JP2018536641A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018536641A5 JP2018536641A5 JP2018520090A JP2018520090A JP2018536641A5 JP 2018536641 A5 JP2018536641 A5 JP 2018536641A5 JP 2018520090 A JP2018520090 A JP 2018520090A JP 2018520090 A JP2018520090 A JP 2018520090A JP 2018536641 A5 JP2018536641 A5 JP 2018536641A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- optionally substituted
- formula
- iron
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 50
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 36
- 229910052757 nitrogen Inorganic materials 0.000 claims 19
- 229910052742 iron Inorganic materials 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 125000005842 heteroatoms Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 206010065973 Iron overload Diseases 0.000 claims 5
- 238000010521 absorption reaction Methods 0.000 claims 5
- 238000002648 combination therapy Methods 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 206010001897 Alzheimer's disease Diseases 0.000 claims 3
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 3
- 206010061536 Parkinson's disease Diseases 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 208000007502 Anemia Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- ZIUSSTSXXLLKKK-HWUZOJPISA-N Curcumin Natural products C1=C(O)C(OC)=CC(\C=C\C(\O)=C/C(=O)/C=C/C=2C=C(OC)C(O)=CC=2)=C1 ZIUSSTSXXLLKKK-HWUZOJPISA-N 0.000 claims 2
- 206010022979 Iron excess Diseases 0.000 claims 2
- 102100017041 SLC40A1 Human genes 0.000 claims 2
- 108091006892 SLC40A1 Proteins 0.000 claims 2
- 208000002903 Thalassemia Diseases 0.000 claims 2
- 201000006288 alpha thalassemia Diseases 0.000 claims 2
- 244000052616 bacterial pathogens Species 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000003793 myelodysplastic syndrome Diseases 0.000 claims 2
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- TZXKOCQBRNJULO-UHFFFAOYSA-N 1,2-Dimethyl-3-hydroxypyrid-4-one Chemical compound CC1=C(O)C(=O)C=CN1C TZXKOCQBRNJULO-UHFFFAOYSA-N 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N 3-hydroxy-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 229960004308 ACETYLCYSTEINE Drugs 0.000 claims 1
- 229960004676 ANTITHROMBOTIC AGENTS Drugs 0.000 claims 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 229940109262 Curcumin Drugs 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 229960001489 Deferasirox Drugs 0.000 claims 1
- FMSOAWSKCWYLBB-VBGLAJCLSA-N Deferasirox Chemical compound C1=CC(C(=O)O)=CC=C1N(N\C(N\1)=C\2C(C=CC=C/2)=O)C/1=C\1C(=O)C=CC=C/1 FMSOAWSKCWYLBB-VBGLAJCLSA-N 0.000 claims 1
- 229960000958 Deferoxamine Drugs 0.000 claims 1
- 229940052760 Dopamine agonists Drugs 0.000 claims 1
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 claims 1
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 206010018872 Haemochromatosis Diseases 0.000 claims 1
- 206010053215 Haemoglobin E disease Diseases 0.000 claims 1
- 208000007475 Hemolytic Anemia Diseases 0.000 claims 1
- 206010020718 Hyperplasia Diseases 0.000 claims 1
- 229960003444 IMMUNOSUPPRESSANTS Drugs 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 206010022983 Iron metabolism disease Diseases 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims 1
- 108009000578 Oxidative Stress Proteins 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 229960000329 Ribavirin Drugs 0.000 claims 1
- 208000007056 Sickle Cell Anemia Diseases 0.000 claims 1
- 206010043390 Thalassaemia alpha Diseases 0.000 claims 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N Tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 1
- 229960000707 Tobramycin Drugs 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 229960003165 Vancomycin Drugs 0.000 claims 1
- 108010059993 Vancomycin Proteins 0.000 claims 1
- 241000607265 Vibrio vulnificus Species 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003110 anti-inflammatory Effects 0.000 claims 1
