JP2019176877A5 - - Google Patents
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- Publication number
- JP2019176877A5 JP2019176877A5 JP2019118495A JP2019118495A JP2019176877A5 JP 2019176877 A5 JP2019176877 A5 JP 2019176877A5 JP 2019118495 A JP2019118495 A JP 2019118495A JP 2019118495 A JP2019118495 A JP 2019118495A JP 2019176877 A5 JP2019176877 A5 JP 2019176877A5
- Authority
- JP
- Japan
- Prior art keywords
- activity
- puf domain
- binding sequence
- protein
- cas9
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 claims 69
- 108091033409 CRISPR Proteins 0.000 claims 31
- 108091033319 polynucleotide Proteins 0.000 claims 21
- 102000040430 polynucleotide Human genes 0.000 claims 21
- 239000002157 polynucleotide Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 11
- 108020004414 DNA Proteins 0.000 claims 10
- 238000000338 in vitro Methods 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 108010042407 Endonucleases Proteins 0.000 claims 6
- 102000004533 Endonucleases Human genes 0.000 claims 6
- 108020005004 Guide RNA Proteins 0.000 claims 5
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 4
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 4
- 102000016397 Methyltransferase Human genes 0.000 claims 4
- 108060004795 Methyltransferase Proteins 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 4
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 4
- 108091000080 Phosphotransferase Proteins 0.000 claims 4
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 4
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 4
- 102000005421 acetyltransferase Human genes 0.000 claims 4
- 108020002494 acetyltransferase Proteins 0.000 claims 4
- 230000006154 adenylylation Effects 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 230000009504 deubiquitination Effects 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 102000020233 phosphotransferase Human genes 0.000 claims 4
- 230000010741 sumoylation Effects 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 102220605874 Cytosolic arginine sensor for mTORC1 subunit 2_D10A_mutation Human genes 0.000 claims 3
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 3
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 3
- 230000002255 enzymatic effect Effects 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 2
- 230000006114 demyristoylation Effects 0.000 claims 2
- 230000007498 myristoylation Effects 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562132644P | 2015-03-13 | 2015-03-13 | |
| US62/132,644 | 2015-03-13 | ||
| US201562221249P | 2015-09-21 | 2015-09-21 | |
| US62/221,249 | 2015-09-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566611A Division JP6588995B2 (ja) | 2015-03-13 | 2016-03-09 | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020192362A Division JP2021036899A (ja) | 2015-03-13 | 2020-11-19 | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019176877A JP2019176877A (ja) | 2019-10-17 |
| JP2019176877A5 true JP2019176877A5 (https=) | 2020-02-20 |
| JP6867440B2 JP6867440B2 (ja) | 2021-04-28 |
Family
ID=55642857
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566611A Active JP6588995B2 (ja) | 2015-03-13 | 2016-03-09 | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
| JP2019118495A Active JP6867440B2 (ja) | 2015-03-13 | 2019-06-26 | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
| JP2020192362A Pending JP2021036899A (ja) | 2015-03-13 | 2020-11-19 | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566611A Active JP6588995B2 (ja) | 2015-03-13 | 2016-03-09 | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020192362A Pending JP2021036899A (ja) | 2015-03-13 | 2020-11-19 | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11434484B2 (https=) |
