KR102424756B1 - 제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스 - Google Patents

제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스 Download PDF

Info

Publication number
KR102424756B1
KR102424756B1 KR1020217027031A KR20217027031A KR102424756B1 KR 102424756 B1 KR102424756 B1 KR 102424756B1 KR 1020217027031 A KR1020217027031 A KR 1020217027031A KR 20217027031 A KR20217027031 A KR 20217027031A KR 102424756 B1 KR102424756 B1 KR 102424756B1
Authority
KR
South Korea
Prior art keywords
human
mouse
gene segment
light chain
immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217027031A
Other languages
English (en)
Korean (ko)
Other versions
KR20210107911A (ko
Inventor
존 맥훠터
린 맥도날드
션 스티븐스
앤드류 제이. 머피
Original Assignee
리제너론 파마슈티칼스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/798,455 external-priority patent/US9796788B2/en
Application filed by 리제너론 파마슈티칼스 인코포레이티드 filed Critical 리제너론 파마슈티칼스 인코포레이티드
Publication of KR20210107911A publication Critical patent/KR20210107911A/ko
Application granted granted Critical
Publication of KR102424756B1 publication Critical patent/KR102424756B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020217027031A 2013-03-13 2014-03-13 제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스 Active KR102424756B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13/798,455 2013-03-13
US13/798,455 US9796788B2 (en) 2010-02-08 2013-03-13 Mice expressing a limited immunoglobulin light chain repertoire
PCT/US2014/026040 WO2014160202A1 (en) 2013-03-13 2014-03-13 Mice expressing a limited immunoglobulin light chain repertoire
KR1020157026152A KR102295842B1 (ko) 2013-03-13 2014-03-13 제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157026152A Division KR102295842B1 (ko) 2013-03-13 2014-03-13 제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스

Publications (2)

Publication Number Publication Date
KR20210107911A KR20210107911A (ko) 2021-09-01
KR102424756B1 true KR102424756B1 (ko) 2022-07-25

Family

ID=50483561

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020217027031A Active KR102424756B1 (ko) 2013-03-13 2014-03-13 제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스
KR1020157026152A Active KR102295842B1 (ko) 2013-03-13 2014-03-13 제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020157026152A Active KR102295842B1 (ko) 2013-03-13 2014-03-13 제한된 면역글로불린 경쇄 레퍼토리를 발현하는 마우스

Country Status (26)

Country Link
EP (4) EP3501272B1 (https=)
JP (4) JP6529957B2 (https=)
KR (2) KR102424756B1 (https=)
CN (2) CN105188357B (https=)
AU (3) AU2014244020B2 (https=)
BR (1) BR112015022034B1 (https=)
CA (1) CA2903698C (https=)
CY (1) CY1121545T1 (https=)
DK (2) DK2967013T3 (https=)
ES (3) ES2712207T3 (https=)
FI (1) FI3501272T3 (https=)
HR (2) HRP20230490T1 (https=)
HU (2) HUE061977T2 (https=)
IL (2) IL240563B (https=)
LT (2) LT2967013T (https=)
MX (3) MX391010B (https=)
PL (2) PL3501272T3 (https=)
PT (2) PT2967013T (https=)
RS (2) RS64185B1 (https=)
RU (1) RU2689664C2 (https=)
SG (2) SG10201801101QA (https=)
SI (2) SI3501272T1 (https=)
SM (2) SMT201900196T1 (https=)
TR (1) TR201901668T4 (https=)
WO (1) WO2014160202A1 (https=)
ZA (2) ZA201505835B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2501817T2 (sl) 2010-02-08 2021-09-30 Regeneron Pharmaceuticals, Inc. Miš z navadno lahko verigo
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
RS59728B1 (sr) 2011-08-05 2020-02-28 Regeneron Pharma Humanizovani miševi univerzalnog lakog lanca
KR20160098514A (ko) 2011-10-17 2016-08-18 리제너론 파아마슈티컬스, 인크. 제한된 면역글로불린 중쇄 마우스
PT3597037T (pt) 2012-06-12 2021-06-01 Regeneron Pharma Animais não humanos humanizados com lócus de cadeia pesada de imunoglobulina restrito
EP2840892B1 (en) * 2013-02-20 2018-04-18 Regeneron Pharmaceuticals, Inc. Non-human animals with modified immunoglobulin heavy chain sequences
KR102276752B1 (ko) 2014-03-21 2021-07-13 리제너론 파마슈티칼스 인코포레이티드 단일 도메인 결합 단백질을 생산하는 비-인간 동물
EP3271403A1 (en) 2015-03-19 2018-01-24 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
AU2017206785C1 (en) 2016-01-13 2023-09-07 Regeneron Pharmaceuticals, Inc. Rodents having an engineered heavy chain diversity region
MY199789A (en) * 2017-09-29 2023-11-23 Regeneron Pharma Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof
IL318469A (en) 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
WO2020132557A1 (en) * 2018-12-21 2020-06-25 Compass Therapeutics Llc Transgenic mouse expressing common human light chain
EP3927832A4 (en) 2019-02-18 2022-11-30 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMANIZED IMMUNOGLOBULIN LOCUS
JP2022520819A (ja) 2019-02-22 2022-04-01 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 遺伝子改変ナトリウムチャネルを有する齧歯類およびその使用方法
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
KR20230018439A (ko) 2020-06-02 2023-02-07 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물
TW202242114A (zh) 2020-12-23 2022-11-01 美商再生元醫藥公司 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法
CA3165366A1 (en) 2020-12-23 2022-06-30 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
CN114736927A (zh) * 2022-05-19 2022-07-12 东北大学 一种单抗克隆与表达载体的构建及应用
TW202430641A (zh) * 2023-01-18 2024-08-01 美商基利科學股份有限公司 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途
WO2026019824A1 (en) * 2024-07-16 2026-01-22 Gilead Sciences, Inc. Human immunoglobulin common light chain transgene constructs and uses thereof
CN121628915A (zh) * 2024-08-29 2026-03-10 上海泰槿生物技术有限公司 产生限制的免疫球蛋白轻链库的细胞、动物和方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20060015957A1 (en) 1991-08-28 2006-01-19 Genpharm International, Inc. Transgenic non-human animals for producing chimeric antibodies
WO2009157771A2 (en) 2008-06-27 2009-12-30 Merus B.V. Antibody producing non-human mammals
US20100310586A1 (en) 2007-07-27 2010-12-09 ARETA INTERNATIONAL S.r.l Idiotypic vaccine
WO2011097603A1 (en) 2010-02-08 2011-08-11 Regeneron Pharmaceuticals, Inc. Common light chain mouse
WO2012148873A2 (en) 2011-04-25 2012-11-01 Regeneron Pharmaceuticals, Inc. Non-human animals expressing antibodies having a common light chain

