JP2019152675A - 羊水を同定するための診断組成物 - Google Patents
羊水を同定するための診断組成物 Download PDFInfo
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Abstract
Description
本発明は、医療診断薬の分野、より具体的には羊水の同定に関する。
羊膜嚢の前期破水は、妊婦のおよそ10%に起こる一般的障害である。前期破水の処置に失敗すると、羊膜内感染、胎児肺発達の中断、および周産期死亡を起こす場合がある。
本発明は、複数のポリマーと;可塑化剤と;界面活性剤と;イオンバランス試薬と;酸と;指示薬と、を含み、湿潤剤を含まない、膣分泌物中の羊水を検出する指示薬組成物を開示する。本発明は、羊水を同定するための診断物品、およびそれを利用する方法をさらに開示する。
(a)複数のポリマー;非環式可塑化剤;親水性界面活性剤;芳香族カルボン酸;イオンバランス試薬;および指示薬を含み、湿潤剤を含まない、指示薬組成物を含む、分泌モニタリング物品を配置させて、対象から分泌された生体液を受け取ること;
(b)前記物品を膣分泌物と接触させること;ならびに
(c)変色が羊水の存在を示す該物品を観察すること、
を含む、膣分泌物中の羊水漏出を診断する方法が提供される。
例示的実施形態が、参照される図に示されている。本明細書に開示された実施形態および図は、制限ではなくむしろ例示と見なされなければならない。図を以下に列挙する。
本発明は、羊水漏出の直後に明瞭で信頼性のある同定を得るための指示薬組成物、それを含む診断物品、およびそれの使用方法を提供する。
(a)吸収材と、複数のポリマー;芳香族酸;非環式可塑化剤;疎水性界面活性剤;イオンバランス試薬;および指示薬を含み、湿潤剤を含まない、指示薬組成物と、を含む分泌モニタリング物品を配置させて、対象から分泌された生体液を受け取ること;
(b)前記物品を膣分泌物と接触させること;ならびに
(c)変色が羊水の存在を示す物品を観察すること、
を含む、膣分泌物中の羊水漏出を診断する方法が提供される。
実施例1:臨床試験
尿および羊水の試料を、以下の区分に従って妊婦83名から採取した:尿および羊水を8名から採取し、尿のみを63名から採取し、羊水を12名から採取した。
(i)18〜50歳の妊婦。
(ii)対象は、インフォームドコンセントの書式に署名する準備ができている。
(iii)対象は、羊膜切開を受けるために分娩室に到着している。
(iv)対象は、出血している。
(v)対象は、試験の手順に協力することができない、またはその意思がない。
(vi)対象は現在、別の臨床試験に参加している。
1.pHおよび他の尿パラメータのためのディップスティック(Roche DiagnosticsのCombur−Test(登録商標)ストリップ使用)
2.羊水100μlを各候補器具および参照器具(AL−SENSEおよびAmniScreen)に滴下した。
3.尿400μlを各候補器具(8種の候補配合剤のうちの1種を含むパンティーライナー)および各参照器具(AmniScreenまたはAl−Sense配合剤を含むパンティーライナー)に滴下した。
4.試験コーディネータが、「実生活」での使用を模倣するように、各パンティーライナーをかき回した。
5.羊水および尿試料では、コーディネータが、テストされたパッドで観察された色に基づいて、直後(0〜2分)および5分後、10分後、15分後、20分後、30分後、60分後および120分後の結果の状態(陽性または陰性)を記録した。黄色のパンティーライナーが、淡色であっても任意のサイズまたは形状の青緑の染色に見えた場合には、陽性結果と結論づけた。パンティーライナーの色が黄色のままであれば、陰性結果と結論づけた。
診断組成物ALM1(以後、「AL SENSE Blue」とも称される)を含む物品での一次有効性分析を、試験プロトコルを遵守した合計43名の女性で実施し、分析に有効なデータを有した。該分析は、AL SENSE Blueの結果の患者判定と臨床診断との比較からなる。
物品の調製は最初、候補および参照配合剤(3Mar1および3Mar2など)のそれぞれを溶液の形態で調製することを含んだ。この目的で、ニトラジンイエローを除く各配合剤の固体部分を、アセトン50mlに溶解した。ニトラジンイエローを水2mlに溶解し、その後、該アセトン溶液に添加した。
Claims (20)
- 複数のポリマーと;非環式可塑化剤と;親水性界面活性剤と;芳香族カルボン酸と;イオンバランス試薬と;指示薬と、を含み、湿潤剤を含まない、膣分泌物中の羊水を検出する指示薬組成物。
- 前記芳香族カルボン酸が、サリチル酸、安息香酸またはそれらの組み合わせを含む、請求項1に記載の指示薬組成物。
- 前記芳香族カルボン酸が、サリチル酸である、請求項1に記載の指示薬組成物。
- 前記親水性界面活性剤が、非イオン性界面活性剤である、請求項1に記載の指示薬組成物。
- 前記親水性界面活性剤が、ポリマーである、請求項1に記載の指示薬組成物。
- 前記親水性界面活性剤が、ブロック共重合体界面活性剤を含む、請求項5に記載の指示薬組成物。
- 前記指示薬が、負電荷を有する、請求項1に記載の指示薬組成物。
- 前記イオンバランス試薬が、第四級アンモニウム塩である、請求項1に記載の指示薬組成物。
- 前記非環式可塑化剤が、トリエステル可塑化剤である、請求項1に記載の指示薬組成物。
- 複数のポリマーと;非環式可塑化剤と;親水性界面活性剤と;芳香族カルボン酸と;イオンバランス試薬と;指示薬と、からなる、請求項1に記載の指示薬組成物。
- ヒトから分泌された生体液を吸収するための吸収材と、請求項1〜10のいずれか1項または複数の項に記載の指示薬組成物と、を含む、膣分泌物中の羊水を検出するための物品。
- 前記吸収材が、スワブ、ガーゼ、パンティーシールド、衛生ナプキン、おむつおよび陰唇間吸収材構造からなる群から選択される、請求項11に記載の物品。
- (d)請求項1に記載の指示薬組成物を含む分泌モニタリング物品を配置させて、対象から分泌された生体液を受け取ること;
(e)前記物品を膣分泌物と接触させること;および
(f)変色が羊水の存在を示す前記物品を観察すること、
を含む、膣分泌物中の羊水漏出を診断する方法。 - 前記変色が、前記分泌モニタリング物品の背景に関して濃い染色である、請求項13に記載の方法。
- 前記濃い染色が、暗青色の染色または暗緑色の染色である、請求項14に記載の方法。
- 前記観察が、前記接触後10分未満で実施される、請求項13に記載の方法。
- 前記観察が、前記接触後5分未満で実施される、請求項16に記載の方法。
- 前記指示薬組成物が、複数のポリマーと;非環式可塑化剤と;親水性界面活性剤と;芳香族カルボン酸と;イオンバランス試薬と;指示薬と、からなる、請求項13に記載の方法。
- 膣分泌物中の羊水を検出するための請求項11に記載の物品と、使用説明書と、を含むキット。
- 前記物品と羊水との接触によって現れると予測される色を表す色スケールをさらに含む、請求項19に記載のキット。
