JP2018536405A5 - - Google Patents
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- JP2018536405A5 JP2018536405A5 JP2018524443A JP2018524443A JP2018536405A5 JP 2018536405 A5 JP2018536405 A5 JP 2018536405A5 JP 2018524443 A JP2018524443 A JP 2018524443A JP 2018524443 A JP2018524443 A JP 2018524443A JP 2018536405 A5 JP2018536405 A5 JP 2018536405A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- polynucleotide
- linker
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562254139P | 2015-11-11 | 2015-11-11 | |
| US62/254,139 | 2015-11-11 | ||
| PCT/US2016/061668 WO2017083750A1 (en) | 2015-11-11 | 2016-11-11 | Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536405A JP2018536405A (ja) | 2018-12-13 |
| JP2018536405A5 true JP2018536405A5 (https=) | 2019-12-19 |
| JP6976244B2 JP6976244B2 (ja) | 2021-12-08 |
Family
ID=57543150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524443A Expired - Fee Related JP6976244B2 (ja) | 2015-11-11 | 2016-11-11 | 心臓状態および他の病態の処置のための複数の生物学的に活性なポリペプチドを単一のベクターから発現させるための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11154622B2 (https=) |
| EP (1) | EP3387010A1 (https=) |
| JP (1) | JP6976244B2 (https=) |
| KR (1) | KR20180069081A (https=) |
| CN (1) | CN108713025A (https=) |
| AU (1) | AU2016353342B2 (https=) |
| BR (1) | BR112018009645A2 (https=) |
| CA (1) | CA3004742A1 (https=) |
| HK (1) | HK1259137A1 (https=) |
| MA (1) | MA43404A (https=) |
| MX (1) | MX2018005886A (https=) |
| RU (1) | RU2758489C2 (https=) |
| SG (1) | SG11201803934YA (https=) |
| WO (1) | WO2017083750A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3021572A1 (en) | 2016-04-20 | 2017-10-26 | Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas | Compositions and methods for enhanced gene expression of pklr |
| KR20190102259A (ko) | 2017-01-10 | 2019-09-03 | 인트렉손 코포레이션 | 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절 |
| KR102712841B1 (ko) * | 2017-09-29 | 2024-10-04 | (주)벳바젠 | 심부전의 예방 또는 치료용 약학적 조성물 |
| EP3697452A4 (en) | 2017-10-16 | 2021-11-24 | Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A., M.P. | LENTIVIRAL VECTORS FOR ADMINISTRATION OF PKLR TO TREAT PYRUVATE KINASE DEFECTS |
| WO2019173465A1 (en) | 2018-03-06 | 2019-09-12 | Intrexon Corporation | Human papillomavirus vaccines and uses of the same |
| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| BR112020020841A2 (pt) | 2018-04-11 | 2021-01-19 | Fundacion Para La Investigacion Biomedica Del Hospital Infantil Universitario Nino Jesus | Composições e métodos para transplante de célulastronco |
| CA3096293A1 (en) | 2018-04-27 | 2019-10-31 | Rocket Pharmaceuticals, Ltd. | Gene therapy for cns degeneration |
| US20210220463A1 (en) * | 2018-05-18 | 2021-07-22 | UNIVERSITé LAVAL | Vectors for dna vaccination |
| US12528848B2 (en) * | 2018-05-25 | 2026-01-20 | The Wistar Institute Of Anatomy And Biology | Tumor-specific neoantigens and methods of using the same |
| AU2019354391A1 (en) | 2018-10-01 | 2021-05-06 | Adicet Therapeutics, Inc. | Compositions and methods regarding engineered and non- engineered γδ-Τ cells for treatment of hematological tumors |
| CN113272016A (zh) | 2018-10-01 | 2021-08-17 | 阿迪塞特生物股份有限公司 | 关于治疗实体肿瘤的工程化和非工程化γδ-T细胞的组合物和方法 |
