JP2019089848A5 - - Google Patents

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Publication number
JP2019089848A5
JP2019089848A5 JP2019041615A JP2019041615A JP2019089848A5 JP 2019089848 A5 JP2019089848 A5 JP 2019089848A5 JP 2019041615 A JP2019041615 A JP 2019041615A JP 2019041615 A JP2019041615 A JP 2019041615A JP 2019089848 A5 JP2019089848 A5 JP 2019089848A5
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JP
Japan
Prior art keywords
compound
alkyl
medical device
group
crystalline
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019041615A
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English (en)
Japanese (ja)
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JP2019089848A (ja
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Publication date
Application filed filed Critical
Publication of JP2019089848A publication Critical patent/JP2019089848A/ja
Publication of JP2019089848A5 publication Critical patent/JP2019089848A5/ja
Priority to JP2021078418A priority Critical patent/JP2021121601A/ja
Priority to JP2023136964A priority patent/JP2023164476A/ja
Pending legal-status Critical Current

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JP2019041615A 2013-03-15 2019-03-07 ラパマイシン誘導体の精製 Pending JP2019089848A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021078418A JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361799857P 2013-03-15 2013-03-15
US61/799,857 2013-03-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016503426A Division JP2016519086A (ja) 2013-03-15 2014-03-17 ラパマイシン誘導体の精製

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021078418A Division JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製

Publications (2)

Publication Number Publication Date
JP2019089848A JP2019089848A (ja) 2019-06-13
JP2019089848A5 true JP2019089848A5 (https=) 2019-08-29

Family

ID=51538094

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016503426A Withdrawn JP2016519086A (ja) 2013-03-15 2014-03-17 ラパマイシン誘導体の精製
JP2019041615A Pending JP2019089848A (ja) 2013-03-15 2019-03-07 ラパマイシン誘導体の精製
JP2021078418A Pending JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A Pending JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016503426A Withdrawn JP2016519086A (ja) 2013-03-15 2014-03-17 ラパマイシン誘導体の精製

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021078418A Pending JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A Pending JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Country Status (8)

Country Link
US (5) US9598439B2 (https=)
EP (1) EP2972258B1 (https=)
JP (4) JP2016519086A (https=)
CN (2) CN105102967B (https=)
CA (1) CA2901162C (https=)
ES (1) ES2897473T3 (https=)
SG (3) SG10202112135VA (https=)
WO (1) WO2014145780A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8715150B2 (en) 2009-11-02 2014-05-06 Pulse Therapeutics, Inc. Devices for controlling magnetic nanoparticles to treat fluid obstructions
WO2014145780A1 (en) 2013-03-15 2014-09-18 Biosensors International Group, Ltd. Purification of rapamycin derivatives
CN109851626B (zh) * 2019-01-08 2021-11-02 扬子江药业集团四川海蓉药业有限公司 一种替西罗莫司的分离纯化方法
CN116102576B (zh) * 2021-11-09 2025-08-29 上海博畅医疗科技有限公司 一种优美莫司晶体的制造方法及其应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US20060198867A1 (en) * 1997-09-25 2006-09-07 Abbott Laboratories, Inc. Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
WO2004089958A2 (en) * 2003-03-31 2004-10-21 TEVA Gyógyszergyár Részvénytársaság Crystallization and purification of macrolides
US7220755B2 (en) * 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
EP1697383B1 (en) * 2003-12-05 2014-04-23 Biocon Limited Process for the purification of tacrolimus
JP4716280B2 (ja) * 2004-03-01 2011-07-06 テルモ株式会社 Ｏ−アルキル化ラパマイシン誘導体の製造法
JP4224115B2 (ja) * 2004-04-14 2009-02-12 ワイス ラパマイシン４２−エステル誘導体の位置特異的合成
CA2584430A1 (en) 2004-12-01 2006-06-08 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods for preparing pimecrolimus
RU2007130406A (ru) * 2005-03-02 2009-04-10 Вайет (Us) Очистка рапамицина
US20060222627A1 (en) * 2005-03-30 2006-10-05 Andrew Carter Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue
WO2007067566A2 (en) * 2005-12-07 2007-06-14 Wyeth Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
US7700614B2 (en) * 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
CN101394867A (zh) 2006-03-07 2009-03-25 惠氏公司 大环内酯类免疫抑制剂的水溶性聚乙二醇结合物的制备方法
US7812032B2 (en) * 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
US7820812B2 (en) * 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
US20100029933A1 (en) * 2006-11-10 2010-02-04 Biocon Limited Pure form of rapamycin and a process for recovery and purification thereof
EP2090580B1 (en) 2006-11-27 2014-06-04 Terumo Kabushiki Kaisha Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
US20080287675A1 (en) * 2007-05-18 2008-11-20 Abbott Laboratories Cascade system
CN101077334A (zh) * 2007-06-29 2007-11-28 济南康泉医药科技有限公司 含酪氨酸激酶抑制剂的抗癌组合物
TW200948361A (en) 2008-05-26 2009-12-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Method for synthesizing Biolimus A9 and the like and method for improving stability of the same
US20100055145A1 (en) * 2008-08-29 2010-03-04 Biosensors International Group Stent coatings for reducing late stent thrombosis
WO2010124098A2 (en) 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of drug polymorphs to achieve controlled drug delivery from a coated medical device
CN102464669B (zh) * 2010-11-17 2014-04-16 浙江海正药业股份有限公司 无定形依维莫司及其制备方法
US8669360B2 (en) * 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN102786534A (zh) * 2012-05-25 2012-11-21 上海现代制药股份有限公司 一种依维莫司的制备方法
WO2014145780A1 (en) 2013-03-15 2014-09-18 Biosensors International Group, Ltd. Purification of rapamycin derivatives

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