN 108779463B
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rna complex
asirna
rna
antisense strand
pharmaceutical composition
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CN108779463A (zh
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D·K·李
S·W·弘
H·李
D·于
J·严
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Olix Pharmaceuticals Inc
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CN201780015898.1A 2016-02-02 2017-02-01 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘 Active CN108779463B (zh)

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US201662290298P 2016-02-02 2016-02-02
US62/290,298 2016-02-02
PCT/IB2017/000166 WO2017134525A1 (en) 2016-02-02 2017-02-01 TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGET lL4Rα, TRPA1, OR F2RL1

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CN108779463A CN108779463A (zh) 2018-11-09
CN108779463B true CN108779463B (zh) 2022-05-24

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EP (1) EP3411480B1 (enExample)
JP (1) JP6944942B2 (enExample)
KR (1) KR102825946B1 (enExample)
CN (1) CN108779463B (enExample)
CA (1) CA3022874A1 (enExample)
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EP3377630A4 (en) 2015-11-16 2020-01-01 Olix Pharmaceuticals, Inc. Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3
JP6944942B2 (ja) 2016-02-02 2021-10-06 オリックス ファーマシューティカルズ，インコーポレーテッド ＩＬ４Ｒα、ＴＲＰＡ１、またはＦ２ＲＬ１を標的とするＲＮＡ複合体を用いたアトピー性皮膚炎および喘息の治療
EP3411481A4 (en) 2016-02-02 2020-02-26 Olix Pharmaceuticals, Inc. TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENESIS USING ANGPT2 AND PDGFB TARGETED RNA COMPLEXES
WO2017178883A2 (en) 2016-04-11 2017-10-19 Olix Pharmaceuticals, Inc. Treatment of idiopathic pulmonary fibrosis using rna complexes that target connective tissue growth factor
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
EP3580339A4 (en) 2017-02-10 2020-12-23 Research & Business Foundation Sungkyunkwan University LONG DOUBLE STRAND RNA FOR RNA INTERFERENCE
US20220125935A1 (en) * 2018-11-07 2022-04-28 Seasun Therapeutics Composition for preventing or treating atopic dermatitis comprising skin-penetrating nucleic acid complex as effective component
AU2020239987A1 (en) * 2019-03-15 2021-11-04 University Of Massachusetts Oligonucleotides for tissue specific ApoE modulation
KR102460570B1 (ko) 2020-02-18 2022-10-28 주식회사 피코엔텍 신규한 돌연변이 효모를 함유하는 아토피 억제 조성물
CN114657133A (zh) * 2020-12-22 2022-06-24 未来智人再生医学研究院(广州)有限公司 一种表达靶向IL-4 Rα的shRNA和/或shRNA-miR的多能干细胞

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