| IL286675B2 (en) * | 2019-03-29 | 2026-02-01 | Abiomed Inc | Systems and methods for left ventricular unloading in biological therapy or vector gene therapy |
| CN114450411A (zh) | 2019-04-01 | 2022-05-06 | 特纳亚治疗股份有限公司 | 具有工程化衣壳的腺相关病毒 |
| US20210290753A1 (en) * | 2019-05-21 | 2021-09-23 | UNIVERSITé LAVAL | Crimean-congo hemorrhagic fever virus immunogenic compositions |
| JP7717677B2 (ja) * | 2019-08-07 | 2025-08-04 | ノースウェスタン ユニバーシティ | 心臓内遺伝子送達のための材料及び方法 |
| KR20220066914A (ko) * | 2019-09-20 | 2022-05-24 | 유씨엘 비즈니스 리미티드 | 부정맥 유발성 우심실 심근병증의 유전자 요법 조성물 및 치료 |
| IL297391A (en) | 2020-04-20 | 2022-12-01 | Tenaya Therapeutics Inc | An adeno-associated virus with an engineered capsid |
| JP2023538519A (ja) | 2020-08-07 | 2023-09-08 | スペースクラフト セブン リミテッド ライアビリティ カンパニー | Ａａｖベクターを使用したプラコフィリン－２（ｐｋｐ２）遺伝子治療 |
| IL301675A (en) | 2020-10-09 | 2023-05-01 | Tenaya Therapeutics Inc | Methods and preparations for placophilin-2 gene therapy |
| US11781156B2 (en) * | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
| AU2022325237A1 (en) * | 2021-08-12 | 2024-03-21 | Renovacor, Inc. | Retrograde coronary venous or sinus administration of therapeutics |
| WO2023232984A1 (en) * | 2022-06-02 | 2023-12-07 | Patrick Most | S100a1 protein for use in treating and preventing infarct extension |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4985461A (en) | 1985-10-21 | 1991-01-15 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
| US5117057A (en) | 1985-10-21 | 1992-05-26 | Rohm And Haas Company | Insecticidal N' substituted-N-N'-disubstituted-hydrazines |
| US5225443A (en) | 1986-05-01 | 1993-07-06 | Rohm And Haas Company | Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| IL100643A (en) | 1991-01-25 | 1996-10-31 | Nippon Kayaku Kk | History of hydrazine and pesticides containing these histories as an active ingredient |
| US5530028A (en) | 1992-11-23 | 1996-06-25 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
| US6013836A (en) | 1992-02-28 | 2000-01-11 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-disubstitutedhydrazines |
| JP5031967B2 (ja) | 2000-03-22 | 2012-09-26 | イントレキソン コーポレーション | 新規エクジソン受容体ベースの誘導性遺伝子発現系 |
| US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
| US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
| ES2424812T3 (es) | 2001-02-20 | 2013-10-08 | Intrexon Corporation | Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso |
| CA2438133C (en) | 2001-02-20 | 2015-01-27 | Rheogene, Inc. | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| EP1373470B1 (en) | 2001-02-20 | 2013-04-24 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| WO2002066613A2 (en) | 2001-02-20 | 2002-08-29 | Rheogene Holdings, Inc | Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system |
| US20030027751A1 (en) * | 2001-04-10 | 2003-02-06 | Genvec, Inc. | VEGF fusion proteins |
| WO2003027289A1 (en) | 2001-09-26 | 2003-04-03 | Rheo Gene Holdings, Inc. | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
| CA2459807C (en) | 2001-09-26 | 2013-09-03 | Jianzhong Zhang | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
