JP2019500340A5 - - Google Patents
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- Publication number
- JP2019500340A5 JP2019500340A5 JP2018528946A JP2018528946A JP2019500340A5 JP 2019500340 A5 JP2019500340 A5 JP 2019500340A5 JP 2018528946 A JP2018528946 A JP 2018528946A JP 2018528946 A JP2018528946 A JP 2018528946A JP 2019500340 A5 JP2019500340 A5 JP 2019500340A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- formoterol
- corticosteroid
- composition according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 58
- 238000000034 method Methods 0.000 claims 38
- 229960002848 formoterol Drugs 0.000 claims 34
- -1 formoterol compound Chemical class 0.000 claims 22
- 239000003246 corticosteroid Substances 0.000 claims 21
- 239000004094 surface-active agent Substances 0.000 claims 19
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 claims 18
- 239000003380 propellant Substances 0.000 claims 15
- 239000012535 impurity Substances 0.000 claims 14
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 10
- 229910052782 aluminium Inorganic materials 0.000 claims 10
- 238000003860 storage Methods 0.000 claims 8
- 229940071648 metered dose inhaler Drugs 0.000 claims 7
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 238000000354 decomposition reaction Methods 0.000 claims 5
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 229960004436 budesonide Drugs 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960002714 fluticasone Drugs 0.000 claims 2
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 239000000787 lecithin Substances 0.000 claims 2
- 229940067606 lecithin Drugs 0.000 claims 2
- 235000010445 lecithin Nutrition 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 1
- WXGNWUVNYMJENI-UHFFFAOYSA-N 1,1,2,2-tetrafluoroethane Chemical compound FC(F)C(F)F WXGNWUVNYMJENI-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 229920002943 EPDM rubber Polymers 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229940092705 beclomethasone Drugs 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- 229920005557 bromobutyl Polymers 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 229920005556 chlorobutyl Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- 239000013536 elastomeric material Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960001664 mometasone Drugs 0.000 claims 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 1
- 201000004193 respiratory failure Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019232074A JP6899889B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
| JP2019232073A JP6931383B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1521456.2A GB201521456D0 (en) | 2015-12-04 | 2015-12-04 | Pharmaceutical composition |
| GB1521456.2 | 2015-12-04 | ||
| GB1615916.2 | 2016-09-19 | ||
| GB1615916.2A GB2554092A (en) | 2016-09-19 | 2016-09-19 | Pharmaceutical composition |
| PCT/GB2016/053812 WO2017093758A1 (en) | 2015-12-04 | 2016-12-02 | Pharmaceutical composition |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019232073A Division JP6931383B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
| JP2019232074A Division JP6899889B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500340A JP2019500340A (ja) | 2019-01-10 |
| JP2019500340A5 true JP2019500340A5 (OSRAM) | 2020-01-09 |
| JP6899824B2 JP6899824B2 (ja) | 2021-07-07 |
Family
ID=57750288
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528946A Active JP6899824B2 (ja) | 2015-12-04 | 2016-12-02 | 薬学的組成物 |
| JP2019232073A Active JP6931383B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
