JP2020515582A5 - - Google Patents

Info

Publication number

JP2020515582A5

JP2020515582A5 JP2019553244A JP2019553244A JP2020515582A5 JP 2020515582 A5 JP2020515582 A5 JP 2020515582A5 JP 2019553244 A JP2019553244 A JP 2019553244A JP 2019553244 A JP2019553244 A JP 2019553244A JP 2020515582 A5 JP2020515582 A5 JP 2020515582A5

Authority

JP

Japan

Prior art keywords

tumor

cancer

use according

related macrophages

conjugate

Prior art date

2017-09-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

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• 210000002540 macrophage Anatomy 0.000 claims 24
• 201000011510 cancer Diseases 0.000 claims 12
• 241001465754 Metazoa Species 0.000 claims 9
• 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 6
• 102100022338 Integrin alpha-M Human genes 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
• 230000037396 body weight Effects 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 4
• 102000003814 Interleukin-10 Human genes 0.000 claims 3
• 108090000174 Interleukin-10 Proteins 0.000 claims 3
• 101100260702 Mus musculus Tinagl1 gene Proteins 0.000 claims 3
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
• 101150088826 arg1 gene Proteins 0.000 claims 3
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• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
• 239000006201 parenteral dosage form Substances 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
• 101800003838 Epidermal growth factor Proteins 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010027406 Mesothelioma Diseases 0.000 claims 1
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
• 208000013056 classic Hodgkin lymphoma Diseases 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 229940116977 epidermal growth factor Drugs 0.000 claims 1
• 229960000304 folic acid Drugs 0.000 claims 1
• 235000019152 folic acid Nutrition 0.000 claims 1
• 239000011724 folic acid Substances 0.000 claims 1
• 210000002165 glioblast Anatomy 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 201000002713 kidney leiomyosarcoma Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 201000004595 synovitis Diseases 0.000 claims 1
• 201000002510 thyroid cancer Diseases 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1