JP2016535270A5 - - Google Patents
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- JP2016535270A5 JP2016535270A5 JP2016533958A JP2016533958A JP2016535270A5 JP 2016535270 A5 JP2016535270 A5 JP 2016535270A5 JP 2016533958 A JP2016533958 A JP 2016533958A JP 2016533958 A JP2016533958 A JP 2016533958A JP 2016535270 A5 JP2016535270 A5 JP 2016535270A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- proteins
- protein
- protein kinase
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 102000004169 proteins and genes Human genes 0.000 claims 49
- 108090000623 proteins and genes Proteins 0.000 claims 49
- 206010028980 Neoplasm Diseases 0.000 claims 37
- 239000000090 biomarker Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 16
- 201000002528 pancreatic cancer Diseases 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 14
- 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 claims 13
- 102100032822 Homeodomain-interacting protein kinase 1 Human genes 0.000 claims 11
- 101710110794 Homeodomain-interacting protein kinase 1 Proteins 0.000 claims 11
- 230000009822 protein phosphorylation Effects 0.000 claims 11
- 229940079593 drug Drugs 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 108010074596 Myosin-Light-Chain Kinase Proteins 0.000 claims 7
- 108010001441 Phosphopeptides Proteins 0.000 claims 7
- 102100025352 Serine/threonine-protein kinase MRCK alpha Human genes 0.000 claims 7
- 101710112530 Serine/threonine-protein kinase MRCK alpha Proteins 0.000 claims 7
- 230000035945 sensitivity Effects 0.000 claims 7
- 101001022780 Homo sapiens Myosin light chain kinase, smooth muscle Proteins 0.000 claims 6
- 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 claims 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 6
- 230000001394 metastastic effect Effects 0.000 claims 5
- 206010061289 metastatic neoplasm Diseases 0.000 claims 5
- 108700015928 Mitogen-activated protein kinase 13 Proteins 0.000 claims 4
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 230000026731 phosphorylation Effects 0.000 claims 4
- 238000006366 phosphorylation reaction Methods 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 101001031598 Dictyostelium discoideum Probable serine/threonine-protein kinase fhkC Proteins 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- 239000007853 buffer solution Substances 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 210000004923 pancreatic tissue Anatomy 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 230000009870 specific binding Effects 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims 2
- 102000012334 Integrin beta4 Human genes 0.000 claims 2
- 108010022238 Integrin beta4 Proteins 0.000 claims 2
- 108700027649 Mitogen-Activated Protein Kinase 3 Proteins 0.000 claims 2
- 102100024192 Mitogen-activated protein kinase 3 Human genes 0.000 claims 2
- 101710113459 RAC-alpha serine/threonine-protein kinase Proteins 0.000 claims 2
- 102100035221 Tyrosine-protein kinase Fyn Human genes 0.000 claims 2
- 101710102899 Tyrosine-protein kinase Fyn Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 230000029087 digestion Effects 0.000 claims 2
- 230000003828 downregulation Effects 0.000 claims 2
- 230000003827 upregulation Effects 0.000 claims 2
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 108010069682 CSK Tyrosine-Protein Kinase Proteins 0.000 claims 1
- 102100028003 Catenin alpha-1 Human genes 0.000 claims 1
- 101710106615 Catenin alpha-1 Proteins 0.000 claims 1
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 1
- 101000876610 Dictyostelium discoideum Extracellular signal-regulated kinase 2 Proteins 0.000 claims 1
- 102100022975 Glycogen synthase kinase-3 alpha Human genes 0.000 claims 1
- 102000015616 Histone Deacetylase 1 Human genes 0.000 claims 1
- 108010024124 Histone Deacetylase 1 Proteins 0.000 claims 1
- 108010023981 Histone Deacetylase 2 Proteins 0.000 claims 1
- 102100039999 Histone deacetylase 2 Human genes 0.000 claims 1
- 102000009331 Homeodomain Proteins Human genes 0.000 claims 1
- 108010048671 Homeodomain Proteins Proteins 0.000 claims 1
- 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 claims 1
- 101100087590 Homo sapiens RICTOR gene Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000014748 Junctional Adhesion Molecules Human genes 0.000 claims 1
- 108010064064 Junctional Adhesion Molecules Proteins 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 239000002067 L01XE06 - Dasatinib Substances 0.000 claims 1
- 101001018085 Lysobacter enzymogenes Lysyl endopeptidase Proteins 0.000 claims 1
- 108040008097 MAP kinase activity proteins Proteins 0.000 claims 1
- 102000019149 MAP kinase activity proteins Human genes 0.000 claims 1
- 102000043136 MAP kinase family Human genes 0.000 claims 1
- 108091054455 MAP kinase family Proteins 0.000 claims 1
- 101710166115 Mitogen-activated protein kinase 2 Proteins 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 102000003505 Myosin Human genes 0.000 claims 1
- 108060008487 Myosin Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 108010029869 Proto-Oncogene Proteins c-raf Proteins 0.000 claims 1
- 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 claims 1