- 230000000111 anti-oxidant Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 208000005980 beta-Thalassemia Diseases 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 239000003124 biologic agent Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229940000425 combination drugs Drugs 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- 229960003266 deferiprone Drugs 0.000 claims 1
- 208000006602 delta-Thalassemia Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 230000000925 erythroid Effects 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 201000002433 hemoglobin H disease Diseases 0.000 claims 1
- 102000018511 hepcidin family Human genes 0.000 claims 1
- 108060003558 hepcidin family Proteins 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 230000001861 immunosuppresant Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000000297 inotrophic Effects 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- 230000036542 oxidative stress Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000000069 prophylaxis Effects 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 1
- 230000000033 vasopressor Effects 0.000 claims 1
- 235000019195 vitamin supplement Nutrition 0.000 claims 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15191179 | 2015-10-23 | ||
EP15191179.9 | 2015-10-23 | ||
EP15191176 | 2015-10-23 | ||
EP15191176.5 | 2015-10-23 | ||
PCT/EP2016/075305 WO2017068089A2 (en) | 2015-10-23 | 2016-10-21 | Novel ferroportin inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2018536641A JP2018536641A (ja) | 2018-12-13 |
JP2018536641A5 true JP2018536641A5 (US07846941-20101207-C00217.png) | 2019-04-25 |
JP6810988B2 JP6810988B2 (ja) | 2021-01-13 |
Family
ID=57178421
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018520089A Active JP6710754B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
JP2018520090A Active JP6810988B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
JP2020091830A Active JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018520089A Active JP6710754B2 (ja) | 2015-10-23 | 2016-10-21 | 新規なフェロポーチン阻害剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020091830A Active JP6967112B2 (ja) | 2015-10-23 | 2020-05-27 | 新規なフェロポーチン阻害剤 |
Country Status (22)
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2968443T3 (pl) | 2013-03-15 | 2022-02-07 | Protagonist Therapeutics, Inc. | Analogi hepcydyny i ich zastosowania |
TWI722031B (zh) | 2015-10-23 | 2021-03-21 | 瑞士商威佛(國際)股份有限公司 | 新穎的膜鐵運輸蛋白(ferroportin)抑制劑 |
JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
CN108314687A (zh) * | 2017-12-27 | 2018-07-24 | 重庆文理学院 | 1,2-二氢苯并[4,5]咪唑并[1,2-a]吡嗪-3(4H)-酮衍生物的合成 |
EP3749345A4 (en) | 2018-02-08 | 2022-04-06 | Protagonist Therapeutics, Inc. | CONJUGATED HEPCIDIN MIMETICS |
US20210252106A1 (en) * | 2018-04-30 | 2021-08-19 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
EP3894416B1 (en) | 2018-12-13 | 2022-11-09 | Global Blood Therapeutics, Inc. | Ferroportin inhibitors and methods of use |
TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛(國際)股份有限公司 | 新穎的鐵螯合物 |
US20220273634A1 (en) * | 2019-07-19 | 2022-09-01 | Vifor (International) Ag | Ferroportin-Inhibitors For The Use In The Treatment Of Transfusion-Dependent Beta-Thalassemia (TDT) |
BR112022001063A2 (pt) * | 2019-07-19 | 2022-03-15 | Vifor Int Ag | Inibidores de ferroportina para o uso na prevenção e tratamento de lesões renais |
EP3782702A1 (en) * | 2019-08-21 | 2021-02-24 | AC BioScience SA | Compounds and use thereof for the treatment of infectious diseases and cancer |
EP4025592A4 (en) | 2019-09-03 | 2023-08-02 | Protagonist Therapeutics, Inc. | CONJUGATED HEPCIDIN MIMETICS |
CA3154524A1 (en) | 2019-10-22 | 2021-04-21 | Vania Manolova | Methods and compositions for treating sickle cell disease with a ferroportin inhibitor (vit-2763) |
AU2021243494A1 (en) | 2020-03-24 | 2022-08-25 | Vifor (International) Ag | Process for the production of ferroportin inhibitors |
