JP2018536405A5 - - Google Patents
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- JP2018536405A5 JP2018536405A5 JP2018524443A JP2018524443A JP2018536405A5 JP 2018536405 A5 JP2018536405 A5 JP 2018536405A5 JP 2018524443 A JP2018524443 A JP 2018524443A JP 2018524443 A JP2018524443 A JP 2018524443A JP 2018536405 A5 JP2018536405 A5 JP 2018536405A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- polynucleotide
- linker
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562254139P | 2015-11-11 | 2015-11-11 | |
| US62/254,139 | 2015-11-11 | ||
| PCT/US2016/061668 WO2017083750A1 (en) | 2015-11-11 | 2016-11-11 | Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536405A JP2018536405A (ja) | 2018-12-13 |
| JP2018536405A5 true JP2018536405A5 (https=) | 2019-12-19 |
| JP6976244B2 JP6976244B2 (ja) | 2021-12-08 |
Family
ID=57543150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524443A Expired - Fee Related JP6976244B2 (ja) | 2015-11-11 | 2016-11-11 | 心臓状態および他の病態の処置のための複数の生物学的に活性なポリペプチドを単一のベクターから発現させるための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11154622B2 (https=) |
| EP (1) | EP3387010A1 (https=) |
| JP (1) | JP6976244B2 (https=) |
| KR (1) | KR20180069081A (https=) |
| CN (1) | CN108713025A (https=) |
| AU (1) | AU2016353342B2 (https=) |
| BR (1) | BR112018009645A2 (https=) |
| CA (1) | CA3004742A1 (https=) |
| HK (1) | HK1259137A1 (https=) |
| MA (1) | MA43404A (https=) |
| MX (1) | MX2018005886A (https=) |
| RU (1) | RU2758489C2 (https=) |
| SG (1) | SG11201803934YA (https=) |
| WO (1) | WO2017083750A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE055862T2 (hu) | 2016-04-20 | 2021-12-28 | Centro De Investig Energeticas | Készítmények és eljárások PKLR fokozott génexpressziójára |
| EP3568474A1 (en) | 2017-01-10 | 2019-11-20 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
| CN111465697B (zh) * | 2017-09-29 | 2023-10-13 | 贝特基因 | 用于预防或治疗心力衰竭的药物组合物 |
| SG11202002263TA (en) | 2017-10-16 | 2020-04-29 | Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas | Lentiviral vectors for delivery of pklr to treat pyruvate kinase deficiency |
| KR20250136930A (ko) | 2018-03-06 | 2025-09-16 | 프레시전 인코포레이티드 | 사람 파필로마바이러스 백신 및 이의 용도 |
| IL277128B2 (en) | 2018-03-06 | 2025-11-01 | Precigen Inc | Hepatitis b vaccines and uses of the same |
| WO2019200167A1 (en) | 2018-04-11 | 2019-10-17 | Rocket Pharmaceuticals, Ltd. | Compositions and methods for stem cell transplant |
| MX2020011386A (es) | 2018-04-27 | 2021-01-29 | Spacecraft Seven Llc | Terapia genica para la degeneracion del snc. |
| CA3100070A1 (en) * | 2018-05-18 | 2019-11-21 | Universite Laval | Vectors for dna vaccination |
| WO2019227106A1 (en) * | 2018-05-25 | 2019-11-28 | The Wistar Institute | Tumor-specific neoantigens and methods of using the same |
| SG11202103234RA (en) | 2018-10-01 | 2021-04-29 | Adicet Bio Inc | COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED γδ -T CELLS FOR TREATMENT OF SOLID TUMORS |
| US20210388100A1 (en) | 2018-10-01 | 2021-12-16 | Adicet Bio, Inc. | Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of hematological tumors |
| JP7562559B2 (ja) * | 2019-03-29 | 2024-10-07 | アビオメド インコーポレイテッド | 生物学的療法またはベクター遺伝子療法における左心室の負荷を軽減するためのシステムおよび方法 |
