JP2019070057A5 - - Google Patents
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- Publication number
- JP2019070057A5 JP2019070057A5 JP2019026534A JP2019026534A JP2019070057A5 JP 2019070057 A5 JP2019070057 A5 JP 2019070057A5 JP 2019026534 A JP2019026534 A JP 2019026534A JP 2019026534 A JP2019026534 A JP 2019026534A JP 2019070057 A5 JP2019070057 A5 JP 2019070057A5
- Authority
- JP
- Japan
- Prior art keywords
- endotherm
- imidazol
- methyl
- dihydroisochromeno
- oxobutan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000013078 crystal Substances 0.000 claims 2
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- -1 naphtho [1,2-d] imidazol-2-yl Chemical group 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462010919P | 2014-06-11 | 2014-06-11 | |
| US62/010,919 | 2014-06-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572253A Division JP2017517532A (ja) | 2014-06-11 | 2015-06-08 | 抗ウイルス化合物の固体形態 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019133593A Division JP2019172711A (ja) | 2014-06-11 | 2019-07-19 | 抗ウイルス化合物の固体形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019070057A JP2019070057A (ja) | 2019-05-09 |
| JP2019070057A5 true JP2019070057A5 (https=) | 2019-08-29 |
Family
ID=53443009
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572253A Withdrawn JP2017517532A (ja) | 2014-06-11 | 2015-06-08 | 抗ウイルス化合物の固体形態 |
| JP2019026534A Ceased JP2019070057A (ja) | 2014-06-11 | 2019-02-18 | 抗ウイルス化合物の固体形態 |
| JP2019133593A Pending JP2019172711A (ja) | 2014-06-11 | 2019-07-19 | 抗ウイルス化合物の固体形態 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572253A Withdrawn JP2017517532A (ja) | 2014-06-11 | 2015-06-08 | 抗ウイルス化合物の固体形態 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019133593A Pending JP2019172711A (ja) | 2014-06-11 | 2019-07-19 | 抗ウイルス化合物の固体形態 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9630972B2 (https=) |
| EP (3) | EP3822275A1 (https=) |
| JP (3) | JP2017517532A (https=) |
| KR (3) | KR20190007533A (https=) |
| CN (1) | CN106661042A (https=) |
| AR (1) | AR103194A1 (https=) |
| AU (2) | AU2015274961A1 (https=) |
| BR (1) | BR112016028843A2 (https=) |
| CA (1) | CA2951188C (https=) |
| EA (1) | EA201692220A1 (https=) |
| ES (1) | ES2785409T3 (https=) |
| IL (1) | IL249041A0 (https=) |
| MX (1) | MX2016016299A (https=) |
| PL (1) | PL3154983T3 (https=) |
| PT (1) | PT3154983T (https=) |
| SG (1) | SG11201609810YA (https=) |
| SI (1) | SI3154983T1 (https=) |
| TW (1) | TWI721947B (https=) |
| WO (1) | WO2015191431A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2345657A1 (en) | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| SI2640719T1 (sl) | 2010-11-17 | 2017-07-31 | Gilead Pharmasset Llc | Antivirusne spojine |
| JP6082749B2 (ja) | 2011-11-16 | 2017-02-15 | ギリアド ファーマセット エルエルシー | 抗ウイルス化合物としての縮合イミダゾリルイミダゾール |
| EA201690473A1 (ru) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Комбинированный состав двух противовирусных соединений |
| TW202014413A (zh) | 2014-06-11 | 2020-04-16 | 美商基利法瑪席特有限責任公司 | 製備抗病毒化合物之方法 |
| TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
| JOP20170127A1 (ar) | 2016-06-02 | 2017-12-02 | Gilead Pharmasset Llc | صيغة مشتركة مكونة من ثلاث مركبات مضادة للفيروسات |
| CN108368123B (zh) * | 2016-07-08 | 2021-02-19 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的咪唑基化合物及其药物组合物 |
| CN106432253B (zh) * | 2016-09-21 | 2019-06-14 | 上海众强药业有限公司 | 一种维帕他韦新晶型及其制备方法 |