GB202012969D0 (en) * | 2020-08-19 | 2020-09-30 | Univ Of Oxford | Inhibitor compounds |
EP4281072A1 (en) | 2021-01-20 | 2023-11-29 | Vifor (International) Ag | Ferroportin-inhibitors for the use in the treatment of myelodysplastic syndromes (mds) |
WO2022173818A1 (en) * | 2021-02-09 | 2022-08-18 | University Of Virginia Patent Foundation | Use of biliverdin reductase b inhibitors to allow malaria eradication in patients with g6pd deficiency |
TW202304896A (zh) | 2021-04-22 | 2023-02-01 | 瑞士商威佛(國際)股份有限公司 | 經修飾的膜鐵運輸蛋白(ferroportin)抑制劑 |
AU2022353058A1 (en) | 2021-09-21 | 2024-03-21 | Vifor (International) Ag | N-substituted ferroportin inhibitors |
WO2024083980A1 (en) | 2022-10-21 | 2024-04-25 | Vifor (International) Ag | Bicyclic ferroportin inhibitors |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB937879A (en) | 1959-12-24 | 1963-09-25 | Ciba Ltd | New pyrazole-carboxylic acid hydrazides |
MY129541A (en) | 1996-06-25 | 2007-04-30 | Novartis Ag | Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators |
US5922761A (en) | 1996-09-06 | 1999-07-13 | Medinox, Inc. | Methods for in vivo reduction of iron levels and compositions useful therefor |
AR009655A1 (es) | 1996-12-10 | 2000-04-26 | Novartis Ag | Una composicion parenteralmente inyectable, un metodo para su preparacion, metodos para el tratamiento de enfermedades, una modificacion decristal de 1-decansulfonato de desferrioxamina, su uso, un proceso para la produccion de dicha modificacion de cristal y una preparacion farmaceutica que |
EP0946587A2 (en) * | 1996-12-16 | 1999-10-06 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds |
CA2368026A1 (en) | 1999-03-22 | 2000-09-28 | Bi-Huang Hu | Oxazole and thiazole combinatorial libraries |
EP1072265A1 (en) | 1999-07-20 | 2001-01-31 | MEDIS S.r.l. Medical Infusion Systems | Use of plant polyphenols for treating iron overload |
EP1074254A3 (en) | 1999-07-20 | 2002-09-11 | MEDIS S.r.l. Medical Infusion Systems | Use of plant polyphenols with vitamines for treating iron overload |
KR20030029997A (ko) | 2000-09-15 | 2003-04-16 | 아노르메드 인코포레이티드 | 케모킨 수용체 결합 헤테로사이클릭 화합물 |
DE10063173A1 (de) * | 2000-12-18 | 2002-06-20 | Merck Patent Gmbh | Harnstoff- und Urethanderivate |
WO2003027068A2 (en) | 2001-09-24 | 2003-04-03 | Elan Pharmaceuticals, Inc. | Substituted amines for the treatment of neurological disorders |
US20030109548A1 (en) | 2001-11-09 | 2003-06-12 | Royt Paulette W. | Compositions and methods of treating iron excess |
US6933308B2 (en) | 2002-12-20 | 2005-08-23 | Bristol-Myers Squibb Company | Aminoalkyl thiazole derivatives as KCNQ modulators |
JP2006528157A (ja) | 2003-07-21 | 2006-12-14 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | アリールジカルボキシアミド |
WO2005014576A1 (ja) | 2003-08-12 | 2005-02-17 | Takeda Pharmaceutical Company Limited | イソキノリノン誘導体、その製造法および用途 |
DE10356409B4 (de) | 2003-11-28 | 2006-12-28 | Biofrontera Discovery Gmbh | Neues Arzneimittel Oxachelin und Derivate |
FR2870271B1 (fr) | 2004-05-11 | 2008-03-14 | Bruno Merand | Procede de construction d'une maison en bois et moyens pour la mise en oeuvre du procede. |
WO2006040646A1 (en) * | 2004-10-14 | 2006-04-20 | Pfizer, Inc. | Benzimidazole or indole amides as inhibitors of pin1 |
JP2008007405A (ja) | 2004-12-07 | 2008-01-17 | Takeda Chem Ind Ltd | カルボキサミド誘導体 |
JP5063366B2 (ja) * | 2005-02-16 | 2012-10-31 | ザ ジェネラル ホスピタル コーポレイション | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
WO2006116355A1 (en) * | 2005-04-22 | 2006-11-02 | Kalypsys, Inc. | Ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders |
US20090118200A1 (en) | 2005-05-23 | 2009-05-07 | Bergman Jeffrey M | Proline bis-amide orexin receptor antagonists |
CA2610172A1 (en) | 2005-06-08 | 2006-12-14 | Japan Tobacco Inc. | Heterocyclic compound |
EP1928865A1 (en) * | 2005-08-17 | 2008-06-11 | Schering Corporation | Novel high affinity thiophene-based and furan-based kinase ligands |
