JP2019501363A5 - - Google Patents
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- JP2019501363A5 JP2019501363A5 JP2018516113A JP2018516113A JP2019501363A5 JP 2019501363 A5 JP2019501363 A5 JP 2019501363A5 JP 2018516113 A JP2018516113 A JP 2018516113A JP 2018516113 A JP2018516113 A JP 2018516113A JP 2019501363 A5 JP2019501363 A5 JP 2019501363A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- protein
- reactive probe
- moiety
- reactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562244881P | 2015-10-22 | 2015-10-22 | |
| US62/244,881 | 2015-10-22 | ||
| US201662345710P | 2016-06-03 | 2016-06-03 | |
| US62/345,710 | 2016-06-03 | ||
| PCT/US2016/058308 WO2017070611A1 (en) | 2015-10-22 | 2016-10-21 | Cysteine reactive probes and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501363A JP2019501363A (ja) | 2019-01-17 |
| JP2019501363A5 true JP2019501363A5 (enExample) | 2020-01-30 |
| JP6953400B2 JP6953400B2 (ja) | 2021-10-27 |
Family
ID=58558160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516113A Expired - Fee Related JP6953400B2 (ja) | 2015-10-22 | 2016-10-21 | システイン反応性プローブとその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10670605B2 (enExample) |
| EP (1) | EP3365686A4 (enExample) |
| JP (1) | JP6953400B2 (enExample) |
| CA (1) | CA3001847A1 (enExample) |
| WO (1) | WO2017070611A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10782295B2 (en) | 2013-08-13 | 2020-09-22 | The Scripps Research Institute | Cysteine-reactive ligand discovery in proteomes |
| US10670605B2 (en) | 2015-10-22 | 2020-06-02 | The Scripps Research Institute | Cysteine reactive probes and uses thereof |
| ES2863873T3 (es) | 2016-05-18 | 2021-10-11 | Mirati Therapeutics Inc | Inhibidores de KRAS G12C |
| US20190216893A1 (en) * | 2016-06-03 | 2019-07-18 | The Scripps Research Institute | Compositions and methods of modulating immune response |
| CA3050260A1 (en) | 2017-01-18 | 2018-07-26 | The Scripps Research Institute | Photoreactive ligands and uses thereof |
| WO2018144869A1 (en) * | 2017-02-03 | 2018-08-09 | The Regents Of The University Of California | Compositons and methods for modulating uba5 |
| SG11201906671SA (en) * | 2017-02-03 | 2019-08-27 | Univ California | Compositions and methods for inhibiting reticulon 4 |
| US20200054651A1 (en) * | 2017-02-03 | 2020-02-20 | The Regents Of The University Of California | Compositions and methods for modulating ppp2r1a |
| EP3688472A4 (en) * | 2017-09-27 | 2021-06-23 | The Scripps Research Institute | CONJUGATED PROTEINS AND THEIR USES |
| WO2019067733A1 (en) * | 2017-09-27 | 2019-04-04 | Vividion Therapeutics, Inc. | COMPOUNDS AND METHODS FOR MODULATING PROTEIN DEGRADATION |
| US10807951B2 (en) | 2017-10-13 | 2020-10-20 | The Regents Of The University Of California | mTORC1 modulators |
| US10647715B2 (en) | 2017-11-15 | 2020-05-12 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| CA3082579A1 (en) | 2017-11-15 | 2019-05-23 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| WO2019113724A1 (zh) * | 2017-12-11 | 2019-06-20 | 广州君赫生物科技有限公司 | 双硫仑的新应用 |
| WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| SMT202500028T1 (it) | 2018-09-10 | 2025-03-12 | Mirati Therapeutics Inc | Terapie combinate |
| CA3112043A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| AU2019338207B2 (en) | 2018-09-10 | 2025-01-02 | Mirati Therapeutics, Inc. | Combination therapies |
| US12208099B2 (en) | 2018-09-10 | 2025-01-28 | Mirati Therapeutics, Inc. | Combination therapies |
| US12377101B2 (en) | 2018-12-05 | 2025-08-05 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2020146613A1 (en) | 2019-01-10 | 2020-07-16 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| US12366579B2 (en) | 2019-03-21 | 2025-07-22 | University Of Virginia Patent Foundation | Sulfur-heterocycle exchange chemistry and uses thereof |
| EP4010459A4 (en) | 2019-08-05 | 2023-09-06 | Bridgene Biosciences, Inc. | Method for proteome-wide discovery of covalent ligands and compositions thereof |
| CN114615981B (zh) | 2019-08-29 | 2024-04-12 | 米拉蒂治疗股份有限公司 | Kras g12d抑制剂 |
| CN114761012B (zh) | 2019-09-24 | 2025-03-21 | 米拉蒂治疗股份有限公司 | 组合疗法 |
| CN114787632A (zh) * | 2019-10-15 | 2022-07-22 | 杰那医疗公司 | 反应性亲和探针相互作用发现平台 |
| US20240123078A1 (en) * | 2019-10-16 | 2024-04-18 | Vividion Therapeutics, Inc. | Compounds and methods for modulating immune-related proteins |
| EP4045050A4 (en) * | 2019-10-16 | 2023-11-08 | The Scripps Research Institute | An activity-guided map of electrophile-cysteine interactions in primary human immune cells |