- 102000046941 Rapamycin-Insensitive Companion of mTOR Human genes 0.000 claims 1
- 108700019586 Rapamycin-Insensitive Companion of mTOR Proteins 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 102100031167 Tyrosine-protein kinase CSK Human genes 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229960002448 dasatinib Drugs 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 108010049611 glycogen synthase kinase 3 alpha Proteins 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- AXTAPYRUEKNRBA-JTQLQIEISA-N n-[(2s)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide Chemical compound CN1N=CC(Cl)=C1C1=C(Cl)OC(C(=O)N[C@H](CN)CC=2C=C(F)C(F)=CC=2)=C1 AXTAPYRUEKNRBA-JTQLQIEISA-N 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 239000012474 protein marker Substances 0.000 claims 1
- 208000011581 secondary neoplasm Diseases 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 229960000235 temsirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- 229960000237 vorinostat Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1314485.2 | 2013-08-13 | ||
| GBGB1314485.2A GB201314485D0 (en) | 2013-08-13 | 2013-08-13 | Materials and methods relating to pancreatic cancer |
| PCT/GB2014/052475 WO2015022530A2 (en) | 2013-08-13 | 2014-08-13 | Materials and methods relating to pancreatic cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016535270A JP2016535270A (ja) | 2016-11-10 |
| JP2016535270A5 true JP2016535270A5 (enExample) | 2017-12-28 |
Family
ID=49262110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533958A Pending JP2016535270A (ja) | 2013-08-13 | 2014-08-13 | 膵臓癌に関連する物質及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160195536A1 (enExample) |
| EP (1) | EP3033624A2 (enExample) |
| JP (1) | JP2016535270A (enExample) |
| CN (1) | CN105637367A (enExample) |
| CA (1) | CA2920946A1 (enExample) |
| GB (1) | GB201314485D0 (enExample) |
| WO (1) | WO2015022530A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3347720A1 (en) * | 2015-09-09 | 2018-07-18 | Somalogic, Inc. | Methods for developing personalized drug treatment plans and targeted drug development based on proteomic profiles |
| US10617720B2 (en) * | 2016-10-20 | 2020-04-14 | Miltenyi Biotech, GmbH | Chimeric antigen receptor specific for tumor cells |
| KR20190111932A (ko) * | 2016-12-20 | 2019-10-02 | 트리트포라이프 에이비 | 질량 분석법에 의해서 braf 돌연변이 및 야생형 braf 단백질을 결정하는 방법 |
| US11624082B2 (en) * | 2018-06-21 | 2023-04-11 | Universiteit Utrecht Holding B.V. | Method for monitoring kinase activity in a sample |
| CN111066727B (zh) * | 2019-12-20 | 2021-08-27 | 中国人民解放军陆军军医大学 | 在低氧性血睾屏障通透中作用机制的小鼠模型构建方法 |
| IT202000016807A1 (it) * | 2020-07-10 | 2022-01-10 | Humanitas Mirasole Spa | Peptidi associati a tumore e loro impiego |
| JP7866750B2 (ja) * | 2021-01-14 | 2026-05-28 | 公立大学法人福島県立医科大学 | がんの予後バイオマーカー |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE318832T1 (de) | 1990-06-11 | 2006-03-15 | Gilead Sciences Inc | Verfahren zur vervendung von nukleinsäureliganden |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| AU2002323139A1 (en) | 2001-08-14 | 2003-03-03 | President And Fellows Of Harvard College | Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry |
| CN1726395A (zh) * | 2002-12-17 | 2006-01-25 | 北京诺赛基因组研究中心有限公司 | 胰腺癌的特异标记 |
| WO2004055519A2 (en) * | 2002-12-17 | 2004-07-01 | Sinogenomax Co. Ltd. | Specific markers for pancreatic cancer |
| US8346482B2 (en) * | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| DE102006056784A1 (de) * | 2006-12-01 | 2008-06-05 | Meyer, Helmut E., Prof.Dr. | Biomarker für die Diagnose von Pankreaskrebs |
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| US20110224313A1 (en) * | 2008-06-05 | 2011-09-15 | British Columbia Cancer Agency Branch | Compositions and methods for classifying lung cancer and prognosing lung cancer survival |
| JP2012516445A (ja) * | 2009-01-27 | 2012-07-19 | ホロジック，インコーポレイテッド | 体液における新生児敗血症の検出のためのバイオマーカー |
| US20130023436A1 (en) * | 2010-01-15 | 2013-01-24 | Bryan William Jones | Disease diagnosis and treatment using computational molecular phenotyping |
| TW201130830A (en) * | 2010-02-01 | 2011-09-16 | Ab Science | Combined treatment of pancreatic cancer with gemcitabine and masitinib |
| AU2011242990B2 (en) * | 2010-04-19 | 2015-02-12 | Biomarker Strategies, Llc. | Compositions and methods for prediction of drug sensitivity, resistance, and disease progression |
| CN108872579A (zh) * | 2010-06-01 | 2018-11-23 | 梅坦诺米克斯保健有限公司 | 用于在受试者中诊断胰腺癌的工具和方法 |
| CN103068851B (zh) * | 2010-06-16 | 2015-03-11 | 高等教育联邦系统-匹兹堡大学 | 内质蛋白的抗体及其用途 |
| AU2012267888A1 (en) * | 2011-06-07 | 2014-01-30 | Caris Mpi, Inc. | Molecular profiling for cancer |
-
2013
- 2013-08-13 GB GBGB1314485.2A patent/GB201314485D0/en not_active Ceased
-
2014
- 2014-08-13 WO PCT/GB2014/052475 patent/WO2015022530A2/en not_active Ceased
- 2014-08-13 JP JP2016533958A patent/JP2016535270A/ja active Pending
- 2014-08-13 EP EP14755897.7A patent/EP3033624A2/en not_active Withdrawn
- 2014-08-13 CN CN201480056359.9A patent/CN105637367A/zh active Pending
- 2014-08-13 CA CA2920946A patent/CA2920946A1/en not_active Abandoned
- 2014-08-13 US US14/912,299 patent/US20160195536A1/en not_active Abandoned
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