JP2019187424A5 - - Google Patents
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- Publication number
- JP2019187424A5 JP2019187424A5 JP2019104273A JP2019104273A JP2019187424A5 JP 2019187424 A5 JP2019187424 A5 JP 2019187424A5 JP 2019104273 A JP2019104273 A JP 2019104273A JP 2019104273 A JP2019104273 A JP 2019104273A JP 2019187424 A5 JP2019187424 A5 JP 2019187424A5
- Authority
- JP
- Japan
- Prior art keywords
- polymerase
- seq
- amino acid
- dna polymerase
- acid substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021086806A JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562161571P | 2015-05-14 | 2015-05-14 | |
| US62/161,571 | 2015-05-14 | ||
| US201562202895P | 2015-08-09 | 2015-08-09 | |
| US62/202,895 | 2015-08-09 | ||
| US15/012,317 US10308918B2 (en) | 2015-02-02 | 2016-02-01 | Polymerase variants |
| US15/012,317 | 2016-02-01 | ||
| US15/151,364 US10526588B2 (en) | 2015-05-14 | 2016-05-10 | Polymerase variants and uses thereof |
| US15/151,364 | 2016-05-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559318A Division JP2018515103A (ja) | 2015-05-14 | 2016-05-13 | ポリメラーゼバリアントおよびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021086806A Division JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019187424A JP2019187424A (ja) | 2019-10-31 |
| JP2019187424A5 true JP2019187424A5 (https=) | 2020-04-09 |
Family
ID=57248698
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559318A Pending JP2018515103A (ja) | 2015-05-14 | 2016-05-13 | ポリメラーゼバリアントおよびその使用 |
| JP2019104273A Pending JP2019187424A (ja) | 2015-05-14 | 2019-06-04 | ポリメラーゼバリアントおよびその使用 |
| JP2021086806A Pending JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559318A Pending JP2018515103A (ja) | 2015-05-14 | 2016-05-13 | ポリメラーゼバリアントおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021086806A Pending JP2021121221A (ja) | 2015-05-14 | 2021-05-24 | ポリメラーゼバリアントおよびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10526588B2 (https=) |
| EP (1) | EP3294749A4 (https=) |
| JP (3) | JP2018515103A (https=) |
| CN (1) | CN107636004A (https=) |
| CA (2) | CA2978194C (https=) |
| WO (1) | WO2016183403A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6736565B2 (ja) | 2015-02-02 | 2020-08-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ポリメラーゼバリアント |
| US10526588B2 (en) * | 2015-05-14 | 2020-01-07 | Roche Sequencing Solutions, Inc. | Polymerase variants and uses thereof |
| US10745685B2 (en) | 2015-11-16 | 2020-08-18 | Stratos Genomics, Inc. | DP04 polymerase variants |
| EP3423574B1 (en) * | 2016-02-29 | 2021-03-17 | Genia Technologies, Inc. | Polymerase-template complexes for nanopore sequencing |
| CN108699539B (zh) | 2016-02-29 | 2022-11-18 | 吉尼亚科技公司 | 外切核酸酶缺陷的聚合酶 |
| US10590480B2 (en) | 2016-02-29 | 2020-03-17 | Roche Sequencing Solutions, Inc. | Polymerase variants |
| US10655174B2 (en) | 2016-05-27 | 2020-05-19 | Roche Sequencing Solutions, Inc. | Tagged multi-nucleotides useful for nucleic acid sequencing |
| US10669580B2 (en) | 2016-08-26 | 2020-06-02 | Roche Sequencing Solutions, Inc. | Tagged nucleotides useful for nanopore detection |
| US10829747B2 (en) | 2016-09-22 | 2020-11-10 | Roche Sequencing Solutions, Inc. | Polymerase variants |
| WO2018204707A1 (en) | 2017-05-04 | 2018-11-08 | Stratos Genomics Inc. | Dp04 polymerase variants |
| CA3084812A1 (en) | 2017-12-11 | 2019-06-20 | Stratos Genomics, Inc. | Dpo4 polymerase variants with improved accuracy |
| WO2019166457A1 (en) | 2018-02-28 | 2019-09-06 | F. Hoffmann-La Roche Ag | Tagged nucleoside compounds useful for nanopore detection |
| CN112041331B (zh) | 2018-02-28 | 2024-05-28 | 豪夫迈·罗氏有限公司 | α-溶血素变体及其用途 |
| WO2021156370A1 (en) | 2020-02-06 | 2021-08-12 | F. Hoffmann-La Roche Ag | Compositions that reduce template threading into a nanopore |
| EP4196608B1 (en) | 2020-08-11 | 2024-10-23 | F. Hoffmann-La Roche AG | Nucleoside-5'-oligophosphates tagged with positively-charged polymers, nanopores incorporating negative charges, and methods and systems using the same |