WO2007058346A1 (ja) | 2005-11-21 | 2007-05-24 | Shionogi & Co., Ltd. | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
EP1976835A2 (en) | 2006-01-13 | 2008-10-08 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
EP2132178B1 (en) * | 2006-12-20 | 2015-08-19 | Merck Sharp & Dohme Corp. | Jnk inhibitors |
CL2008000666A1 (es) | 2007-03-07 | 2008-06-13 | Xenon Pharmaceuticals Inc | Compuestos derivados de triciclos sustituidos, inhibidores del transportador de metales divalentes-1; y uso para tratar una enfermedad asociada con un trastorno del hierro. |
AR065785A1 (es) | 2007-03-19 | 2009-07-01 | Xenon Pharmaceuticals Inc | Compuestos biarilo y biheteroarilo de utilidad en el tratamiento de trastornos de hierro |
US20100093871A1 (en) | 2007-03-20 | 2010-04-15 | Meiji Seika Kaisha, Ltd. | Agent for prevention or treatment of iron overload disorders |
CL2008000793A1 (es) | 2007-03-23 | 2008-05-30 | Xenon Pharmaceuticals Inc | Compuestos derivados de dihidroindazol; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno del hierro. |
EP2133339A4 (en) * | 2007-03-28 | 2010-04-21 | Santen Pharmaceutical Co Ltd | NOVEL (2-AMINOPHENYL) PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE |
EP2068855A2 (en) | 2007-06-05 | 2009-06-17 | Xenon Pharmaceuticals Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
WO2009154739A2 (en) | 2008-06-17 | 2009-12-23 | Duke University | Smoothened receptor modulators |
EP2331518A1 (en) | 2008-08-22 | 2011-06-15 | Evotec AG | New bradykinin b1 antagonists |
AU2009296839A1 (en) | 2008-09-26 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Azaindazole compounds as CCR1 receptor antagonists |
RU2011123647A (ru) | 2008-11-10 | 2012-12-20 | Вертекс Фармасьютикалз Инкорпорейтед | Соединения, полезные в качестве ингибиторов atr киназы |
CN102282138A (zh) | 2008-11-19 | 2011-12-14 | 先灵公司 | 二酰基甘油酰基转移酶的抑制剂 |
AU2009334997A1 (en) | 2008-12-30 | 2011-08-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as Raf kinase inhibitors |
AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
TW201111379A (en) * | 2009-09-09 | 2011-04-01 | Vifor Int Ag | Novel thiazole-and oxazole-hepcidine-antagonists |
EP2776411B1 (en) | 2011-11-07 | 2019-06-26 | The University of Queensland | Modulators of c3a receptors |
AU2012327226C1 (en) | 2011-12-09 | 2017-03-02 | The Regents Of The University Of California | Modified mini-hepcidin peptides and methods of using thereof |
EP2620142A1 (en) | 2012-01-27 | 2013-07-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Hedgehog signaling pathway involved in energy metabolism |
AU2013235491A1 (en) | 2012-03-22 | 2014-09-11 | Nanotherapeutics, Inc. | Compositions and methods for oral delivery of encapsulated diethylenetriaminepentaacetate particles |
US9193723B2 (en) * | 2012-05-11 | 2015-11-24 | Abbvie Inc. | NAMPT inhibitors |
CN103508957B (zh) | 2012-06-25 | 2017-02-08 | 中国科学院上海药物研究所 | 羟乙基吡唑类化合物或氨乙基吡唑类化合物及其制备方法和用途 |
AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
US10441669B2 (en) | 2013-10-04 | 2019-10-15 | Illinois Institute Of Technology | Multifunctional chelators, complexes, and compositions thereof, and methods of using same |
WO2015069660A2 (en) | 2013-11-05 | 2015-05-14 | New York Blood Center, Inc. | Methods and compositions for increasing hepcidin expression using modified iron binding/releasing transferrin |
CA2930966A1 (en) | 2013-11-22 | 2015-05-28 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
TWI722031B (zh) * | 2015-10-23 | 2021-03-21 | 瑞士商威佛(國際)股份有限公司 | 新穎的膜鐵運輸蛋白(ferroportin)抑制劑 |
-
2016
- 2016-10-21 TW TW105134089A patent/TWI722031B/zh active
- 2016-10-21 CN CN201680061941.3A patent/CN108290878B/zh active Active
- 2016-10-21 EP EP16797462.5A patent/EP3365339A1/en active Pending
- 2016-10-21 WO PCT/EP2016/075305 patent/WO2017068089A2/en active Application Filing
- 2016-10-21 NZ NZ740675A patent/NZ740675A/en unknown
- 2016-10-21 BR BR112018007977-4A patent/BR112018007977B1/pt active IP Right Grant
