JP2019137675A5 - - Google Patents
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- JP2019137675A5 JP2019137675A5 JP2019019212A JP2019019212A JP2019137675A5 JP 2019137675 A5 JP2019137675 A5 JP 2019137675A5 JP 2019019212 A JP2019019212 A JP 2019019212A JP 2019019212 A JP2019019212 A JP 2019019212A JP 2019137675 A5 JP2019137675 A5 JP 2019137675A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- conjugate according
- seq
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001413 amino acids Chemical group 0.000 claims 68
- 102000007238 Transferrin Receptors Human genes 0.000 claims 16
- 108010033576 Transferrin Receptors Proteins 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 210000003205 muscle Anatomy 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 210000004899 c-terminal region Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 102100033448 Lysosomal alpha-glucosidase Human genes 0.000 claims 5
- 230000004064 dysfunction Effects 0.000 claims 5
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 claims 4
- 208000033868 Lysosomal disease Diseases 0.000 claims 4
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 208000024720 Fabry Disease Diseases 0.000 claims 3
- 208000032007 Glycogen storage disease due to acid maltase deficiency Diseases 0.000 claims 3
- 206010053185 Glycogen storage disease type II Diseases 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 201000004502 glycogen storage disease II Diseases 0.000 claims 3
- 230000002132 lysosomal effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000004220 muscle function Effects 0.000 claims 3
- 230000005996 muscular dysfunction Effects 0.000 claims 3
- YWAQATDNEKZFFK-BYPYZUCNSA-N Gly-Gly-Ser Chemical compound NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O YWAQATDNEKZFFK-BYPYZUCNSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 108010028144 alpha-Glucosidases Proteins 0.000 claims 2
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 1
- 101000718525 Homo sapiens Alpha-galactosidase A Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 1
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108010067216 glycyl-glycyl-glycine Proteins 0.000 claims 1
- 102000043404 human GLA Human genes 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 230000001766 physiological effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023150649A JP7591340B2 (ja) | 2018-02-05 | 2023-09-19 | 薬剤を筋肉に送達するための方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018018652 | 2018-02-05 | ||
| JP2018018652 | 2018-02-05 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150649A Division JP7591340B2 (ja) | 2018-02-05 | 2023-09-19 | 薬剤を筋肉に送達するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019137675A JP2019137675A (ja) | 2019-08-22 |
| JP2019137675A5 true JP2019137675A5 (enExample) | 2022-01-18 |
Family
ID=67479985
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019019212A Pending JP2019137675A (ja) | 2018-02-05 | 2019-02-05 | 薬剤を筋肉に送達するための方法 |
| JP2023150649A Active JP7591340B2 (ja) | 2018-02-05 | 2023-09-19 | 薬剤を筋肉に送達するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150649A Active JP7591340B2 (ja) | 2018-02-05 | 2023-09-19 | 薬剤を筋肉に送達するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20210038739A1 (enExample) |
| EP (1) | EP3750921A4 (enExample) |
| JP (2) | JP2019137675A (enExample) |
| KR (1) | KR20200116952A (enExample) |
| CN (1) | CN111683972A (enExample) |
| AU (1) | AU2019215782A1 (enExample) |
| BR (1) | BR112020013305A2 (enExample) |
| CA (1) | CA3090373A1 (enExample) |
| EA (1) | EA202091816A1 (enExample) |
| IL (1) | IL276327B2 (enExample) |
| MX (1) | MX2020008041A (enExample) |
| SG (1) | SG11202006433PA (enExample) |
| WO (1) | WO2019151539A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110809583A (zh) | 2017-06-07 | 2020-02-18 | 瑞泽恩制药公司 | 用于内化酶的组合物和方法 |
| KR20200118151A (ko) | 2018-02-07 | 2020-10-14 | 리제너론 파마슈티칼스 인코포레이티드 | 치료 단백질 전달을 위한 방법 및 조성물 |
