JP2019203032A5 - - Google Patents
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- JP2019203032A5 JP2019203032A5 JP2019162836A JP2019162836A JP2019203032A5 JP 2019203032 A5 JP2019203032 A5 JP 2019203032A5 JP 2019162836 A JP2019162836 A JP 2019162836A JP 2019162836 A JP2019162836 A JP 2019162836A JP 2019203032 A5 JP2019203032 A5 JP 2019203032A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- antiarrhythmic agent
- nebulizer
- atomizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 claims description 4
- DJBNUMBKLMJRSA-UHFFFAOYSA-N Flecainide Chemical compound FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(C(=O)NCC2NCCCC2)=C1 DJBNUMBKLMJRSA-UHFFFAOYSA-N 0.000 claims description 3
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 3
- 229960004166 diltiazem Drugs 0.000 claims description 3
- 229960000449 flecainide Drugs 0.000 claims description 3
- IXTMWRCNAAVVAI-UHFFFAOYSA-N dofetilide Chemical compound C=1C=C(NS(C)(=O)=O)C=CC=1CCN(C)CCOC1=CC=C(NS(C)(=O)=O)C=C1 IXTMWRCNAAVVAI-UHFFFAOYSA-N 0.000 claims description 2
- 229960002994 dofetilide Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 17
- 239000003416 antiarrhythmic agent Substances 0.000 claims 7
- 239000006199 nebulizer Substances 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 235000011054 acetic acid Nutrition 0.000 claims 1
- 230000003288 anthiarrhythmic effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000003748 coronary sinus Anatomy 0.000 claims 1
- 238000002565 electrocardiography Methods 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- -1 organic acid salt Chemical class 0.000 claims 1
- 239000006174 pH buffer Substances 0.000 claims 1
- 239000006179 pH buffering agent Substances 0.000 claims 1
- 230000033764 rhythmic process Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 description 2
- 229960003745 esmolol Drugs 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21038209P | 2009-03-18 | 2009-03-18 | |
| US61/210,382 | 2009-03-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204914A Division JP6715305B2 (ja) | 2009-03-18 | 2018-10-31 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019203032A JP2019203032A (ja) | 2019-11-28 |
| JP2019203032A5 true JP2019203032A5 (enExample) | 2022-01-11 |
| JP7071949B2 JP7071949B2 (ja) | 2022-05-19 |
Family
ID=42739985
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500945A Withdrawn JP2012520890A (ja) | 2009-03-18 | 2010-03-18 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
| JP2015149197A Withdrawn JP2015193657A (ja) | 2009-03-18 | 2015-07-29 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
| JP2017123029A Pending JP2017160268A (ja) | 2009-03-18 | 2017-06-23 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
| JP2018204914A Active JP6715305B2 (ja) | 2009-03-18 | 2018-10-31 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
| JP2019162836A Active JP7071949B2 (ja) | 2009-03-18 | 2019-09-06 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500945A Withdrawn JP2012520890A (ja) | 2009-03-18 | 2010-03-18 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
| JP2015149197A Withdrawn JP2015193657A (ja) | 2009-03-18 | 2015-07-29 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
| JP2017123029A Pending JP2017160268A (ja) | 2009-03-18 | 2017-06-23 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
| JP2018204914A Active JP6715305B2 (ja) | 2009-03-18 | 2018-10-31 | 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8974828B2 (enExample) |
| EP (3) | EP2413902B1 (enExample) |
| JP (5) | JP2012520890A (enExample) |
| AU (1) | AU2010226613B2 (enExample) |
| CA (2) | CA2835771C (enExample) |
| DK (1) | DK2413902T3 (enExample) |
| ES (3) | ES3036464T3 (enExample) |
| PL (1) | PL2413902T3 (enExample) |
| WO (1) | WO2010107964A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2835771C (en) | 2009-03-18 | 2017-01-24 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
| CA3114582A1 (en) | 2010-12-22 | 2012-06-28 | Syqe Medical Ltd. | Method and system for drug delivery |