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US201462019439P | 2014-07-01 | 2014-07-01 | |
US62/019,439 | 2014-07-01 |
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JP2016572788A Division JP6526722B2 (ja) | 2014-07-01 | 2015-06-30 | 羊水を同定するための診断組成物 |
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JP6744452B2 JP6744452B2 (ja) | 2020-08-19 |
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JP2019088668A Active JP6744452B2 (ja) | 2014-07-01 | 2019-05-08 | 羊水を同定するための診断組成物 |
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US (2) | US10238766B2 (ja) |
EP (1) | EP3164103B1 (ja) |
JP (2) | JP6526722B2 (ja) |
CN (2) | CN109613177B (ja) |
AU (2) | AU2015283587B2 (ja) |
BR (1) | BR112016030057B1 (ja) |
CA (1) | CA2953886C (ja) |
DK (1) | DK3164103T3 (ja) |
ES (1) | ES2728973T3 (ja) |
HK (1) | HK1221014A1 (ja) |
HU (1) | HUE045228T2 (ja) |
IL (1) | IL249728B (ja) |
PL (1) | PL3164103T3 (ja) |
PT (1) | PT3164103T (ja) |
RS (1) | RS58843B1 (ja) |
TR (1) | TR201906876T4 (ja) |
WO (1) | WO2016001918A1 (ja) |
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CN109613177B (zh) | 2014-07-01 | 2021-08-20 | 科蒙森斯公司 | 用于鉴定羊水的诊断组合物 |
CN107576653B (zh) * | 2017-06-24 | 2023-03-17 | 中瀚利加(北京)科技有限公司 | 一种用于鉴定孕妇羊水的组合物 |
WO2022153291A1 (en) * | 2021-01-12 | 2022-07-21 | Peptonic Medical Israel Ltd | Wearable device for detection of amniotic fluid |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2664879A (en) | 1950-09-08 | 1954-01-05 | Hardy Lowell Macomber | Instrument for testing ph values of body canal liquids and color comparator for use therewith |
US3427225A (en) | 1967-06-05 | 1969-02-11 | Jeanne T Harvill | Test composition,device and method for detecting urea in aqueous fluids |
US3509872A (en) | 1967-11-30 | 1970-05-05 | Andrew Truhan | Body fluid test stick |
US4029598A (en) | 1969-03-14 | 1977-06-14 | E. Merck A. G. | Non-bleeding indicator and dyes therefor |
US4029597A (en) | 1969-03-14 | 1977-06-14 | E. Merck A. G. | Non-bleeding indicators and dyes therefor used in pH determination process |
US3954563A (en) | 1971-10-29 | 1976-05-04 | Mennen Frederick C | Apparatus especially useful for detection of neisseria gonorrhoeae and the like in females |
YU218175A (en) | 1974-09-12 | 1984-04-30 | Schwartzhaupt Kg | Process for total or individual determination of lactate dehydrogenase isoenzyme |
DE3231287C2 (de) | 1982-08-23 | 1984-09-06 | MEDI-PHARMA Vertriebsgesellschaft mbH, 5000 Köln | Verfahren zum Herstellen einer diagnostischen Vorrichtung |
US4532216A (en) | 1982-12-27 | 1985-07-30 | Miles Laboratories, Inc. | Use of quaternary ammonium polyelectrolyte salts in test means, test device and method for determining the ionic strength or specific gravity of a liquid sample |
US5275591A (en) | 1987-07-27 | 1994-01-04 | Mcneil-Ppc, Inc. | Fluid barrier seal for sanitary napkin having undergarment protecting flaps |
IL84443A (en) | 1987-11-11 | 1993-01-14 | Schoenfeld A | Vaginal tampon |
US5459078A (en) | 1988-01-29 | 1995-10-17 | Abbott Laboratories | Methods and reagents for performing ion-capture digoxin assays |
US5094955A (en) | 1988-03-15 | 1992-03-10 | Akzo N.V. | Device and method for detecting microorganisms |
