JP2019089848A5 - - Google Patents

Download PDF

Info

Publication number
JP2019089848A5
JP2019089848A5 JP2019041615A JP2019041615A JP2019089848A5 JP 2019089848 A5 JP2019089848 A5 JP 2019089848A5 JP 2019041615 A JP2019041615 A JP 2019041615A JP 2019041615 A JP2019041615 A JP 2019041615A JP 2019089848 A5 JP2019089848 A5 JP 2019089848A5
Authority
JP
Japan
Prior art keywords
compound
alkyl
medical device
group
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019041615A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019089848A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2019089848A publication Critical patent/JP2019089848A/ja
Publication of JP2019089848A5 publication Critical patent/JP2019089848A5/ja
Priority to JP2021078418A priority Critical patent/JP2021121601A/ja
Priority to JP2023136964A priority patent/JP2023164476A/ja
Pending legal-status Critical Current

Links

JP2019041615A 2013-03-15 2019-03-07 ラパマイシン誘導体の精製 Pending JP2019089848A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021078418A JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361799857P 2013-03-15 2013-03-15
US61/799,857 2013-03-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016503426A Division JP2016519086A (ja) 2013-03-15 2014-03-17 ラパマイシン誘導体の精製

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021078418A Division JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製

Publications (2)

Publication Number Publication Date
JP2019089848A JP2019089848A (ja) 2019-06-13
JP2019089848A5 true JP2019089848A5 (https=) 2019-08-29

Family

ID=51538094

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016503426A Withdrawn JP2016519086A (ja) 2013-03-15 2014-03-17 ラパマイシン誘導体の精製
JP2019041615A Pending JP2019089848A (ja) 2013-03-15 2019-03-07 ラパマイシン誘導体の精製
JP2021078418A Pending JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A Pending JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016503426A Withdrawn JP2016519086A (ja) 2013-03-15 2014-03-17 ラパマイシン誘導体の精製

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021078418A Pending JP2021121601A (ja) 2013-03-15 2021-05-06 ラパマイシン誘導体の精製
JP2023136964A Pending JP2023164476A (ja) 2013-03-15 2023-08-25 ラパマイシン誘導体の精製

Country Status (8)

Country Link
US (5) US9598439B2 (https=)
EP (1) EP2972258B1 (https=)
JP (4) JP2016519086A (https=)
CN (2) CN108864149B (https=)
CA (1) CA2901162C (https=)
ES (1) ES2897473T3 (https=)
SG (3) SG11201507406YA (https=)
WO (1) WO2014145780A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101616465B1 (ko) 2009-11-02 2016-04-28 펄스 테라퓨틱스, 인코포레이티드 기자성 스테이터 시스템 및 마그네틱 로터의 무선제어 방법
ES2897473T3 (es) 2013-03-15 2022-03-01 Biosensors Int Group Ltd Purificación de derivados de la rapamicina
CN109851626B (zh) * 2019-01-08 2021-11-02 扬子江药业集团四川海蓉药业有限公司 一种替西罗莫司的分离纯化方法
CN116102576B (zh) * 2021-11-09 2025-08-29 上海博畅医疗科技有限公司 一种优美莫司晶体的制造方法及其应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US20060198867A1 (en) * 1997-09-25 2006-09-07 Abbott Laboratories, Inc. Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
TR200500302T3 (tr) * 2003-03-31 2005-04-21 Biogal Gyogyszergyar Rt. Makrolidlerin kristalizasyonu ve saflaştırılması.
US7645876B2 (en) 2004-12-01 2010-01-12 TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság Processes for producing crystalline macrolides
US7220755B2 (en) * 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
RU2317991C1 (ru) * 2003-12-05 2008-02-27 Байокон Лимитид Способ выделения и очистки макролидов
JP4716280B2 (ja) * 2004-03-01 2011-07-06 テルモ株式会社 Ｏ−アルキル化ラパマイシン誘導体の製造法
JP4224115B2 (ja) * 2004-04-14 2009-02-12 ワイス ラパマイシン４２−エステル誘導体の位置特異的合成
JP2008531686A (ja) * 2005-03-02 2008-08-14 ワイス ラパマイシンの精製
US20060222627A1 (en) * 2005-03-30 2006-10-05 Andrew Carter Optimizing pharmacodynamics of therapeutic agents for treating vascular tissue
BRPI0619592A2 (pt) * 2005-12-07 2016-09-06 Wyeth Corp métodos para medir a qualidade da partícula de um composto de rapamicina, para determinar o tamanho de partícula médio de uma amostra e a cristalinidade de um composto de rapamicina, e para a purificação de rapamicina
US7700614B2 (en) * 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
GB0601406D0 (en) * 2006-01-24 2006-03-08 Novartis Ag Organic Compounds
MX2008011458A (es) 2006-03-07 2008-09-24 Wyeth Corp Procedimiento para preparar conjugados de polietilenglicol solubles en agua de inmunosupresores de macrolidos.
US7812032B2 (en) * 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
US7820812B2 (en) * 2006-07-25 2010-10-26 Abbott Laboratories Methods of manufacturing crystalline forms of rapamycin analogs
AU2006350684B2 (en) * 2006-11-10 2012-07-05 Biocon Limited A pure form of rapamycin and a process for recovery and purification thereof
WO2008065887A1 (en) * 2006-11-27 2008-06-05 Terumo Kabushiki Kaisha Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
US20080287675A1 (en) * 2007-05-18 2008-11-20 Abbott Laboratories Cascade system
CN101077334A (zh) * 2007-06-29 2007-11-28 济南康泉医药科技有限公司 含酪氨酸激酶抑制剂的抗癌组合物
TW200948361A (en) 2008-05-26 2009-12-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Method for synthesizing Biolimus A9 and the like and method for improving stability of the same
US20100055145A1 (en) * 2008-08-29 2010-03-04 Biosensors International Group Stent coatings for reducing late stent thrombosis
EP2421571A2 (en) 2009-04-24 2012-02-29 Boston Scientific Scimed, Inc. Use of drug polymorphs to achieve controlled drug delivery from a coated medical device
CN102464669B (zh) * 2010-11-17 2014-04-16 浙江海正药业股份有限公司 无定形依维莫司及其制备方法
WO2013022458A1 (en) 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) * 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN102786534A (zh) * 2012-05-25 2012-11-21 上海现代制药股份有限公司 一种依维莫司的制备方法
ES2897473T3 (es) 2013-03-15 2022-03-01 Biosensors Int Group Ltd Purificación de derivados de la rapamicina