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
EP1644417B1 (en) * 2003-07-15 2014-04-30 Therapeutic Human Polyclonals, Inc. Humanized immunoglobulin loci
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
AU2007235496B2 (en) * 2006-03-31 2013-11-21 E. R. Squibb & Sons, L.L.C. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
ES2398076T3 (es) 2006-06-02 2013-03-13 Regeneron Pharmaceuticals, Inc. Anticuerpos de alta afinidad contra el receptor de IL-6 humano
JP5827127B2 (ja) * 2008-12-18 2015-12-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
JP5816170B2 (ja) 2009-06-26 2015-11-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体
US20130045492A1 (en) * 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US9012717B2 (en) * 2010-06-22 2015-04-21 Regeneron Pharmaceuticals, Inc. Human lambda light chain mice
SG10201912639SA (en) * 2010-08-02 2020-02-27 Regeneron Pharma Mice that make binding proteins comprising vl domains
RU2460287C1 (ru) * 2011-03-29 2012-09-10 Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии
RS59728B1 (sr) * 2011-08-05 2020-02-28 Regeneron Pharma Humanizovani miševi univerzalnog lakog lanca
GB201122047D0 (en) * 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060015957A1 (en) 1991-08-28 2006-01-19 Genpharm International, Inc. Transgenic non-human animals for producing chimeric antibodies
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JP2004524841A (ja) 2001-02-16 2004-08-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 真核生物細胞を改変する方法
US20100310586A1 (en) 2007-07-27 2010-12-09 ARETA INTERNATIONAL S.r.l Idiotypic vaccine
WO2009157771A2 (en) 2008-06-27 2009-12-30 Merus B.V. Antibody producing non-human mammals
WO2011097603A1 (en) 2010-02-08 2011-08-11 Regeneron Pharmaceuticals, Inc. Common light chain mouse
WO2012148873A2 (en) 2011-04-25 2012-11-01 Regeneron Pharmaceuticals, Inc. Non-human animals expressing antibodies having a common light chain