| EP3947700A4 (en) | 2019-04-01 | 2023-01-04 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| CA3106735A1 (en) * | 2019-05-21 | 2020-11-26 | Universite Laval | Crimean-congo hemorrhagic fever virus immunogenic compositions |
| JP7717677B2 (ja) * | 2019-08-07 | 2025-08-04 | ノースウェスタン ユニバーシティ | 心臓内遺伝子送達のための材料及び方法 |
| TWI897882B (zh) * | 2019-09-20 | 2025-09-21 | 英商Ｕｃｌ商業有限責任公司 | 右心室心律失常性心肌病之基因療法組合物及治療 |
| US12552838B2 (en) | 2020-04-20 | 2026-02-17 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| KR20230043869A (ko) * | 2020-08-07 | 2023-03-31 | 스페이스크래프트 세븐, 엘엘씨 | Aav 벡터를 사용한 플라코필린-2(pkp2) 유전자 요법 |
| US11781156B2 (en) * | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
| BR112023006305A2 (pt) | 2020-10-09 | 2023-05-09 | Tenaya Therapeutics Inc | Métodos e composições de terapia gênica com placofilina-2 |
| AU2022325237A1 (en) * | 2021-08-12 | 2024-03-21 | Renovacor, Inc. | Retrograde coronary venous or sinus administration of therapeutics |
| AU2023281902A1 (en) * | 2022-06-02 | 2024-11-28 | Hugo A. Katus | S100a1 protein for use in treating and preventing infarct extension |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5117057A (en) | 1985-10-21 | 1992-05-26 | Rohm And Haas Company | Insecticidal N' substituted-N-N'-disubstituted-hydrazines |
| US4985461A (en) | 1985-10-21 | 1991-01-15 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
| US5225443A (en) | 1986-05-01 | 1993-07-06 | Rohm And Haas Company | Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| IL100643A (en) | 1991-01-25 | 1996-10-31 | Nippon Kayaku Kk | History of hydrazine and pesticides containing these histories as an active ingredient |
| US5530028A (en) | 1992-11-23 | 1996-06-25 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
| US6013836A (en) | 1992-02-28 | 2000-01-11 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-disubstitutedhydrazines |
| US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
| AU2001249315A1 (en) | 2000-03-22 | 2001-10-03 | Rheogene, Inc. | Ecdysone receptor-based inducible gene expression system |
| US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
| WO2002066614A2 (en) | 2001-02-20 | 2002-08-29 | Rheogene Holdings, Inc. | Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system |
| EP1534738B1 (en) | 2001-02-20 | 2012-06-20 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| EP1373470B1 (en) | 2001-02-20 | 2013-04-24 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| JP4955904B2 (ja) | 2001-02-20 | 2012-06-20 | イントレキソン コーポレーション | 新規エクジソン受容体／無脊椎動物レチノイドｘ受容体−ベースの誘導性遺伝子発現システム |
| US20030027751A1 (en) * | 2001-04-10 | 2003-02-06 | Genvec, Inc. | VEGF fusion proteins |
| MXPA04002810A (es) | 2001-09-26 | 2005-06-06 | Rheogene Holdings Inc | Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos. |
| US7919269B2 (en) | 2001-09-26 | 2011-04-05 | Intrexon Corporation | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
| US7375093B2 (en) | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| US7304162B2 (en) | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| US9034650B2 (en) | 2005-02-02 | 2015-05-19 | Intrexon Corporation | Site-specific serine recombinases and methods of their use |