- 2016-10-21 UA UAA201805740A patent/UA123219C2/uk unknown
- 2016-10-21 EP EP16784510.6A patent/EP3364967A2/en active Pending
- 2016-10-21 KR KR1020187011524A patent/KR102352829B1/ko active IP Right Grant
- 2016-10-21 SG SG10202005377VA patent/SG10202005377VA/en unknown
- 2016-10-21 AU AU2016342310A patent/AU2016342310B2/en active Active
- 2016-10-21 SG SG11201802480YA patent/SG11201802480YA/en unknown
- 2016-10-21 SG SG11201802665VA patent/SG11201802665VA/en unknown
- 2016-10-21 JP JP2018520089A patent/JP6710754B2/ja active Active
- 2016-10-21 AU AU2016342309A patent/AU2016342309B2/en active Active
- 2016-10-21 CA CA3002418A patent/CA3002418C/en active Active
- 2016-10-21 CO CONC2018/0004165A patent/CO2018004165A2/es unknown
- 2016-10-21 MA MA044474A patent/MA44474A/fr unknown
- 2016-10-21 US US15/768,025 patent/US10738041B2/en active Active
- 2016-10-21 CN CN202210353448.6A patent/CN114668761A/zh active Pending
- 2016-10-21 JP JP2018520090A patent/JP6810988B2/ja active Active
- 2016-10-21 MX MX2018004882A patent/MX2018004882A/es unknown
- 2016-10-21 WO PCT/EP2016/075306 patent/WO2017068090A1/en active Application Filing
- 2016-10-21 US US15/769,148 patent/US10364239B2/en active Active
- 2016-10-21 PE PE2018000572A patent/PE20181496A1/es unknown
- 2016-10-21 CA CA3002416A patent/CA3002416C/en active Active
- 2016-10-23 JO JOP/2016/0229A patent/JO3780B1/ar active
-
2018
- 2018-03-15 IL IL258159A patent/IL258159B/en unknown
- 2018-03-15 IL IL258158A patent/IL258158B2/en unknown
- 2018-04-06 PH PH12018500769A patent/PH12018500769A1/en unknown
- 2018-04-20 MX MX2021015106A patent/MX2021015106A/es unknown
- 2018-04-20 CL CL2018001031A patent/CL2018001031A1/es unknown
- 2018-09-14 HK HK18111856.0A patent/HK1252543A1/zh unknown
-
2019
- 2019-06-12 US US16/438,596 patent/US11001579B2/en active Active
-
2020
- 2020-05-27 JP JP2020091830A patent/JP6967112B2/ja active Active
- 2020-11-24 AU AU2020277121A patent/AU2020277121C1/en active Active
- 2020-12-03 US US17/110,465 patent/US11066399B2/en active Active
-
2021
- 2021-06-07 US US17/340,692 patent/US20220363675A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2018536641A5 (US07846941-20101207-C00217.png) | ||
JP2018535203A5 (US07846941-20101207-C00217.png) | ||
JP6777638B2 (ja) | ベンゾ複素環化合物および薬剤 | |
IL258158B2 (en) | Compounds for the use of profortin in the prevention and/or treatment of iron metabolism disorders | |
AU2014251087B2 (en) | Formulations of oxabicycloheptanes and oxabicycloheptenes | |
DK2799070T3 (en) | EFFECTIVE AMPLIFIER FOR ANTITUMUM AGENTS | |
JP2019506430A5 (US07846941-20101207-C00217.png) | ||
JP2018535244A (ja) | 関節疾患及び皮膚疾患の治療のためのラパマイシンとメトホルミンの併用 | |
CA2443950A1 (en) | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas | |
JP2004531517A5 (US07846941-20101207-C00217.png) | ||
KR20080004495A (ko) | 암을 치료하기 위한 조합물, 방법 및 조성물 | |
JP2017537886A5 (US07846941-20101207-C00217.png) | ||
JP2019521988A5 (US07846941-20101207-C00217.png) | ||
RU2019100164A (ru) | Гетероциклическое соединение, используемое как ингибитор fgfr | |
RU2011133128A (ru) | Противоопухолевые соединения дигидропиран-2-она | |
JP2022116304A (ja) | 血液がんの治療のためのPPARγアゴニスト | |
EP3171870A1 (en) | Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes | |
MX2014002663A (es) | Nuevo esquema de administracion de la n-hidroxi-4-{2-[3-(n,n-dimet ilaminometil)benzofuran-2-ilcarbonilamino]etoxi}benzamida. | |
RU2015140611A (ru) | Коньюгат бензофуранона и индола или азаиндола, его получение и применения | |
KR20160005356A (ko) | 방사선완화 약제학적 제형 | |
PH12021550878A1 (en) | Cyclodextrin-based formulation of a bcl-2 inhibitor | |
RU2013136861A (ru) | Новое производное индола или индазола или его соль | |
RU2013112003A (ru) | Противоопухолевые соединения | |
Souza et al. | Design, synthesis and biological activities of isatin derivatives | |
FR3056108A1 (fr) | Utilisation des harringtonines dans le traitement cancer du sein, notamment triple-negatif |