| JP2019232074A Active JP6899889B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019232073A Active JP6931383B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
| JP2019232074A Active JP6899889B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11559505B2 (OSRAM) |
| EP (4) | EP3556348B1 (OSRAM) |
| JP (3) | JP6899824B2 (OSRAM) |
| CN (2) | CN108289843B (OSRAM) |
| AU (3) | AU2016364650B2 (OSRAM) |
| BR (2) | BR122020022602B1 (OSRAM) |
| CA (1) | CA3007050C (OSRAM) |
| ES (3) | ES2796177T5 (OSRAM) |
| MX (1) | MX375783B (OSRAM) |
| WO (1) | WO2017093758A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| CN108289843B (zh) | 2015-12-04 | 2021-08-17 | 墨西哥氟石股份公司 | 药物组合物 |
| WO2018051128A1 (en) | 2016-09-19 | 2018-03-22 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
| CN116898804A (zh) * | 2016-09-19 | 2023-10-20 | 墨西哥氟石股份公司 | 药物组合物 |
| US10792256B2 (en) * | 2016-09-19 | 2020-10-06 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
| JP6781831B2 (ja) * | 2016-09-19 | 2020-11-04 | メキシケム フロー エセ・ア・デ・セ・ヴェ | 医薬組成物 |
| AU2017328907B2 (en) | 2016-09-19 | 2020-04-09 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
| CN109771398B (zh) * | 2019-02-25 | 2019-09-20 | 广州南鑫药业有限公司 | 一种帕拉米韦溶液型吸入剂及其制备方法 |
| GB2584686A (en) * | 2019-06-11 | 2020-12-16 | Mexichem Fluor Sa De Cv | Methods |
| CN110840864B (zh) * | 2019-12-20 | 2022-02-22 | 广州健康元呼吸药物工程技术有限公司 | 一种β2受体激动剂吸入气雾剂及包含该吸入气雾剂的产品 |
| GEP20247594B (en) * | 2020-01-28 | 2024-02-12 | Chiesi Farm Spa | Pressurised metered dose inhalers comprising a buffered pharmaceutical formulation |
| GB202001537D0 (en) * | 2020-02-05 | 2020-03-18 | Consort Medical Plc | Pressurised dispensing container |
| WO2021165348A1 (en) * | 2020-02-20 | 2021-08-26 | Chiesi Farmaceutici S.P.A. | Pressurised metered dose inhalers comprising a buffered pharmaceutical formulation |
| CN116338014A (zh) * | 2021-12-23 | 2023-06-27 | 上海医药工业研究院有限公司 | 一种吸入用药物组合物的组分分离检测方法 |
| FR3137830A1 (fr) * | 2022-07-13 | 2024-01-19 | Aptar France Sas | Composition pharmaceutique comprenant du salbutamol |
Family Cites Families (53)
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| IL97065A (en) | 1990-02-02 | 1994-01-25 | Fisons Plc | Repellent preparations for aerosol |
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| MX9203481A (es) | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| US6123924A (en) | 1991-09-25 | 2000-09-26 | Fisons Plc | Pressurized aerosol inhalation compositions |
| WO1993011773A1 (en) * | 1991-12-18 | 1993-06-24 | Aktiebolaget Astra | New combination of formoterol and budesonide |
| US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
| SK81197A3 (en) | 1994-12-22 | 1997-11-05 | Astra Ab | Aerosol drug formulations, method for production thereof and its use |
| JPH11503352A (ja) | 1995-04-14 | 1999-03-26 | グラクソ、ウェルカム、インコーポレーテッド | プロピオン酸フルチカゾン用計量投与用吸入器 |
| AU718967B2 (en) | 1997-02-05 | 2000-05-04 | Jagotec Ag | Medical aerosol formulations |
| SE9703407D0 (sv) | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
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| US6103266A (en) | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
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| CA2338680C (en) | 1998-08-04 | 2008-10-14 | Jago Research Ag | Medicinal aerosol formulations |
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| HRP20021025B1 (hr) | 2000-05-22 | 2013-11-22 | Chiesi Farmaceutici S.P.A. | Formulacije stabilnih farmaceutskih otopina za inhalatore s odmjerenom dozom pod tlakom |
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| CN1144582C (zh) | 2000-11-28 | 2004-04-07 | 中国药科大学 | 治疗呼吸系统疾病的无氟里昂药用气雾剂 |
