JP2019501882A5 - - Google Patents
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- JP2019501882A5 JP2019501882A5 JP2018528340A JP2018528340A JP2019501882A5 JP 2019501882 A5 JP2019501882 A5 JP 2019501882A5 JP 2018528340 A JP2018528340 A JP 2018528340A JP 2018528340 A JP2018528340 A JP 2018528340A JP 2019501882 A5 JP2019501882 A5 JP 2019501882A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- seq
- derived
- beclin
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 50
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 15
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 15
- 241000713666 Lentivirus Species 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 239000013603 viral vector Substances 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 102000004072 Beclin-1 Human genes 0.000 claims 5
- 108090000524 Beclin-1 Proteins 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 241000702421 Dependoparvovirus Species 0.000 claims 4
- 241000125945 Protoparvovirus Species 0.000 claims 4
- 239000003623 enhancer Substances 0.000 claims 4
- 241001430294 unidentified retrovirus Species 0.000 claims 4
- 230000026683 transduction Effects 0.000 claims 3
- 238000010361 transduction Methods 0.000 claims 3
- 102000010310 Beclin-2 Human genes 0.000 claims 2
- 108050001838 Beclin-2 Proteins 0.000 claims 2
- 108010016626 Dipeptides Proteins 0.000 claims 2
- 101710121417 Envelope glycoprotein Proteins 0.000 claims 2
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 102100021696 Syncytin-1 Human genes 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000000582 semen Anatomy 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 101710150451 Protein Bel-1 Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000000423 cell based assay Methods 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021162777A JP2022002530A (ja) | 2015-12-03 | 2021-10-01 | ウイルスベクター効率を改善するための組成物及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15306924.0 | 2015-12-03 | ||
| EP15306924 | 2015-12-03 | ||
| EP16194180 | 2016-10-17 | ||
| EP16194180.2 | 2016-10-17 | ||
| PCT/EP2016/079304 WO2017093330A1 (en) | 2015-12-03 | 2016-11-30 | Compositions and methods for improving viral vector efficiency |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162777A Division JP2022002530A (ja) | 2015-12-03 | 2021-10-01 | ウイルスベクター効率を改善するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501882A JP2019501882A (ja) | 2019-01-24 |
| JP2019501882A5 true JP2019501882A5 (https=) | 2019-10-24 |
| JP7350485B2 JP7350485B2 (ja) | 2023-09-26 |
Family
ID=57485463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528340A Active JP7350485B2 (ja) | 2015-12-03 | 2016-11-30 | ウイルスベクター効率を改善するための組成物及び方法 |
| JP2021162777A Pending JP2022002530A (ja) | 2015-12-03 | 2021-10-01 | ウイルスベクター効率を改善するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162777A Pending JP2022002530A (ja) | 2015-12-03 | 2021-10-01 | ウイルスベクター効率を改善するための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11371061B2 (https=) |
| EP (1) | EP3383896A1 (https=) |
| JP (2) | JP7350485B2 (https=) |
| CN (1) | CN108699135B (https=) |
| CA (1) | CA3004971A1 (https=) |
| WO (1) | WO2017093330A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104080799B (zh) * | 2011-06-30 | 2021-03-12 | 吉尼松公司 | 具有病毒感染增强性质的肽及其用途 |
| WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
| SG11201703148TA (en) | 2014-11-05 | 2017-05-30 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
| CA3193811A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| CN119876138A (zh) | 2014-11-14 | 2025-04-25 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| HK1245326A1 (zh) | 2014-12-12 | 2018-08-24 | Voyager Therapeutics, Inc. | 用於生产scaav的组合物和方法 |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| CA3024449A1 (en) | 2016-05-18 | 2017-11-23 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
| CA3024448C (en) | 2016-05-18 | 2025-09-09 | Voyager Therapeutics, Inc. | MODULATING POLYNUCLEOTIDES |
| WO2018044933A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| EP3618839A4 (en) | 2017-05-05 | 2021-06-09 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