| EP (2) | EP3858992A1 (https=) |
| JP (3) | JP6588995B2 (https=) |
| KR (1) | KR102004076B1 (https=) |
| CN (1) | CN107922942B (https=) |
| AU (2) | AU2016233648B2 (https=) |
| CA (2) | CA2979567C (https=) |
| ES (1) | ES2886901T3 (https=) |
| IL (2) | IL254428B (https=) |
| SG (2) | SG10202008443UA (https=) |
| WO (1) | WO2016148994A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| JP6588995B2 (ja) | 2015-03-13 | 2019-10-09 | ザ ジャクソン ラボラトリーＴｈｅ Ｊａｃｋｓｏｎ Ｌａｂｏｒａｔｏｒｙ | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017327384B2 (en) | 2016-09-13 | 2021-05-20 | The Jackson Laboratory | Targeted enhanced DNA demethylation |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| KR102013798B1 (ko) * | 2017-10-25 | 2019-08-23 | 성균관대학교산학협력단 | 노화 모델 제조 방법 및 이에 의해 제조된 세포 또는 동물 노화 모델 |
| GB2568255A (en) * | 2017-11-08 | 2019-05-15 | Evox Therapeutics Ltd | Exosomes comprising RNA therapeutics |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3755726A4 (en) * | 2018-02-23 | 2022-07-20 | Shanghaitech University | Fusion proteins for base editing |
| WO2019183630A2 (en) * | 2018-03-23 | 2019-09-26 | The Trustees Of Columbia University In The City Of New York | Gene editing for autosomal dominant diseases |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| EP3575401A1 (en) * | 2018-05-29 | 2019-12-04 | Ecole Polytechnique Federale De Lausanne (Epfl) | Methods of treating or preventing an aging-related disease |
| EP3823633A4 (en) | 2018-06-29 | 2023-05-03 | Editas Medicine, Inc. | SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| CN109055375B (zh) * | 2018-07-26 | 2021-11-12 | 东南大学 | 一种crispr辅助反式增强子激活基因表达的方法及其应用 |
| WO2020041172A1 (en) * | 2018-08-21 | 2020-02-27 | The Jackson Laboratory | Methods and compositions for recruiting dna repair proteins |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| CN111793627A (zh) * | 2019-04-08 | 2020-10-20 | 中国科学院上海生命科学研究院 | 利用人工构建rna编辑酶进行rna定点编辑及相关应用 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| AU2020310201A1 (en) * | 2019-07-10 | 2022-01-27 | Locanabio, Inc. | RNA-targeting knockdown and replacement compositions and methods for use |
| WO2021034585A1 (en) * | 2019-08-16 | 2021-02-25 | The Jackson Laboratory | Live cell imaging of non-repetitive genomic loci |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| KR20220110739A (ko) | 2019-10-30 | 2022-08-09 | 페어와이즈 플랜츠 서비시즈, 인크. | 유형 v crispr-cas 염기 편집제 및 그의 사용 방법 |
| US11859172B2 (en) | 2020-01-02 | 2024-01-02 | The Trustees Of Columbia University In The City Of New York | Programmable and portable CRISPR-Cas transcriptional activation in bacteria |
| WO2021173977A1 (en) * | 2020-02-28 | 2021-09-02 | The Jackson Laboratory | Activation of lytic genes in cancer cells |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| EP4176058A1 (en) | 2020-08-07 | 2023-05-10 | The Jackson Laboratory | Targeted sequence insertion compositions and methods |
| WO2022272294A1 (en) * | 2021-06-23 | 2022-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for efficient retron recruitment to dna breaks |
| CN113637658A (zh) * | 2021-08-19 | 2021-11-12 | 中国农业科学院棉花研究所 | 基于dCas9-oToV的基因转录系统及其应用 |
| CN114058641B (zh) * | 2022-01-17 | 2022-04-01 | 苏州大学 | 一种载体系统和应用及通过其降解目的蛋白的方法 |
| US12258625B2 (en) | 2022-04-07 | 2025-03-25 | Trustees Of Boston University | Compositions and methods relating to nucleic acid interaction reporters |
| WO2023224327A1 (ko) * | 2022-05-20 | 2023-11-23 | 한국생명공학연구원 | 오토라이신을 활용한 미세조류의 유전자 교정 효율을 증대시키기 위한 시스템 및 방법 |