| US7375093B2 (en) | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| US7304162B2 (en) | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| US9034650B2 (en) | 2005-02-02 | 2015-05-19 | Intrexon Corporation | Site-specific serine recombinases and methods of their use |
| PL2043662T3 (pl) | 2006-07-26 | 2016-03-31 | Intrexon Corp | Sposoby i kompozycje do leczenia choroby |
| US7719424B2 (en) | 2007-01-19 | 2010-05-18 | Igt | Table monitoring identification system, wager tagging and felt coordinate mapping |
| CN104761466A (zh) | 2007-05-29 | 2015-07-08 | 英特拉克森公司 | 通过蜕皮素受体复合物调节外源性基因表达的手性二酰基肼配体 |
| KR101666228B1 (ko) * | 2007-09-28 | 2016-10-13 | 인트렉손 코포레이션 | 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도 |
| HUE035406T2 (en) | 2007-10-08 | 2018-05-02 | Intrexon Corp | Engineered dendritic cells and uses for the treatment of cancer |
| WO2009114702A2 (en) * | 2008-03-14 | 2009-09-17 | Humanzyme Limited | Recombinant production of authentic human proteins using human cell expression systems |
| CN102575227A (zh) | 2008-10-08 | 2012-07-11 | 英特瑞克斯顿股份有限公司 | 表达多种免疫调节剂的工程改造细胞及其应用 |
| CA2772610C (en) | 2009-08-28 | 2018-01-23 | The Cleveland Clinic Foundation | Sdf-1 delivery for treating ischemic tissue |
| CA2794196A1 (en) | 2010-03-23 | 2011-09-29 | Intrexon Corporation | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
| SG10201600912SA (en) | 2011-03-04 | 2016-03-30 | Intrexon Corp | Vectors conditionally expressing protein |
| AU2012394394A1 (en) * | 2012-11-16 | 2015-06-04 | United Biomedical, Inc. | Synthetic peptide-based emergency vaccine against foot and mouth disease (FMD) |
| WO2014089121A2 (en) * | 2012-12-03 | 2014-06-12 | Thomas Ichim | Retrograde delivery of cells and nucleic acids for treatment of cardiovascular diseases |
| CN105377268A (zh) | 2013-03-15 | 2016-03-02 | 克利夫兰临床医学基金会 | 用于治疗心肌梗塞的sdf-1的逆行递送 |
| WO2016187585A1 (en) | 2015-05-20 | 2016-11-24 | Viventia Bio Inc. | Deimmunized linker and methods of use |
| CN105754990A (zh) * | 2016-01-29 | 2016-07-13 | 深圳精准医疗科技有限公司 | 一种pd-1/ctla-4双特异性抗体的制备方法及其应用 |
-
2016
- 2016-11-11 WO PCT/US2016/061668 patent/WO2017083750A1/en not_active Ceased
- 2016-11-11 AU AU2016353342A patent/AU2016353342B2/en not_active Ceased
- 2016-11-11 JP JP2018524443A patent/JP6976244B2/ja not_active Expired - Fee Related
- 2016-11-11 RU RU2018117674A patent/RU2758489C2/ru active
- 2016-11-11 HK HK19101096.0A patent/HK1259137A1/zh unknown
- 2016-11-11 MA MA043404A patent/MA43404A/fr unknown
- 2016-11-11 CA CA3004742A patent/CA3004742A1/en active Pending
- 2016-11-11 CN CN201680078586.0A patent/CN108713025A/zh active Pending
- 2016-11-11 EP EP16810130.1A patent/EP3387010A1/en not_active Withdrawn
- 2016-11-11 MX MX2018005886A patent/MX2018005886A/es unknown
- 2016-11-11 BR BR112018009645A patent/BR112018009645A2/pt not_active IP Right Cessation
- 2016-11-11 SG SG11201803934YA patent/SG11201803934YA/en unknown
- 2016-11-11 KR KR1020187016185A patent/KR20180069081A/ko not_active Withdrawn
-
2018
- 2018-05-11 US US15/978,036 patent/US11154622B2/en not_active Expired - Fee Related
-
2021
- 2021-09-22 US US17/481,938 patent/US20220072159A1/en not_active Abandoned
-
2023
- 2023-10-12 US US18/485,838 patent/US20240148908A1/en not_active Abandoned
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