JP2019500355A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019500355A5 JP2019500355A5 JP2018530561A JP2018530561A JP2019500355A5 JP 2019500355 A5 JP2019500355 A5 JP 2019500355A5 JP 2018530561 A JP2018530561 A JP 2018530561A JP 2018530561 A JP2018530561 A JP 2018530561A JP 2019500355 A5 JP2019500355 A5 JP 2019500355A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- item
- disease
- disorder
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562273246P | 2015-12-30 | 2015-12-30 | |
| US62/273,246 | 2015-12-30 | ||
| PCT/US2016/069511 WO2017117538A1 (en) | 2015-12-30 | 2016-12-30 | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019500355A JP2019500355A (ja) | 2019-01-10 |
| JP2019500355A5 true JP2019500355A5 (https=) | 2020-01-30 |
Family
ID=57868367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530561A Pending JP2019500355A (ja) | 2015-12-30 | 2016-12-30 | 汎インテグリンアンタゴニストとしてのメタ−アザ環式アミノ安息香酸誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10035778B2 (https=) |
| EP (2) | EP3738953A1 (https=) |
| JP (1) | JP2019500355A (https=) |
| KR (1) | KR20180107121A (https=) |
| CN (1) | CN108779077A (https=) |
| AU (1) | AU2016381336A1 (https=) |
| BR (1) | BR112018012981A2 (https=) |
| CA (1) | CA3008023A1 (https=) |
| CO (1) | CO2018007278A2 (https=) |
| ES (1) | ES2806276T3 (https=) |
| HK (1) | HK1244806A1 (https=) |
| IL (1) | IL259951A (https=) |
| PH (1) | PH12018501362A1 (https=) |
| RU (1) | RU2729518C2 (https=) |
| SG (1) | SG11201805387RA (https=) |
| WO (1) | WO2017117538A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201805387RA (en) * | 2015-12-30 | 2018-07-30 | Univ Saint Louis | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
| MX394210B (es) | 2017-02-28 | 2025-03-04 | Morphic Therapeutic Inc | INHIBIDORES DE INTEGRINA AVß6. |
| MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| US11739326B2 (en) * | 2017-11-14 | 2023-08-29 | Massachusetts Eye And Ear Infirmary | RUNX1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition |
| SI3844162T1 (sl) | 2018-08-29 | 2025-06-30 | Morphic Therapeutic, Inc. | Zaviralci integrina alfa v beta6 |
| WO2020047239A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | INHIBITING αV β6 INTEGRIN |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| EP4034236A1 (en) | 2019-09-26 | 2022-08-03 | Abionyx Pharma SA | Compounds useful for treating liver diseases |
| US20230060422A1 (en) * | 2019-12-20 | 2023-03-02 | Novartis Ag | Combination treatment of liver diseases using integrin inhibitors |
| KR20230011967A (ko) | 2020-05-14 | 2023-01-25 | 유비이 가부시키가이샤 | 1,4,5,6-테트라하이드로피리미딘-2-아민 유도체 |
| WO2022189856A1 (en) | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| WO2023085396A1 (ja) | 2021-11-12 | 2023-05-19 | Ｕｂｅ株式会社 | アルポート症候群を治療または予防するための医薬組成物 |
| EP4733297A1 (en) * | 2023-06-22 | 2026-04-29 | Antibody Therapeutics, Inc. | Integrin-inhibiting small molecule compound |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602155A (en) | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| US5639765A (en) | 1995-01-17 | 1997-06-17 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss |
| US5681820A (en) | 1995-05-16 | 1997-10-28 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis |
| IL123164A (en) * | 1995-08-30 | 2001-03-19 | Searle & Co | Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them |
| US6100423A (en) | 1995-08-30 | 2000-08-08 | G. D. Searle & Co. | Amino benzenepropanoic acid compounds and derivatives thereof |
| US6013651A (en) * | 1995-08-30 | 2000-01-11 | G. D. Searle & Co. | Meta-azacyclic amino benzoic acid compounds and derivatives thereof |
| DK0894084T3 (da) | 1996-03-29 | 2002-10-14 | Searle & Co | Kanelsyrederivater og deres anvendelse som integrinantagonister |
| DE69706407T2 (de) | 1996-03-29 | 2002-05-29 | G.D. Searle & Co., Chicago | META-SUBSTITUIERTE PHENYLENDERIVATE UND IHRE VERWENDUNG ALS ALPHAvBETA3 INTERGRIN-ANTAGONISTEN ODER INHIBITOREN |
| DE69710319T2 (de) | 1996-03-29 | 2002-08-14 | G.D. SEARLE & CO., CHICAGO | Para-substituierte phenylpropansäure derivate als integrin-antagonisten |
| EP0912495B1 (en) | 1996-07-12 | 2001-11-21 | G.D. SEARLE & CO. | Asymetric synthesis of chiral beta-amino acids |
| US6172256B1 (en) | 1998-03-04 | 2001-01-09 | G.D. Searle & Co. | Chiral-β-amino acid compounds and derivatives thereof |
| US6372719B1 (en) | 1998-03-04 | 2002-04-16 | Jay Cunningham | ανβ3 integrin antagonists in combination with chemotherapeutic agents |
| ZA991105B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Synthesis of chiral beta-amino acids. |
| ZA994406B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Meta-azacyclic amino benzoic acid and derivatives thereof. |
| ZA991107B (en) | 1998-03-04 | 2000-02-14 | Searle & Co | Process for preparing 3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino] benzoic acid. |
| KR20010042614A (ko) | 1998-04-10 | 2001-05-25 | 윌리암스 로저 에이 | 비트로넥틴 길항제로서 복소환식 글리실 베타-알라닌 유도체 |