| US9713687B2 (en) | 2012-08-21 | 2017-07-25 | Philip Morris Usa Inc. | Ventilator aerosol delivery system with transition adapter for introducing carrier gas |
| US11191755B2 (en) | 2014-01-17 | 2021-12-07 | Cornell University | Compositions and methods for providing cardioprotective effects |
| TWI590837B (zh) * | 2014-03-25 | 2017-07-11 | 林信湧 | 一種用於治療心臟病之吸入式醫藥組成物及其備製方法 |
| PL3160565T3 (pl) * | 2014-06-30 | 2022-01-10 | Syqe Medical Ltd. | Urządzenia i systemy do dopłucnego dostarczania środków aktywnych |
| CN106604755B (zh) | 2014-06-30 | 2020-08-11 | Syqe医药有限公司 | 流量调节的吸入器装置 |
| US11298477B2 (en) | 2014-06-30 | 2022-04-12 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
| WO2016118625A1 (en) * | 2015-01-20 | 2016-07-28 | Incarda Therapeutics, Inc. | Unit aerosol doses for anticoagulation |
| ES2778673T3 (es) * | 2015-04-14 | 2020-08-11 | Milestone Pharmaceuticals Inc | Sales altamente solubles de un inhibidor de los canales de calcio de fenilalquilamina de corta acción y usos de las mismas |
| ES2874087T3 (es) | 2016-01-06 | 2021-11-04 | Syqe Medical Ltd | Tratamiento terapéutico con dosis bajas |
| SG11201805788WA (en) | 2016-02-01 | 2018-08-30 | Incarda Therapeutics Inc | Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation |
| CA3060702A1 (en) * | 2017-05-10 | 2018-11-15 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
| WO2019183470A2 (en) * | 2018-03-22 | 2019-09-26 | Incarda Therapeutics, Inc. | A novel method to slow ventricular rate |
| CN112533664A (zh) * | 2018-06-05 | 2021-03-19 | 英凯达治疗公司 | 使用气雾剂诊断Brugada综合征的方法 |
| WO2019241597A1 (en) * | 2018-06-14 | 2019-12-19 | Cornell University | Compositions and methods for providing cardioprotective effects |
| US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
| US11344518B2 (en) * | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
| US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US12396970B2 (en) | 2021-08-20 | 2025-08-26 | AltaThera Pharmaceuticals LLC | Anti-arrhythmic compositions and methods |
| CN114144177A (zh) * | 2019-08-01 | 2022-03-04 | 英凯达治疗公司 | 抗心律失常制剂 |
| US11020384B2 (en) | 2019-08-01 | 2021-06-01 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
| AU2021400335A1 (en) | 2020-12-17 | 2023-06-22 | Incarda Therapeutics, Inc. | Kits and methods for induction of cardioversion in subjects with atrial arrhythmias |
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| CA2835771C (en) | 2009-03-18 | 2017-01-24 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
-
2010
- 2010-03-18 CA CA2835771A patent/CA2835771C/en active Active
- 2010-03-18 EP EP10754091.6A patent/EP2413902B1/en active Active
- 2010-03-18 AU AU2010226613A patent/AU2010226613B2/en active Active
- 2010-03-18 EP EP19176272.3A patent/EP3552602B1/en active Active
- 2010-03-18 CA CA2755809A patent/CA2755809C/en active Active
- 2010-03-18 JP JP2012500945A patent/JP2012520890A/ja not_active Withdrawn
- 2010-03-18 ES ES19176272T patent/ES3036464T3/es active Active
- 2010-03-18 WO PCT/US2010/027740 patent/WO2010107964A1/en not_active Ceased
- 2010-03-18 ES ES19176305T patent/ES3003038T3/es active Active
- 2010-03-18 EP EP19176305.1A patent/EP3552603B1/en active Active
- 2010-03-18 ES ES10754091T patent/ES2750359T3/es active Active
- 2010-03-18 DK DK10754091.6T patent/DK2413902T3/da active
- 2010-03-18 US US13/257,249 patent/US8974828B2/en active Active
- 2010-03-18 PL PL10754091T patent/PL2413902T3/pl unknown
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2015
- 2015-02-26 US US14/632,252 patent/US10045939B2/en active Active
- 2015-07-29 JP JP2015149197A patent/JP2015193657A/ja not_active Withdrawn
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2017
- 2017-06-23 JP JP2017123029A patent/JP2017160268A/ja active Pending
-
2018
- 2018-06-20 US US16/013,178 patent/US20180318213A1/en not_active Abandoned
- 2018-06-20 US US16/013,165 patent/US20180296480A1/en not_active Abandoned
- 2018-10-26 US US16/172,456 patent/US20190060230A1/en not_active Abandoned
- 2018-10-31 JP JP2018204914A patent/JP6715305B2/ja active Active
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2019
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