JP2019500320A5 - - Google Patents
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- Publication number
- JP2019500320A5 JP2019500320A5 JP2018522569A JP2018522569A JP2019500320A5 JP 2019500320 A5 JP2019500320 A5 JP 2019500320A5 JP 2018522569 A JP2018522569 A JP 2018522569A JP 2018522569 A JP2018522569 A JP 2018522569A JP 2019500320 A5 JP2019500320 A5 JP 2019500320A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- rsv
- protein
- virus
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 27
- 230000002163 immunogen Effects 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 26
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 241000700605 Viruses Species 0.000 claims description 8
- 210000003501 vero cell Anatomy 0.000 claims description 8
- 239000002671 adjuvant Substances 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000002238 attenuated effect Effects 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 2
- 108091006027 G proteins Proteins 0.000 claims description 2
- 102000030782 GTP binding Human genes 0.000 claims description 2
- 108091000058 GTP-Binding Proteins 0.000 claims description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 2
- 229940087168 alpha tocopherol Drugs 0.000 claims description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 claims description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims description 2
- 239000007764 o/w emulsion Substances 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 229940031439 squalene Drugs 0.000 claims description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 229960000984 tocofersolan Drugs 0.000 claims description 2
- 239000002076 α-tocopherol Substances 0.000 claims description 2
- 235000004835 α-tocopherol Nutrition 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 description 3
- 241000144282 Sigmodon Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 241000144290 Sigmodon hispidus Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023065428A JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562247962P | 2015-10-29 | 2015-10-29 | |
| US62/247,962 | 2015-10-29 | ||
| US201662334547P | 2016-05-11 | 2016-05-11 | |
| US62/334,547 | 2016-05-11 | ||
| PCT/US2016/058976 WO2017075125A1 (en) | 2015-10-29 | 2016-10-27 | Chimeric RSV, Immunogenic Compositions, and Methods of Use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023065428A Division JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500320A JP2019500320A (ja) | 2019-01-10 |
| JP2019500320A5 true JP2019500320A5 (cg-RX-API-DMAC7.html) | 2019-12-05 |
| JP7311872B2 JP7311872B2 (ja) | 2023-07-20 |
Family
ID=58630734
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522569A Active JP7311872B2 (ja) | 2015-10-29 | 2016-10-27 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
| JP2023065428A Pending JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023065428A Pending JP2023100654A (ja) | 2015-10-29 | 2023-04-13 | キメラｒｓｖ、免疫原性組成物、及び使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11235050B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3368547A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7311872B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180085730A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108602858A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018008708A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3003726A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2018005462A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201803581VA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017075125A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105189756B (zh) | 2013-03-14 | 2021-06-11 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| PT3439672T (pt) | 2016-04-05 | 2021-02-24 | Janssen Vaccines & Prevention Bv | Proteína f do rsv pré-fusão solúvel e estabilizada para uso na profilaxia de infeção por rsv |
| EP4559869A3 (en) | 2017-04-04 | 2025-08-20 | University of Washington | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use |
| WO2019169120A1 (en) | 2018-02-28 | 2019-09-06 | University Of Washington | Self-asssembling nanostructure vaccines |
| PH12021550974A1 (en) * | 2018-11-13 | 2022-05-02 | Janssen Vaccines & Prevention Bv | Stablized pre-fusion rsv f proteins |
| CN117693360A (zh) * | 2021-04-08 | 2024-03-12 | 科达金尼克斯有限公司 | 引发针对呼吸道合胞病毒的免疫应答的方法 |
| US12304929B2 (en) * | 2021-04-12 | 2025-05-20 | Sk Bioscience Co., Ltd. | Recombinant RSV live vaccine strain and the preparing method thereof |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| IL105456A (en) | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
| AT401526B (de) | 1993-02-10 | 1996-09-25 | Scheirer Winfried | Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung |
| DK0702085T4 (da) | 1994-07-18 | 2010-04-06 | Conzelmann Karl Klaus Prof Dr | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus |
| US7465574B2 (en) | 1994-09-30 | 2008-12-16 | Medimmune, Llc | Recombinant RSV virus expression systems and vaccines |