| EP2043662B1 (en) | 2006-07-26 | 2015-09-09 | Intrexon Corporation | Methods and compositions for treating disease |
| US7719424B2 (en) | 2007-01-19 | 2010-05-18 | Igt | Table monitoring identification system, wager tagging and felt coordinate mapping |
| CA2689137C (en) | 2007-05-29 | 2017-05-02 | Intrexon Corporation | Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| MX2010003371A (es) | 2007-09-28 | 2010-05-05 | Intrexon Corp | Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos. |
| BRPI0818287A2 (pt) | 2007-10-08 | 2015-11-03 | Intrexon Corp | células dendríticas manipuladas e usos para o tratamento do câncer. |
| JP5634272B2 (ja) * | 2008-03-14 | 2014-12-03 | ヒューマンザイム リミテッド | ヒト細胞発現系を用いる真正ヒトタンパク質の組換え生産 |
| RU2573912C2 (ru) | 2008-10-08 | 2016-01-27 | Интрексон Корпорейшн | Сконструированные клетки, экспрессирующие множественные иммуномодуляторы, и их применения |
| WO2011026041A2 (en) | 2009-08-28 | 2011-03-03 | The Cleveland Clinic Foundation | Sdf-1 delivery for treating ischemic tissue |
| KR20130010121A (ko) | 2010-03-23 | 2013-01-25 | 인트렉손 코포레이션 | 치료적 단백질을 조건부로 발현하는 벡터，상기 벡터를 포함하는 숙주 세포 및 이의 용도 |
| JP6189754B2 (ja) | 2011-03-04 | 2017-08-30 | イントレキソン コーポレーション | タンパク質を条件的に発現するベクター |
| MX382968B (es) * | 2012-11-16 | 2025-03-12 | United Biomedical Inc | Vacuna de emergencia basada en péptidos sintéticos contra la fiebre aftosa. |
| WO2014089121A2 (en) * | 2012-12-03 | 2014-06-12 | Thomas Ichim | Retrograde delivery of cells and nucleic acids for treatment of cardiovascular diseases |
| EP2968608A4 (en) | 2013-03-15 | 2016-10-26 | Cleveland Clinic Foundation | RETROGRADE ADMINISTRATION OF SDF-1 FOR THE TREATMENT OF MYOCARDIAL INFARCTION |
| WO2016187585A1 (en) | 2015-05-20 | 2016-11-24 | Viventia Bio Inc. | Deimmunized linker and methods of use |
| CN105754990A (zh) * | 2016-01-29 | 2016-07-13 | 深圳精准医疗科技有限公司 | 一种pd-1/ctla-4双特异性抗体的制备方法及其应用 |
-
2016
- 2016-11-11 SG SG11201803934YA patent/SG11201803934YA/en unknown
- 2016-11-11 BR BR112018009645A patent/BR112018009645A2/pt not_active IP Right Cessation
- 2016-11-11 MA MA043404A patent/MA43404A/fr unknown
- 2016-11-11 EP EP16810130.1A patent/EP3387010A1/en not_active Withdrawn
- 2016-11-11 RU RU2018117674A patent/RU2758489C2/ru active
- 2016-11-11 CN CN201680078586.0A patent/CN108713025A/zh active Pending
- 2016-11-11 MX MX2018005886A patent/MX2018005886A/es unknown
- 2016-11-11 KR KR1020187016185A patent/KR20180069081A/ko not_active Withdrawn
- 2016-11-11 AU AU2016353342A patent/AU2016353342B2/en not_active Ceased
- 2016-11-11 JP JP2018524443A patent/JP6976244B2/ja not_active Expired - Fee Related
- 2016-11-11 HK HK19101096.0A patent/HK1259137A1/zh unknown
- 2016-11-11 WO PCT/US2016/061668 patent/WO2017083750A1/en not_active Ceased
- 2016-11-11 CA CA3004742A patent/CA3004742A1/en active Pending
-
2018
- 2018-05-11 US US15/978,036 patent/US11154622B2/en not_active Expired - Fee Related
-
2021
- 2021-09-22 US US17/481,938 patent/US20220072159A1/en not_active Abandoned
-
2023
- 2023-10-12 US US18/485,838 patent/US20240148908A1/en not_active Abandoned
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