Similar Documents

Publication Publication Date Title
JP2019089848A5 (https=)
JP2020514291A5 (https=)
RU2010101804A (ru) Частицы антагониста crth2
Fletcher et al. Synthesis of highly-functionalised pyridines via hetero-Diels–Alder methodology: reaction of 3-siloxy-1-aza-1, 3-butadienes with electron deficient acetylenes
CN112079805A (zh) 一种三氟甲基色酮类化合物的制备方法
WO2022111564A1 (zh) 一种吡啶衍生物的消旋方法及应用
CN114409549A (zh) 富勒烯衍生物材料及其制备方法及钙钛矿太阳能电池
WO2016016852A1 (en) Process for the purification of canagliflozin
CN105102967B (zh) 雷帕霉素衍生物的纯化
CN111848473B (zh) 一种芳烯基硫醚类化合物及其制备方法
Samai et al. Water–the best solvent for DMAP-mediated dual cyclization towards metal-free first synthesis of fully substituted phthalimides
US20190308935A1 (en) Photoinitators
Mądrzak-Litwa et al. Synthesis of isomeric dimers of deoxycholic acid derivatives linked by 1, 2, 3-triazole
CN112645937B (zh) 氮杂螺环、多环穿心莲内酯类化合物及其制备方法、药物组合物及其应用
Tamura et al. Syntheses and some properties of 4-acyl-1-methyl-2-azathiabenzene 1-oxides
JP2016534065A (ja) カバジタキセルの結晶性無水和物形態、その調製方法ならびにその医薬組成物
CN105693778B (zh) N-甲氧基甲酰胺导向合成二茂铁并吡啶酮衍生物的方法
Barton et al. The synthesis of 1-hydroxy-3-phenylsulphonylpiperidine-2-thione derivatives utilizing methylthiothiocarbonylation as the key original step
CN107721917B (zh) 一种多取代烟酸酯类化合物的绿色合成方法
CN115028505B (zh) 一种β,β-二(杂)芳基-α,α-二氟酮类化合物的制备方法
CN107200688B (zh) 亚甲基富勒烯的异构体选择性合成
Baraznenok et al. Synthesis of CF3-heterocycles based on 4-dimethylamino-1, 1, 1-trifluoro-3-buten-2-one
CN115583902B (zh) 一种炔基硫醚类化合物的制备方法
CN112159375B (zh) 一种2，3-二氢呋喃类化合物的绿色制备方法
JPH0480910B2 (https=)