KR20180069081A - 심장 이상 및 기타 병리 이상의 치료를 위한 복수의 생물학적으로 활성화된 폴리펩티드를 단일 벡터로부터 발현하기 위한 조성물 및 방법 - Google Patents

심장 이상 및 기타 병리 이상의 치료를 위한 복수의 생물학적으로 활성화된 폴리펩티드를 단일 벡터로부터 발현하기 위한 조성물 및 방법 Download PDF

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KR20180069081A
KR20180069081A KR1020187016185A KR20187016185A KR20180069081A KR 20180069081 A KR20180069081 A KR 20180069081A KR 1020187016185 A KR1020187016185 A KR 1020187016185A KR 20187016185 A KR20187016185 A KR 20187016185A KR 20180069081 A KR20180069081 A KR 20180069081A
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polypeptide
seq
sequence
polynucleotide
linker
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딤키 에스. 파텔
아밋 엔. 파텔
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인트렉손 코포레이션
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2840/00—Vectors comprising a special translation-regulating system
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/007—Vectors comprising a special translation-regulating system cell or tissue specific

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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KR1020187016185A 2015-11-11 2016-11-11 심장 이상 및 기타 병리 이상의 치료를 위한 복수의 생물학적으로 활성화된 폴리펩티드를 단일 벡터로부터 발현하기 위한 조성물 및 방법 Withdrawn KR20180069081A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254139P 2015-11-11 2015-11-11
US62/254,139 2015-11-11
PCT/US2016/061668 WO2017083750A1 (en) 2015-11-11 2016-11-11 Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies

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Publication Number Publication Date
KR20180069081A true KR20180069081A (ko) 2018-06-22

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KR1020187016185A Withdrawn KR20180069081A (ko) 2015-11-11 2016-11-11 심장 이상 및 기타 병리 이상의 치료를 위한 복수의 생물학적으로 활성화된 폴리펩티드를 단일 벡터로부터 발현하기 위한 조성물 및 방법

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US (3) US11154622B2 (https=)
EP (1) EP3387010A1 (https=)
JP (1) JP6976244B2 (https=)
KR (1) KR20180069081A (https=)
CN (1) CN108713025A (https=)
AU (1) AU2016353342B2 (https=)
BR (1) BR112018009645A2 (https=)
CA (1) CA3004742A1 (https=)
HK (1) HK1259137A1 (https=)
MA (1) MA43404A (https=)
MX (1) MX2018005886A (https=)
RU (1) RU2758489C2 (https=)
SG (1) SG11201803934YA (https=)
WO (1) WO2017083750A1 (https=)

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WO2017083750A1 (en) 2017-05-18
CN108713025A (zh) 2018-10-26
JP6976244B2 (ja) 2021-12-08
HK1259137A1 (zh) 2019-11-29
US20240148908A1 (en) 2024-05-09
EP3387010A1 (en) 2018-10-17
RU2018117674A (ru) 2019-12-13
MX2018005886A (es) 2018-08-15
US11154622B2 (en) 2021-10-26
BR112018009645A2 (pt) 2018-11-13
AU2016353342A1 (en) 2018-05-24
US20220072159A1 (en) 2022-03-10
SG11201803934YA (en) 2018-06-28
MA43404A (fr) 2018-10-17
US20180360992A1 (en) 2018-12-20
RU2758489C2 (ru) 2021-10-28
RU2018117674A3 (https=) 2020-04-20
JP2018536405A (ja) 2018-12-13
CA3004742A1 (en) 2017-05-18
AU2016353342B2 (en) 2021-04-01

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