| AU2592600A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US7119098B2 (en) | 2000-06-15 | 2006-10-10 | Pharmacia Corporation | Heteroarylakanoic acids as intergrin receptor antagonists |
| NZ524104A (en) | 2000-09-08 | 2004-12-24 | Pharmacia Italia S | Exemestane as chemopreventing agent |
| MXPA03006607A (es) | 2001-01-26 | 2003-09-22 | Upjohn Co | Metodo combinado para tratar trastornos dependientes de hormonas. |
| US20040082557A1 (en) | 2001-01-26 | 2004-04-29 | Wajszczuk Charles Paul | Methods for treating estrogen-dependent disorders |
| EP1435967A2 (en) | 2001-10-10 | 2004-07-14 | Pharmacia Italia S.p.A. | Methods for preventing and treating bone loss with steroid compounds |
| TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
| JP2006514050A (ja) * | 2002-12-20 | 2006-04-27 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニスト誘導体としてのβ−アミノ酸化合物のＲ異性体 |
| ATE399542T1 (de) | 2003-10-01 | 2008-07-15 | Merck Patent Gmbh | Alfavbeta3 und alfavbeta6 integrin antagonisten als antifibrotische mittel |
| TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| EP2730282A1 (en) | 2007-11-08 | 2014-05-14 | The General Hospital Corporation | Methods and compositions for the treatment of proteinuric diseases |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| WO2010048499A1 (en) | 2008-10-24 | 2010-04-29 | Wake Forest University | Platinum acridine anti-cancer compounds and methods thereof |
| DE102009000854A1 (de) | 2009-02-13 | 2010-08-19 | Ernst-Moritz-Arndt-Universität Greifswald | Osteopontin-Rezeptor-Liganden zur Behandlung des chronischen Nierenversagens |
| US8614221B2 (en) | 2009-03-11 | 2013-12-24 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| JP5862669B2 (ja) | 2010-08-26 | 2016-02-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
| WO2013033430A1 (en) | 2011-09-02 | 2013-03-07 | Wake Forest School Of Medicine | Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof |
| US8716226B2 (en) * | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| WO2014015054A1 (en) * | 2012-07-18 | 2014-01-23 | Saint Louis University | Beta amino acid derivatives as integrin antagonists |
| US11971402B2 (en) | 2015-04-24 | 2024-04-30 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| SG11201805387RA (en) * | 2015-12-30 | 2018-07-30 | Univ Saint Louis | Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists |
-
2016
- 2016-12-30 SG SG11201805387RA patent/SG11201805387RA/en unknown
- 2016-12-30 JP JP2018530561A patent/JP2019500355A/ja active Pending
- 2016-12-30 EP EP20169477.5A patent/EP3738953A1/en not_active Withdrawn
- 2016-12-30 BR BR112018012981-0A patent/BR112018012981A2/pt not_active Application Discontinuation
- 2016-12-30 ES ES16829387T patent/ES2806276T3/es active Active
- 2016-12-30 CN CN201680081360.6A patent/CN108779077A/zh active Pending
- 2016-12-30 WO PCT/US2016/069511 patent/WO2017117538A1/en not_active Ceased
- 2016-12-30 CA CA3008023A patent/CA3008023A1/en not_active Abandoned
- 2016-12-30 EP EP16829387.6A patent/EP3294716B1/en active Active
- 2016-12-30 KR KR1020187021837A patent/KR20180107121A/ko not_active Withdrawn
- 2016-12-30 AU AU2016381336A patent/AU2016381336A1/en not_active Abandoned
- 2016-12-30 HK HK18104335.6A patent/HK1244806A1/zh unknown
- 2016-12-30 RU RU2018120935A patent/RU2729518C2/ru active
-
2017
- 2017-11-14 US US15/812,986 patent/US10035778B2/en active Active
-
2018
- 2018-06-11 IL IL259951A patent/IL259951A/en unknown
- 2018-06-25 PH PH12018501362A patent/PH12018501362A1/en unknown
- 2018-07-12 CO CONC2018/0007278A patent/CO2018007278A2/es unknown
- 2018-07-30 US US16/049,679 patent/US10577330B2/en active Active
-
2020
- 2020-03-02 US US16/806,963 patent/US20200199079A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019500355A5 (https=) | ||
| RU2018120935A (ru) | Мета-азациклические производные аминобензойной кислоты в качестве антагонистов пан-интегрина | |
| US11969419B2 (en) | Method of treating cancer | |
| US11504363B2 (en) | Method of treating cancer and bone cancer pain | |
| US20150133494A1 (en) | Method of Treating Cancer | |
| JP2015524412A5 (https=) | ||
| JP2003500450A5 (https=) | ||
| JP2019504890A5 (https=) | ||
| JP2008531537A5 (https=) | ||
| JP2020504120A5 (https=) | ||
| RU2012135093A (ru) | Производные пиразина | |
| CN103936815A (zh) | 一类具有双重功能的齐墩果酸类衍生物及其制备方法和应用 | |
| US20230203025A1 (en) | Enhancers of particulate guanylyl cyclase receptor a | |
| JP2020515582A5 (https=) | ||
| JP2005513017A5 (https=) | ||
| JP2005538974A5 (https=) | ||
| WO2008124823A1 (en) | Method of treating melanoma | |
| JP2018506534A5 (https=) | ||
| CN109369727B (zh) | 一种抗癌靶向配合物及其制备方法和应用 | |
| US20240076296A1 (en) | Thiazole derivatives for therapeutic use | |
| TWI757573B (zh) | 化合物在製備治療出血性腦中風的藥物中的應用 | |
| US20020198235A1 (en) | Use of benzothiopenes to treat and prevent prostate cancer | |
| JP2008538099A5 (https=) | ||
| JP2021502374A5 (https=) | ||
| WO1997015572A1 (en) | Lubeluzole n-oxide |