US4925268A (en) | 1988-07-25 | 1990-05-15 | Abbott Laboratories | Fiber-optic physiological probes |
US5445147A (en) | 1988-09-08 | 1995-08-29 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
US5252459A (en) | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
IT215747Z2 (it) | 1989-03-07 | 1990-11-05 | Prospero Nucci | Sonda monouso per la determinazione del ph vaginale e di altri indici. |
JP3045761B2 (ja) | 1990-11-14 | 2000-05-29 | 株式会社京都第一科学 | 補正用紙片を有する呈色試験紙 |
US5214821A (en) | 1991-05-07 | 1993-06-01 | The Morgan Crucible Company Plc | Low contamination swab employing tubular knit fabric |
ES2136090T3 (es) | 1991-05-30 | 1999-11-16 | Abbott Lab | Reactivos que contienen un inhibidor de fijacion no especifico para analisis de fijacion con captura de iones. |
US5384411A (en) | 1991-06-20 | 1995-01-24 | Hewlett-Packard Company | Immobilization of PH-sensitive dyes to solid supports |
US5853669A (en) | 1991-09-30 | 1998-12-29 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Sensor membrane for indicating the PH of a sample, the fabrication and use thereof |
US5304648A (en) | 1992-09-29 | 1994-04-19 | Nestec S.A. | Pyrazine preparation |
JP3298217B2 (ja) * | 1993-03-31 | 2002-07-02 | 凸版印刷株式会社 | 水分インジケータ用インキ組成物及びそれを用いた記録媒体 |
US5468236A (en) | 1993-06-09 | 1995-11-21 | Kimberly-Clark Corporation | Disposable absorbent product incorporating chemically reactive substance |
GB9315440D0 (en) | 1993-07-26 | 1993-09-08 | Cambridge Res & Innovation | An amine tester for diagnosing bacterial vaginosis and vaginitus |
US5925318A (en) | 1993-08-26 | 1999-07-20 | Ferro Sensor, Inc. | Iron detecting sensors |
US5425377A (en) | 1994-08-25 | 1995-06-20 | Caillouette; James C. | pH measurement of body fluid |
EP0782703B1 (fr) | 1994-09-22 | 1999-06-23 | Bernard Chaffringeon | Dispositif a usage unique de detection ou analyse d'un liquide corporel |
JP3441529B2 (ja) * | 1994-09-30 | 2003-09-02 | ナカライテスク株式会社 | アンモニアの定量方法 |
US5672335A (en) | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
US5593895A (en) | 1995-04-27 | 1997-01-14 | Bayer Corporation | Method for the detection of protein in urine |
DE29514562U1 (de) | 1995-09-04 | 1995-11-16 | Ruehl Britta | Fruchtwasserindikator zur Selbstkontrolle über Fruchtwasserverlust |
US5874216A (en) | 1996-02-23 | 1999-02-23 | Ensys Environmental Products, Inc. | Indirect label assay device for detecting small molecules and method of use thereof |
US5823953A (en) | 1996-06-20 | 1998-10-20 | Roskin; Amy C. | Secretion analysis apparatus and method |
US5876389A (en) | 1996-06-24 | 1999-03-02 | Ezy-Detek (Edi) Inc. | Sanitary napkins and method for collecting samples of bodily substances |
US5660790A (en) | 1996-08-13 | 1997-08-26 | Litmus Concepts, Inc. | PH and amine test elements |
WO1999045976A1 (en) * | 1998-03-12 | 1999-09-16 | The Procter & Gamble Company | Proton donating actives in absorbent articles |
JP2000039401A (ja) | 1998-03-24 | 2000-02-08 | Dainippon Printing Co Ltd | 表面プラズモン共鳴バイオセンサ―用測定セル及びその製造方法 |
CZ20004852A3 (cs) | 1998-06-29 | 2001-08-15 | The Procter & Gamble Company | Zařízení pro manipulaci a odstranění odpadních látek |
