JP2019023181A5 - - Google Patents

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JP2019023181A5
JP2019023181A5 JP2018119595A JP2018119595A JP2019023181A5 JP 2019023181 A5 JP2019023181 A5 JP 2019023181A5 JP 2018119595 A JP2018119595 A JP 2018119595A JP 2018119595 A JP2018119595 A JP 2018119595A JP 2019023181 A5 JP2019023181 A5 JP 2019023181A5
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formula
compound
enantiomeric excess
salt
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JP2018119595A
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JP6917949B2 (ja
JP2019023181A (ja
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Priority claimed from EP17178755.9A external-priority patent/EP3421455B1/en
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JP2018119595A 2017-06-29 2018-06-25 トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法 Active JP6917949B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17178755.9 2017-06-29
EP17178755.9A EP3421455B1 (en) 2017-06-29 2017-06-29 Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib

Publications (3)

Publication Number Publication Date
JP2019023181A JP2019023181A (ja) 2019-02-14
JP2019023181A5 true JP2019023181A5 (enExample) 2021-05-20
JP6917949B2 JP6917949B2 (ja) 2021-08-11

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JP2018119595A Active JP6917949B2 (ja) 2017-06-29 2018-06-25 トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法

Country Status (4)

Country Link
US (1) US20190002407A1 (enExample)
EP (1) EP3421455B1 (enExample)
JP (1) JP6917949B2 (enExample)
CN (1) CN109206361A (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109761884B (zh) * 2019-01-30 2020-03-31 湖北扬信医药科技有限公司 一种手性胺b的制备方法及其应用
KR102890724B1 (ko) * 2019-04-05 2025-11-25 주식회사유한양행 (3r,4r)-1-벤질-n,4-디메틸피페리딘-3-아민 또는 이의 염의 제조방법 및 이를 이용한 토파시티닙의 제조방법
CN113125587B (zh) * 2019-12-30 2022-05-24 成都百裕制药股份有限公司 一种托法替尼中间体及其对映异构体的检测方法
CN113899831B (zh) * 2021-10-11 2023-08-15 湖北科益药业股份有限公司 一种枸橼酸托法替布起始物料的液相色谱检测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258979B1 (en) * 1999-11-22 2001-07-10 Henri Kagan Chiral ferrocene phosphines active in asymmetric catalysis
RS20050380A (sr) * 2002-11-21 2007-11-15 Pfizer Products Inc., Derivati 3-aminopiperidina i postupci njihove proizvodnje
AU2005272033A1 (en) * 2004-07-08 2006-02-16 Merck & Co., Inc. Formation of tetra-substituted enamides and stereoselective reduction thereof
WO2007012953A2 (en) * 2005-07-29 2007-02-01 Pfizer Products Inc. Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis
PE20081849A1 (es) * 2007-01-04 2009-01-26 Prosidion Ltd Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr
AR070176A1 (es) * 2008-01-17 2010-03-17 Novartis Ag Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
CA2759026C (en) * 2009-04-20 2019-01-15 Auspex Pharmaceuticals, Inc. Piperidine inhibitors of janus kinase 3
US9085529B2 (en) * 2010-08-23 2015-07-21 Novartis Ag Process for the preparation of intermediates useful for the manufacture NEP inhibitors
IN2014DN00137A (enExample) * 2011-07-18 2015-05-22 Adolor Corp
US9126906B2 (en) * 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds
EP2956461A1 (en) * 2013-02-12 2015-12-23 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
WO2014195978A2 (en) 2013-06-05 2014-12-11 Msn Laboratories Limited PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS
DK3019476T3 (en) * 2013-07-08 2018-04-16 Syngenta Participations Ag 4-membered ring carboxamides used as nematicides
TW201617321A (zh) * 2014-09-18 2016-05-16 第一三共股份有限公司 光學活性吉草酸衍生物之製法
EP3078665A1 (en) * 2015-04-10 2016-10-12 OLON S.p.A. Efficient method for the preparation of tofacitinib citrate

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