JP6917949B2 - トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法 - Google Patents
トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法 Download PDFInfo
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- JP6917949B2 JP6917949B2 JP2018119595A JP2018119595A JP6917949B2 JP 6917949 B2 JP6917949 B2 JP 6917949B2 JP 2018119595 A JP2018119595 A JP 2018119595A JP 2018119595 A JP2018119595 A JP 2018119595A JP 6917949 B2 JP6917949 B2 JP 6917949B2
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- PECKJJLXPJQABJ-UHFFFAOYSA-N CC(CCN(Cc1ccccc1)C1)C1NC(OC)=O Chemical compound CC(CCN(Cc1ccccc1)C1)C1NC(OC)=O PECKJJLXPJQABJ-UHFFFAOYSA-N 0.000 description 3
- NVKDDQBZODSEIN-UHFFFAOYSA-N CC(CCN(Cc1ccccc1)C1)C1NC Chemical compound CC(CCN(Cc1ccccc1)C1)C1NC NVKDDQBZODSEIN-UHFFFAOYSA-N 0.000 description 2
- FZTYHUQYOISLBQ-UHFFFAOYSA-N CC(CCN(Cc1ccccc1)C1)=C1NC(OC)=O Chemical compound CC(CCN(Cc1ccccc1)C1)=C1NC(OC)=O FZTYHUQYOISLBQ-UHFFFAOYSA-N 0.000 description 1
- PECKJJLXPJQABJ-OCCSQVGLSA-N C[C@H](CCN(Cc1ccccc1)C1)[C@H]1NC(OC)=O Chemical compound C[C@H](CCN(Cc1ccccc1)C1)[C@H]1NC(OC)=O PECKJJLXPJQABJ-OCCSQVGLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2291—Olefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/822—Rhodium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/84—Metals of the iron group
- B01J2531/842—Iron
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17178755.9 | 2017-06-29 | ||
| EP17178755.9A EP3421455B1 (en) | 2017-06-29 | 2017-06-29 | Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019023181A JP2019023181A (ja) | 2019-02-14 |
| JP2019023181A5 JP2019023181A5 (enExample) | 2021-05-20 |
| JP6917949B2 true JP6917949B2 (ja) | 2021-08-11 |
Family
ID=59258098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018119595A Active JP6917949B2 (ja) | 2017-06-29 | 2018-06-25 | トファシチニブの調製のための有用な中間体であるキラル３−アミノ−ピペリジンの調製のための改良された方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20190002407A1 (enExample) |
| EP (1) | EP3421455B1 (enExample) |
| JP (1) | JP6917949B2 (enExample) |
| CN (1) | CN109206361A (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109761884B (zh) * | 2019-01-30 | 2020-03-31 | 湖北扬信医药科技有限公司 | 一种手性胺b的制备方法及其应用 |
| WO2020204647A1 (en) * | 2019-04-05 | 2020-10-08 | Yuhan Corporation | Processes for preparing (3r,4r)-1-benzyl-n,4-dimethylpiperidin-3-amine or a salt thereof and processes for preparing tofacitinib using the same |
| CN113125587B (zh) * | 2019-12-30 | 2022-05-24 | 成都百裕制药股份有限公司 | 一种托法替尼中间体及其对映异构体的检测方法 |
| CN113899831B (zh) * | 2021-10-11 | 2023-08-15 | 湖北科益药业股份有限公司 | 一种枸橼酸托法替布起始物料的液相色谱检测方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258979B1 (en) * | 1999-11-22 | 2001-07-10 | Henri Kagan | Chiral ferrocene phosphines active in asymmetric catalysis |
| EP1572649A2 (en) * | 2002-11-21 | 2005-09-14 | Pfizer Products Inc. | 3-amino-piperidine derivatives and processes for their preparation |
| CN1984877A (zh) * | 2004-07-08 | 2007-06-20 | 默克公司 | 四取代的烯酰胺的形成及其立体选择性还原 |
| MX2008001334A (es) * | 2005-07-29 | 2008-03-24 | Pfizer Prod Inc | Derivados de pirrolo [2,3-d]pirimidina, sus intermedios y sintesis. |
| CL2008000017A1 (es) * | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
| AR070176A1 (es) * | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
| CN102459270B (zh) * | 2009-04-20 | 2015-04-29 | 奥斯拜客斯制药有限公司 | Janus激酶3的哌啶抑制剂 |
| ES2608780T3 (es) * | 2010-08-23 | 2017-04-17 | Novartis Ag | Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP |
| AU2012284127A1 (en) * | 2011-07-18 | 2013-05-02 | Adolor Corporation | Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto |
| US9126906B2 (en) * | 2012-02-21 | 2015-09-08 | Celgene Corporation | Asymmetric synthetic processes for the preparation of aminosulfone compounds |
| CA2900595A1 (en) * | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| WO2014195978A2 (en) | 2013-06-05 | 2014-12-11 | Msn Laboratories Limited | PROCESS FOR THE PREPARATION OF (3R,4R)-4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL-AMINO)-ß-OXO-1-PIPERIDINEPROPANENITRILE AND ITS SALTS |
| AU2014289431B2 (en) * | 2013-07-08 | 2018-01-18 | Syngenta Crop Protection Ag | 4-membered ring carboxamides used as nematicides |
| TW201617321A (zh) * | 2014-09-18 | 2016-05-16 | 第一三共股份有限公司 | 光學活性吉草酸衍生物之製法 |
| EP3078665A1 (en) * | 2015-04-10 | 2016-10-12 | OLON S.p.A. | Efficient method for the preparation of tofacitinib citrate |
-
2017
- 2017-06-29 EP EP17178755.9A patent/EP3421455B1/en active Active
-
2018
- 2018-06-05 CN CN201810568925.4A patent/CN109206361A/zh active Pending
- 2018-06-25 JP JP2018119595A patent/JP6917949B2/ja active Active
- 2018-06-25 US US16/017,390 patent/US20190002407A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3421455A1 (en) | 2019-01-02 |
| CN109206361A (zh) | 2019-01-15 |
| US20190002407A1 (en) | 2019-01-03 |
| EP3421455B1 (en) | 2019-03-27 |
| JP2019023181A (ja) | 2019-02-14 |
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