US20010025140A1 (en) | 1998-07-22 | 2001-09-27 | Torok Brian A. | System for identifying premature rupture of membrane during pregnancy |
US6149590A (en) | 1998-07-22 | 2000-11-21 | Smith; Ramada S. | System for identifying premature rupture of membrane during pregnancy |
US6126597A (en) | 1998-07-22 | 2000-10-03 | Smith; Ramada S. | System for identifying premature rupture of membrane during pregnancy |
DE19914037A1 (de) | 1999-03-27 | 2000-09-28 | Hartmann Paul Ag | Hygieneartikel zum einmaligen Gebrauch |
CA2370509A1 (en) | 1999-04-26 | 2000-11-02 | The Procter & Gamble Company | A blood detection composition |
JP2000346850A (ja) | 1999-06-07 | 2000-12-15 | Beseru:Kk | 膣分泌物のpH測定用具 |
US6562297B1 (en) | 1999-08-12 | 2003-05-13 | Common Sense Ltd. | pH sensor for indicating the pH of a sample |
US6203496B1 (en) | 1999-08-12 | 2001-03-20 | Michael R. Gael | Apparatus with reagents for detection of medical conditions |
GB9919134D0 (en) | 1999-08-14 | 1999-10-13 | Inverclyde Biolog | Assay |
US6426227B1 (en) | 1999-08-31 | 2002-07-30 | Common Sense Ltd. | Method for analyzing secreted bodily fluids |
DE10016383A1 (de) | 1999-10-28 | 2001-06-07 | Erich Saling | Vorrichtungen und Verfahren zur Bestimmung von Eigenschaften menschlicher Körperflüssigkeiten, insbesondere Körpersekreten |
US20020041897A1 (en) | 2000-07-07 | 2002-04-11 | Wenbin Dang | Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same |
US6610904B1 (en) | 2000-09-22 | 2003-08-26 | Tredegar Film Products Corporation | Acquisition distribution layer having void volumes for an absorbent article |
US7947467B2 (en) * | 2001-07-19 | 2011-05-24 | Common Sense Ltd. | Methods for monitoring pathological conditions in a female subject |
US6627394B2 (en) * | 2001-07-19 | 2003-09-30 | Common Sense Ltd. | Diagnostic pad |
US6921647B2 (en) | 2001-07-19 | 2005-07-26 | Common Sense Ltd. | Secretion-monitoring article |
US20070134740A1 (en) * | 2005-12-12 | 2007-06-14 | David Brusilovsky | Compositions and articles for detection of analytes exceeding a pre-set threshold |
US7314752B2 (en) | 2001-07-19 | 2008-01-01 | Common Sense, Ltd. | Secretion-monitoring article |
US8097433B2 (en) * | 2005-11-22 | 2012-01-17 | Common Sense, Ltd. | Diagnostic composition and article for monitoring intravaginal infections |
WO2003007997A2 (en) * | 2001-07-19 | 2003-01-30 | Common Sense Ltd. | Secretion-monitoring article |
US6719691B2 (en) | 2001-07-26 | 2004-04-13 | Common Sense Ltd. | Method, device and kit for obtaining biological samples |
US20030120180A1 (en) | 2001-12-21 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Method and apparatus for collecting and testing biological samples |
CA2533915C (en) | 2002-08-13 | 2020-09-22 | N-Dia, Inc. | Devices and methods for detecting amniotic fluid in vaginal secretions |
EP1402862B1 (en) | 2002-09-24 | 2007-11-28 | The Procter & Gamble Company | An absorbent article comprising an absorbent element comprising a liquid absorbent thermoplastic composition |
