SG10202008443UA - A three-component crispr/cas complex system and uses thereof - Google Patents
A three-component crispr/cas complex system and uses thereofInfo
- Publication number
- SG10202008443UA SG10202008443UA SG10202008443UA SG10202008443UA SG10202008443UA SG 10202008443U A SG10202008443U A SG 10202008443UA SG 10202008443U A SG10202008443U A SG 10202008443UA SG 10202008443U A SG10202008443U A SG 10202008443UA SG 10202008443U A SG10202008443U A SG 10202008443UA
- Authority
- SG
- Singapore
- Prior art keywords
- complex system
- cas complex
- component crispr
- crispr
- component
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Confectionery (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562132644P | 2015-03-13 | 2015-03-13 | |
| US201562221249P | 2015-09-21 | 2015-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202008443UA true SG10202008443UA (en) | 2020-10-29 |
Family
ID=55642857
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201707393SA SG11201707393SA (en) | 2015-03-13 | 2016-03-09 | A three-component crispr/cas complex system and uses thereof |
| SG10202008443UA SG10202008443UA (en) | 2015-03-13 | 2016-03-09 | A three-component crispr/cas complex system and uses thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201707393SA SG11201707393SA (en) | 2015-03-13 | 2016-03-09 | A three-component crispr/cas complex system and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11434484B2 (en) |
| EP (2) | EP3858992A1 (en) |
| JP (3) | JP6588995B2 (en) |
| KR (1) | KR102004076B1 (en) |
| CN (1) | CN107922942B (en) |
| AU (2) | AU2016233648B2 (en) |
| CA (2) | CA2979567C (en) |
| ES (1) | ES2886901T3 (en) |
| HK (2) | HK1249545A1 (en) |
| IL (2) | IL254428B (en) |
| SG (2) | SG11201707393SA (en) |
| WO (1) | WO2016148994A1 (en) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| IL294014B1 (en) | 2015-10-23 | 2024-03-01 | Harvard College | Nucleobase editors and uses thereof |
| AU2017306676B2 (en) | 2016-08-03 | 2024-02-22 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN109982710A (en) | 2016-09-13 | 2019-07-05 | 杰克逊实验室 | Target the DNA demethylation of enhancing |
| CN110214180A (en) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | The AAV of nucleobase editing machine is delivered |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (en) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Base-editing factor from cytosine to guanine |
| KR20190130613A (en) | 2017-03-23 | 2019-11-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Nucleobase edits comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2019014564A1 (en) | 2017-07-14 | 2019-01-17 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| KR102013798B1 (en) * | 2017-10-25 | 2019-08-23 | 성균관대학교산학협력단 | Method for producing aging model and aging model of cell or animal produced thereby |
| WO2019161783A1 (en) * | 2018-02-23 | 2019-08-29 | Shanghaitech University | Fusion proteins for base editing |
| EP3768327A4 (en) | 2018-03-23 | 2022-04-13 | The Trustees of Columbia University in the City of New York | Gene editing for autosomal dominant diseases |
| EP3575401A1 (en) * | 2018-05-29 | 2019-12-04 | Ecole Polytechnique Federale De Lausanne (Epfl) | Methods of treating or preventing an aging-related disease |
| CN109055375B (en) * | 2018-07-26 | 2021-11-12 | 东南大学 | Method for activating gene expression by CRISPR (clustered regularly interspaced short palindromic repeats) auxiliary trans-enhancer and application of method |
| WO2020041172A1 (en) * | 2018-08-21 | 2020-02-27 | The Jackson Laboratory | Methods and compositions for recruiting dna repair proteins |
| EP3942040A1 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| CN114555826A (en) * | 2019-08-16 | 2022-05-27 | 杰克逊实验室 | Live cell imaging of non-repetitive genomic loci |
| US11859172B2 (en) | 2020-01-02 | 2024-01-02 | The Trustees Of Columbia University In The City Of New York | Programmable and portable CRISPR-Cas transcriptional activation in bacteria |
| WO2021173977A1 (en) * | 2020-02-28 | 2021-09-02 | The Jackson Laboratory | Activation of lytic genes in cancer cells |
| MX2022014008A (en) | 2020-05-08 | 2023-02-09 | Broad Inst Inc | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence. |
| US20230295615A1 (en) | 2020-08-07 | 2023-09-21 | The Jackson Laboratory | Targeted Sequence Insertion Compositions and Methods |
| WO2022272294A1 (en) * | 2021-06-23 | 2022-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for efficient retron recruitment to dna breaks |
| CN113637658A (en) * | 2021-08-19 | 2021-11-12 | 中国农业科学院棉花研究所 | dCas 9-oToV-based gene transcription system and application thereof |
| CN114058641B (en) * | 2022-01-17 | 2022-04-01 | 苏州大学 | Carrier system, application and method for degrading target protein through carrier system |
| WO2023196274A1 (en) * | 2022-04-07 | 2023-10-12 | Trustees Of Boston University | Compositions and methods relating to nucleic acid interaction reporters |
