JP2019070023A5 - - Google Patents
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- Publication number
- JP2019070023A5 JP2019070023A5 JP2019004688A JP2019004688A JP2019070023A5 JP 2019070023 A5 JP2019070023 A5 JP 2019070023A5 JP 2019004688 A JP2019004688 A JP 2019004688A JP 2019004688 A JP2019004688 A JP 2019004688A JP 2019070023 A5 JP2019070023 A5 JP 2019070023A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkoxy
- alkyl
- substituted
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 40
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 39
- 125000005843 halogen group Chemical group 0.000 claims 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims 24
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 18
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 17
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 13
- 125000005841 biaryl group Chemical class 0.000 claims 13
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 12
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 8
- 125000006766 (C2-C6) alkynyloxy group Chemical group 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- -1 pentafluorosulfanyl group Chemical group 0.000 claims 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 5
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 4
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 4
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015185966 | 2015-09-18 | ||
| JP2015185966 | 2015-09-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539924A Division JP6469238B2 (ja) | 2015-09-18 | 2016-09-14 | ビアリール誘導体及びそれを含有する医薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019070023A JP2019070023A (ja) | 2019-05-09 |
| JP2019070023A5 true JP2019070023A5 (enExample) | 2019-10-24 |
| JP6868650B2 JP6868650B2 (ja) | 2021-05-12 |
Family
ID=58289324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539924A Active JP6469238B2 (ja) | 2015-09-18 | 2016-09-14 | ビアリール誘導体及びそれを含有する医薬 |
| JP2019004688A Active JP6868650B2 (ja) | 2015-09-18 | 2019-01-15 | ビアリール誘導体及びそれを含有する医薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539924A Active JP6469238B2 (ja) | 2015-09-18 | 2016-09-14 | ビアリール誘導体及びそれを含有する医薬 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10647675B2 (enExample) |
| EP (1) | EP3351533B1 (enExample) |
| JP (2) | JP6469238B2 (enExample) |
| KR (1) | KR20180052635A (enExample) |
| CN (1) | CN108290838B (enExample) |
| AR (1) | AR106047A1 (enExample) |
| AU (1) | AU2016325143B2 (enExample) |
| BR (1) | BR112018004447A2 (enExample) |
| CA (1) | CA2997537C (enExample) |
| ES (1) | ES3039645T3 (enExample) |
| IL (1) | IL258160B (enExample) |
| MX (1) | MX381444B (enExample) |
| MY (1) | MY195201A (enExample) |
| PH (1) | PH12018500434A1 (enExample) |
| RU (1) | RU2760373C2 (enExample) |
| SG (1) | SG11201801856XA (enExample) |
| TW (1) | TWI730002B (enExample) |
| WO (1) | WO2017047602A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017047602A1 (ja) * | 2015-09-18 | 2017-03-23 | 科研製薬株式会社 | ビアリール誘導体及びそれを含有する医薬 |
| CN108727404B (zh) * | 2017-04-14 | 2020-05-12 | 中国科学院上海药物研究所 | 噻吩并[3,2-d]嘧啶类化合物、其制备方法及用途 |
| CA3081163A1 (en) | 2017-10-30 | 2019-05-09 | Kaken Pharmaceutical Co., Ltd. | External preparation for treating trichophytosis unguium |
| AU2019390907B2 (en) * | 2018-11-30 | 2025-05-08 | Otsuka Pharmaceutical Co., Ltd. | Heterocyclic compounds for the treatment of epilepsy |
| JP2021187859A (ja) * | 2020-05-29 | 2021-12-13 | 大塚製薬株式会社 | 複素環化合物の医薬用途 |