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| SE0200312D0 (sv) * | 2002-02-01 | 2002-02-01 | Astrazeneca Ab | Novel composition |
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| GB0323685D0 (en) * | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
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| US20060018840A1 (en) | 2004-06-28 | 2006-01-26 | Nektar Therapeutics | Aerosolizable formulation comprising nicotine |
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| GB0915106D0 (en) | 2009-08-28 | 2009-10-07 | Glaxo Group Ltd | Process |
| KR101778814B1 (ko) * | 2009-10-02 | 2017-09-15 | 키에시 파르마슈티시 엣스. 피. 에이. | 포모테롤 및 베클로메타손 디프로피오네이트의 약학적 에어로졸 제제 |
| GEP20166479B (en) | 2009-12-23 | 2016-05-25 | Chiesi Farma Spa | Aerosol formulation for copd |
| CN110237260A (zh) * | 2010-07-16 | 2019-09-17 | 希普拉有限公司 | 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物 |
| RU2013142268A (ru) * | 2011-02-17 | 2015-03-27 | Сипла Лимитед | Фармацевтическая композиция |
| GB201108039D0 (en) * | 2011-05-13 | 2011-06-29 | Mexichem Amanco Holding Sa | Compositions |
| GB201117621D0 (en) * | 2011-10-12 | 2011-11-23 | Mexichem Amanco Holding Sa | Compositions |
| GB201117619D0 (en) * | 2011-10-12 | 2011-11-23 | Mexichem Amanco Holding Sa | Compositions |
| CN102362860A (zh) | 2011-10-27 | 2012-02-29 | 江阴长风医药科技有限公司 | 以氢氟烷烃为抛射剂的布地奈德和福莫特罗气雾剂制剂 |
| WO2014016548A2 (en) | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
| WO2014064410A2 (en) | 2012-10-23 | 2014-05-01 | Cipla Limited | Pharmaceutical composition |
| GB201306984D0 (en) | 2013-04-17 | 2013-05-29 | Mexichem Amanco Holding Sa | Composition |
| BR112016014583B1 (pt) | 2013-12-30 | 2022-12-20 | Chiesi Farmaceutici S.P.A | Composição de solução farmacêutica em aerossol, inalador pressurizado de dose calibrada e uso da dita composição |
| CN108289843B (zh) | 2015-12-04 | 2021-08-17 | 墨西哥氟石股份公司 | 药物组合物 |
| US10792256B2 (en) | 2016-09-19 | 2020-10-06 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
-
2016
- 2016-12-02 CN CN201680071126.5A patent/CN108289843B/zh active Active
- 2016-12-02 BR BR122020022602-1A patent/BR122020022602B1/pt active IP Right Grant
- 2016-12-02 WO PCT/GB2016/053812 patent/WO2017093758A1/en not_active Ceased
- 2016-12-02 EP EP19178843.9A patent/EP3556348B1/en active Active
- 2016-12-02 ES ES16822716T patent/ES2796177T5/es active Active
- 2016-12-02 MX MX2018006800A patent/MX375783B/es active IP Right Grant
- 2016-12-02 ES ES19178832T patent/ES2869176T3/es active Active
- 2016-12-02 AU AU2016364650A patent/AU2016364650B2/en active Active
- 2016-12-02 EP EP20169450.2A patent/EP3701940B1/en active Active
- 2016-12-02 JP JP2018528946A patent/JP6899824B2/ja active Active
- 2016-12-02 US US15/781,045 patent/US11559505B2/en active Active
- 2016-12-02 EP EP19178832.2A patent/EP3556347B1/en active Active
- 2016-12-02 CN CN202011316904.7A patent/CN112472689B/zh active Active
- 2016-12-02 EP EP16822716.3A patent/EP3383366B2/en active Active
- 2016-12-02 CA CA3007050A patent/CA3007050C/en active Active
- 2016-12-02 BR BR112018011266-6A patent/BR112018011266B1/pt active IP Right Grant
- 2016-12-02 ES ES19178843T patent/ES2866175T3/es active Active
-
2019
- 2019-04-24 AU AU2019202874A patent/AU2019202874C1/en active Active
- 2019-04-24 AU AU2019202875A patent/AU2019202875B2/en active Active
- 2019-09-18 US US16/575,069 patent/US11559506B2/en active Active
- 2019-09-18 US US16/575,168 patent/US11559507B2/en active Active
- 2019-12-23 JP JP2019232073A patent/JP6931383B2/ja active Active
- 2019-12-23 JP JP2019232074A patent/JP6899889B2/ja active Active
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