| WO2023224327A1 (en) * | 2022-05-20 | 2023-11-23 | 한국생명공학연구원 | System and method for increasing gene editing efficiency of microalgae by using autolysin |
| WO2024105633A1 (en) * | 2022-11-18 | 2024-05-23 | Kyoto Prefectural Public University Corporation | Compositions for mitophagy induction and uses thereof |
| CN117860773A (en) * | 2023-11-28 | 2024-04-12 | 四川大学华西医院 | Medicament for promoting AR gene methylation and application thereof in preventing or treating androgenic alopecia |
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| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| CA2115742A1 (en) | 1991-08-20 | 1993-03-04 | Ronald G. Crystal | Adenovirus mediated transfer of genes to the gastrointestinal tract |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| FR2688514A1 (en) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Defective recombinant adenoviruses expressing cytokines and antitumour drugs containing them |
| AU680459B2 (en) | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
| JP3532566B2 (en) | 1993-06-24 | 2004-05-31 | エル． グラハム，フランク | Adenovirus vectors for gene therapy |
| DE69434594T2 (en) | 1993-10-25 | 2006-09-21 | Canji, Inc., San Diego | RECOMBINANT ADENOVIRUS VECTOR AND METHOD OF USE |
| US7078387B1 (en) | 1998-12-28 | 2006-07-18 | Arch Development Corp. | Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors |
| EP1083231A1 (en) | 1999-09-09 | 2001-03-14 | Introgene B.V. | Smooth muscle cell promoter and uses thereof |
| US7169874B2 (en) | 2001-11-02 | 2007-01-30 | Bausch & Lomb Incorporated | High refractive index polymeric siloxysilane compositions |
| WO2010089132A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
| WO2011160052A2 (en) * | 2010-06-18 | 2011-12-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for sequence specific rna endonucleases |
| US9580714B2 (en) * | 2010-11-24 | 2017-02-28 | The University Of Western Australia | Peptides for the specific binding of RNA targets |
| PT2800811T (en) | 2012-05-25 | 2017-08-17 | Univ California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| US9549899B2 (en) | 2012-07-06 | 2017-01-24 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
| CN109982710A (en) * | 2016-09-13 | 2019-07-05 | 杰克逊实验室 | Target the DNA demethylation of enhancing |
-
2016
- 2016-03-09 CA CA2979567A patent/CA2979567C/en active Active
- 2016-03-09 SG SG11201707393SA patent/SG11201707393SA/en unknown
- 2016-03-09 KR KR1020177029329A patent/KR102004076B1/en active IP Right Grant
- 2016-03-09 JP JP2017566611A patent/JP6588995B2/en active Active
- 2016-03-09 CN CN201680027107.2A patent/CN107922942B/en active Active
- 2016-03-09 EP EP21157844.8A patent/EP3858992A1/en active Pending
- 2016-03-09 AU AU2016233648A patent/AU2016233648B2/en active Active
- 2016-03-09 WO PCT/US2016/021491 patent/WO2016148994A1/en active Application Filing
- 2016-03-09 SG SG10202008443UA patent/SG10202008443UA/en unknown
- 2016-03-09 CA CA3091771A patent/CA3091771A1/en active Pending
- 2016-03-09 ES ES16713184T patent/ES2886901T3/en active Active
- 2016-03-09 EP EP16713184.6A patent/EP3268472B1/en active Active
-
2017
- 2017-09-11 IL IL254428A patent/IL254428B/en active IP Right Grant
- 2017-09-13 US US15/702,944 patent/US11434484B2/en active Active
-
2018
- 2018-07-11 HK HK18108993.0A patent/HK1249545A1/en unknown
- 2018-10-15 HK HK18113197.4A patent/HK1254126A1/en unknown
-
2019
- 2019-06-26 JP JP2019118495A patent/JP6867440B2/en active Active
-
2020
- 2020-01-14 AU AU2020200256A patent/AU2020200256B2/en active Active
- 2020-08-24 IL IL276894A patent/IL276894B2/en unknown
- 2020-11-19 JP JP2020192362A patent/JP2021036899A/en active Pending
-
2022
- 2022-07-28 US US17/815,621 patent/US20230071712A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN107922942B (en) | 2021-08-31 |
| AU2020200256B2 (en) | 2022-03-31 |
| HK1254126A1 (en) | 2019-07-12 |
| SG11201707393SA (en) | 2017-10-30 |
| KR102004076B1 (en) | 2019-07-25 |
| CA3091771A1 (en) | 2016-09-22 |
| KR20170124601A (en) | 2017-11-10 |
| JP2018507713A (en) | 2018-03-22 |
| EP3268472A1 (en) | 2018-01-17 |
| US11434484B2 (en) | 2022-09-06 |
| JP6588995B2 (en) | 2019-10-09 |
| IL276894B (en) | 2022-12-01 |
| IL276894A (en) | 2020-10-29 |
| CN107922942A (en) | 2018-04-17 |
| JP6867440B2 (en) | 2021-04-28 |
| IL276894B2 (en) | 2023-04-01 |
| EP3858992A1 (en) | 2021-08-04 |
| IL254428A0 (en) | 2017-11-30 |
| WO2016148994A8 (en) | 2016-11-03 |
| JP2021036899A (en) | 2021-03-11 |
| WO2016148994A1 (en) | 2016-09-22 |
| EP3268472B1 (en) | 2021-05-05 |
| US20230071712A1 (en) | 2023-03-09 |
| AU2020200256A1 (en) | 2020-02-06 |
| HK1249545A1 (en) | 2018-11-02 |
| CA2979567A1 (en) | 2016-09-22 |
| CA2979567C (en) | 2020-10-13 |
| JP2019176877A (en) | 2019-10-17 |
| AU2016233648A1 (en) | 2017-10-05 |
| ES2886901T3 (en) | 2021-12-21 |
| IL254428B (en) | 2020-08-31 |
| US20180094257A1 (en) | 2018-04-05 |
| AU2016233648B2 (en) | 2019-11-07 |
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