| BR112022024394A2 (pt) * | 2020-06-04 | 2023-01-31 | Bayer Ag | Heterociclil pirimidinas e triazinas como novos fungicidas |
| WO2023027162A1 (ja) * | 2021-08-27 | 2023-03-02 | 科研製薬株式会社 | ２－（４－エチルフェノキシ）－４'－メトキシ－３，３'－ビピリジンの結晶及びその製造方法 |
| WO2023146512A1 (en) * | 2022-01-25 | 2023-08-03 | Vivace Therapeutics, Inc. | Compounds and methods of use thereof |
| WO2023146511A1 (en) * | 2022-01-25 | 2023-08-03 | Vivace Therapeutics, Inc. | Compounds and methods of use thereof |
| WO2024129896A1 (en) * | 2022-12-14 | 2024-06-20 | The Regents Of The University Of California | Inhibitors of procaspase-6 activation and uses thereof |
| EP4634158A2 (en) * | 2022-12-14 | 2025-10-22 | The Regents of University of California | Inhibitors of procaspase-6 activation and uses thereof |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9505651D0 (en) * | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
| MX9708802A (es) * | 1995-05-17 | 1998-02-28 | Du Pont | Amidas ciclicas fungicidas. |
| AU2001285774A1 (en) | 2000-06-23 | 2002-01-02 | Basf Aktiengesellschaft | Enhancement of the activity of carotenoid biosynthesis inhibitor herbicides |
| DE10038019A1 (de) * | 2000-08-04 | 2002-02-14 | Bayer Ag | Substituierte Triazolopyrid(az)ine |
| AU2003274025A1 (en) * | 2002-10-17 | 2004-05-04 | Syngenta Participations Ag | Pyridine derivatives useful as herbicides |
| AU2003293376A1 (en) * | 2002-12-10 | 2004-06-30 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
| GB0305142D0 (en) | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
| WO2004078756A2 (en) | 2003-03-06 | 2004-09-16 | Eisai Co., Ltd. | Jnk inhibitors |
| WO2004080972A1 (en) | 2003-03-12 | 2004-09-23 | Vertex Pharmaceuticals Incorporated | Pirazole modulators of atp-binding cassette transporters |
| US7880000B2 (en) * | 2004-05-07 | 2011-02-01 | Amgen Inc. | Protein kinase modulators and method of use |
| ATE499370T1 (de) | 2005-01-19 | 2011-03-15 | Bristol Myers Squibb Co | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen |
| JP2008540656A (ja) | 2005-05-18 | 2008-11-20 | ワイス | Ｔｐｌ２キナーゼの３−シアノキノリン阻害物質ならびにそれを製造および使用する方法 |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| RU2380365C1 (ru) * | 2005-10-31 | 2010-01-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Гетероциклические замещенные производные пиримидина и содержащий их противогрибковый агент |
| CA2637658C (en) | 2006-01-23 | 2012-07-17 | Amgen Inc. | Aurora kinase modulators and method of use |
| US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
| MX2009003222A (es) | 2006-10-04 | 2009-04-06 | Hoffmann La Roche | Derivados de 3-piridinocarboxamida y 2-pirazinocarboxamida como agentes elevadores de colesterol de lipoproteina de alta densidad. |
| WO2008057280A1 (en) | 2006-10-27 | 2008-05-15 | Amgen Inc. | Multi-cyclic compounds and methods of use |
| WO2008135824A1 (en) | 2007-05-02 | 2008-11-13 | Pfizer Limited | Oxyalkylpyrazole compounds useful in therapy |
| CN101952275B (zh) | 2008-02-22 | 2014-06-18 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉样蛋白的调节剂 |
| TWI396689B (zh) * | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶１０抑制劑之吡衍生物 |
| AR074343A1 (es) | 2008-11-14 | 2011-01-12 | Amgen Inc | Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10 |
| ES2397934T3 (es) | 2008-12-17 | 2013-03-12 | Amgen Inc. | Compuestos de aminopiridina y carboxipiridina como inhibidores de fosfodiesterasa 10 |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| CA2771190C (en) | 2009-08-17 | 2020-01-21 | Memorial Sloan-Kettering Cancer Center | Heat shock protein binding compounds, compositions, and methods for making and using same |
