CN108713025A - 用于治疗心脏病况和其他病理的从单个载体表达多种生物活性多肽的组合物和方法 - Google Patents

用于治疗心脏病况和其他病理的从单个载体表达多种生物活性多肽的组合物和方法 Download PDF

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Publication number
CN108713025A
CN108713025A CN201680078586.0A CN201680078586A CN108713025A CN 108713025 A CN108713025 A CN 108713025A CN 201680078586 A CN201680078586 A CN 201680078586A CN 108713025 A CN108713025 A CN 108713025A
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polypeptide
seq
sequence
polynucleotides
polypeptides
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CN201680078586.0A
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Chinese (zh)
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迪姆基·S·帕特尔
艾米特·N·帕特尔
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Precigen Inc
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Intrexon Corp
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1738—Calcium binding proteins, e.g. calmodulin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/007—Vectors comprising a special translation-regulating system cell or tissue specific

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201680078586.0A 2015-11-11 2016-11-11 用于治疗心脏病况和其他病理的从单个载体表达多种生物活性多肽的组合物和方法 Pending CN108713025A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254139P 2015-11-11 2015-11-11
US62/254,139 2015-11-11
PCT/US2016/061668 WO2017083750A1 (en) 2015-11-11 2016-11-11 Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies

Publications (1)

Publication Number Publication Date
CN108713025A true CN108713025A (zh) 2018-10-26

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US (3) US11154622B2 (https=)
EP (1) EP3387010A1 (https=)
JP (1) JP6976244B2 (https=)
KR (1) KR20180069081A (https=)
CN (1) CN108713025A (https=)
AU (1) AU2016353342B2 (https=)
BR (1) BR112018009645A2 (https=)
CA (1) CA3004742A1 (https=)
HK (1) HK1259137A1 (https=)
MA (1) MA43404A (https=)
MX (1) MX2018005886A (https=)
RU (1) RU2758489C2 (https=)
SG (1) SG11201803934YA (https=)
WO (1) WO2017083750A1 (https=)

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KR20180069081A (ko) 2018-06-22
MX2018005886A (es) 2018-08-15
RU2758489C2 (ru) 2021-10-28
WO2017083750A1 (en) 2017-05-18
JP6976244B2 (ja) 2021-12-08
US11154622B2 (en) 2021-10-26
US20240148908A1 (en) 2024-05-09
JP2018536405A (ja) 2018-12-13
MA43404A (fr) 2018-10-17
US20220072159A1 (en) 2022-03-10
EP3387010A1 (en) 2018-10-17
RU2018117674A (ru) 2019-12-13
US20180360992A1 (en) 2018-12-20
SG11201803934YA (en) 2018-06-28
AU2016353342A1 (en) 2018-05-24
RU2018117674A3 (https=) 2020-04-20
HK1259137A1 (zh) 2019-11-29
AU2016353342B2 (en) 2021-04-01
CA3004742A1 (en) 2017-05-18
BR112018009645A2 (pt) 2018-11-13

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