| EP4355757A1 (en) | 2021-06-17 | 2024-04-24 | F. Hoffmann-La Roche AG | Nucleoside-5 -oligophosphates having a cationically-modified nucleobase |
| US20250283162A1 (en) | 2021-06-17 | 2025-09-11 | Roche Sequencing Solutions, Inc. | Engineered nanopore with a negatively charged polymer threaded through the channel |
| CN117999346A (zh) | 2021-07-21 | 2024-05-07 | 豪夫迈·罗氏有限公司 | 形成窄通道孔的α-溶血素变体及其用途 |
| WO2023089175A1 (en) | 2021-11-22 | 2023-05-25 | F. Hoffmann-La Roche Ag | Thermostable polymerase variants |
| WO2026050292A1 (en) | 2024-08-29 | 2026-03-05 | Roche Sequencing Solutions, Inc. | Optimized reagent introduction during a nanopore sequencing assay |
| WO2026050290A1 (en) | 2024-08-29 | 2026-03-05 | Roche Sequencing Solutions, Inc. | Lipid composition and methods of use in a nanopore sequencing assay |
| WO2026050289A1 (en) | 2024-08-29 | 2026-03-05 | Roche Sequencing Solutions, Inc. | Pre-and post-sequencing cleaning protocols for nanopore sequencing |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| CA2243985C (en) | 1997-09-11 | 2004-08-10 | F. Hoffmann-La Roche Ag | Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes |
| US7238485B2 (en) | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
| WO2006120433A1 (en) | 2005-05-10 | 2006-11-16 | Solexa Limited | Improved polymerases |
| GB0509508D0 (en) | 2005-05-10 | 2005-06-15 | Solexa Ltd | Improved polymerases |
| WO2009122191A1 (en) | 2008-04-04 | 2009-10-08 | It-Is International Ltd | Thermal control system and method for chemical and biochemical reactions |
| CA2742594C (en) * | 2008-11-03 | 2020-03-24 | Kapa Biosystems, Inc. | Modified type a dna polymerases |
| CA2995178C (en) | 2010-02-08 | 2023-09-12 | Genia Technologies, Inc. | Method and system for forming a nanopore in a lipid bilayer |
| GB201002362D0 (en) | 2010-02-11 | 2010-03-31 | Isis Innovation | Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds |
| US8936911B2 (en) | 2010-09-22 | 2015-01-20 | Pacific Biosciences Of California, Inc. | Purified extended polymerase/template complex for sequencing |
| EP2652153B1 (en) | 2010-12-17 | 2017-07-05 | The Trustees of Columbia University in the City of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| EP2689028B1 (en) | 2011-03-23 | 2017-08-30 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| US10059984B2 (en) | 2011-06-16 | 2018-08-28 | The Regents Of The University Of California | Salt-tolerant DNA polymerases |
| CN103857805B (zh) | 2011-08-10 | 2017-07-18 | 生命技术公司 | 聚合酶组合物、制备和使用所述聚合酶组合物的方法 |
| CA2876095A1 (en) | 2012-06-15 | 2013-12-19 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| US9567630B2 (en) | 2013-10-23 | 2017-02-14 | Genia Technologies, Inc. | Methods for forming lipid bilayers on biochips |
| JP6736565B2 (ja) | 2015-02-02 | 2020-08-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ポリメラーゼバリアント |
| JP2016171215A (ja) | 2015-03-12 | 2016-09-23 | 株式会社東芝 | 半導体記憶装置 |
| US10526588B2 (en) | 2015-05-14 | 2020-01-07 | Roche Sequencing Solutions, Inc. | Polymerase variants and uses thereof |
| WO2017148862A1 (en) | 2016-02-29 | 2017-09-08 | Genia Technologies, Inc. | Polymerase variants |
| CN108699539B (zh) | 2016-02-29 | 2022-11-18 | 吉尼亚科技公司 | 外切核酸酶缺陷的聚合酶 |
-
2016
- 2016-05-10 US US15/151,364 patent/US10526588B2/en active Active
- 2016-05-13 WO PCT/US2016/032258 patent/WO2016183403A2/en not_active Ceased
- 2016-05-13 EP EP16793584.0A patent/EP3294749A4/en not_active Withdrawn
- 2016-05-13 CA CA2978194A patent/CA2978194C/en active Active
- 2016-05-13 CA CA3028797A patent/CA3028797C/en active Active
- 2016-05-13 CN CN201680027667.8A patent/CN107636004A/zh active Pending
- 2016-05-13 JP JP2017559318A patent/JP2018515103A/ja active Pending
-
2019
- 2019-06-04 JP JP2019104273A patent/JP2019187424A/ja active Pending
- 2019-11-25 US US16/694,985 patent/US10968438B2/en active Active
-
2021
- 2021-03-05 US US17/249,605 patent/US11788073B2/en active Active
- 2021-05-24 JP JP2021086806A patent/JP2021121221A/ja active Pending
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