US7255832B2 (en) | 2003-09-19 | 2007-08-14 | Quidel Corporation | Iconic colorimetric test device with reduced susceptibility to false positive and false negative readings |
US20050191704A1 (en) | 2004-03-01 | 2005-09-01 | Kimberly-Clark Worldwide, Inc. | Assay devices utilizing chemichromic dyes |
US8617819B2 (en) | 2004-09-17 | 2013-12-31 | Massachusetts Institute Of Technology | Polymers for analyte detection |
EP1669758A1 (en) | 2004-12-01 | 2006-06-14 | The Jordanian Pharmaceutical Manufacturing Co. | Lateral-flow test device providing improved test result validity |
EP1937709A4 (en) * | 2005-09-15 | 2011-06-08 | Swiss Asian Property Ltd | MARKER FOR EARLY BLEEDING (PROM) |
US7476201B2 (en) | 2005-09-26 | 2009-01-13 | Femteck Llc | Digital type color comparisons in vaginal moisture pH determination |
DE102006013531A1 (de) * | 2006-03-24 | 2007-09-27 | Lts Lohmann Therapie-Systeme Ag | Polylactid-Nanopartikel |
DE102006026624A1 (de) * | 2006-06-08 | 2007-12-13 | Oxeno Olefinchemie Gmbh | Tripentylcitrate und deren Verwendung |
MX2010004156A (es) | 2007-10-18 | 2011-04-13 | Momtec Life Ltd | Un dispositivo de diagnostico para identificar la ruptura de la membrana durante el embarazo. |
EP2257803A4 (en) | 2008-03-11 | 2012-04-25 | Urobiologics Llc | REDUCTION / OXIDATION ACTIVITY OF MOTHERICAL HARM AS INDICATOR OF FETAL GENDER SPECIFIC CHARACTERISTICS |
CN201752403U (zh) * | 2010-04-01 | 2011-03-02 | 苏州市玮琪生物科技有限公司 | 连续监测胎膜早破诊断工具 |
CN101813702B (zh) * | 2010-04-01 | 2014-05-14 | 顾瑜 | 一种连续监测胎膜早破诊断工具及诊断方法 |
JP2012184369A (ja) * | 2011-03-08 | 2012-09-27 | Nitto Denko Corp | 粘着テープ又はシート |
IL214096A (en) * | 2011-07-14 | 2016-02-29 | Gideon Mor | A system for detecting meconium in amniotic fluid |
JP2015533894A (ja) * | 2012-09-26 | 2015-11-26 | ザ プロクター アンド ギャンブルカンパニー | 永久着色剤を有する液体活性化処方物 |
WO2014082083A1 (en) * | 2012-11-26 | 2014-05-30 | Caris Science, Inc. | Biomarker compositions and methods |
JP6292763B2 (ja) * | 2013-04-11 | 2018-03-14 | 株式会社リブドゥコーポレーション | 吸収性物品 |
CN109613177B (zh) | 2014-07-01 | 2021-08-20 | 科蒙森斯公司 | 用于鉴定羊水的诊断组合物 |
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JP6526722B2 (ja) | 2019-06-05 |
EP3164103A4 (en) | 2018-02-21 |
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CN105277656B (zh) | 2018-12-25 |
BR112016030057A2 (pt) | 2017-08-22 |
CA2953886A1 (en) | 2016-01-07 |
HK1221014A1 (zh) | 2017-05-19 |
ES2728973T3 (es) | 2019-10-29 |
RS58843B1 (sr) | 2019-07-31 |
CN109613177A (zh) | 2019-04-12 |
PT3164103T (pt) | 2019-06-05 |
HUE045228T2 (hu) | 2019-12-30 |
EP3164103A1 (en) | 2017-05-10 |
AU2015283587A1 (en) | 2017-01-12 |
EP3164103B1 (en) | 2019-03-20 |
AU2015283587B2 (en) | 2019-03-21 |
AU2019204327A1 (en) | 2019-07-11 |
PL3164103T3 (pl) | 2019-09-30 |
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WO2016001918A1 (en) | 2016-01-07 |
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IL249728A0 (en) | 2017-02-28 |
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US20190240373A1 (en) | 2019-08-08 |
US11135338B2 (en) | 2021-10-05 |
US10238766B2 (en) | 2019-03-26 |
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CN105277656A (zh) | 2016-01-27 |
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