| MX2020012350A (es) | 2018-05-17 | 2021-01-29 | Regeneron Pharma | Anticuerpos anti-cd63, conjugados y usos de estos. |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| JP2021533200A (ja) | 2018-08-02 | 2021-12-02 | ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. | 顔面・肩甲・上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用 |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US20210308273A1 (en) | 2018-08-02 | 2021-10-07 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| CN115335062A (zh) * | 2020-01-10 | 2022-11-11 | 达因疗法公司 | 肌肉靶向复合物及其用于调节与肌肉健康相关的基因的用途 |
| MX2022009418A (es) * | 2020-01-31 | 2022-08-25 | Dyne Therapeutics Inc | Anticuerpo del receptor anti-transferrina (tfr) y usos del mismo. |
| EP4108676A4 (en) | 2020-02-22 | 2024-06-05 | JCR Pharmaceuticals Co., Ltd. | HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| EP4366784A1 (en) | 2021-07-09 | 2024-05-15 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating dystrophinopathies |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| JPWO2023022234A1 (enExample) | 2021-08-19 | 2023-02-23 | ||
| US20240366775A1 (en) | 2021-08-24 | 2024-11-07 | Peptidream Inc. | Human transferrin receptor binding antibody-peptide conjugate |
| US11827702B2 (en) | 2021-09-01 | 2023-11-28 | Biogen Ma Inc. | Anti-transferrin receptor antibodies and uses thereof |
| TW202332767A (zh) * | 2022-02-02 | 2023-08-16 | 美商雷傑納榮製藥公司 | 用於治療龐貝氏症之抗ＴｆＲ：ＧＡＡ及抗ＣＤ６３：ＧＡＡ插入 |
| KR20250004770A (ko) | 2022-04-15 | 2025-01-08 | 다인 세라퓨틱스, 인크. | 근긴장성 이영양증을 치료하기 위한 근육 표적화 복합체 및 제제 |
| TW202434613A (zh) | 2023-02-17 | 2024-09-01 | 日商肽夢想股份有限公司 | 人類運鐵蛋白受體結合肽 |
| WO2025029657A2 (en) * | 2023-07-28 | 2025-02-06 | Regeneron Pharmaceuticals, Inc. | Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6261558B1 (en) | 1993-10-19 | 2001-07-17 | The Scripps Research Institute | Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus |
| AUPN523995A0 (en) | 1995-09-05 | 1995-09-28 | Crc For Biopharmaceutical Research Pty Ltd | Method for producing phage display vectors |
| WO2006108052A2 (en) * | 2005-04-06 | 2006-10-12 | Genzyme Corporation | Peg and polysialic lysosomal enzyme conjugates via acid labile linkers for therapeutic targeting |
| US20130244231A1 (en) | 2010-11-08 | 2013-09-19 | Jcr Pharmaceuticals Co., Ltd. | Novel expression vector |
| WO2013118165A1 (en) * | 2012-02-07 | 2013-08-15 | Jcr Pharmaceuticals Co., Ltd. | Pharmaceutical agents fused with atf for improved bioavailability |
| WO2014130723A1 (en) * | 2013-02-20 | 2014-08-28 | Valerion Therapeutics, Llc | Methods and compositions for treatment of pompe disease |
| EP4324480A3 (en) * | 2013-05-20 | 2024-05-08 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies and methods of use |
| EA039366B1 (ru) * | 2015-06-24 | 2022-01-19 | Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. | Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер |
| MX2018007061A (es) * | 2015-12-08 | 2018-08-15 | Regeneron Pharma | Composiciones y metodos para enzimas de internalizacion. |
| WO2018038243A1 (ja) * | 2016-08-25 | 2018-03-01 | Ｊｃｒファーマ株式会社 | 抗体融合蛋白質の製造方法 |
-
2019
- 2019-02-05 KR KR1020207024561A patent/KR20200116952A/ko not_active Ceased
- 2019-02-05 JP JP2019019212A patent/JP2019137675A/ja active Pending
- 2019-02-05 EP EP19747769.8A patent/EP3750921A4/en active Pending
- 2019-02-05 BR BR112020013305-1A patent/BR112020013305A2/pt unknown
- 2019-02-05 CA CA3090373A patent/CA3090373A1/en active Pending
- 2019-02-05 AU AU2019215782A patent/AU2019215782A1/en not_active Abandoned
- 2019-02-05 WO PCT/JP2019/004123 patent/WO2019151539A1/ja not_active Ceased
- 2019-02-05 EA EA202091816A patent/EA202091816A1/ru unknown
- 2019-02-05 SG SG11202006433PA patent/SG11202006433PA/en unknown
- 2019-02-05 IL IL276327A patent/IL276327B2/en unknown
- 2019-02-05 US US16/963,956 patent/US20210038739A1/en not_active Abandoned
- 2019-02-05 MX MX2020008041A patent/MX2020008041A/es unknown
- 2019-02-05 CN CN201980011522.2A patent/CN111683972A/zh active Pending
-
2023
- 2023-09-19 JP JP2023150649A patent/JP7591340B2/ja active Active
-
2024
- 2024-03-08 US US18/599,591 patent/US20240245797A1/en active Pending
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