| KR101301533B1 (ko) * | 2010-02-09 | 2013-09-04 | 한미사이언스 주식회사 | 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체 |
| CA2800998A1 (en) * | 2010-04-29 | 2011-11-10 | Deciphera Pharmaceuticals, Llc | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| WO2011161201A1 (en) | 2010-06-22 | 2011-12-29 | Kancera Ab | Bisarylsulfonamides useful as kinase inhibitors in the treatment of inflammation and cancer |
| US8906943B2 (en) | 2010-08-05 | 2014-12-09 | John R. Cashman | Synthetic compounds and methods to decrease nicotine self-administration |
| EP2630136A1 (en) | 2010-10-21 | 2013-08-28 | Universität des Saarlandes | Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases |
| JP5937102B2 (ja) | 2010-12-14 | 2016-06-22 | エレクトロフォレティクス リミテッド | カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤 |
| SG10201604682VA (en) | 2011-06-10 | 2016-07-28 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| PT2573073E (pt) | 2011-09-26 | 2015-02-05 | Sanofi Sa | Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica |
| US20140235616A1 (en) | 2011-09-26 | 2014-08-21 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
| JP5729889B2 (ja) | 2011-10-17 | 2015-06-03 | 日本曹達株式会社 | 含窒素ヘテロ環化合物および農園芸用殺菌剤 |
| TW201329067A (zh) | 2011-12-08 | 2013-07-16 | Amgen Inc | 作為ｇｋａ活化劑之脲化合物 |
| RU2592554C2 (ru) | 2011-12-14 | 2016-07-27 | Зингента Партисипейшнс Аг | Фунгицидные композиции |
| CN105230625A (zh) * | 2011-12-14 | 2016-01-13 | 先正达参股股份有限公司 | 杀真菌组合物 |
| CN104797555B (zh) | 2012-07-06 | 2017-12-22 | 基因泰克公司 | N‑取代的苯甲酰胺及其使用方法 |
| WO2013171729A2 (en) | 2013-01-08 | 2013-11-21 | Glenmark Pharmaceuticals S.A. | Aryl and heteroaryl amide compounds as rorgamat modulator |
| CA3082427A1 (en) | 2013-03-15 | 2014-09-25 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| JPWO2016098793A1 (ja) | 2014-12-17 | 2017-09-28 | 塩野義製薬株式会社 | 環状グアニジル基を有するチアゾール誘導体 |
| CN108026050B (zh) | 2015-08-03 | 2021-04-30 | 格兰马克药品股份有限公司 | 作为RORγ调节剂的新型化合物 |
| WO2017047602A1 (ja) * | 2015-09-18 | 2017-03-23 | 科研製薬株式会社 | ビアリール誘導体及びそれを含有する医薬 |
-
2016
- 2016-09-14 WO PCT/JP2016/077029 patent/WO2017047602A1/ja not_active Ceased
- 2016-09-14 MY MYPI2018700864A patent/MY195201A/en unknown
- 2016-09-14 RU RU2018114077A patent/RU2760373C2/ru active
- 2016-09-14 BR BR112018004447-4A patent/BR112018004447A2/pt not_active Application Discontinuation
- 2016-09-14 MX MX2018003318A patent/MX381444B/es unknown
- 2016-09-14 CA CA2997537A patent/CA2997537C/en active Active
- 2016-09-14 JP JP2017539924A patent/JP6469238B2/ja active Active
- 2016-09-14 AU AU2016325143A patent/AU2016325143B2/en not_active Ceased
- 2016-09-14 TW TW105129975A patent/TWI730002B/zh not_active IP Right Cessation
- 2016-09-14 SG SG11201801856XA patent/SG11201801856XA/en unknown
- 2016-09-14 CN CN201680054037.XA patent/CN108290838B/zh active Active
- 2016-09-14 EP EP16846473.3A patent/EP3351533B1/en active Active
- 2016-09-14 KR KR1020187007282A patent/KR20180052635A/ko not_active Ceased
- 2016-09-14 ES ES16846473T patent/ES3039645T3/es active Active
- 2016-09-14 US US15/759,125 patent/US10647675B2/en active Active
- 2016-09-16 AR ARP160102826A patent/AR106047A1/es unknown
-
2018
- 2018-02-28 PH PH12018500434A patent/PH12018500434A1/en unknown
- 2018-03-15 IL IL258160A patent/IL258160B/en unknown
-
2019
- 2019-01-15 JP JP2019004688A patent/JP6868650B2/ja active Active
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