JP2019213549A5 - - Google Patents
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- Publication number
- JP2019213549A5 JP2019213549A5 JP2019148806A JP2019148806A JP2019213549A5 JP 2019213549 A5 JP2019213549 A5 JP 2019213549A5 JP 2019148806 A JP2019148806 A JP 2019148806A JP 2019148806 A JP2019148806 A JP 2019148806A JP 2019213549 A5 JP2019213549 A5 JP 2019213549A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- gene segment
- mouse
- genetically modified
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,455 | 2013-03-13 | ||
| US13/798,455 US9796788B2 (en) | 2010-02-08 | 2013-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006738A Division JP6790136B2 (ja) | 2013-03-13 | 2019-01-18 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020128111A Division JP2020182490A (ja) | 2013-03-13 | 2020-07-29 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019213549A JP2019213549A (ja) | 2019-12-19 |
| JP2019213549A5 true JP2019213549A5 (https=) | 2020-09-10 |
| JP7010902B2 JP7010902B2 (ja) | 2022-02-10 |
Family
ID=50483561
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502035A Active JP6529957B2 (ja) | 2013-03-13 | 2014-03-13 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019006738A Active JP6790136B2 (ja) | 2013-03-13 | 2019-01-18 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019148806A Active JP7010902B2 (ja) | 2013-03-13 | 2019-08-14 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2020128111A Pending JP2020182490A (ja) | 2013-03-13 | 2020-07-29 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502035A Active JP6529957B2 (ja) | 2013-03-13 | 2014-03-13 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019006738A Active JP6790136B2 (ja) | 2013-03-13 | 2019-01-18 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020128111A Pending JP2020182490A (ja) | 2013-03-13 | 2020-07-29 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Country Status (26)
| Country | Link |
|---|---|
| EP (4) | EP4545567A3 (https=) |
| JP (4) | JP6529957B2 (https=) |
| KR (2) | KR102424756B1 (https=) |
| CN (2) | CN108611369B (https=) |
| AU (3) | AU2014244020B2 (https=) |
| BR (1) | BR112015022034B1 (https=) |
| CA (1) | CA2903698C (https=) |
| CY (1) | CY1121545T1 (https=) |
| DK (2) | DK3501272T5 (https=) |
| ES (3) | ES2712207T3 (https=) |
| FI (1) | FI3501272T3 (https=) |
| HR (2) | HRP20190706T1 (https=) |
| HU (2) | HUE044003T2 (https=) |
| IL (2) | IL240563B (https=) |
| LT (2) | LT2967013T (https=) |
| MX (3) | MX377146B (https=) |
| PL (2) | PL3501272T3 (https=) |
| PT (2) | PT2967013T (https=) |
| RS (2) | RS64185B1 (https=) |
| RU (1) | RU2689664C2 (https=) |
| SG (2) | SG10201801101QA (https=) |
| SI (2) | SI2967013T1 (https=) |
| SM (2) | SMT201900196T1 (https=) |
| TR (1) | TR201901668T4 (https=) |
| WO (1) | WO2014160202A1 (https=) |
| ZA (2) | ZA201505835B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| HUE047278T2 (hu) | 2011-08-05 | 2020-04-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| SG11201401181YA (en) | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| ME03551B (me) | 2012-06-12 | 2020-07-20 | Regeneron Pharma | Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca |
| MY178882A (en) * | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| CA3124228C (en) | 2014-03-21 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| KR20230006929A (ko) | 2016-01-13 | 2023-01-11 | 리제너론 파마슈티칼스 인코포레이티드 | 조작된 중쇄 다양성 영역을 갖는 설치류 |
| CA3076632A1 (en) * | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| US12467062B2 (en) | 2018-12-21 | 2025-11-11 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| CA3125380A1 (en) | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| BR112021016173A2 (pt) | 2019-02-22 | 2021-11-03 | Regeneron Pharma | Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| JP2023529846A (ja) | 2020-06-02 | 2023-07-12 | バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド | 共通軽鎖免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物 |
| IL303865A (en) | 2020-12-23 | 2023-08-01 | Regeneron Pharma | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce them |
| CA3165366A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN114736927A (zh) * | 2022-05-19 | 2022-07-12 | 东北大学 | 一种单抗克隆与表达载体的构建及应用 |
| TW202430641A (zh) * | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途 |
| WO2026019824A1 (en) * | 2024-07-16 | 2026-01-22 | Gilead Sciences, Inc. | Human immunoglobulin common light chain transgene constructs and uses thereof |
| CN121628915A (zh) * | 2024-08-29 | 2026-03-10 | 上海泰槿生物技术有限公司 | 产生限制的免疫球蛋白轻链库的细胞、动物和方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| ES2473596T3 (es) * | 2003-07-15 | 2014-07-07 | Therapeutic Human Polyclonals, Inc. | Loci de inmunoglobulina humanizada |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| AU2007235496B2 (en) * | 2006-03-31 | 2013-11-21 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| ITMI20071522A1 (it) * | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| EP2147594B1 (en) * | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| JP5827127B2 (ja) * | 2008-12-18 | 2015-12-02 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用 |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT202600080T1 (it) * | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| PT3034608T (pt) * | 2010-06-22 | 2019-05-28 | Regeneron Pharma | Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana |
| SMT201700023T1 (it) * | 2010-08-02 | 2017-03-08 | Regeneron Pharma | Topi che producono proteine leganti vl |
| RU2460287C1 (ru) * | 2011-03-29 | 2012-09-10 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии |
| HUE047278T2 (hu) * | 2011-08-05 | 2020-04-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
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2014
- 2014-03-13 EP EP24223729.5A patent/EP4545567A3/en active Pending
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 DK DK18210518.9T patent/DK3501272T5/da active
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
- 2014-03-13 MX MX2018008279A patent/MX377146B/es unknown
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en not_active Ceased
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 EP EP23151398.7A patent/EP4218409B1/en active Active
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active Active
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 SM SM20190196T patent/SMT201900196T1/it unknown
- 2014-03-13 ES ES23151398T patent/ES3013063T3/es active Active
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active Active
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 MX MX2020010837A patent/MX391010B/es unknown
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 SM SM20230112T patent/SMT202300112T1/it unknown
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
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2015
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
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2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
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2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
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2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
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2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
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2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783B2/en active Active
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