| US6713066B1 (en) | 1996-07-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
| US7846455B2 (en) | 1996-07-15 | 2010-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated chimeric respiratory syncytial virus |
| AU727923B2 (en) | 1995-09-27 | 2001-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| US6923971B2 (en) | 1995-09-27 | 2005-08-02 | The United States Of America As Represented By The Department Of Health & Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
| US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
| US6689367B1 (en) | 1995-09-27 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
| US6214805B1 (en) | 1996-02-15 | 2001-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | RNase L activators and antisense oligonucleotides effective to treat RSV infections |
| JP4413999B2 (ja) | 1996-07-15 | 2010-02-10 | アメリカ合衆国 | クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造 |
| US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| US6074859A (en) | 1997-07-08 | 2000-06-13 | Kikkoman Corporation | Mutant-type bioluminescent protein, and process for producing the mutant-type bioluminescent protein |
| US20040005542A1 (en) | 2001-06-22 | 2004-01-08 | Krempl Christine D | Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes |
| AU2001263443A1 (en) * | 2000-05-25 | 2001-12-03 | Med Immune, Inc. | F-protein epitope-based vaccine for respiratory syncytial virus infection |
| JP4783726B2 (ja) | 2003-03-28 | 2011-09-28 | メディミューン，エルエルシー | 呼吸器合胞体ウイルスサブグループｂ株９３２０に関連する組成物および方法 |
| AU2004303719B2 (en) | 2003-12-24 | 2010-11-11 | Intravacc B.V. | A respiratory syncytial virus with a genomic deficiency complemented in trans |
| WO2006042156A2 (en) | 2004-10-08 | 2006-04-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS represneted by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION | Modulation of replicative fitness by using less frequently used synonymous codons |
| US7951384B2 (en) | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| EP2099486A2 (en) | 2006-11-30 | 2009-09-16 | Government Of The United States Of America, As Represented by the Secretary | Codon modified immunogenic compositions and methods of use |
| PL2139515T5 (pl) | 2007-03-30 | 2024-04-08 | The Research Foundation Of The State University Of New York | Atenuowane wirusy przydatne w szczepionkach |
| WO2010039224A2 (en) | 2008-09-30 | 2010-04-08 | University Of Massachusetts Medical School | Respiratory syncytial virus (rsv) sequences for protein expression and vaccines |
| RU2011122615A (ru) | 2008-11-05 | 2012-12-20 | Мерк Шарп Энд Домэ Корп. | Живой аттенуированный респираторно-синцитиальный вирус |
| EP3718566B1 (en) | 2008-12-09 | 2024-06-12 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| CN102639147B (zh) | 2009-07-15 | 2015-11-25 | 诺华股份有限公司 | Rsv f 蛋白组合物和其制作方法 |
| US20110097358A1 (en) | 2009-10-12 | 2011-04-28 | Techno Vax, Inc. | RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRUS-LIKE PARTICLES (VLPs) |
| US10227569B2 (en) | 2011-04-12 | 2019-03-12 | Emory University | Respiratory syncytial virus expression vectors |
| SG194755A1 (en) * | 2011-05-13 | 2013-12-30 | Novartis Ag | Pre-fusion rsv f antigens |
| EP2729169A1 (en) | 2011-07-06 | 2014-05-14 | Nanobio Corporation | Human respiratory syncytial virus vaccine |
| US8816081B2 (en) | 2012-08-06 | 2014-08-26 | Basf Se | Boron containing perylene monoimides, a process for their production, their use as building blocks for the production of perylene monoimide derivatives, monoimide derivatives and their use in dye-sensitized solar cells |
| ES2952387T3 (es) | 2013-02-08 | 2023-10-31 | Us Health | Atenuación del virus respiratorio sincitial humano mediante la desoptimización de pares de codones a escala genómica |
| WO2014160463A1 (en) | 2013-03-13 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prefusion rsv f proteins and their use |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| CN105189756B (zh) | 2013-03-14 | 2021-06-11 | 爱默蕾大学 | 具有沉默突变的重组rsv、其相关疫苗和方法 |
| US9060975B2 (en) * | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
-
2016
- 2016-10-27 BR BR112018008708-4A patent/BR112018008708A2/en not_active Application Discontinuation
- 2016-10-27 US US15/772,275 patent/US11235050B2/en active Active
- 2016-10-27 EP EP16860742.2A patent/EP3368547A4/en not_active Withdrawn
- 2016-10-27 CA CA3003726A patent/CA3003726A1/en active Pending
- 2016-10-27 KR KR1020187014777A patent/KR20180085730A/ko not_active Ceased
- 2016-10-27 JP JP2018522569A patent/JP7311872B2/ja active Active
- 2016-10-27 WO PCT/US2016/058976 patent/WO2017075125A1/en not_active Ceased
- 2016-10-27 CN CN201680072681.XA patent/CN108602858A/zh active Pending
- 2016-10-27 SG SG11201803581VA patent/SG11201803581VA/en unknown
- 2016-10-27 MX MX2018005462A patent/MX2018005462A/es unknown
-
2022
- 2022-01-14 US US17/575,829 patent/US12257296B2/en active Active
-
2023
- 2023-04-13 JP JP2023065428A patent/JP2023100654A/ja active Pending
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