| CN111063389B (zh) * | 2019-12-04 | 2021-10-29 | 浙江工业大学 | 一种基于深度卷积神经网络的配体绑定残基预测方法 |
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| US12655160B2 (en) | 2020-08-04 | 2026-06-16 | Mirati Therapeutics, Inc. | KRAS G12D inhibitors |
| EP4210833A4 (en) | 2020-09-11 | 2024-09-11 | Mirati Therapeutics, Inc. | CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR |
| EP4216951B1 (en) | 2020-09-22 | 2026-04-01 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| CN112255396A (zh) * | 2020-10-15 | 2021-01-22 | 南开大学 | 一种测量小分子药物抑制蛋白核酸互作的单分子力学方法 |
| EP4262807A4 (en) | 2020-12-15 | 2025-04-23 | Mirati Therapeutics, Inc. | Azachinazoline pan-KRAS inhibitors |
| WO2022133038A1 (en) | 2020-12-16 | 2022-06-23 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| CN117956996A (zh) * | 2021-05-11 | 2024-04-30 | Opna 生物公司 | 用于yap/tead调节的化合物和方法及其适应证 |
| US20250034216A1 (en) * | 2021-11-22 | 2025-01-30 | The Scripps Research Institute | Stereoselective covalent ligands for oncogenic and immunological proteins |
| US20260079154A1 (en) * | 2022-09-12 | 2026-03-19 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Composition, device, system, and methods for detecting environmental toxicants |
| WO2024073486A2 (en) * | 2022-09-28 | 2024-04-04 | The General Hospital Corporation | Probes and methods to identify ligandable fatty acylation sites for therapeutic target identification |
| CN116466423B (zh) * | 2023-04-26 | 2026-05-01 | 中国科学院化学研究所 | 一种手性选择的光滤波器及其应用 |
| CN116790698B (zh) * | 2023-06-21 | 2024-06-18 | 南京大学 | 基于氧化脱羧酶的硫醛合成方法及其应用 |
| WO2025182683A1 (ja) * | 2024-02-29 | 2025-09-04 | 国立大学法人 東京大学 | タンパク質の活性／反応性部位の、活性／反応性の評価方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6344330B1 (en) | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| WO2000077184A1 (en) * | 1999-06-10 | 2000-12-21 | Pharmacia & Upjohn Company | Caspase-8 crystals, models and methods |
| AU2573102A (en) * | 2000-11-21 | 2002-06-03 | Sunesis Pharmaceuticals Inc | An extended tethering approach for rapid identification of ligands |
| WO2005118833A2 (en) | 2004-06-01 | 2005-12-15 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with sterile-alpha motif and leucine zipper containing kinase (zak) |
| US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| WO2008094205A2 (en) * | 2006-08-04 | 2008-08-07 | The Board Of Trustees Of The Leland Stanford Junior University | A mild chemically cleavable linker system |
| JPWO2008029924A1 (ja) * | 2006-09-08 | 2010-01-21 | 大日本住友製薬株式会社 | 環状アミノアルキルカルボキサミド誘導体 |
| US20090068107A1 (en) | 2006-10-02 | 2009-03-12 | The Scripps Research Institute | Enzyme regulating ether lipid signaling pathways |
| CN101219219B (zh) * | 2007-01-10 | 2013-02-13 | 北京普罗吉生物科技发展有限公司 | 包含血管抑素或其片段的复合物、其制备方法及应用 |
| EP1947193A1 (en) | 2007-01-17 | 2008-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Screening method for anti-diabetic compounds |
| WO2008109997A1 (en) * | 2007-03-09 | 2008-09-18 | The University Of British Columbia | Procaspase 8-mediated disease targeting |
| EP2254574A1 (en) * | 2008-02-26 | 2010-12-01 | Ludwig-Maximilians-Universität München | Beta-lactones as antibacterial agents |
| WO2013192364A1 (en) * | 2012-06-22 | 2013-12-27 | The University Of Vermont And State Agricultural College | Treatments of oxidative stress conditions |
| US20140357512A1 (en) | 2013-06-03 | 2014-12-04 | Acetylon Pharmaceuticals, Inc. | Histone deacetylase (hdac) biomarkers in multiple myeloma |
| US10782295B2 (en) | 2013-08-13 | 2020-09-22 | The Scripps Research Institute | Cysteine-reactive ligand discovery in proteomes |
| WO2016029037A1 (en) | 2014-08-21 | 2016-02-25 | Srx Cardio, Llc | Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(pcsk9) protein activity |
| US10670605B2 (en) * | 2015-10-22 | 2020-06-02 | The Scripps Research Institute | Cysteine reactive probes and uses thereof |
| CA3050260A1 (en) | 2017-01-18 | 2018-07-26 | The Scripps Research Institute | Photoreactive ligands and uses thereof |
-
2016
- 2016-10-21 US US15/331,745 patent/US10670605B2/en active Active
- 2016-10-21 WO PCT/US2016/058308 patent/WO2017070611A1/en not_active Ceased
- 2016-10-21 CA CA3001847A patent/CA3001847A1/en active Pending
- 2016-10-21 EP EP16858391.2A patent/EP3365686A4/en not_active Withdrawn
- 2016-10-21 JP JP2018516113A patent/JP6953400B2/ja not_active Expired - Fee Related
-
2020
- 2020-06-02 US US16/890,966 patent/US20200292555A1/en not_active Abandoned
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