| JP7221275B2 (ja) | 2017-08-03 | 2023-02-13 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖを送達するための組成物および方法 |
| EP3665285A4 (en) * | 2017-08-10 | 2021-08-11 | Aadigen, LLC | PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR VIRUS ADMINISTRATION |
| CN107686523B (zh) * | 2017-09-15 | 2021-05-14 | 山西大学 | 一种肿瘤酸度响应自噬诱导多肽及其制备方法和应用 |
| US20200263199A1 (en) | 2017-09-29 | 2020-08-20 | Voyager Therapeutics, Inc. | Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
| SG11202011296VA (en) | 2018-05-15 | 2020-12-30 | Voyager Therapeutics Inc | Compositions and methods for the treatment of parkinson's disease |
| US12281321B2 (en) | 2018-09-28 | 2025-04-22 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| US20220280602A1 (en) * | 2019-07-31 | 2022-09-08 | Lemonex Inc. | Anticancer agent and method for preparation of porous silica particle |
| US20240025959A1 (en) * | 2020-08-24 | 2024-01-25 | University Of Southern California | Beclin 2 and uses thereof for treating cancer and neurodegenerative diseases |
| MX2023009554A (es) * | 2021-02-15 | 2023-09-13 | Biomarin Pharm Inc | Uso de peptidos ricos en histidina como reactivo de transfeccion para la produccion de raav y rbv. |
| CN113713082B (zh) * | 2021-08-27 | 2023-07-18 | 福建医科大学 | 一种用于阿尔茨海默症的纳米自噬诱导剂及其制备方法与应用 |
| CN114316065B (zh) * | 2021-10-29 | 2023-09-22 | 新乡医学院 | 小分子肽及其应用、细胞培养基、核酸分子 |
| WO2024243639A1 (en) * | 2023-05-31 | 2024-12-05 | The Florey Institute Of Neuroscience And Mental Health | Autophagy-inducing peptides |
| WO2025179154A1 (en) * | 2024-02-21 | 2025-08-28 | Vycellix, Inc. | Compositions and methods for enhancing transduction efficiency of viral vectors with heparin and analogues thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083979B1 (en) | 1994-03-25 | 2006-08-01 | Indiana University Foundation | Methods for enhanced retroviral-mediated gene transfer |
| WO2011106684A2 (en) * | 2010-02-25 | 2011-09-01 | San Diego State University Foundation | Compositions and methods for modulating autophagy |
| CN104080799B (zh) * | 2011-06-30 | 2021-03-12 | 吉尼松公司 | 具有病毒感染增强性质的肽及其用途 |
| WO2013119377A1 (en) | 2012-02-11 | 2013-08-15 | Board Of Regents, The University Of Texas System | Autophagy-inducing peptide |
| US20150352228A1 (en) | 2013-01-11 | 2015-12-10 | Bruce TORBET | Methods and compositions for enhancing transduction efficiency of retroviral vectors |
| US20140271584A1 (en) | 2013-03-15 | 2014-09-18 | The Research Foundation For The State University Of New York | Methods and Compositions for Direct Reprogramming of Somatic Cells to Stem Cells, and Uses of these Cells |
| EP3046571A4 (en) | 2013-09-18 | 2017-03-15 | Ndsu Research Foundation | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH y-HERPESVIRUSES |
| WO2016119856A1 (en) | 2015-01-29 | 2016-08-04 | Universite De Strasbourg | Autophagy-inducing molecules for increasing insulin release |
| EP3141680B1 (en) * | 2015-09-09 | 2018-01-31 | U-Shin Italia S.p.A. | Electronic handle for a vehicle door |
| CN108431033A (zh) * | 2015-09-28 | 2018-08-21 | 泰莱托恩基金会 | 骨生长病症的治疗 |
| US10993983B2 (en) * | 2016-03-18 | 2021-05-04 | Trustees Of Tufts College | Cyclic peptide epitopes and small-molecule mimics for inducing autophagy |
| WO2018013568A1 (en) * | 2016-07-11 | 2018-01-18 | University Of North Texas Health Science Center At Fort Worth | Treatment for glaucoma and other eye diseases |
| TW201910511A (zh) * | 2017-05-30 | 2019-03-16 | 美商維泰克斯製藥公司 | C3融合蛋白以及其製備及使用方法 |
-
2016
- 2016-11-30 CN CN201680070996.0A patent/CN108699135B/zh not_active Expired - Fee Related
- 2016-11-30 JP JP2018528340A patent/JP7350485B2/ja active Active
- 2016-11-30 CA CA3004971A patent/CA3004971A1/en active Pending
- 2016-11-30 US US15/772,902 patent/US11371061B2/en active Active
- 2016-11-30 WO PCT/EP2016/079304 patent/WO2017093330A1/en not_active Ceased
- 2016-11-30 EP EP16806032.5A patent/EP3383896A1/en not_active Withdrawn
-
2021
- 2021-10-01 JP JP2021162777A patent/JP2022002530A/ja active Pending
-
2022
- 2022-05-23 US US17/750,705 patent/US20230117384A1/en not_active Abandoned
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