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| US5858389A (en) | 1996-08-28 | 1999-01-12 | Shaker H. Elsherbini | Squalene is an antiviral compound for treating hepatitis C virus carriers |
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| JPWO2004089933A1 (ja) * | 2003-04-02 | 2006-07-06 | アステラス製薬株式会社 | フルオロベンズアミド誘導体の新規結晶 |
| KR101164070B1 (ko) | 2003-05-09 | 2012-07-12 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｃ형 간염 바이러스 ｎｓ5ｂ 폴리머라제 억제제 결합 포켓 |
| AR047541A1 (es) | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
| US7157492B2 (en) | 2004-02-26 | 2007-01-02 | Wyeth | Dibenzo chromene derivatives and their use as ERβ selective ligands |
| FR2875409B1 (fr) | 2004-09-17 | 2010-05-07 | Sanofi Aventis | Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose |
| EP1799685B1 (en) * | 2004-09-22 | 2012-03-28 | Pfizer Inc. | Polymorphic forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one |
| AU2007248282B2 (en) | 2006-05-05 | 2011-12-08 | Merck Patent Gmbh | Crystalline (3-cyano-1H-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate |
| US8891379B2 (en) | 2006-06-02 | 2014-11-18 | Riverbed Technology, Inc. | Traffic flow inference based on link loads and gravity measures |
| US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| JP2009286694A (ja) * | 2006-09-07 | 2009-12-10 | Eisai R & D Management Co Ltd | ５−［２−アミノ−４−（２−フリル）ピリミジン−５−イル］−１−メチルピリジン−２（１ｈ）−オンの塩およびそれらの結晶 |
| CA2823981C (en) | 2006-12-07 | 2016-05-17 | Daiichi Sankyo Company, Limited | Film-coated preparation having improved stability |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
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| ATE551337T1 (de) | 2008-02-12 | 2012-04-15 | Bristol Myers Squibb Co | Inhibitoren des hepatitis-c-virus |
| HRP20120706T1 (hr) | 2008-02-13 | 2012-09-30 | Bristol-Myers Squibb Company | Imidazolil bifenil imidazoli kao inhibitori virusa hepatitisa c |
| US7704992B2 (en) | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| CA2732777A1 (en) | 2008-08-07 | 2010-02-11 | Schering Corporation | Pharmaceutical formulations of an hcv protease inhibitor in a solid molecular dispersion |
| US20100256184A1 (en) | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US8729077B2 (en) | 2008-11-28 | 2014-05-20 | Glaxosmithkline Llc | Anti-viral compounds, compositions, and methods of use |
| SI2373172T1 (sl) | 2008-12-03 | 2013-12-31 | Presidio Pharmaceuticals, Inc. | Inhibitorji HCV NS5A |
| WO2010065668A1 (en) | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| WO2010096777A1 (en) | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| KR101411889B1 (ko) | 2009-02-27 | 2014-06-27 | 이난타 파마슈티칼스, 인코포레이티드 | Ｃ형 간염 바이러스 억제제 |
| WO2010111673A1 (en) | 2009-03-27 | 2010-09-30 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic hcv inhibitors |
| SG174883A1 (en) | 2009-03-27 | 2011-11-28 | Presidio Pharmaceuticals Inc | Fused ring inhibitors of hepatitis c |
| SG174929A1 (en) | 2009-03-27 | 2011-11-28 | Merck Sharp & Dohme | Inhibitors of hepatitis c virus replication |
| WO2010132538A1 (en) | 2009-05-12 | 2010-11-18 | Schering Corporation | Fused tricyclic aryl compounds useful for the treatment of viral diseases |
| PT3309157T (pt) | 2009-05-13 | 2019-12-02 | Gilead Pharmasset Llc | Compostos antivirais |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EA201290089A1 (ru) | 2009-09-04 | 2012-09-28 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Химические соединения |
| WO2011031904A1 (en) | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
| UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| JP2013512246A (ja) | 2009-11-25 | 2013-04-11 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス疾患治療に有用な縮合型三環式化合物およびその誘導体 |
| US8476225B2 (en) | 2009-12-04 | 2013-07-02 | Gilead Sciences, Inc. | Antiviral compounds |
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| US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
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| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
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| US9079887B2 (en) | 2012-05-16 | 2015-07-14 | Gilead Sciences, Inc. | Antiviral compounds |
| US20130309196A1 (en) | 2012-05-16 | 2013-11-21 | Gilead Sciences, Inc. | Antiviral compounds |
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| TW201434949A (zh) | 2013-01-31 | 2014-09-16 | Nitto Denko Corp | 環氧組合物及環氧樹脂成形體 |
| EA201690473A1 (ru) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Комбинированный состав двух противовирусных соединений |
| US20150064252A1 (en) | 2013-08-27 | 2015-03-05 | Gilead Pharmasset Llc | Solid dispersion formulation of an antiviral compound |
| TWI721947B (zh) * | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
| TW202014413A (zh) | 2014-06-11 | 2020-04-16 | 美商基利法瑪席特有限責任公司 | 製備抗病毒化合物之方法 |
| JP2016051146A (ja) | 2014-09-02 | 2016-04-11 | ウシオ電機株式会社 | 光検出装置 |
| EP3588013A1 (de) | 2018-06-26 | 2020-01-01 | XelectriX Power GmbH | Verfahren zur abgabe von elektrischer energie |
-
2015
- 2015-05-28 TW TW104117182A patent/TWI721947B/zh active
- 2015-06-08 EP EP20213940.8A patent/EP3822275A1/en not_active Withdrawn
- 2015-06-08 KR KR1020197001272A patent/KR20190007533A/ko not_active Ceased
- 2015-06-08 EA EA201692220A patent/EA201692220A1/ru unknown
- 2015-06-08 SG SG11201609810YA patent/SG11201609810YA/en unknown
- 2015-06-08 KR KR1020177000696A patent/KR20170015506A/ko not_active Ceased
- 2015-06-08 PT PT157306218T patent/PT3154983T/pt unknown
- 2015-06-08 US US14/733,101 patent/US9630972B2/en active Active
- 2015-06-08 WO PCT/US2015/034649 patent/WO2015191431A1/en not_active Ceased
- 2015-06-08 CN CN201580031460.3A patent/CN106661042A/zh active Pending
- 2015-06-08 KR KR1020207036803A patent/KR20200145852A/ko not_active Ceased
- 2015-06-08 AU AU2015274961A patent/AU2015274961A1/en not_active Abandoned
- 2015-06-08 MX MX2016016299A patent/MX2016016299A/es unknown
- 2015-06-08 PL PL15730621T patent/PL3154983T3/pl unknown
- 2015-06-08 CA CA2951188A patent/CA2951188C/en active Active
- 2015-06-08 EP EP15730621.8A patent/EP3154983B1/en active Active
- 2015-06-08 BR BR112016028843A patent/BR112016028843A2/pt not_active IP Right Cessation
- 2015-06-08 ES ES15730621T patent/ES2785409T3/es active Active
- 2015-06-08 EP EP20155444.1A patent/EP3666775A1/en not_active Withdrawn
- 2015-06-08 SI SI201531097T patent/SI3154983T1/sl unknown
- 2015-06-08 JP JP2016572253A patent/JP2017517532A/ja not_active Withdrawn
- 2015-06-10 AR ARP150101835A patent/AR103194A1/es unknown
-
2016
- 2016-11-17 IL IL249041A patent/IL249041A0/en unknown
-
2017
- 2017-03-15 US US15/459,785 patent/US9884873B2/en active Active
- 2017-12-18 US US15/845,837 patent/US10604530B2/en active Active
-
2018
- 2018-03-19 AU AU2018201948A patent/AU2018201948B2/en active Active
-
2019
- 2019-02-18 JP JP2019026534A patent/JP2019070057A/ja not_active Ceased
- 2019-07-19 JP JP2019133593A patent/JP2019172711A/ja active Pending
-
2020
- 2020-02-21 US US16/797,793 patent/US11203599B2/en active Active
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