Also Published As

Publication number Publication date
IL280892B1 (en) 2023-01-01
EP3501272A1 (en) 2019-06-26
ES2712207T3 (es) 2019-05-09
CA2903698A1 (en) 2014-10-02
HUE061977T2 (hu) 2023-09-28
JP2019213549A (ja) 2019-12-19
CN105188357B (zh) 2018-04-24
EP4218409A3 (en) 2023-08-30
JP6790136B2 (ja) 2020-11-25
HRP20230490T1 (hr) 2023-08-04
AU2020203238B2 (en) 2023-04-13
MX377146B (es) 2025-03-07
CN108611369A (zh) 2018-10-02
EP3501272B1 (en) 2023-03-01
ES2942413T3 (es) 2023-06-01
LT3501272T (lt) 2023-03-27
KR20210107911A (ko) 2021-09-01
DK3501272T5 (da) 2024-09-02
MX357308B (es) 2018-07-04
AU2014244020B2 (en) 2020-06-04
EP4218409B1 (en) 2025-02-12
SG11201506278RA (en) 2015-09-29
FI3501272T3 (fi) 2023-04-06
EP4545567A3 (en) 2025-08-13
ES3013063T3 (en) 2025-04-10
JP6529957B2 (ja) 2019-06-12
IL280892B2 (en) 2023-05-01
AU2014244020A1 (en) 2015-09-24
DK2967013T3 (en) 2019-03-11
KR20150126871A (ko) 2015-11-13
RU2019115237A (ru) 2019-06-11
TR201901668T4 (tr) 2019-02-21
AU2023202783A1 (en) 2023-05-25
EP2967013B1 (en) 2019-01-16
IL240563A0 (en) 2015-09-24
RU2689664C2 (ru) 2019-05-28
NZ711776A (en) 2021-09-24
KR102295842B1 (ko) 2021-08-31
CY1121545T1 (el) 2020-05-29
ZA201505835B (en) 2019-09-25
IL280892A (en) 2021-04-29
JP2019076109A (ja) 2019-05-23
HK1218493A1 (en) 2017-02-24
MX391010B (es) 2025-03-21
LT2967013T (lt) 2019-04-25
WO2014160202A4 (en) 2014-11-13
MX2020010837A (es) 2022-03-28
EP4218409C0 (en) 2025-02-12
HRP20190706T1 (hr) 2019-10-18
JP2020182490A (ja) 2020-11-12
RU2015143110A (ru) 2017-04-18
RS58669B1 (sr) 2019-06-28
JP7010902B2 (ja) 2022-02-10
PL3501272T3 (pl) 2023-07-03
IL240563B (en) 2021-03-25
MX2015012539A (es) 2016-06-28
BR112015022034A2 (pt) 2017-08-29
JP2016512034A (ja) 2016-04-25
SI2967013T1 (sl) 2019-03-29
EP4218409A2 (en) 2023-08-02
DK3501272T3 (da) 2023-04-03
WO2014160202A1 (en) 2014-10-02
EP2967013A1 (en) 2016-01-20
SG10201801101QA (en) 2018-04-27
SI3501272T1 (sl) 2023-05-31
BR112015022034B1 (pt) 2023-02-28
AU2023202783B2 (en) 2026-02-12
PT3501272T (pt) 2023-03-29
PL2967013T3 (pl) 2019-07-31
HUE044003T2 (hu) 2019-09-30
CN108611369B (zh) 2022-08-26
ZA201805369B (en) 2021-08-25
CN105188357A (zh) 2015-12-23
SMT202300112T1 (it) 2023-05-12
AU2020203238A1 (en) 2020-06-11
CA2903698C (en) 2023-02-28
PT2967013T (pt) 2019-04-03
EP4545567A2 (en) 2025-04-30
SMT201900196T1 (it) 2019-05-10
RS64185B1 (sr) 2023-05-31

Similar Documents

Publication Publication Date Title
US12389888B2 (en) Mice expressing a limited immunoglobulin light chain repertoire
AU2023202783B2 (en) Mice expressing a limited immunoglobulin light chain repertoire
US20190071519A1 (en) Methods for making fully human bispecific antibodies using a common light chain
KR20150126863A (ko) 공통 경쇄 마우스
HK40126399A (en) Mice expressing a limited immunoglobulin light chain repertoire
HK40097135A (en) Mice expressing a limited immunoglobulin light chain repertoire
HK40097135B (en) Mice expressing a limited immunoglobulin light chain repertoire
RU2812814C2 (ru) Мыши, экспрессирующие ограниченный репертуар легких цепей иммуноглобулина
HK40010381A (en) Mice expressing a limited immunoglobulin light chain repertoire
HK40010381B (en) Mice expressing a limited immunoglobulin light chain repertoire
NZ711776B2 (en) Mice expressing a limited immunoglobulin light chain repertoire
HK1218493B (en) Mice expressing a limited immunoglobulin light chain repertoire

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20210825

Application number text: 1020157026152

Filing date: 20150922

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20210917

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20210929

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20220425

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20220720

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20220721

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20250630

Start annual number: 4

End annual number: 4