| JP2025537861A (ja) * | 2022-11-18 | 2025-11-20 | 京都府公立大学法人 | マイトファジー誘導のための組成物およびその使用 |
| CN117860773B (zh) * | 2023-11-28 | 2024-07-16 | 四川大学华西医院 | 促进ar基因甲基化的药物及其在预防或治疗雄性激素脱发中的用途 |
| WO2025217591A1 (en) * | 2024-04-12 | 2025-10-16 | Strand Therapeutics Inc. | Human-derived synthetic regulators and uses thereof |
| WO2026012450A1 (zh) * | 2024-07-11 | 2026-01-15 | 石药集团中奇制药技术（石家庄）有限公司 | 一种非病毒载体介导的大片段dna定点敲入系统 |
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| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| JP3534749B2 (ja) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| AU680459B2 (en) | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
| ES2249761T3 (es) | 1993-06-24 | 2006-04-01 | Advec Inc. | Vectores de adenovirus para terapia genica. |
| EP1637608B1 (en) | 1993-10-25 | 2009-07-22 | CANJI, Inc. | Recombinant adenoviral vector and methods of use |
| US7078387B1 (en) | 1998-12-28 | 2006-07-18 | Arch Development Corp. | Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors |
| EP1083231A1 (en) | 1999-09-09 | 2001-03-14 | Introgene B.V. | Smooth muscle cell promoter and uses thereof |
| US7169874B2 (en) | 2001-11-02 | 2007-01-30 | Bausch & Lomb Incorporated | High refractive index polymeric siloxysilane compositions |
| CA2751667C (en) | 2009-02-06 | 2016-12-13 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| US9499805B2 (en) * | 2010-06-18 | 2016-11-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for synthetic RNA endonucleases |
| WO2012068627A1 (en) * | 2010-11-24 | 2012-05-31 | The University Of Western Australia | Peptides for the specific binding of rna targets |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| AU2013285988A1 (en) | 2012-07-06 | 2015-02-12 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
| JP6588995B2 (ja) | 2015-03-13 | 2019-10-09 | ザ ジャクソン ラボラトリーＴｈｅ Ｊａｃｋｓｏｎ Ｌａｂｏｒａｔｏｒｙ | 三構成要素ＣＲＩＳＰＲ／Ｃａｓ複合体系およびその使用 |
| WO2017074943A1 (en) | 2015-10-27 | 2017-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of inducibly targeting chromatin effectors and compositions for use in the same |
| AU2017327384B2 (en) * | 2016-09-13 | 2021-05-20 | The Jackson Laboratory | Targeted enhanced DNA demethylation |
-
2016
- 2016-03-09 JP JP2017566611A patent/JP6588995B2/ja active Active
- 2016-03-09 EP EP21157844.8A patent/EP3858992A1/en active Pending
- 2016-03-09 AU AU2016233648A patent/AU2016233648B2/en active Active
- 2016-03-09 WO PCT/US2016/021491 patent/WO2016148994A1/en not_active Ceased
- 2016-03-09 SG SG10202008443UA patent/SG10202008443UA/en unknown
- 2016-03-09 CN CN201680027107.2A patent/CN107922942B/zh active Active
- 2016-03-09 CA CA2979567A patent/CA2979567C/en active Active
- 2016-03-09 ES ES16713184T patent/ES2886901T3/es active Active
- 2016-03-09 CA CA3091771A patent/CA3091771A1/en active Pending
- 2016-03-09 SG SG11201707393SA patent/SG11201707393SA/en unknown
- 2016-03-09 EP EP16713184.6A patent/EP3268472B1/en active Active
- 2016-03-09 KR KR1020177029329A patent/KR102004076B1/ko active Active
-
2017
- 2017-09-11 IL IL254428A patent/IL254428B/en active IP Right Grant
- 2017-09-13 US US15/702,944 patent/US11434484B2/en active Active
-
2019
- 2019-06-26 JP JP2019118495A patent/JP6867440B2/ja active Active
-
2020
- 2020-01-14 AU AU2020200256A patent/AU2020200256B2/en active Active
- 2020-08-24 IL IL276894A patent/IL276894B2/en unknown
- 2020-11-19 JP JP2020192362A patent/JP2021036899A/ja active Pending
-
2022
- 2022-07-28 US US17/815,621 patent/US12428638B2/en active Active
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